J Defelipe

Summary

Country: Spain

Publications

  1. ncbi request reprint Catecholaminergic innervation of pyramidal neurons in the human temporal cortex
    Ruth Benavides-Piccione
    Instituto Cajal CSIC, Madrid, Spain
    Cereb Cortex 15:1584-91. 2005
  2. ncbi request reprint PSA-NCAM immunoreactivity in chandelier cell axon terminals of the human temporal cortex
    Jon I Arellano
    Instituto Cajal, CSIC, E 28002 Madrid, Spain
    Cereb Cortex 12:617-24. 2002
  3. ncbi request reprint Cortical interneurons: from Cajal to 2001
    Javier DeFelipe
    Instituto Cajal CSIC, Avenida del Doctor Arce 37, 28002 Madrid, Spain
    Prog Brain Res 136:215-38. 2002
  4. ncbi request reprint Pyramidal cell specialization in the occipitotemporal cortex of the vervet monkey
    Guy N Elston
    Vision, Touch and Hearing Research Centre, School of Biomedical Sciences and Queensland Brain Institute, The University of Queensland, Queensland 4072, Australia
    Neuroreport 16:967-70. 2005
  5. ncbi request reprint Double-bouquet cells in the monkey and human cerebral cortex with special reference to areas 17 and 18
    Javier DeFelipe
    Cajal Institute CSIC, Avenida Dr Arce 37, 28002 Madrid, Spain
    Prog Brain Res 154:15-32. 2006
  6. doi request reprint Cajal and the discovery of a new artistic world: the neuronal forest
    Javier DeFelipe
    Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, Universidad Politecnica de Madrid, Madrid, Spain Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain Electronic address
    Prog Brain Res 203:201-20. 2013
  7. pmc New insights into the classification and nomenclature of cortical GABAergic interneurons
    Javier DeFelipe
    Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, Universidad Politecnica de Madrid, Campus Montegancedo S N, Pozuelo de Alarcon, 28223 Madrid, Spain
    Nat Rev Neurosci 14:202-16. 2013
  8. ncbi request reprint Estimation of the number of synapses in the cerebral cortex: methodological considerations
    J Defelipe
    Instituto Cajal CSIC, Madrid, Spain
    Cereb Cortex 9:722-32. 1999
  9. ncbi request reprint Cortical microanatomy and human brain disorders: epilepsy
    Javier DeFelipe
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Cortex 40:232-3. 2004
  10. ncbi request reprint [The neuropathology of temporal lobe epilepsy: primary and secondary changes in the cortical circuits and epileptogenicity]
    J DeFelipe Oroquieta
    Unidad de Neuropatologia, Instituto Cajal, CSIC, Madrid, 28002, Espana
    Rev Neurol 34:401-8. 2002

Detail Information

Publications66

  1. ncbi request reprint Catecholaminergic innervation of pyramidal neurons in the human temporal cortex
    Ruth Benavides-Piccione
    Instituto Cajal CSIC, Madrid, Spain
    Cereb Cortex 15:1584-91. 2005
    ..Thus, this aspect of human cortical organization is likely to have important implications in cortical function...
  2. ncbi request reprint PSA-NCAM immunoreactivity in chandelier cell axon terminals of the human temporal cortex
    Jon I Arellano
    Instituto Cajal, CSIC, E 28002 Madrid, Spain
    Cereb Cortex 12:617-24. 2002
    ..The results suggest that chandelier terminals in layers II and III of the human entorhinal cortex and temporal neocortex might be particularly susceptible to plastic changes...
  3. ncbi request reprint Cortical interneurons: from Cajal to 2001
    Javier DeFelipe
    Instituto Cajal CSIC, Avenida del Doctor Arce 37, 28002 Madrid, Spain
    Prog Brain Res 136:215-38. 2002
    ..10. Given the complexity of cortical circuits and the areal and species differences, it is impossible to draw a "sufficiently" complete basic diagram of cortical microcircuitry that is valid for all cortical areas and species...
