C Dobano

Summary

Country: Spain

Publications

  1. pmc Low antibodies against Plasmodium falciparum and imbalanced pro-inflammatory cytokines are associated with severe malaria in Mozambican children: a case-control study
    Eduard Rovira-Vallbona
    Barcelona Centre for International Health Research, CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Malar J 11:181. 2012
  2. pmc Immunoglobulins against the surface of Plasmodium falciparum-infected erythrocytes increase one month after delivery
    Alfredo Mayor
    Barcelona Centre for International Health Research, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Malar J 11:130. 2012
  3. pmc A direct comparison of real time PCR on plasma and blood to detect Plasmodium falciparum infection in children
    Abigail A Lamikanra
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, and National Health Service Blood and Transplant, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK
    Malar J 11:201. 2012
  4. pmc Intermittent preventive treatment with sulfadoxine-pyrimethamine does not modify plasma cytokines and chemokines or intracellular cytokine responses to Plasmodium falciparum in Mozambican children
    Diana Quelhas
    Centro de Investigação em Saúde da Manhiça, Manhiça, Mozambique
    BMC Immunol 13:5. 2012
  5. pmc Age-dependent IgG subclass responses to Plasmodium falciparum EBA-175 are differentially associated with incidence of malaria in Mozambican children
    Carlota Dobano
    Barcelona Centre for International Health Research, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Clin Vaccine Immunol 19:157-66. 2012
  6. pmc Comparison of commercial kits to measure cytokine responses to Plasmodium falciparum by multiplex microsphere suspension array technology
    Tamara K Berthoud
    Barcelona Centre for International Health Research, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Malar J 10:115. 2011
  7. ncbi request reprint Enhancement of antibody and cellular immune responses to malaria DNA vaccines by in vivo electroporation
    Carlota Dobano
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, United States
    Vaccine 25:6635-45. 2007
  8. ncbi request reprint Understanding protective immune mechanisms induced by malaria vaccines in the context of clinical trials
    Carlota Dobano
    Barcelona Centre for International Health Research CRESIB, Hospital Clinic IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Hum Vaccin 5:562-5. 2009
  9. doi request reprint Plasmodium: mammalian codon optimization of malaria plasmid DNA vaccines enhances antibody responses but not T cell responses nor protective immunity
    Carlota Dobano
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Exp Parasitol 122:112-23. 2009
  10. pmc Expression of merozoite surface protein markers by Plasmodium falciparum-infected erythrocytes in peripheral blood and tissues of children with fatal malaria
    Carlota Dobano
    Centre de Salut Internacional, Hospital Clinic IDIBAPS, Universitat de Barcelona, E 08036 Barcelona, Spain
    Infect Immun 75:643-52. 2007

