Juan J Diez

Summary

Country: Spain

Publications

  1. ncbi request reprint Peritoneal dialysis in the comprehensive management of end-stage renal disease patients with liver cirrhosis and ascites: practical aspects and review of the literature
    Rafael Selgas
    REDinREN Spanish Renal Research Network and Hospital Universitario La Paz, Paseo de la Castellana 261, Madrid, Spain
    Perit Dial Int 28:118-22. 2008
  2. ncbi request reprint Serum concentrations of leptin, adiponectin and resistin, and their relationship with cardiovascular disease in patients with end-stage renal disease
    Juan J Diez
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Clin Endocrinol (Oxf) 62:242-9. 2005
  3. ncbi request reprint Inhaled insulin--a new therapeutic option in the treatment of diabetes mellitus
    Juan Jose Diez
    Travesía Téllez 8, 4R, 28007 Madrid, Spain
    Expert Opin Pharmacother 4:191-200. 2003
  4. ncbi request reprint The role of the novel adipocyte-derived hormone adiponectin in human disease
    Juan J Diez
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Eur J Endocrinol 148:293-300. 2003
  5. ncbi request reprint Hyperthyroidism in patients older than 55 years: an analysis of the etiology and management
    Juan J Diez
    Department of Endocrinology, Hospital La Paz, Madrid, Spain
    Gerontology 49:316-23. 2003
  6. ncbi request reprint Effects of cinacalcet on gastrointestinal hormone release in patients with secondary hyperparathyroidism undergoing dialysis
    Juan J Diez
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera de Colmenar Km 9, 28034 Madrid, Spain
    Nephrol Dial Transplant 23:1387-95. 2008
  7. ncbi request reprint Pharmacological therapy of Cushing's syndrome: drugs and indications
    Juan J Diez
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera de Colmenar Km 9, 28034 Madrid, Spain
    Mini Rev Med Chem 7:467-80. 2007
  8. ncbi request reprint Growth hormone and insulin-like growth factor binding protein-1 responses to oral glucose in patients with primary hyperparathyroidism
    Juan J Diez
    Department of Endocrinology, Hospital Ramon and Cajal, Madrid, Spain
    Clin Endocrinol (Oxf) 65:27-34. 2006
  9. ncbi request reprint Spontaneous normalization of thyrotropin concentrations in patients with subclinical hypothyroidism
    Juan J Diez
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera Colmenar km 9, 28034 Madrid, Spain
    J Clin Endocrinol Metab 90:4124-7. 2005
  10. ncbi request reprint Goiter in adult patients aged 55 years and older: etiology and clinical features in 634 patients
    Juan J Diez
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera de Colmenar, Km 9, 28034 Madrid, Spain
    J Gerontol A Biol Sci Med Sci 60:920-3. 2005

Collaborators

Detail Information

Publications103 found, 100 shown here

  1. ncbi request reprint Peritoneal dialysis in the comprehensive management of end-stage renal disease patients with liver cirrhosis and ascites: practical aspects and review of the literature
    Rafael Selgas
    REDinREN Spanish Renal Research Network and Hospital Universitario La Paz, Paseo de la Castellana 261, Madrid, Spain
    Perit Dial Int 28:118-22. 2008
    ..The experiences with peritoneal dialysis suggest consideration of this treatment as the first choice for cirrhotic patients with ascites and that need to start dialysis...
  2. ncbi request reprint Serum concentrations of leptin, adiponectin and resistin, and their relationship with cardiovascular disease in patients with end-stage renal disease
    Juan J Diez
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Clin Endocrinol (Oxf) 62:242-9. 2005
    ....
  3. ncbi request reprint Inhaled insulin--a new therapeutic option in the treatment of diabetes mellitus
    Juan Jose Diez
    Travesía Téllez 8, 4R, 28007 Madrid, Spain
    Expert Opin Pharmacother 4:191-200. 2003
    ..Inhaled insulin currently represents the most viable alternative insulin delivery method to preprandial subcutaneous injection...
  4. ncbi request reprint The role of the novel adipocyte-derived hormone adiponectin in human disease
    Juan J Diez
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Eur J Endocrinol 148:293-300. 2003
    ....
  5. ncbi request reprint Hyperthyroidism in patients older than 55 years: an analysis of the etiology and management
    Juan J Diez
    Department of Endocrinology, Hospital La Paz, Madrid, Spain
    Gerontology 49:316-23. 2003
    ....
  6. ncbi request reprint Effects of cinacalcet on gastrointestinal hormone release in patients with secondary hyperparathyroidism undergoing dialysis
    Juan J Diez
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera de Colmenar Km 9, 28034 Madrid, Spain
    Nephrol Dial Transplant 23:1387-95. 2008
    ....
  7. ncbi request reprint Pharmacological therapy of Cushing's syndrome: drugs and indications
    Juan J Diez
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera de Colmenar Km 9, 28034 Madrid, Spain
    Mini Rev Med Chem 7:467-80. 2007
    ..To review the main pharmacological properties and clinical applications of the drugs used in the medical therapy of Cushing's syndrome...
  8. ncbi request reprint Growth hormone and insulin-like growth factor binding protein-1 responses to oral glucose in patients with primary hyperparathyroidism
    Juan J Diez
    Department of Endocrinology, Hospital Ramon and Cajal, Madrid, Spain
    Clin Endocrinol (Oxf) 65:27-34. 2006
    ..GH and IGFBP-1 both play a role in glucose homeostasis...