  4. ncbi request reprint Pyramidal cell specialization in the occipitotemporal cortex of the vervet monkey
    Guy N Elston
    Vision, Touch and Hearing Research Centre, School of Biomedical Sciences and Queensland Brain Institute, The University of Queensland, Queensland 4072, Australia
    Neuroreport 16:967-70. 2005
    ..These findings support earlier reports of interareal specialization in pyramidal cell structure in occipitotemporal visual areas in the macaque monkey...
  5. ncbi request reprint Double-bouquet cells in the monkey and human cerebral cortex with special reference to areas 17 and 18
    Javier DeFelipe
    Cajal Institute CSIC, Avenida Dr Arce 37, 28002 Madrid, Spain
    Prog Brain Res 154:15-32. 2006
    ..This suggests important differences in the microcolumnar organization between these areas, the functional significance of which awaits detailed correlative physiological and microanatomical studies...
  6. doi request reprint Cajal and the discovery of a new artistic world: the neuronal forest
    Javier DeFelipe
    Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, Universidad Politecnica de Madrid, Madrid, Spain Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain Electronic address
    Prog Brain Res 203:201-20. 2013
    ..In the hands of Cajal, the Golgi method represented not only the principal tool that was to change the course of the history of neuroscience but also the discovery of a new artistic world, the neuronal forest. ..
  7. pmc New insights into the classification and nomenclature of cortical GABAergic interneurons
    Javier DeFelipe
    Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, Universidad Politecnica de Madrid, Campus Montegancedo S N, Pozuelo de Alarcon, 28223 Madrid, Spain
    Nat Rev Neurosci 14:202-16. 2013
    ..These results demonstrate a practical and objective approach to the naming, characterization and classification of neurons based on community consensus...
  8. ncbi request reprint Estimation of the number of synapses in the cerebral cortex: methodological considerations
    J Defelipe
    Instituto Cajal CSIC, Madrid, Spain
    Cereb Cortex 9:722-32. 1999
    ..Finally, based on our present results and previous literature, we propose a simple general protocol for estimating the numerical synaptic density by volume in the neuropil of the cerebral cortex...
  9. ncbi request reprint Cortical microanatomy and human brain disorders: epilepsy
    Javier DeFelipe
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Cortex 40:232-3. 2004
  10. ncbi request reprint [The neuropathology of temporal lobe epilepsy: primary and secondary changes in the cortical circuits and epileptogenicity]
    J DeFelipe Oroquieta
    Unidad de Neuropatologia, Instituto Cajal, CSIC, Madrid, 28002, Espana
    Rev Neurol 34:401-8. 2002
    ..This region, in turn, may induce the formation of secondary epileptogenic regions situated at some distance from the primary focus...
  11. ncbi request reprint Spaceflight induces changes in the synaptic circuitry of the postnatal developing neocortex
    J Defelipe
    Instituto Cajal CSIC, Avenida Dr Arce 37, 28002 Madrid, Spain
    Cereb Cortex 12:883-91. 2002
    ..These results indicates that terrestrial gravity is a necessary environmental parameter for normal cortical synaptogenesis. These findings are fundamental in planning future long-term spaceflights...
  12. ncbi request reprint Sesquicentenary of the birthday of Santiago Ramón y Cajal, the father of modern neuroscience
    Javier DeFelipe
    Cajal Institute CSIC, Ave Dr Arce 37, 28002 Madrid, Spain
    Trends Neurosci 25:481-4. 2002
    ..These studies represent the roots of what are today some of the most exciting areas of discovery in terms of the structure and function of the brain in both sickness and health...
  13. ncbi request reprint Microstructure of the neocortex: comparative aspects
    Javier DeFelipe
    Instituto Cajal CSIC, Avenida Dr Arce, 37, 28002 Madrid, Spain
    J Neurocytol 31:299-316. 2002
    ..In turn, the differences probably indicate the evolutionary adaptation of excitatory and inhibitory circuits to particular functions...
  14. ncbi request reprint The human temporal cortex: characterization of neurons expressing nitric oxide synthase, neuropeptides and calcium-binding proteins, and their glutamate receptor subunit profiles
    M C Gonzalez-Albo
    Instituto Cajal CSIC, Avenida Dr Arce, 37, 28002 Madrid, Spain
    Cereb Cortex 11:1170-81. 2001
    ..Thus, various distinct, but overlapping, inhibitory circuits may act in concert in the modulation of normal cortical function, plasticity and disease...
