Jose Luis de la Pompa

Summary

Country: Spain

Publications

  1. ncbi Monitoring Notch1 activity in development: evidence for a feedback regulatory loop
    Gonzalo del Monte
    Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia CSIC, Campus Cantoblanco, Madrid, Spain
    Dev Dyn 236:2594-614. 2007
  2. doi Notch signaling in cardiac development and disease
    Jose Luis de la Pompa
    Laboratorio de Biología Celular y del Desarrollo, Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Darwin 3, Campus de Cantoblanco, 28049 Madrid, Spain
    Pediatr Cardiol 30:643-50. 2009
  3. pmc Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation
    Luis Luna-Zurita
    Laboratorio de Biología Celular y del Desarrollo, Departamento de Biología del Desarrollo Cardiovascular, Centro Nacional de Investigaciones Cardiovasculares CNIC, Madrid, Spain
    J Clin Invest 120:3493-507. 2010
  4. pmc Notch signaling is essential for ventricular chamber development
    Joaquín Grego-Bessa
    Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia CSIC, Darwin 3, Campus de Cantoblanco, E 28049 Madrid, Spain
    Dev Cell 12:415-29. 2007
  5. ncbi Notch signaling in development and cancer
    Victoria Bolós
    Departmento de Inmunología y Oncología, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Darwin 3, Campus de Cantoblanco, E 28049 Madrid, Spain
    Endocr Rev 28:339-63. 2007
  6. pmc CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7R{alpha} gene expression in early human thymopoiesis and leukemia
    Sara Gonzalez-Garcia
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Spain
    J Exp Med 206:779-91. 2009

Collaborators

Detail Information

Publications6

  1. ncbi Monitoring Notch1 activity in development: evidence for a feedback regulatory loop
    Gonzalo del Monte
    Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia CSIC, Campus Cantoblanco, Madrid, Spain
    Dev Dyn 236:2594-614. 2007
    ..We found that Notch1 transcription and activity was severely reduced in zebrafish and mouse Notch pathway mutants, suggesting that vertebrate Notch1 expression is regulated by a positive feedback loop...
  2. doi Notch signaling in cardiac development and disease
    Jose Luis de la Pompa
    Laboratorio de Biología Celular y del Desarrollo, Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Darwin 3, Campus de Cantoblanco, 28049 Madrid, Spain
    Pediatr Cardiol 30:643-50. 2009
    ..Future research will be informative about the involvement of altered NOTCH signaling in chamber abnormalities and other cardiac disorders...
  3. pmc Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation
    Luis Luna-Zurita
    Laboratorio de Biología Celular y del Desarrollo, Departamento de Biología del Desarrollo Cardiovascular, Centro Nacional de Investigaciones Cardiovasculares CNIC, Madrid, Spain
    J Clin Invest 120:3493-507. 2010
    ..This embryonic Notch1-Bmp2-Snail1 relationship may be relevant in adult valve disease, in which decreased NOTCH signaling causes valve mesenchyme cell formation, fibrosis, and calcification...
  4. pmc Notch signaling is essential for ventricular chamber development
    Joaquín Grego-Bessa
    Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia CSIC, Darwin 3, Campus de Cantoblanco, E 28049 Madrid, Spain
    Dev Cell 12:415-29. 2007
    ..We suggest that during trabeculation Notch independently regulates cardiomyocyte proliferation and differentiation, two exquisitely balanced processes whose perturbation may result in congenital heart disease...
  5. ncbi Notch signaling in development and cancer
    Victoria Bolós
    Departmento de Inmunología y Oncología, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Darwin 3, Campus de Cantoblanco, E 28049 Madrid, Spain
    Endocr Rev 28:339-63. 2007
    ..It is essential to understand how Notch integrates inputs from other signaling pathways and how specificity is achieved, because this knowledge may be relevant for future therapeutic applications...
  6. pmc CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7R{alpha} gene expression in early human thymopoiesis and leukemia
    Sara Gonzalez-Garcia
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Spain
    J Exp Med 206:779-91. 2009
    ..Thus, Notch1 controls early T cell development, in part by regulating the stage- and lineage-specific expression of IL-7Ralpha...