  9. ncbi request reprint Spontaneous normalization of thyrotropin concentrations in patients with subclinical hypothyroidism
    Juan J Diez
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera Colmenar km 9, 28034 Madrid, Spain
    J Clin Endocrinol Metab 90:4124-7. 2005
    ..Patients with subclinical hypothyroidism may revert to normal TSH values...
  10. ncbi request reprint Goiter in adult patients aged 55 years and older: etiology and clinical features in 634 patients
    Juan J Diez
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera de Colmenar, Km 9, 28034 Madrid, Spain
    J Gerontol A Biol Sci Med Sci 60:920-3. 2005
    ..Our aim has been to assess the frequency of the diverse etiologies of goiter in adult patients aged 55 years and older, and evaluate the relationships between etiology and age, sex, and goiter features...
  11. ncbi request reprint Spontaneous subclinical hypothyroidism in patients older than 55 years: an analysis of natural course and risk factors for the development of overt thyroid failure
    Juan J Diez
    Department of Endocrinology, Hospital La Paz, 28046 Madrid, Spain
    J Clin Endocrinol Metab 89:4890-7. 2004
    ..Subjects with mildly elevated TSH have a low incidence rate of overt hypothyroidism. We recommend follow-up with clinical and biochemical monitoring in these patients...
  12. ncbi request reprint Serum concentrations of tumour necrosis factor-alpha (TNF-alpha) and soluble TNF-alpha receptor p55 in patients with hypothyroidism and hyperthyroidism before and after normalization of thyroid function
    Juan J Diez
    Department of Endocrinology, Hospital La Paz, Travesía Téllez 8, 4R, 28007 Madrid, Spain
    Clin Endocrinol (Oxf) 57:515-21. 2002
    ....
  13. ncbi request reprint Somatostatin analogs in the treatment of medullary thyroid carcinoma
    J J Diez
    Department of Endocrinology, Hospital La Paz, Madrid, Spain
    J Endocrinol Invest 25:773-8. 2002
    ..In conclusion, therapy with different formulations of octreotide and lanreotide does not seem to modify serum concentrations of ct and carcinoembryonic antigen in patients with recurrent medullary thyroid carcinoma...
  14. ncbi request reprint Cholinergic modulation of growth hormone responses to growth hormone-releasing hormone in uraemic patients on peritoneal dialysis
    J J Diez
    Department of Endocrinology, Hospital La Paz, Madrid, Spain
    Clin Endocrinol (Oxf) 53:587-93. 2000
    ..Blockade of muscarinic receptor with pirenzepine blunts the GH release in several clinical situations. However, little information is available on the role played by central cholinergic pathways in GH regulation in uraemic patients...
  15. ncbi request reprint Hypothyroidism in patients older than 55 years: an analysis of the etiology and assessment of the effectiveness of therapy
    Juan J Diez
    Department of Endocrinology, Hospital La Paz, Madrid, Spain
    J Gerontol A Biol Sci Med Sci 57:M315-20. 2002
    ..Our aim has been to assess the relative frequency of the diverse causes of hypothyroidism in a group of patients older than 55 years and the adequacy of control of thyroid function attained by levothyroxine therapy...
  16. ncbi request reprint Serum ghrelin concentrations in patients with chronic renal failure undergoing dialysis
    Pedro Iglesias
    Department of Endocrinology, Hospital General de Segovia, Spain
    Clin Endocrinol (Oxf) 64:68-73. 2006
    ..Derangements in ghrelin secretion in patients with chronic renal failure (CRF) have not been fully evaluated...
  17. ncbi request reprint Growth hormone, IGF-I and its binding proteins (IGFBP-1 and -3) in adult uraemic patients undergoing peritoneal dialysis and haemodialysis
    Pedro Iglesias
    Department of Endocrinology, Hospital General, Segovia, Spain
    Clin Endocrinol (Oxf) 60:741-9. 2004
    ....
  18. ncbi request reprint Lipoatrophic diabetes in an elderly woman: clinical course and serum adipocytokine concentrations
    Pedro Iglesias
    Department of Endocrinology, Hospital General, Ctra Avila s n, 40002 Segovia, Spain
    Endocr J 51:279-86. 2004
    ..During this period, serum adipocytokines were periodically measured. We comment on the different etiopathogenic mechanisms and the therapeutic modalities of this rare syndrome...
  19. ncbi request reprint Effects of human recombinant erythropoietin on inflammatory status in peritoneal dialysis patients
    Abelardo Aguilera
    Servicio de Nefrologia, Hospitales Universitarios de la Princesa y la Paz, Madrid, Spain
    Adv Perit Dial 18:200-5. 2002
    ..By decreasing leptin, rHuEPO could increase food intake and improve the nutritional status of PD patients. At baseline, we confirm the existence of a chronic inflammatory process in uremia...
  20. ncbi request reprint Serum concentrations of adipocytokines in patients with hyperthyroidism and hypothyroidism before and after control of thyroid function
    Pedro Iglesias
    Department of Endocrinology, Hospital General, Segovia, Spain
    Clin Endocrinol (Oxf) 59:621-9. 2003
    ..The aim of this study was to evaluate the circulating levels of leptin, adiponectin and resistin in patients with thyroid dysfunction before and after normalization of thyroid function with appropriate therapy...
  21. ncbi request reprint Eating behavior disorders in uremia: a question of balance in appetite regulation
    Abelardo Aguilera
    Servicio de Nefrologia, Hospitales Universitarios de la Princesa y la Paz, Madrid, Spain
    Semin Dial 17:44-52. 2004
    ..Uremic anorexia may be explained by a hypothalamic hyperserotoninergic state derived from a high concentration of tryptophan and low branched-chain amino acids...