  15. doi request reprint From the connectome to the synaptome: an epic love story
    Javier DeFelipe
    Instituto Cajal Consejo Superior de Investigaciones Científicas and Laboratorio de Circuitos Corticales Centro de Tecnologí Biomédica, Universidad Politecnica de Madrid, Spain
    Science 330:1198-201. 2010
    ..Nevertheless, advances in our capacity to marry macro- and microscopic data may help establish a realistic statistical model that could describe connectivity at the ultrastructural level, the "synaptome," giving us cause for optimism...
  16. ncbi request reprint Local changes in GTP-binding protein immunoreactivities in human epileptogenic neocortex
    J Defelipe
    Instituto Cajal CSIC, Madrid, Spain
    Exp Brain Res 119:153-8. 1998
    ..Moreover, our results suggest that high levels of Gi1alpha and low levels of the other G-protein subtypes appear to be associated with a greater susceptibility to maintaining spiking activity...
  17. ncbi request reprint Types of neurons, synaptic connections and chemical characteristics of cells immunoreactive for calbindin-D28K, parvalbumin and calretinin in the neocortex
    J Defelipe
    Instituto Cajal CSIC, Madrid, Spain
    J Chem Neuroanat 14:1-19. 1997
    ..However, a certain overlap exits, which also shows regional and species differences...
  18. ncbi request reprint [Chandelier cells and their possible implication in epilepsy]
    J de Felipe
    Instituto Cajal, Madrid
    Neurologia 14:7-19. 1999
    ..In this article, we explain the hypothesis that chandelier cells (which are considered to be the most powerful cortical inhibitory interneuron) may represent a key component in the etiology of epilepsy...
  19. ncbi request reprint Distribution and patterns of connectivity of interneurons containing calbindin, calretinin, and parvalbumin in visual areas of the occipital and temporal lobes of the macaque monkey
    J Defelipe
    Instituto Cajal CSIC, 28002 Madrid, Spain
    J Comp Neurol 412:515-26. 1999
    ..The differences may represent regional specializations related to the different processing of visual stimuli, whereas the similarities may be attributed to general functional requisites for interneuronal circuitry...
  20. ncbi request reprint Chandelier cells and epilepsy
    J Defelipe
    Instituto Cajal CSIC, Madrid, Spain
    Brain 122:1807-22. 1999
    ..Evidence suggests that the loss of chandelier cells may be non-specific and that when this occurs epilepsy may develop. Therefore, these cells might represent a key component in the aetiology of human temporal lobe epilepsy...
  21. ncbi request reprint Brain plasticity and mental processes: Cajal again
    Javier DeFelipe
    Instituto Cajal CSIC, Avenida Dr Arce, 37, Madrid 28002, Spain
    Nat Rev Neurosci 7:811-7. 2006
    ..Here, I focus on some of these early experiments and how they continue to influence studies of brain plasticity...
  22. ncbi request reprint Histopathology and reorganization of chandelier cells in the human epileptic sclerotic hippocampus
    J I Arellano
    Departmento de Neuroanatomía y Biología Celular, Instituto Cajal, CSIC, Madrid, Spain
    Brain 127:45-64. 2004
    ..When considered along with other extrahippocampal alterations, we suggest that these changes are important in the pathophysiology of temporal lobe epilepsy associated with hippocampal sclerosis...
  23. ncbi request reprint Microanatomy of the dysplastic neocortex from epileptic patients
    L Alonso-Nanclares
    Instituto Cajal, CSIC, Madrid, Spain
    Brain 128:158-73. 2005
    ..We discuss the possible relationship between these alterations and epilepsy, bearing in mind the possible limitations that preclude the extrapolation of the results to the whole population of epileptic patients with dysplastic neocortex...
  24. ncbi request reprint Non-synaptic dendritic spines in neocortex
    J I Arellano
    Departamento de Neuroanatomia y Biologia Celular, Instituto Cajal CSIC, Ave Dr Arce, 37, 28002 Madrid, Spain
    Neuroscience 145:464-9. 2007
    ..6% of the spines clearly lacked synapses. Nonsynaptic spines were small and had no clear head, resembling dendritic filopodia, and could represent a source of new synaptic connections in the adult cerebral cortex...
