A de la Sierra

Summary

Country: Spain

Publications

  1. doi request reprint The clinical significance of metabolic syndrome in hypertension: metabolic syndrome increases cardiovascular risk : the pro position
    Alejandro de la Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, University of Barcelona, 170 Villarroel, Barcelona, 08036, Spain
    High Blood Press Cardiovasc Prev 15:53-7. 2008
  2. ncbi request reprint Angiotensin receptor blockers in hypertension and cardiovascular diseases
    Alejandro de la Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, 170 Villarroel, 08036 Barcelona, Spain
    Cardiovasc Hematol Agents Med Chem 4:67-73. 2006
  3. doi request reprint [Differences on the contribution of specific components of the metabolic syndrome between hypertensive Latin American and Spanish patients]
    Alejandro de la Sierra
    Servicio de Medicina Interna, Hospital Clinic Barcelona, Barcelona, Espana
    Med Clin (Barc) 133:47-52. 2009
  4. doi request reprint Prevalence and factors associated with circadian blood pressure patterns in hypertensive patients
    Alejandro de la Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, University of Barcelona, Villarroel 170, E 08036 Barcelona, Spain
    Hypertension 53:466-72. 2009
  5. ncbi request reprint [Effect of antihypertensive therapy on pulse pressure]
    Alejandro de la Sierra
    Unidad de Hipertension, Servicio de Medicina Interna, Hospital Clinic, Barcelona, Spain
    Med Clin (Barc) 119:41-5. 2002
  6. ncbi request reprint [Impact of components and methods of measurement of blood pressure on damage of target organs and cardiovascular complications in arterial hypertension]
    Alejandro de la Sierra
    Unidad de Hipertensión Servicio de Medicina Interna Hospital Clínic IDIBAPS Universidad de Barcelona España
    Med Clin (Barc) 119:125-9. 2002
  7. doi request reprint Mitigation of calcium channel blocker-related oedema in hypertension by antagonists of the renin-angiotensin system
    A de la Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic 170 Villarroel, Barcelona 08036, Spain
    J Hum Hypertens 23:503-11. 2009
  8. pmc Early detection and management of the high-risk patient with elevated blood pressure
    Cristina Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic University of Barcelona, Spain
    Vasc Health Risk Manag 4:289-96. 2008
  9. doi request reprint Main results and clinical interpretations from the TRANSCEND study
    Alejandro de la Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, University of Barcelona, Barcelona, Spain
    J Hypertens Suppl 27:S22-5. 2009
  10. ncbi request reprint Vascular abnormalities in salt-sensitive hypertension
    Alejandro de la Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, 170 Villarroel, 08036 Barcelona, Spain
    Curr Hypertens Rep 5:93-4. 2003

Collaborators

Detail Information

Publications83

  1. doi request reprint The clinical significance of metabolic syndrome in hypertension: metabolic syndrome increases cardiovascular risk : the pro position
    Alejandro de la Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, University of Barcelona, 170 Villarroel, Barcelona, 08036, Spain
    High Blood Press Cardiovasc Prev 15:53-7. 2008
    ..Independently, it is generally accepted that earlier and more aggressive therapy in subjects with metabolic syndrome will result in a future decrease in cardiovascular morbidity and mortality worldwide...
  2. ncbi request reprint Angiotensin receptor blockers in hypertension and cardiovascular diseases
    Alejandro de la Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, 170 Villarroel, 08036 Barcelona, Spain
    Cardiovasc Hematol Agents Med Chem 4:67-73. 2006
    ..They represent an important step in the search for the ideal antihypertensive agent...
  3. doi request reprint [Differences on the contribution of specific components of the metabolic syndrome between hypertensive Latin American and Spanish patients]
    Alejandro de la Sierra
    Servicio de Medicina Interna, Hospital Clinic Barcelona, Barcelona, Espana
    Med Clin (Barc) 133:47-52. 2009
    ..The aim of the present study was to evaluate possible differences in the impact of the components of metabolic syndrome (MS) on hypertensive patients from countries in Latin America and Spain...