  22. doi request reprint Thyroid function tests in acute kidney injury
    Pedro Iglesias
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    J Nephrol 26:164-72. 2013
    ..The aim of this study was to analyze the prevalence, clinical significance and prognostic implications of alterations in thyroid function tests (TFTs) in patients with acute kidney injury (AKI)...
  23. doi request reprint Insulin therapy in renal disease
    Pedro Iglesias
    Department of Endocrinology, Hospital General, Segovia, Spain
    Diabetes Obes Metab 10:811-23. 2008
    ..In this study, we review the more relevant aspects related to insulin therapy in diabetic patients with different degrees of renal failure and in patients with ESRD, both in conservative therapy and dialysis...
  24. doi request reprint High stable serum adiponectin levels are associated with a better outcome in prevalent dialysis patients
    Juan J Diez
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Am J Nephrol 30:244-52. 2009
    ..Our aim was to evaluate the prognostic value of 2 measurements of serum adiponectin levels for all-cause mortality and cardiovascular (CV) mortality in uremic patients...
  25. doi request reprint Selenium and kidney disease
    Pedro Iglesias
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    J Nephrol 26:266-72. 2013
    ..Available data are encouraging and stimulate interest in further studies to clarify the real extent of Se deficiency and the need for Se supplementation in patients with kidney disease...
  26. ncbi request reprint Ghrelin plasma levels and appetite in peritoneal dialysis patients
    Abelardo Aguilera
    Nephrology Services, University Hospitals La Princesa and La Paz, Instituto de Investigación Nefrológica Reina Sofía, Madrid, Spain
    Adv Perit Dial 20:194-9. 2004
    ..The role of ghrelin in appetite modulation is altered in uremic PD patients, and that alteration is possibly associated with disorders in insulin and growth hormone metabolism...
  27. doi request reprint Relationship between serum thyrotropin concentrations and metformin therapy in euthyroid patients with type 2 diabetes
    Juan J Diez
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Clin Endocrinol (Oxf) 78:505-11. 2013
    ..We aimed to evaluate the interplay between metformin therapy and serum TSH concentrations in a group of patients with T2D and normal thyroid function...
  28. doi request reprint Subclinical hyperthyroidism in patients with type 2 diabetes
    Juan J Diez
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera de Colmenar Km 9, 28034, Madrid, Spain
    Endocrine 42:157-63. 2012
    ..The risk for subclinical hyperthyroidism is increased in women with T2D. Advanced age and the presence of goitre are significantly and independently related with the presence of subclinical hyperthyroidism in diabetic population...
  29. doi request reprint Hypothyrodism in male patients: a descriptive, observational and cross-sectional study in a series of 260 men
    Pedro Iglesias
    Department of Endocrinology, Hospital General, Segovia, Spain
    Am J Med Sci 336:315-20. 2008
    ..Adequacy of replacement treatment seems to be mainly related to the degree of thyroid hypofunction and the time from starting therapy...
  30. doi request reprint Acute and one-year effects of cinacalcet in patients with persistent primary hyperparathyroidism after unsuccessful parathyroidectomy
    Pedro Iglesias
    Department of Endocrinology, Hospital General, Segovia, Spain
    Am J Med Sci 335:111-4. 2008
    ....
  31. ncbi request reprint An analysis of the natural course of subclinical hyperthyroidism
    Juan J Diez
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Am J Med Sci 337:225-32. 2009
    ..Our aim was to evaluate the incidence rate of overt hyperthyroidism in a cohort of patients with subclinical hyperthyroidism and to assess the potential risk factors for the development of overt thyroid hyperfunction...
  32. ncbi request reprint The role of the novel adipocyte-derived protein adiponectin in human disease: an update
    Juan J Diez
    Servicio de Endocrinologia, Hospital Ramon y Cajal, Madrid, Spain
    Mini Rev Med Chem 10:856-69. 2010
    ..According to this hypothesis, this protein would behave as an insulin sensitizing and cardioprotective factor in the health state and as a wasting marker in the advanced states of disease...
  33. doi request reprint Biological role, clinical significance, and therapeutic possibilities of the recently discovered metabolic hormone fibroblastic growth factor 21
    Pedro Iglesias
    Department of Endocrinology, Hospital Ramon y Cajal, Ctra de Colmenar, Km 9, 100, 28034 Madrid, Spain
    Eur J Endocrinol 167:301-9. 2012
    ..Direct or indirect potentiation of its effects might be a potential therapeutic target in insulin-resistant states...
  34. doi request reprint Insulinoma-induced hypoglycemia in a patient with nesidiodysplasia after vagomotomy and pyloroplasty for duodenal ulcer
    Pedro Iglesias
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Am J Med Sci 337:377-80. 2009
    ..We report, for the first time, both histologic lesions associated in a patient with a history of vagotomy and pyloroplasty for a duodenal ulcer and we discuss the possible pathogenic mechanisms...
  35. ncbi request reprint Influence of thyroid dysfunction on serum concentrations of adipocytokines
    Pedro Iglesias
    Department of Endocrinology, Hospital General, 40002 Segovia, Spain
    Cytokine 40:61-70. 2007
    ..Finally, discordant results in resistin levels in thyroid dysfunction have been reported in humans...
  36. ncbi request reprint Effects of cholinergic muscarinic blockade on growth hormone responses to growth hormone-releasing hormone in uraemic patients
    J J Diez
    Department of Endocrinology, Hospital La Paz, Madrid, Spain
    Nephrol Dial Transplant 14:1704-9. 1999
    ....