  25. ncbi request reprint Density and morphology of dendritic spines in mouse neocortex
    I Ballesteros-Yáñez
    Cajal Institute CSIC, Avda Dr Arce 37, 28002 Madrid, Spain
    Neuroscience 138:403-9. 2006
    ....
  26. ncbi request reprint Neuropathological findings in a patient with epilepsy and the Parry-Romberg syndrome
    J Defelipe
    Instituto Cajal, CSIC, Madrid, Spain
    Epilepsia 42:1198-203. 2001
    ..This study is the first reported case of the Parry-Romberg syndrome, with intractable temporal lobe epilepsy, in which detailed microanatomic analyses have been performed on resected brain tissue obtained after surgical intervention...
  27. ncbi request reprint Changes in the colocalization of glutamate ionotropic receptor subunits in the human epileptic temporal lobe cortex
    M C Gonzalez-Albo
    Instituto Cajal CSIC, Avenida Dr Arce 37, 28002 Madrid, Spain
    Exp Brain Res 138:398-402. 2001
    ..These changes may lead to profound modifications in the functioning of excitatory synaptic circuits in spiking cortex...
  28. ncbi request reprint Pyramidal cell axons show a local specialization for GABA and 5-HT inputs in monkey and human cerebral cortex
    J Defelipe
    Instituto Cajal CSIC, Ave Dr Arce, 37, 28002 Madrid, Spain
    J Comp Neurol 433:148-55. 2001
    ....
  29. doi request reprint Layer-specific alterations to CA1 dendritic spines in a mouse model of Alzheimer's disease
    P Merino-Serrais
    Instituto Cajal CSIC, Madrid, Spain
    Hippocampus 21:1037-44. 2011
    ..Since dendritic spines bear most of the excitatory synapses in the brain, changes in spine morphology may be one of the factors contributing to the cognitive impairments observed in this AD model...
  30. ncbi request reprint Alterations in the phenotype of neocortical pyramidal cells in the Dyrk1A+/- mouse
    R Benavides-Piccione
    Cajal Institute, Av Dr Arce, 37, 28002 Madrid, Spain
    Neurobiol Dis 20:115-22. 2005
    ..These results suggest that Dyrk1A influences the size and complexity of pyramidal cells, and thus their capability to integrate information...
  31. ncbi request reprint Myr+-Gi2 alpha and Go alpha subunits restore the efficacy of opioids, clonidine and neurotensin giving rise to antinociception in G-protein knock-down mice
    J Garzon
    Instituto de Neurobiologia Santiago Ramon y Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Neuropharmacology 38:1861-73. 1999
    ..As G-proteins have been implicated in the pathophysiology of several neural disorders, this finding may be valuable in the therapy of such dysfunctions...
  32. ncbi request reprint A study of SMI 32-stained pyramidal cells, parvalbumin-immunoreactive chandelier cells, and presumptive thalamocortical axons in the human temporal neocortex
    M R del Rio
    Instituto Cajal CSIC, Madrid, Spain
    J Comp Neurol 342:389-408. 1994
    ....
  33. ncbi request reprint Perisomatic glutamatergic axon terminals: a novel feature of cortical synaptology revealed by vesicular glutamate transporter 1 immunostaining
    L Alonso-Nanclares
    Instituto Cajal CSIC, Avenida Dr Arce 37, 28002 Madrid, Spain
    Neuroscience 123:547-56. 2004
    ....
  34. ncbi request reprint The distribution of chandelier cell axon terminals that express the GABA plasma membrane transporter GAT-1 in the human neocortex
    M C Inda
    Instituto Cajal, CSIC, 28002 Madrid, Spain
    Cereb Cortex 17:2060-71. 2007
    ..These differences might be related to the different functional attributes of the cortical regions examined...