  4. doi request reprint Prevalence and factors associated with circadian blood pressure patterns in hypertensive patients
    Alejandro de la Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, University of Barcelona, Villarroel 170, E 08036 Barcelona, Spain
    Hypertension 53:466-72. 2009
    ..A clinical pattern of high cardiovascular risk is associated with nondipping, suggesting that the blunted nocturnal BP dip may be merely a marker of high cardiovascular risk...
  5. ncbi request reprint [Effect of antihypertensive therapy on pulse pressure]
    Alejandro de la Sierra
    Unidad de Hipertension, Servicio de Medicina Interna, Hospital Clinic, Barcelona, Spain
    Med Clin (Barc) 119:41-5. 2002
    ..However, data regarding the effect of antihypertensive treatment on pulse pressure (PP) are scarce. In the present study, we evaluate the effect of six classes of antihypertensive drugs on PP in an elderly hypertensive cohort...
  6. ncbi request reprint [Impact of components and methods of measurement of blood pressure on damage of target organs and cardiovascular complications in arterial hypertension]
    Alejandro de la Sierra
    Unidad de Hipertensión Servicio de Medicina Interna Hospital Clínic IDIBAPS Universidad de Barcelona España
    Med Clin (Barc) 119:125-9. 2002
    ....
  7. doi request reprint Mitigation of calcium channel blocker-related oedema in hypertension by antagonists of the renin-angiotensin system
    A de la Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic 170 Villarroel, Barcelona 08036, Spain
    J Hum Hypertens 23:503-11. 2009
    ..ARB/CCB and ACEI/CCB combination therapy is also more effective than CCB monotherapy in controlling blood pressure. These combinations represent an important advance in the management of hypertension...
  8. pmc Early detection and management of the high-risk patient with elevated blood pressure
    Cristina Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic University of Barcelona, Spain
    Vasc Health Risk Manag 4:289-96. 2008
    ..The objective would be to impair the progression or to induce the regression of silent vascular damage before a clinical event develops...
  9. doi request reprint Main results and clinical interpretations from the TRANSCEND study
    Alejandro de la Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, University of Barcelona, Barcelona, Spain
    J Hypertens Suppl 27:S22-5. 2009
    ..14.8%; P = 0.046). In conclusion, telmisartan reduces cardiovascular events in high-risk patients with the exception of heart failure hospitalization and can be considered as the first-line therapy in those intolerant to ACE inhibitors...
  10. ncbi request reprint Vascular abnormalities in salt-sensitive hypertension
    Alejandro de la Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, 170 Villarroel, 08036 Barcelona, Spain
    Curr Hypertens Rep 5:93-4. 2003
  11. ncbi request reprint [Prevalence and clinical characteristics of microalbuminuria in the Spanish hypertensive population]
    Alejandro de la Sierra
    Unidad de Hipertension, Servicio de Medicina Interna, Hospital Clinic, Barcelona, Espana
    Med Clin (Barc) 130:201-5. 2008
    ....
  12. pmc Effects of eprosartan on target organ protection
    Alejandro de la Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, IDIBAPS, University of Barcelona, Spain
    Vasc Health Risk Manag 2:79-85. 2006
    ....
  13. ncbi request reprint Comparison of the antihypertensive effects of the fixed dose combination enalapril 10 mg/nitrendipine 20 mg vs losartan 50 mg/hydrochlorothiazide 12.5 mg, assessed by 24-h ambulatory blood pressure monitoring, in essential hypertensive patients
    A de la Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, Barcelona, Spain
    J Hum Hypertens 18:215-22. 2004
    ..E/N achieved a significantly higher office SBP control rate, but this was accompanied by an apparently higher proportion of mild adverse events...
  14. ncbi request reprint Combinations as a first-step therapy in hypertension
    Alejandro de la Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, 170 Villarroel, 08036 Barcelona, Spain
    Curr Hypertens Rep 9:251-2. 2007
  15. ncbi request reprint Management of cardiovascular risk factors in patients with metabolic syndrome
    Alejandro de la Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain
    Cardiovasc Hematol Agents Med Chem 5:209-14. 2007
    ..There is an urgent need for consensus in the treatment of subjects with metabolic syndrome in order to prevent very high future rates of type 2 diabetes and cardiovascular disease...