Collaborators

Detail Information

Publications25

  1. pmc Low antibodies against Plasmodium falciparum and imbalanced pro-inflammatory cytokines are associated with severe malaria in Mozambican children: a case-control study
    Eduard Rovira-Vallbona
    Barcelona Centre for International Health Research, CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Malar J 11:181. 2012
    ..Altered antibody and cellular immunity against P. falciparum might contribute to increase the risk of developing SM...
  2. pmc Immunoglobulins against the surface of Plasmodium falciparum-infected erythrocytes increase one month after delivery
    Alfredo Mayor
    Barcelona Centre for International Health Research, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Malar J 11:130. 2012
    ..Immunological and physiological alterations associated with pregnancy that persist after delivery may contribute to the susceptibility to P. falciparum during early postpartum period...
  3. pmc A direct comparison of real time PCR on plasma and blood to detect Plasmodium falciparum infection in children
    Abigail A Lamikanra
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, and National Health Service Blood and Transplant, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK
    Malar J 11:201. 2012
    ..However the efficiencies of each method have not been compared using samples obtained from infants less than one year old...
  4. pmc Intermittent preventive treatment with sulfadoxine-pyrimethamine does not modify plasma cytokines and chemokines or intracellular cytokine responses to Plasmodium falciparum in Mozambican children
    Diana Quelhas
    Centro de Investigação em Saúde da Manhiça, Manhiça, Mozambique
    BMC Immunol 13:5. 2012
    ..Multiple cytokines and chemokines were quantified in plasma by luminex, and antigen-specific cytokine production in whole blood was determined by intracellular cytokine staining and flow cytometry, at ages 5, 9, 12 and 24 months...
  5. pmc Age-dependent IgG subclass responses to Plasmodium falciparum EBA-175 are differentially associated with incidence of malaria in Mozambican children
    Carlota Dobano
    Barcelona Centre for International Health Research, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Clin Vaccine Immunol 19:157-66. 2012
    ..Deeper understanding of the acquisition of antibodies against vaccine target antigens in early infancy is crucial for the rational development and deployment of malaria control tools in this vulnerable population...
  6. pmc Comparison of commercial kits to measure cytokine responses to Plasmodium falciparum by multiplex microsphere suspension array technology
    Tamara K Berthoud
    Barcelona Centre for International Health Research, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Malar J 10:115. 2011
    ..A series of comparison experiments were carried out to determine the most appropriate method for our subsequent studies...
  7. ncbi request reprint Enhancement of antibody and cellular immune responses to malaria DNA vaccines by in vivo electroporation
    Carlota Dobano
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, United States
    Vaccine 25:6635-45. 2007
    ..Moreover, IFN-gamma responses were increased by approximately 2-fold. Data demonstrate the potential of EP to enhance immune responses to DNA vaccines against infectious agents...
  8. ncbi request reprint Understanding protective immune mechanisms induced by malaria vaccines in the context of clinical trials
    Carlota Dobano
    Barcelona Centre for International Health Research CRESIB, Hospital Clinic IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Hum Vaccin 5:562-5. 2009
    ..The best strategy is to take advantage of large clinical trials in endemic countries to better understand immunity to malaria, vaccine take and identify surrogates of protection...
  9. doi request reprint Plasmodium: mammalian codon optimization of malaria plasmid DNA vaccines enhances antibody responses but not T cell responses nor protective immunity
    Carlota Dobano
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Exp Parasitol 122:112-23. 2009
    ..These data demonstrate that the effect of mammalian codon optimization is antigen-dependent and may not be beneficial for vaccines designed to induce T cell dependent protective immunity in this malaria model...
  10. pmc Expression of merozoite surface protein markers by Plasmodium falciparum-infected erythrocytes in peripheral blood and tissues of children with fatal malaria
    Carlota Dobano
    Centre de Salut Internacional, Hospital Clinic IDIBAPS, Universitat de Barcelona, E 08036 Barcelona, Spain
    Infect Immun 75:643-52. 2007
    ..These findings do not support the hypothesis that cerebral malaria is caused by cerebral sequestration of certain virulent types...
  11. ncbi request reprint Mutating the anchor residues associated with MHC binding inhibits and deviates CD8+ T cell mediated protective immunity against malaria
    C Dobano
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Mol Immunol 44:2235-48. 2007
    ....
  12. ncbi request reprint Identification of minimal CD8+ and CD4+ T cell epitopes in the Plasmodium yoelii hepatocyte erythrocyte protein 17kDa
    C Dobano
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Mol Immunol 44:3037-48. 2007
    ..The identification of these epitopes will allow the evaluation of delivery systems for malaria vaccine candidates as well as the delineation of protective immune mechanisms...
  13. ncbi request reprint Targeting antigen to MHC Class I and Class II antigen presentation pathways for malaria DNA vaccines
    Carlota Dobano
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, United States