  35. ncbi request reprint Transport of CSF antibodies to Galpha subunits across neural membranes requires binding to the target protein and protein kinase C activity
    J Garzon
    Instituto de Neurobiologia Santiago Ramon y Cajal, Consejo Superior de Investigaciones Cientificas, Dr Arce 37, E 28002, Madrid, Spain
    Brain Res Mol Brain Res 65:151-66. 1999
    ..These results indicate that IgGs delivered into the CSF show a saturable binding to Galpha subunits that translocate to the external side of the neural membrane before being internalized by a PKCbeta1-dependent mechanism...
  36. doi request reprint Differential distribution of neurons in the gyral white matter of the human cerebral cortex
    V Garcia-Marin
    Laboratorio de Circuitos Corticales, Centro de Tecnología Biomédica, Universidad Politecnica de Madrid, Madrid, Spain
    J Comp Neurol 518:4740-59. 2010
    ..By contrast, both symmetric and asymmetric axodendritic synapses were observed in the neuropil. We discuss the possible functional implications of these findings in terms of cortical circuits...
  37. ncbi request reprint Chandelier cell axons are immunoreactive for GAT-1 in the human neocortex
    J Defelipe
    Instituto Cajal, CSIC, Madrid, Spain
    Neuroreport 9:467-70. 1998
    ..These experiments showed that the vast majority of Ch-terminals immunoreactive for GAT-1 were also immunoreactive for PV. We concluded that GAT-1 transporter may have an important functional role in controlling pyramidal cell activity...
  38. ncbi request reprint Chronic cocaine treatment alters dendritic arborization in the adult motor cortex through a CB1 cannabinoid receptor-dependent mechanism
    I Ballesteros-Yáñez
    Cajal Institute, CSIC, Avda Doctor Arce 37, 28002 Madrid, Spain
    Neuroscience 146:1536-45. 2007
    ..Our data demonstrate that microanatomy and synaptic connectivity are affected by cocaine, the magnitude and nature of these changes depend on the presence of CB1 receptors...
  39. ncbi request reprint Synaptology of the proximal segment of pyramidal cell basal dendrites
    L Alonso-Nanclares
    Instituto Cajal CSIC Ave Doctor Arce 37, 28002 Madrid, Spain
    Eur J Neurosci 19:771-6. 2004
    ..These data further support the idea that inhibitory terminals exclusively innervate the proximal region of basal dendrites...
  40. ncbi request reprint Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus
    A Andrioli
    Instituto Cajal CSIC, Avda Dr Arce 37, 28002 Madrid, Spain
    Neuroscience 149:131-43. 2007
    ..These findings suggest that, the apparently normal subiculum from sclerotic patients also shows unexpected changes in the density and proportion of PV-ir neurons...
  41. ncbi request reprint The effects of morphine self-administration on cortical pyramidal cell structure in addiction-prone lewis rats
    I Ballesteros-Yáñez
    Cajal Institute, Spanish National Research Council, Avenida Doctor Arce, 37, 28002 Madrid, Spain
    Cereb Cortex 17:238-49. 2007
    ..These results suggest that at least part of the behavioral changes produced by repeated opiate administration may be attributed to alterations in pyramidal cell structure...
  42. pmc Gender differences in human cortical synaptic density
    L Alonso-Nanclares
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Avda Doctor Arce, 37, 28002 Madrid, Spain
    Proc Natl Acad Sci U S A 105:14615-9. 2008
    ..These differences may represent a microanatomical substrate contributing to the functional gender differences in brain activity...
  43. ncbi request reprint Lack of thyroid hormone receptor alpha1 is associated with selective alterations in behavior and hippocampal circuits
    A Guadano-Ferraz
    Instituto de Investigaciones Biomedicas Alberto Sols, CSIC UAM, Madrid, Spain
    Mol Psychiatry 8:30-8. 2003
    ....
  44. ncbi request reprint On dendrites in Down syndrome and DS murine models: a spiny way to learn
    R Benavides-Piccione
    Cajal Institute, 28002 Madrid, Spain
    Prog Neurobiol 74:111-26. 2004
    ....
  45. doi request reprint Widespread changes in dendritic spines in a model of Alzheimer's disease
    S Knafo
    Instituto Cajal CSIC, 28002 Madrid, Spain
    Cereb Cortex 19:586-92. 2009
    ..Because large spines are considered to be the physical traces of long-term memory, widespread decrease in the frequency of large spines likely contributes to the cognitive impairments observed in this AD model...