  37. doi request reprint Gonadal dysfunction in men with chronic kidney disease: clinical features, prognostic implications and therapeutic options
    Pedro Iglesias
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    J Nephrol 25:31-42. 2012
    ..Although there are encouraging data suggesting plausible benefits from testosterone replacement therapy, further studies are needed with regards to safety and effectiveness of this therapy...
  38. ncbi request reprint Gastrointestinal and pancreatic function in peritoneal dialysis patients: their relationship with malnutrition and peritoneal membrane abnormalities
    Abelardo Aguilera
    Servicio de Nefrologa, Gastroenterologa y Laboratorio de Gastroenterologa, Hospitales Universitario de la Princesa y La Paz, Madrid, Spain
    Am J Kidney Dis 42:787-96. 2003
    ..Malnutrition is frequent in peritoneal dialysis (PD) patients, but the contribution of gastrointestinal (GI) dysfunction has not been well established...
  39. ncbi request reprint Peroxisome proliferator-activated receptor gamma agonists in renal disease
    Pedro Iglesias
    Department of Endocrinology, Hospital General, Segovia, Spain
    Eur J Endocrinol 154:613-21. 2006
    ..Finally, tolerability and safety profile of PPARgamma agonists in patients with reduced glomerular filtration rate are also analysed...
  40. ncbi request reprint Effects of short-term recombinant human growth hormone therapy on plasma leptin concentrations in dialysis patients
    Pedro Iglesias
    Department of Endocrinology, Hospital General de Segovia, C Maria Sevilla Diago, 9, 3o dcha, E 28022 Madrid, Spain
    Nephrol Dial Transplant 17:260-4. 2002
    ..We performed a prospective study to assess plasma leptin concentrations in a group of dialysis patients both before and during short-term rhGH therapy...
  41. doi request reprint Higher daily peritoneal protein clearance when initiating peritoneal dialysis is independently associated with peripheral arterial disease (PAD): a possible new marker of systemic endothelial dysfunction?
    Rafael Sánchez-Villanueva
    Servicio de Nefrologia, Hospital Universitario La Paz, Madrid, Spain
    Nephrol Dial Transplant 24:1009-14. 2009
    ..Peripheral arterial disease (PAD) is increasingly recognized as an entity particularly associated with higher mortality...
  42. ncbi request reprint Hypoalbuminemia is also a marker of fluid excess determined by bioelectrical impedance parameters in dialysis patients
    Secundino Cigarran
    Nephrology Service, Princess University Hospital, Queen Sofia Institute for Nephrological Research, Madrid, Spain
    Ther Apher Dial 11:114-20. 2007
    ..We conclude that hypoalbuminemia is also a marker of fluid excess. The SA is associated to the fluid index and the PA allows assessment of the dry weight and its variations in an individualized manner in dialysis patients...
  43. doi request reprint [Optimization of the medical treatment for acromegaly]
    Juan J Diez
    Servicio de Endocrinologia, Hospital Ramon y Cajal, Madrid, Espana
    Med Clin (Barc) 140:360-5. 2013
    ..The addition of cabergoline to somatostatin analogue therapy is accompanied by a further decrease in IGF-I levels that is independent of serum prolactin concentrations...
  44. doi request reprint Prolactinomas in men: a multicentre and retrospective analysis of treatment outcome
    Pedro Iglesias
    Department of Endocrinology, Hospital Ramon y Cajal, Madrid, Spain
    Clin Endocrinol (Oxf) 77:281-7. 2012
    ..To assess treatment outcome in male patients with micro- and macroprolactinomas...
  45. ncbi request reprint New drugs for the treatment of hypercholesterolaemia
    Pedro Iglesias
    Department of Endocrinology, Hospital General, Ctra de Avila s n, 40002 Segovia, Spain
    Expert Opin Investig Drugs 12:1777-89. 2003
    ..Other lipid-lowering drugs with the ability to act at the enterocyte level, such as avasimibe and implitapide, are currently being investigated in humans...
  46. doi request reprint [Imaging techniques in the diagnosis of neuroendocrine tumors]
    Juan J Diez
    Servicio de Endocrinologia, Hospital Ramon y Cajal, Madrid, Espana
    Med Clin (Barc) 135:319-25. 2010
    ..PET is a functional imaging technique that reflects tumor metabolism. A multimodality approach, including CT, MRI, SRS, ultrasound and endoscopy, is nowadays recommended for detecting these tumors...
  47. ncbi request reprint Helicobacter pylori infection: a new cause of anorexia in peritoneal dialysis patients
    A Aguilera
    , Hospitales Universitarios de la Princesa y la Paz, Madrid, Spain
    Perit Dial Int 21:S152-6. 2001
    ..Residual renal function seem to have a protective effect on appetite preservation. The present study supports the hypothesis of the involvement of inflammation in the pathogenesis of malnutrition in PD patients...
  48. ncbi request reprint Cultures of human osteoblastic cells from dialysis patients: influence of bone turnover rate on in vitro selection of interleukin-6 and osteoblastic cell makers
    M C Sanchez
    Nephrology and Biochemistry Divisions and Pathology Department, Hospital Universitario La Paz, Madrid, Spain
    Am J Kidney Dis 37:30-37. 2001
    ..Our findings support the hypothesis that factors other than PTH level might have an important role in affecting osteoblastic function in renal osteodystrophy...