  16. ncbi request reprint The effect of treatment with eprosartan on pulse pressure: factors predicting response
    Alejandro de la Sierra
    Hypertension Unit, Internal Medicine Department, Hospital Clinic, Barcelona, Spain
    Can J Cardiol 20:17C-22C. 2004
    ..Pulse pressure is an important cardiovascular risk factor, particularly in the elderly and in patients with isolated systolic hypertension. The differential impact of antihypertensive agents on pulse pressure is not known...
  17. ncbi request reprint [Value of pulse pressure as a cardiovascular risk marker]
    Alejandro de la Sierra
    Servicio de Medicina Interna, Hospital Clinic, Universidad de Barcelona, Barcelona, Spain
    Med Clin (Barc) 126:384-8. 2006
    ..Nevertheless, the independence of this protection regarding other blood pressure components or the existence of clear differences between antihypertensive drug classes on pulse pressure reduction are still unknown...
  18. ncbi request reprint [Prevalence and general features of the metabolic syndrome in the Spanish hypertensive population]
    Alejandro de la Sierra
    Servicio de Medicina Interna, Hospital Clinic, Barcelona, Spain
    Med Clin (Barc) 126:406-9. 2006
    ..The aim of the present study was to assess the prevalence and clinical characteristics of metabolic syndrome in a sample of the hypertensive population...
  19. doi request reprint Effectiveness and tolerability of fixed-dose combination enalapril plus nitrendipine in hypertensive patients: results of the 3-month observational, post-marketing, multicentre, prospective CENIT study
    Alejandro de la Sierra
    Hypertension Unit, Hospital Clinic Barcelona, Barcelona, Spain
    Clin Drug Investig 29:459-69. 2009
    ..This study aimed to evaluate the effectiveness (systolic BP [SBP]/diastolic BP [DBP] control) and tolerability of the fixed-dose combination enalapril/nitrendipine 10 mg/20 mg administered as a single daily dose in hypertensive patients...
  20. ncbi request reprint Lack of correlation between two methods for the assessment of salt sensitivity in essential hypertension
    A de la Sierra
    Hypertension Unit, Department of Internal Medicine, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    J Hum Hypertens 16:255-60. 2002
    ....
  21. ncbi request reprint Microalbuminuria in essential hypertension: clinical and biochemical profile
    A de la Sierra
    Hypertension Unit, Department of Internal Medicine, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Spain
    Br J Biomed Sci 57:287-91. 2000
    ..Likewise, microalbuminuria is associated with the degree of renal impairment, and with increased uric acid and triglycerides and decreased HDL-cholesterol...
  22. ncbi request reprint Effect of eprosartan on pulse pressure and blood pressure components in patients with isolated systolic hypertension
    Alejandro de la Sierra
    Hypertension Unit, Internal Medicine Department, Hospital Clinic Barcelona, Spain
    Blood Press Suppl 2:5-10. 2004
    ..In these patients, isolated systolic hypertension (ISH) is an important risk factor for cardiovascular morbidity and mortality...
  23. ncbi request reprint Treatment of hypertension in diabetes mellitus
    A de la Sierra
    Hypertension Unit, Hospital Clinic, 170 Villarroel, 08036 Barcelona, Spain
    Curr Hypertens Rep 2:335-42. 2000
    ..The potential role of this new class in the treatment of hypertension in diabetes will depend on the results of ongoing trials...
  24. doi request reprint Application of hypertension guidelines in clinical practice: implementation of the 2007 ESH/ESC European practice Guidelines in Spain
    Alejandro de la Sierra
    Hypertension Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain
    J Hypertens Suppl 27:S27-32. 2009
    ....
  25. ncbi request reprint Genetic variation of the gamma subunit of the epithelial Na+ channel and essential hypertension. Relationship with salt sensitivity
    E Poch
    Servicio de Nefrologia, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Universidad de Barcelona, Spain
    Am J Hypertens 13:648-53. 2000
    ..Although these data do not support a major causative role for this polymorphism, we cannot exclude that a functional mutation elsewhere in ENaC might be associated with essential hypertension...