  46. ncbi request reprint Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation
    E Yus-Najera
    Instituto Cajal, CSIC, Avenida Dr Arce 37, 28002 Madrid, Spain
    Neuroscience 120:353-64. 2003
    ....
  47. ncbi request reprint Aromatase expression in the human temporal cortex
    J G Yague
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, E 28002 Madrid, Spain
    Neuroscience 138:389-401. 2006
    ....
  48. ncbi request reprint Spine distribution in cortical pyramidal cells: a common organizational principle across species
    Guy N Elston
    Vision, Touch and Hearing Research Centre, Department of Physiology and Pharmacology, University of Queensland, St Lucia, QLD 4072, Australia
    Prog Brain Res 136:109-33. 2002
  49. ncbi request reprint Cation-chloride cotransporters and GABA-ergic innervation in the human epileptic hippocampus
    Alberto Munoz
    Instituto Cajal, CSIC, Madrid, Spain
    Epilepsia 48:663-73. 2007
    ....
  50. ncbi request reprint Neocortical circuits: evolutionary aspects and specificity versus non-specificity of synaptic connections. Remarks, main conclusions and general comments and discussion
    Javier DeFelipe
    Instituto Cajal CSIC, Madrid, Spain
    J Neurocytol 31:387-416. 2002
  51. pmc Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
    Giorgio A Ascoli
    Molecular Neuroscience Department and Center for Neural Informatics, Structures, and Plasticity, Krasnow Institute for Advanced Study, George Mason University, MS2A1, 4400 University Drive, Fairfax, Virginia 22030, USA
    Nat Rev Neurosci 9:557-68. 2008
    ..Consistent adoption will be important for the success of such an initiative, and we also encourage the active involvement of the broader scientific community in the dynamic evolution of this project...
  52. ncbi request reprint Correlation of transcriptome profile with electrical activity in temporal lobe epilepsy
    Dominique Arion
    Department of Psychiatry and Neurobiology, University of Pittsburgh, School of Medicine, School of Medicine, W1655 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Neurobiol Dis 22:374-87. 2006
    ....
  53. ncbi request reprint A study of pyramidal cell structure in the cingulate cortex of the macaque monkey with comparative notes on inferotemporal and primary visual cortex
    Guy N Elston
    Vision, Touch and Hearing Research Centre, Department of Physiology and Pharmacology, School of Biomedical Sciences, The University of Queensland, Queensland 4072, Australia
    Cereb Cortex 15:64-73. 2005
    ..These results provide further evidence for a parallel between structural and functional specialization in cortex...
  54. ncbi request reprint Specialization in pyramidal cell structure in the cingulate cortex of the Chacma baboon (Papio ursinus): an intracellular injection study of the posterior and anterior cingulate gyrus with comparative notes on the macaque and vervet monkeys
    Guy N Elston
    Vision, Touch and Hearing Research Centre, School of Biomedical Sciences and Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia
    Neurosci Lett 387:130-5. 2005
    ..Moreover, the complexity in pyramidal cell structure in both the anterior and posterior cingulate gyrus of the baboon differed to that in the corresponding regions in either the macaque or vervet monkeys...
  55. ncbi request reprint Specialization in pyramidal cell structure in the sensory-motor cortex of the Chacma baboon (Papio ursinus) with comparative notes on macaque and vervet monkeys
    Guy N Elston
    Vision, Touch and Hearing Research Centre, Department of Physiology and Pharmacology, School of Biomedical Sciences and Queensland Brain Institute, University of Queensland, Queensland, Australia
    Anat Rec A Discov Mol Cell Evol Biol 286:854-65. 2005
    ..In addition, we found subtle differences in the extent of the interareal differences in pyramidal cell structure between homologous cortical areas in the three species...
  56. ncbi request reprint Cortical area and species differences in dendritic spine morphology
    Ruth Benavides-Piccione
    Instituto Cajal, Madrid, Spain
    J Neurocytol 31:337-46. 2002
    ..Our data suggests that the average synaptic input is modulated according to cortical area and differs among species. We discuss the implications of these findings for common algorithms of cortical processing...