  49. ncbi request reprint Increased severity of Escherichia coli peritonitis in peritoneal dialysis patients independent of changes in in vitro antimicrobial susceptibility testing
    Jorge Valdés-Sotomayor
    Department of Nephrology, Hospital Universitario de la Princesa, Hospital Universitario La Paz, Instituto Reina Sofia de Investigacion Nefrologica, Madrid, Spain
    Perit Dial Int 23:450-5. 2003
    ..With its very low response rate to broad-spectrum antibiotics, the increased severity of E. coli peritonitis deteriorates peritoneal function and affects patient outcome...
  50. ncbi request reprint Low vs standard calcium dialysate in peritoneal dialysis: differences in treatment, biochemistry and bone histomorphometry. A randomized multicentre study
    Carmen Sanchez
    Department of Nephrology, University Hospital La Paz, Madrid, Spain
    Nephrol Dial Transplant 19:1587-93. 2004
    ..Our aim was to compare the effects on bone metabolism of LCD (calcium: 1.25 mmol/l) with that of a standard calcium dialysate (SCD; calcium: 1.75 mmol/l)...
  51. ncbi request reprint Virus-specific effector CD4+ T-cell responses in hemodialysis patients with hepatitis C virus infection
    Miguel A Rico
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
    J Med Virol 72:66-74. 2004
    ..In conclusion, hemodialysis patients show limited HCV-specific effector CD4(+) Th1-cell responses which nonetheless seem unrelated to the anti-HCV status and are not more impaired due to the ongoing hemodialysis...
  52. doi request reprint BMP-7 blocks mesenchymal conversion of mesothelial cells and prevents peritoneal damage induced by dialysis fluid exposure
    Jesus Loureiro
    Unidad de Biologia Molecular, Hospital Universitario de la Princesa, Madrid, Spain
    Nephrol Dial Transplant 25:1098-108. 2010
    ..Herein, we analysed the modulating role of BMP-7 on EMT of MC in vitro and its protective effects in a rat PD model...
  53. ncbi request reprint Ultrafiltration and small solute transport at initiation of PD: questioning the paradigm of peritoneal function
    Rafael Selgas
    Servicio de Nefrologia, Hospital Universitario La Princesa, Madrid, Spain
    Perit Dial Int 25:68-76. 2005
    ..Human peritoneal function on commencing peritoneal dialysis (PD) is not yet adequately understood. The objective of this study was to determine peritoneal functional patterns on commencing PD...
  54. doi request reprint Tissue distribution of hyalinazing vasculopathy lesions in peritoneal dialysis patients: an autopsy study
    Jose A Jimenez-Heffernan
    Department of Pathology, University Hospital, Puerta de Hierro, Madrid, Spain
    Pathol Res Pract 204:563-7. 2008
    ..This observation suggests that PD-related factors are the main contributors to the severity of vasculopathy. Uremia may participate in the development of the lesion but it does not seem to be responsible for its severity...
  55. ncbi request reprint Risk factors for abdominal wall complications in peritoneal dialysis patients
    Gloria del Peso
    Servicio de Nefrologia, Hospital Universitario La Paz, Madrid, Spain
    Perit Dial Int 23:249-54. 2003
    ..Patients treated with peritoneal dialysis (PD) have increased intra-abdominal pressure and a high prevalence of abdominal wall complications...
  56. ncbi request reprint Mesenchymal conversion of mesothelial cells as a mechanism responsible for high solute transport rate in peritoneal dialysis: role of vascular endothelial growth factor
    Luiz S Aroeira
    Servicio de Nefrologia, Hospital Universitario de la Princesa, Madrid, Spain
    Am J Kidney Dis 46:938-48. 2005
    ..Sources of VEGF in vivo in PD patients remain unclear. We analyzed the correlation between epithelial-to-mesenchymal transition of mesothelial cells and both VEGF level and peritoneal functional decline...
  57. ncbi request reprint Taming apoptosis in peritoneal dialysis
    Beatriz Santamaria
    Dialysis Unit, Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Instituto Reina Sofia de Investigacion Nefrologica, Universidad Autonoma de Madrid, Madrid, Spain
    Perit Dial Int 29:S45-8. 2009
    ..In addition, novel molecular targets have been identified. Short-term modulation of apoptosis may be useful to accelerate recovery and to prevent irreversible peritoneal injury following peritonitis...
  58. ncbi request reprint Serum albumin levels, an additional factor implicated in hyperparathyroidism outcome in peritoneal dialysis: a prospective study with paired bone biopsies
    M Carmen Sánchez-González
    Nephrology Department, University Hospital La Paz, IRSIN, Madrid, Spain
    Adv Perit Dial 22:198-202. 2006
    ..A change to HTBL was associated with improvement in serum albumin. Protein status is possibly a factor influencing bone lesion outcome...
  59. doi request reprint [Role played by peritoneal dialysis in treating refractory heart failure]
    J D Montejo
    Servicio de Nefrologia, Hospital Universitario La Paz, Madrid, Spain
    Nefrologia 30:21-7. 2010
    ..This article aims to review the role of the nephrologist in HF treatment, with an emphasis on the subgroup of patients with RHF and current evidence regarding the usefulness of peritoneal dialysis (PD) as a chronic coadjuvant treatment...
  60. doi request reprint [Changing the frequency of administration of darbepoetin alfa (from weekly to fortnightly) maintains the haemoglobin levels in patients undergoing peritoneal dialysis]
    M A Bajo
    Servicio de Nefrologia, Hospital La Paz, Madrid, Spain
    Nefrologia 29:136-42. 2009
    ..Less frequent dosing regimens during anemia treatment could benefit Peritoneal Dialysis (PD) patients. We investigated the effectiveness of darbepoetin alfa dosed every-other-week (Q2W) for maintaining hemoglobin (Hb) levels (11-13 g/dL)...