  26. ncbi request reprint Effect of salt intake on endothelium-derived factors in a group of patients with essential hypertension
    E Bragulat
    Hypertension Unit, Department of Internal Medicine, , Hospital Clinic, University of Barcelona, Villarroel 170, 08036-Barcelona, Spain
    Clin Sci (Lond) 101:73-8. 2001
    ..However, these alterations are not correlated with changes in blood pressure induced by the high salt intake...
  27. ncbi request reprint Endothelial dysfunction in salt-sensitive essential hypertension
    E Bragulat
    Hypertension Unit, Department of Internal Medicine, , , Barcelona, Spain
    Hypertension 37:444-8. 2001
    ..Impairment of the L-arginine-nitric oxide pathway may be responsible for this abnormal endothelial response...
  28. ncbi request reprint Assessment of salt sensitivity in essential hypertension by 24-h ambulatory blood pressure monitoring
    A de la Sierra
    Department of Internal Medicine, Hospital Clinic, University of Barcelona, Spain
    Am J Hypertens 8:970-7. 1995
    ....
  29. ncbi request reprint Effect of long-term antihypertensive therapy with angiotensin converting enzyme inhibitors on red cell sodium transport
    A de la Sierra
    Department of Internal Medicine, Hospital Clinic, University of Barcelona, Spain
    Am J Hypertens 8:622-5. 1995
    ....
  30. doi request reprint Urinary albumin excretion is associated with true resistant hypertension
    A Oliveras
    Nephrology Division, Hypertension Unit, Medicine Department, Hospital Universitari del Mar, Universitat Autonoma de Barcelona, 08003 Barcelona, Spain
    J Hum Hypertens 24:27-33. 2010
    ..In patients with suspected RH, assessment of 24 h ambulatory BP is the most accurate way to detect a population with high risk for target-organ damage...
  31. ncbi request reprint Detection of a circulating inhibitor of the Na(+)-K(+)-Cl(-) cotransport system in plasma and urine after high salt intake
    I Parés
    Department of General Internal Medicine, Hospital Clinico, Barcelona, Spain
    Am J Hypertens 8:965-9. 1995
    ..These results provide evidence of an Na(+)-K(+)-Cl- cotransport inhibitor factor in plasma and urine from salt-loaded humans, in concordance with previous reports in salt-loaded rats...
  32. ncbi request reprint Molecular basis of salt sensitivity in human hypertension. Evaluation of renin-angiotensin-aldosterone system gene polymorphisms
    E Poch
    Nephrology Department, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Spain
    Hypertension 38:1204-9. 2001
    ..The BP response to high salt intake was different among genotypes of ACE I/D and 11betaHSD G534A, suggesting that these polymorphisms may be potentially useful genetic markers of salt sensitivity...
  33. ncbi request reprint [Absence of an association between the C825T polymorphism of the G-protein beta 3 subunit and salt-sensitivity in essential arterial hypertension]
    D Gonzalez-Nunez
    Servicio de Nefrologia, IDIBAPS, Hospital Clinic, Universidad de Barcelona, Espana
    Nefrologia 21:355-61. 2001
    ....
  34. ncbi request reprint Effect of long-term irbesartan treatment on endothelium-dependent vasodilation in essential hypertensive patients
    E Bragulat
    Hypertension Unit, Department of Internal Medicine, IDIBAPS, Hospital Clinic, University of Barcelona, Spain
    Br J Biomed Sci 60:191-6. 2003
    ..These actions may play an important role in the vascular protecting effects of irbesartan...
  35. ncbi request reprint [Relationship between cardiovascular risk profile and anti-hypertensive drug use. GEDEC (Spanish group of cardiovascular studies]
    A de la Sierra
    Unidad de Hipertension, Hospital Clinic, Barcelona
    Med Clin (Barc) 115:41-5. 2000
    ..The aim of the present study was to analyze the relationship between the cardiovascular risk profile and co-morbid conditions on antihypertensive drug class use...