  57. ncbi request reprint Macroanatomy and microanatomy of the temporal lobe
    Javier DeFelipe
    Departament of Neuroanatomy and Cell Biology, Instituto Cajal CSIC, Madrid, Spain
    Semin Ultrasound CT MR 28:404-15. 2007
    ..With this purpose we have prepared this article, which highlights the ultastructural and macroanatomy of the temporal lobe seen on MRI...
  58. ncbi request reprint Regional specialization in pyramidal cell structure in the limbic cortex of the vervet monkey (Cercopithecus pygerythrus): an intracellular injection study of the anterior and posterior cingulate gyrus
    Guy N Elston
    Vision, Touch and Hearing Research Centre, School of Biomedical Sciences and Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072, Australia
    Exp Brain Res 167:315-23. 2005
    ..In addition, the extent of the difference in pyramidal cell structure between these two cortical regions was less in the vervet monkey than in the macaque monkey...
  59. pmc Distribution of neurons expressing tyrosine hydroxylase in the human cerebral cortex
    Ruth Benavides-Piccione
    Instituto Cajal CSIC, Madrid, Spain
    J Anat 211:212-22. 2007
    ..These differences further emphasize the variability in the design of microcircuits between cortical areas and species, and they probably reflect an evolutionary adaptation of cortical circuits to particular functions...
  60. ncbi request reprint Dendritic size of pyramidal neurons differs among mouse cortical regions
    Ruth Benavides-Piccione
    Instituto Cajal, Madrid, Spain
    Cereb Cortex 16:990-1001. 2006
    ..Our data suggest that each cortical region is built with specific neuronal components...
  61. ncbi request reprint Specializations of the granular prefrontal cortex of primates: implications for cognitive processing
    Guy N Elston
    Vision, Touch and Hearing Research Centre, School of Biomedical Sciences and Queensland Brain Institute, University of Queensland, Australia
    Anat Rec A Discov Mol Cell Evol Biol 288:26-35. 2006
    ..In particular, the highly branched, spinous neurons in the human gPFC may be a key component of human intelligence...
  62. ncbi request reprint GABABR1 receptor protein expression in human mesial temporal cortex: changes in temporal lobe epilepsy
    Alberto Munoz
    Instituto Cajal, CSIC, Ave Dr Arce 37, 28002 Madrid, Spain
    J Comp Neurol 449:166-79. 2002
    ..This reduction in GABA(B)R1a-b expression could contribute to the pathophysiology of temporal lobe epilepsy...
  63. ncbi request reprint Double bouquet cell in the human cerebral cortex and a comparison with other mammals
    Inmaculada Ballesteros Yáñez
    Cajal Institute, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Comp Neurol 486:344-60. 2005
    ..We conclude that, although these interneurons may be an important element in the organization of cortical microcolumns in primates, this is not the case in other mammalian species...
  64. ncbi request reprint Different populations of tyrosine-hydroxylase-immunoreactive neurons defined by differential expression of nitric oxide synthase in the human temporal cortex
    Ruth Benavides-Piccione
    Instituto Cajal CSIC, Avenida Dr Arce 37, 28002 Madrid, Spain
    Cereb Cortex 13:297-307. 2003
    ..Consequently, it appears that a partial overlap of the catecholaminergic and nitrergic systems is probably due to the intrinsic cortical TH-nNOS-ir neurons...
  65. pmc Voltage-gated ion channels in the axon initial segment of human cortical pyramidal cells and their relationship with chandelier cells
    Maria Carmen Inda
    Departamento de Biologia Celular, Universidad Complutense de Madrid, Jose Antonio Novais 2, 28040 Madrid, Spain
    Proc Natl Acad Sci U S A 103:2920-5. 2006
    ..We suggest that this molecular segregation and the consequent regional specialization of the GABAergic input to the AIS of pyramidal cells may have important functional implications for the control of pyramidal cell activity...
  66. ncbi request reprint Pyramidal cell specialization in the occipitotemporal cortex of the Chacma baboon (Papio ursinus)
    Guy N Elston
    Vision, Touch and Hearing Research Centre, Dept of Physiology and Pharmacology, School of Biomedical Sciences and Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072 Australia
    Exp Brain Res 167:496-503. 2005
    ....