  61. ncbi request reprint Risk factors responsible for ultrafiltration failure in early stages of peritoneal dialysis
    R Selgas
    Hospital Universitario de la Princesa, Madrid, Spain
    Perit Dial Int 20:631-6. 2000
    ..To define risk factors for ultrafiltration failure (UFF) during early stages of peritoneal dialysis (PD)...
  62. ncbi request reprint Effect of bicarbonate/lactate peritoneal dialysis solutions on human mesothelial cell proliferation ex vivo
    M A Bajo
    Hospitales Universitarios La Paz, Madrid, Spain
    Adv Perit Dial 17:37-41. 2001
    ..This finding may demonstrate better biocompatibility for Bic/Lac solution...
  63. ncbi request reprint Alpha replacement method for displaced peritoneal catheter: a simple and effective maneuver
    C Hevia
    , Hospital Universitario La Paz, Madrid, Spain
    Adv Perit Dial 17:138-41. 2001
    ..In consequence, it should be the technique of first choice in these situations. Only when the alpha maneuver fails should invasive methods, including catheter change, be considered...
  64. ncbi request reprint Diverticular disease and treatment with gastric acid inhibitors do not predispose to peritonitis of enteric origin in peritoneal dialysis patients
    G Del Peso
    Nephrology Service, Hospital Universitario La Paz, Madrid, Spain
    Perit Dial Int 21:360-4. 2001
    ..Factors such as diverticular disease and gastric acid inhibitors have been implicated in its appearance. We investigated several risk factors, including those mentioned below, that can influence the development of EP...
  65. doi request reprint [The peritoneal kinetic study performed with hypertonic glucose permits better evaluation of UF capacity and determination of sieving of sodium]
    M J Fernandez-Reyes
    Servicio de Nefrologia, Hospital General de Segovia y Hospital Universitario La Paz, Madrid, Spain
    Nefrologia 30:208-13. 2010
    ..The use of solutions containing hypertonic glucose (3.86%/4.25%) has been postulated as the method of choice for study the peritoneal function, and permits a better evaluation of the ultrafiltration (UF) capacity...
  66. ncbi request reprint Vascular endothelial growth factor (VEGF) levels in peritoneal dialysis effluent
    R Selgas
    La Princesa University Hospital, Madrid, Spain
    J Nephrol 14:270-4. 2001
    ..To further analyze the relationship between peritoneal neoangiogenesis induced by VEGF and peritoneal transport, we studied peritoneal effluent VEGF levels in active PD patients...
  67. pmc TWEAK activates the non-canonical NFkappaB pathway in murine renal tubular cells: modulation of CCL21
    Ana B Sanz
    Servicio de Nefrologia, Fundación para la Investigación Biomédica del Hospital Universitario La Paz, Madrid, Spain
    PLoS ONE 5:e8955. 2010
    ..4 vs 1.8+/-1-fold over healthy control). Our results thus identify TWEAK as a regulator of non-canonical NFkappaB activation and CCL21 expression in tubular cells thus promoting lymphocyte recruitment to the kidney during acute injury...
  68. doi request reprint Pharmacological modulation of epithelial mesenchymal transition caused by angiotensin II. Role of ROCK and MAPK pathways
    Raquel Rodrígues-Díez
    Cellular Biology in Renal Diseases Laboratory, Fundacion Jimenez Diaz, Universidad Autonoma Madrid, Madrid, Spain
    Pharm Res 25:2447-61. 2008
    ..Our aim was to describe potential therapeutic targets in AngII-induced EMT, investigating the blockade of different intracellular pathways...
  69. ncbi request reprint Brain activation in uremic anorexia
    Abelardo Aguilera
    Servicio de Nefrologia, Hospitales Universitarios de la Princesa y la Paz, Madrid, Spain
    J Ren Nutr 17:57-61. 2007
    ..Several uremia-acquired disorders in the CNS such as high cerebrospinal fluid levels of anorexigen substances and disorders in appetite regulator receptors may explain the lack of appetite...
  70. pmc Cyclooxygenase-2 mediates dialysate-induced alterations of the peritoneal membrane
    Luiz S Aroeira
    Instituto Reina Sofía de Investigaciones Nefrológicas, Hospital Universitario La Paz, Madrid, Spain
    J Am Soc Nephrol 20:582-92. 2009
    ..In conclusion, upregulation of COX-2 during EMT may mediate peritoneal inflammation, suggesting COX-2 inhibition as a potential strategy to ameliorate peritoneal deterioration in PD patients...
  71. ncbi request reprint Treatment of anorexia and malnutrition in peritoneal dialysis patients with megestrol acetate
    Olga Costero
    Department of Nephrology, University Hospital La Paz, Madrid, Spain
    Adv Perit Dial 20:209-12. 2004
    ..27 g/L; p = 0.45). No side effects were observed. Our experience suggests that treatment with 160 mg MA daily in PD patients leads to an increase in appetite, serum albumin, and weight gain in most patients, with no negative side effects...
  72. ncbi request reprint Peritoneal dialysis solutions inhibit the differentiation and maturation of human monocyte-derived dendritic cells: effect of lactate and glucose-degradation products
    Amaya Puig-Kroger
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Leukoc Biol 73:482-92. 2003
    ..These findings have important implications for the initiation of immune responses under high lactate conditions, such as those occurring within tumor tissues or after macrophage activation...