  36. ncbi request reprint Antihypertensive, cardiovascular, and pleiotropic effects of angiotensin-receptor blockers
    Cristina Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, IDIBAPS, University of Barcelona, 170 Villaroel, 08036 Barcelona, Spain
    Curr Opin Nephrol Hypertens 14:435-41. 2005
    ..To review the antihypertensive, cardiovascular and pleiotropic effects of angiotensin-receptor blockers (ARBs)...
  37. doi request reprint [Determination of urinary albumin excretion in arterial hypertension]
    A de la Sierra
    Unidad de Hipertension, Servicio de Medicina Interna, Hospital Mutua de Terrassa, Universidad de Barcelona, Terrasa, Barcelona, Espana
    Rev Clin Esp 212:172-8. 2012
    ..The aim of the study was to evaluate the proportion of hypertensives attended in Primary Care who had an evaluation of UAE in the last year, along with the methodology of the measurement...
  38. ncbi request reprint Increased insulin resistance in salt sensitive essential hypertension
    V Giner
    Hypertension Unit, Department of Internal Medicine, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Spain
    J Hum Hypertens 15:481-5. 2001
    ..To determine the possible relationship between insulin resistance and salt sensitivity in essential hypertension...
  39. doi request reprint Endothelial dysfunction is associated with increased levels of biomarkers in essential hypertension
    A de la Sierra
    Department of Internal Medicine, Hospital Mutua Terrassa, University of Barcelona, Terrassa, Spain
    J Hum Hypertens 24:373-9. 2010
    ..These could be potentially helpful markers of high risk in hypertensive patients...
  40. ncbi request reprint The kidney and cardiovascular risk--implications for management: a consensus statement from the European Society of Hypertension
    Luis Ruilope
    Hypertension Unit, Hospital 12 de Octubre, Madrid, Spain
    Blood Press 16:72-9. 2007
    ....
  41. ncbi request reprint Increased levels of atherosclerosis markers in salt-sensitive hypertension
    Maria Larrousse
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, Villaroel 170, 08036 Barcelona, Spain
    Am J Hypertens 19:87-93. 2006
    ..We evaluated several serum markers of atherosclerosis and endothelial function in a group of essential hypertensive patients classified on the basis of their salt sensitivity...
  42. doi request reprint Clinical characteristics of isolated clinic hypertension
    Ernest Vinyoles
    La Mina Primary Care Center, Catalan Health Institute, Barcelona, Spain
    J Hypertens 26:438-45. 2008
    ..To analyze the clinical characteristics of patients with isolated clinic hypertension (ICH) compared with other hypertensive patients, and to evaluate the capacity of physicians to predict a diagnosis of ICH...
  43. ncbi request reprint Chronic hypotension in hemodialysis patients: role of functional vascular changes and vasodilator agents
    E Coll
    Nephrology Unit, Hospital Clinic, Barcelona, Spain
    Clin Nephrol 69:114-20. 2008
    ....
  44. ncbi request reprint Cerebral white matter lesions in essential hypertension
    C Sierra
    Hypertension Unit, Hospital Clinic, 170 Villarroel, 08036 Barcelona, Spain
    Curr Hypertens Rep 3:429-33. 2001
    ..Some authors suggest that the presence of WML in hypertensive patients could be considered an early marker of brain damage...
  45. ncbi request reprint Relation of left ventricular hypertrophy to regional cerebral blood flow: single photon emission computed tomography abnormalities in essential hypertension
    Cristina Sierra
    Hypertension Unit, Department of Internal Medicine, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital ClAnic, University of Barcelona, Spain
    J Clin Hypertens (Greenwich) 8:700-5. 2006
    ..The authors conclude that the presence of LVH in middle-aged patients with essential hypertension is associated with a reduction of regional cerebral blood flow in the striatum area...
  46. ncbi request reprint Once-daily fixed-combination irbesartan 300 mg/ hydrochlorothiazide 25 mg and circadian blood pressure profile in patients with essential hypertension
    Antonio Coca
    Hospital Clinico IDIBAPS, University of Barcelona, Barcelona, Spain
    Clin Ther 25:2849-64. 2003
    ..Tolerable combinations using higher doses of antihypertensive drugs are frequently required to control blood pressure...