    Immunol Lett 111:92-102. 2007
    ..Our data highlight the antigen dependence of immune enhancement strategies that target antigen to the MHC Class I and II pathways for vaccine development...
  14. doi request reprint Differential antibody responses to Plasmodium falciparum merozoite proteins in Malawian children with severe malaria
    Carlota Dobano
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland
    J Infect Dis 197:766-74. 2008
    ..005; for MSP-2, P< .05) or SMA (for MSP-1 and MSP-2, P<.001; for AMA-1, P< .005). These distinct IgG patterns might reflect differences in age, exposure to P. falciparum, and/or genetic factors affecting immune responses...
  15. ncbi request reprint Extended immunization intervals enhance the immunogenicity and protective efficacy of plasmid DNA vaccines
    Gary T Brice
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Microbes Infect 9:1439-46. 2007
    ..Our studies establish that the dosing interval significantly impacts the immunogenicity and protective efficacy of plasmid DNA vaccines...
  16. doi request reprint The effect of intermittent preventive treatment during pregnancy on malarial antibodies depends on HIV status and is not associated with poor delivery outcomes
    Elisa Serra-Casas
    Barcelona Centre for International Health Research, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    J Infect Dis 201:123-31. 2010
    ..However, studies reporting the effect of IPTp on malaria-specific immunity are scarce and are based on findings in human immunodeficiency virus (HIV)-negative primigravidae...
  17. pmc Transcriptionally active PCR for antigen identification and vaccine development: in vitro genome-wide screening and in vivo immunogenicity
    David P Regis
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, United States
    Mol Biochem Parasitol 158:32-45. 2008
    ..These data support the potential of a TAP approach for rapid high throughput functional screening and identification of potential candidate vaccine antigens from genomic sequence data...
  18. pmc Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data
    Denise L Doolan
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Proc Natl Acad Sci U S A 100:9952-7. 2003
    ..The data suggest that immune responses to Plasmodium are dispersed on a relatively large number of parasite antigens. These studies have implications for our understanding of immunodominance and breadth of responses to complex pathogens...
  19. pmc Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum
    D R Cavanagh
    Institute of Cell, Animal and Population Biology, Division of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, Scotland
    Infect Immun 69:1207-11. 2001
    ..The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity...
  20. pmc Parity and placental infection affect antibody responses against Plasmodium falciparum during pregnancy
    Alfredo Mayor
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Infect Immun 79:1654-9. 2011
    ..Results of this study show that parity and placental infection can modulate immune responses during pregnancy against malaria parasites...
  21. pmc Persistence of Plasmodium falciparum parasites in infected pregnant Mozambican women after delivery
    Elisa Serra-Casas
    Barcelona Centre for International Health Research, Hospital Clinic, Universitat de Barcelona, Rosselló 132, 08036 Barcelona, Spain
    Infect Immun 79:298-304. 2011
    ..Interventions that reduce malaria during pregnancy may translate into a lower risk of postpartum infection...
  22. pmc A randomized placebo-controlled trial of intermittent preventive treatment in pregnant women in the context of insecticide treated nets delivered through the antenatal clinic
    Clara Menendez
    Barcelona Center for International Health Research CRESIB and Department of Pathology Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 3:e1934. 2008
    ..Current recommendations to prevent malaria in African pregnant women rely on insecticide treated nets (ITNs) and intermittent preventive treatment (IPTp). However, there is no information on the safety and efficacy of their combined use...
  23. pmc An autopsy study of maternal mortality in Mozambique: the contribution of infectious diseases
    Clara Menendez
    Barcelona Center for International Health Research CRESIB and Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Spain
    PLoS Med 5:e44. 2008
    ..The aim of this study was to accurately describe the causes of maternal death in order to contribute to its reduction, in one of the regions of the world with the highest maternal mortality ratios...
  24. doi request reprint Molecular markers of resistance to sulfadoxine-pyrimethamine during intermittent preventive treatment for malaria in Mozambican infants
    Alfredo Mayor
    Centre de Recerca en Salut Internacional de Barcelona, Hospital Clínic Institut d Investigacions Biomèdicas August Pí i Sunyer, Universitat de Barcelona, Barcelona, Spain
    J Infect Dis 197:1737-42. 2008
    ..There is concern about the impact that increasing in vivo resistance to SP has on the efficacy of IPTi, as well as about the potential contribution of IPTi to increases in resistance...
  25. pmc Insights into long-lasting protection induced by RTS,S/AS02A malaria vaccine: further results from a phase IIb trial in Mozambican children
    Caterina Guinovart
    Barcelona Centre for International Health Research, Hospital Clinic IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 4:e5165. 2009
    ..We performed a new, exploratory analysis to explore differences in the duration of protection among participants to better understand the protection afforded by RTS,S...