  73. pmc A nanoconjugate Apaf-1 inhibitor protects mesothelial cells from cytokine-induced injury
    Beatriz Santamaria
    Dialysis Unit, Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Instituto Reina Sofia de Investigacion Nefrologica, Madrid, Spain
    PLoS ONE 4:e6634. 2009
    ..However there is scarce information on the modulation of cell death by combinations of cytokines and on the therapeutic targets to prevent desmesothelization...
  74. ncbi request reprint Pathogenic significance of hypertrophic mesothelial cells in peritoneal effluent and ex vivo culture
    M Auxiliadora Bajo
    Servicio de Nefrologia, Hospital Universitario La Paz, Madrid, Spain
    Adv Perit Dial 20:43-6. 2004
    ..1 patient died of an unrelated cause after 1 year on PD. 1 patient received a successful kidney graft 5 years after the observation of HMCs. 1 patient developed type I UF failure 10 years after the first observation...
  75. doi request reprint Ultrasonography in kidney transplantation: values and new developments
    Carlos Jimenez
    Nephrology Service, Hospital Universitario La Paz, 28046 Madrid, Spain
    Transplant Rev (Orlando) 23:209-13. 2009
    ....
  76. ncbi request reprint Peritoneal transport in peritoneal dialysis patients is not affected by transitorily successful renal transplantation
    Ernesto J Fernández
    Servicio de Nefrologia, Hospital Universitario La Paz, Madrid, Spain
    Adv Perit Dial 22:33-6. 2006
    ....
  77. doi request reprint Effect of hemodialysis schedules and membranes on hepatocyte growth factor and hepatitis C virus RNA levels
    Guillermina Barril
    Department of Nephrology, Hospital Universitario de la Princesa, Madrid, Spain
    J Med Virol 82:763-7. 2010
    ..These results suggest that changes in HCV RNA and HGF levels during hemodialysis are not influenced by the schedule or type of membrane used...
  78. ncbi request reprint Malnutrition-inflammation syndrome is associated with endothelial dysfunction in peritoneal dialysis patients
    Abelardo Aguilera
    Servicio de Nefrologia, Hospital Universitario de la Princesa, Madrid, Spain
    Adv Perit Dial 19:240-5. 2003
    ..In conclusion, malnutrition-inflammation syndrome may contribute to endothelial dysfunction and, consequently, to prothrombotic and proatherogenic processes in PD patients...
  79. ncbi request reprint Epithelial to mesenchymal transition and peritoneal membrane failure in peritoneal dialysis patients: pathologic significance and potential therapeutic interventions
    Luiz S Aroeira
    Unidad de Biologia Molecular, Hospital Universitario de la Princesa, C Diego de Leon 62, Madrid, Spain
    J Am Soc Nephrol 18:2004-13. 2007
    ....
  80. ncbi request reprint Cystatin C as marker of residual renal function in patients on peritoneal dialysis: relation with parameters of peritoneal function
    Silvia Ros
    Nephrology and Biochemistry Unit, University Hospital La Paz, Madrid, Spain
    J Nephrol 20:468-73. 2007
    ..Cystatin C (CysC) is a nonglycosylated protein of low molecular weight not influenced by age, sex or inflammation. The aim of this paper is to ascertain the usefulness of serum CysC level determination in peritoneal dialysis (PD) patients...
  81. ncbi request reprint Clinical experience with tamoxifen in peritoneal fibrosing syndromes
    Gloria del Peso
    Department of Nephrology, University Hospital La Paz, Madrid, Spain
    Adv Perit Dial 19:32-5. 2003
    ..However, a prospective therapeutic trial is required to confirm our results...
  82. ncbi request reprint European best practice guidelines for peritoneal dialysis. 2 The initiation of dialysis
    Nicholas Dombros
    Peritoneal Dialysis Unit, AHEPA University Hospital, Thessaloniki, Greece
    Nephrol Dial Transplant 20:ix3-ix7. 2005
  83. ncbi request reprint Effect of recombinant human erythropoietin on inflammatory status in dialysis patients
    Abelardo Aguilera
    Servicio de Nefrologia, Hospital de la Princesa, Diego de Leon 62, 28006 Madrid, Spain
    Nephrol Dial Transplant 19:V46-53. 2004
    ..The changes in pro-thrombotic and pro-atherogenic factors in dialysis patients require further study to evaluate all the factors implicated in the atherogenic process...
  84. ncbi request reprint Leptin as a marker of nutrition and cardiovascular risk in peritoneal dialysis patients
    Abelardo Aguilera
    Servicio de Nefrologia, Hospitales Universitarios La Paz, Spain
    Adv Perit Dial 18:212-7. 2002
    ..All of those features suggest that plasma leptin levels could be considered a marker of CV risk and food intake in non obese PD patients without inflammation...
  85. ncbi request reprint European best practice guidelines for peritoneal dialysis. 7 Adequacy of peritoneal dialysis
    Nicholas Dombros
    Peritoneal Dialysis Unit, AHEPA University Hospital, Thessaloniki, Greece
    Nephrol Dial Transplant 20:ix24-ix27. 2005
  86. ncbi request reprint True deficiency of antioxidant vitamins E and A in dialysis patients. Relationship with clinical patterns of atherosclerosis
    Abelardo Aguilera
    Servicio de Nefrologia, Hospitales Universitarios La Paz, Spain
    Adv Perit Dial 18:206-11. 2002
    ..Our results and the findings of other researchers about intracellular vitamin A and E deficiencies may change the traditional concept of hypervitaminosis A and E in uremic patients...