  47. ncbi request reprint [Factors predicting a short length of stay for acute exacerbations of chronic obstructive pulmonary disease]
    Jaume Villalta
    Servei de Medicina Interna, Hospital Clinic de Barcelona, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    Med Clin (Barc) 124:648-50. 2005
    ..We intended to identify the factors predicting a short length of stay in patients with chronic obstructive pulmonary disease (COPD) and acute exacerbations in order to select those who are tributary to be admitted in a short stay unit...
  48. ncbi request reprint Trough-to-peak ratio, smoothness index, and circadian blood pressure profile after treatment with once-daily fixed combination of losartan 100 and hydrochlorothiazide 25 in essential hypertension
    Antonio Coca
    Hypertension Research Foundation of the Catalan Community Hospitals, Barcelona, Spain
    J Cardiovasc Pharmacol 39:824-33. 2002
    ..09 for SBP and 7.15 for DBP. No side effects or changes in metabolic parameters were observed. The fixed combination of losartan 100 mg/hydrochlorothiazide 25 was very effective and well tolerated...
  49. ncbi request reprint Effects of alcohol withdrawal on 24 hour ambulatory blood pressure among alcohol-dependent patients
    Ramon Estruch
    Alcohol Unit, Department of Internal Medicine, Hospital Clinic, University of Barcelona, Institut de Investigacions Biomediques August Pi i Sunyer, Spain
    Alcohol Clin Exp Res 27:2002-8. 2003
    ..We embarked on a study to determine whether different subgroups of alcohol-dependent patients may be identified in relation to the effect of alcohol on BP...
  50. ncbi request reprint [Appropriateness of hospitalization in a short stay unit of a teaching hospital. A controlled study]
    Jaume Villalta
    Servei de Medicina Interna Hospital Clínic, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    Med Clin (Barc) 122:454-6. 2004
    ..Our aim was to evaluate the rate and the reasons for inappropriate hospital use in a medical Short Stay Unit (SSU) in comparison with conventional hospitalization...
  51. ncbi request reprint Silent cerebral white matter lesions and cognitive function in middle-aged essential hypertensive patients
    Cristina Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Am J Hypertens 17:529-34. 2004
    ..The aim of the present study was to evaluate cognitive function in asymptomatic middle-aged hypertensive patients according to the presence or absence of white matter lesions...
  52. ncbi request reprint Blood pressure variability and silent cerebral damage in essential hypertension
    Elisenda Gómez-Angelats
    Department of Internal Medicine, Hospital Clinic, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Spain
    Am J Hypertens 17:696-700. 2004
    ..The aim of this study was to analyze the association between blood pressure variability and the presence of silent cerebral white matter lesions in middle-aged asymptomatic essential hypertensives...
  53. ncbi request reprint Renin-angiotensin system genetic polymorphisms and cerebral white matter lesions in essential hypertension
    Cristina Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, University of Barcelona, Spain
    Hypertension 39:343-7. 2002
    ..However, because of the small sample size, these results require confirmation in a larger study...
  54. ncbi request reprint Silent cerebral white matter lesions in middle-aged essential hypertensive patients
    Cristina Sierra
    Hypertension Unit, Department of Internal Medicine, Hospital Clinic, IDIBAPS, University of Barcelona, Spain
    J Hypertens 20:519-24. 2002
    ..This study investigates which factors related to hypertension per se are associated with the presence of WML in asymptomatic, middle-aged, never-treated essential hypertensive patients...
  55. ncbi request reprint Significance of elevated blood pressure and its management on the short-term outcome of patients with acute ischemic stroke
    Jose Luis Rodriguez-Garcia
    Department of Internal Medicine, Mancha Centro Hospital, 13600 Alcázar de San Juan, Ciudad Real, Spain
    Am J Hypertens 18:379-84. 2005
    ..The objectives of this study were to characterize blood pressure (BP) in acute ischemic stroke and to determine its relationship with short-term functional outcome...