  87. ncbi request reprint Regulation of apoptosis by lethal cytokines in human mesothelial cells
    Marina Penélope Catalan
    Grupo de estudios peritoneales de Madrid Fundación Renal Iñigo Alvarez de Toledo Instituto Reina Sofia de Investigaciones Nefrológicas, Madrid, Spain
    Kidney Int 64:321-30. 2003
    ..In addition, acute peritonitis is characterized by sudden changes in the number of peritoneal leukocytes. However, the factors regulating peritoneal cell survival are poorly understood...
  88. ncbi request reprint European best practice guidelines for peritoneal dialysis. 5 Peritoneal dialysis solutions
    Nicholas Dombros
    Peritoneal Dialysis Unit, AHEPA University Hospital, Thessaloniki, Greece
    Nephrol Dial Transplant 20:ix16-ix20. 2005
  89. ncbi request reprint European best practice guidelines for peritoneal dialysis. 1 General guidelines
    Nicholas Dombros
    Peritoneal Dialysis Unit, AHEPA University Hospital, Thessaloniki, Greece
    Nephrol Dial Transplant 20:ix2. 2005
  90. ncbi request reprint European best practice guidelines for peritoneal dialysis. 6 Automated peritoneal dialysis
    Nicholas Dombros
    Peritoneal Dialysis Unit, AHEPA University Hospital, Thessaloniki, Greece
    Nephrol Dial Transplant 20:ix21-ix23. 2005
  91. ncbi request reprint European best practice guidelines for peritoneal dialysis. 8 Nutrition in peritoneal dialysis
    Nicholas Dombros
    Peritoneal Dialysis Unit, AHEPA University Hospital, Thessaloniki, Greece
    Nephrol Dial Transplant 20:ix28-ix33. 2005
  92. ncbi request reprint European best practice guidelines for peritoneal dialysis. 9 PD and transplantation
    Nicholas Dombros
    Peritoneal Dialysis Unit, AHEPA University Hospital, Thessaloniki, Greece
    Nephrol Dial Transplant 20:ix34-ix35. 2005
  93. ncbi request reprint European best practice guidelines for peritoneal dialysis. 3 Peritoneal access
    Nicholas Dombros
    Peritoneal Dialysis Unit, AHEPA University Hospital, Thessaloniki, Greece
    Nephrol Dial Transplant 20:ix8-ix12. 2005
  94. ncbi request reprint Ex vivo analysis of dialysis effluent-derived mesothelial cells as an approach to unveiling the mechanism of peritoneal membrane failure
    Manuel López-Cabrera
    Unidad de Biologia Molecular, Hospital Universitario de la Princesa, Diego de Leon, 62, 28006 Madrid, Spain
    Perit Dial Int 26:26-34. 2006
    ..Future therapeutic interventions could be designated in order to prevent or reverse epithelial-to-mesenchymal transition of mesothelial cells, or its pernicious effects...
  95. ncbi request reprint On the epithelial-mesenchymal transition of mesothelial cells
    Rafael Selgas
    Kidney Int 66:866-7; author reply 867. 2004
  96. ncbi request reprint Epithelial-to-mesenchymal transition of the mesothelial cell--its role in the response of the peritoneum to dialysis
    Rafael Selgas
    Servicio de Nefrologia, Hospital Universitario La Paz, Castellana, 261, Madrid 28046, Spain
    Nephrol Dial Transplant 21:ii2-7. 2006
    ..Information from multiple origins about TGF-beta and VEGF is integrated into EMT process in a comprehensive manner. Regulation and new targets for inhibition of EMT or its deleterious effects are discussed...
  97. ncbi request reprint Mast cell quantification in normal peritoneum and during peritoneal dialysis treatment
    Jose A Jimenez-Heffernan
    Department of Pathology, University Hospital, Guadalajara, Spain
    Arch Pathol Lab Med 130:1188-92. 2006
    ..These 3 mechanisms participate in the peritoneal pathology secondary to peritoneal dialysis (PD) treatment. Despite their potential relevance to PD-related pathology, few studies have focused on MCs...
  98. ncbi request reprint Risk of technique failure and death in fungal peritonitis is determined mainly by duration on peritoneal dialysis: single-center experience of 24 years
    Joana Felgueiras
    Department of Nephrology, Hospital Garcia de Orta, Almada, Portugal
    Adv Perit Dial 22:77-81. 2006
    ..19 +/- 18 months, p = 0.02). Fungal peritonitis is a rare cause of peritonitis in PD patients, but it is associated with high morbidity and mortality. Longer time on PD is the main factor in technique failure and mortality...
  99. ncbi request reprint [Pseudopheochromocytoma as cause of severe and paroxysmal hypertension]
    Olga Costero
    Med Clin (Barc) 129:358-9. 2007
  100. ncbi request reprint Appetite disorders in uremia
    Juan Jesus Carrero
    Division of Renal Medicine, CLINTEC, Karolinska Institutet, Stockholm, Sweden
    J Ren Nutr 18:107-13. 2008
    ..Based on megestrol acetate interventions and the recent observation that sex may modulate uremic appetite behavior, the potential role of sex hormones in treating chronic kidney disease anorexia needs to be further explored...
  101. ncbi request reprint Severe peritoneal mononucleosis associated with icodextrin use in continuous ambulatory peritoneal dialysis
    Juan Martín
    Servicio de Nefrologia, Hospital Universitario de la Princesa, Madrid, Spain
    Adv Perit Dial 19:191-4. 2003
    ..Although we cannot rule out an allergic cause, the massive peritoneal mononuclear cell recruitment suggests a particular mechanism. This is a new mechanism for peritoneal cell recruitment in PD...