  56. ncbi request reprint Salt intake, endothelial dysfunction, and salt-sensitive hypertension
    Ernesto Bragulat
    Hypertension Unit, Department of Internal Medicine, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic, 170 Villaroel, 08036 Barcelona, Spain
    J Clin Hypertens (Greenwich) 4:41-6. 2002
    ....
  57. ncbi request reprint Correlation between silent cerebral white matter lesions and left ventricular mass and geometry in essential hypertension
    Cristina Sierra
    Department of Internal Medicine, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Spain
    Am J Hypertens 15:507-12. 2002
    ..The aim of this study was to assess the association between the presence of silent WMLs and left ventricular mass and geometry in middle-aged individuals with hypertension that had never been treated...
  58. ncbi request reprint Cerebral hemodynamics and silent cerebral white matter lesions in middle-aged essential hypertensive patients
    Cristina Sierra
    Hypertension Unit, Department of Internal Medicine, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Spain
    Blood Press 13:304-9. 2004
    ..This increased pulsatility is also associated with higher pulse pressure values, suggesting a pathogenetic link between pulse pressure, pulsatility and the development of WML...
  59. ncbi request reprint A multicenter, randomized, double-blind comparison of the efficacy and safety of irbesartan and enalapril in adults with mild to moderate essential hypertension, as assessed by ambulatory blood pressure monitoring: the MAPAVEL Study (Monitorización Ambula
    Antonio Coca
    Hospital Clinic, IDIBAPS, University of Barcelona, Spain
    Clin Ther 24:126-38. 2002
    ....
  60. ncbi request reprint [Endothelial dysfunction in chronic renal failure]
    A Cases
    Servicio de Nefrologia, Unidad de Hipertension Arterial, Hospital Clinic, IDIBAPS, Universidad de Barcelona, Barcelona
    Nefrologia 23:42-51. 2003
  61. ncbi request reprint Disturbances of transmembranous sodium transport systems induced by ethanol in human erythrocytes. An approach to the pressor effect of alcohol
    A Coca
    Department of Internal Medicine, Hospital Clinico, School of Medicine, University of Barcelona, Spain
    Am J Hypertens 2:784-7. 1989
    ..Therefore, alcohol consumption could potentiate those genetic abnormalities of Na+ transport and contribute to the pathogenesis of essential hypertension...
  62. doi request reprint Antihypertensive treatment and stroke prevention: are angiotensin receptor blockers superior to other antihypertensive agents?
    Pedro Armario
    Unit of Hypertension and Vascular Risk, Department of Internal Medicine, Hospital General de L Hospitalet, University of Barcelona, Spain
    Ther Adv Cardiovasc Dis 3:197-204. 2009
    ....
  63. doi request reprint Diurnal blood pressure variation, risk categories and antihypertensive treatment
    Alejandro de la Sierra
    Department of Internal Medicine, Hospital Mutua Terrassa, University of Barcelona, Barcelona, Spain
    Hypertens Res 33:767-71. 2010
    ..Among patients receiving only one drug, non-dihydropyridine calcium channel blockers and alpha-blockers are associated with less nocturnal BP decline than other antihypertensive drug classes, even after adjusting for the level of risk...
  64. doi request reprint [Prevalence of target organ damage and factors associated with cardiovascular events in subjects with refractory hypertension]
    Pedro Armario
    Unidad de Hipertensión y Riesgo Vascular, Servicio de Medicina Interna, Hospital General de L Hospitalet, Universitat de Barcelona, Barcelona, Espana
    Med Clin (Barc) 133:127-31. 2009
    ..To asses the prevalence of target organ damage (TOD) and factors associated with cardiovascular events in subjects with refractory hypertension...
  65. ncbi request reprint G-protein beta3-subunit gene variant, blood pressure and erythrocyte sodium/lithium countertransport in essential hypertension
    Esteban Poch
    Servicio de Nefrologia, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Universidad de Barcelona, Spain
    Br J Biomed Sci 59:101-4. 2002
    ....
  66. ncbi request reprint [Lack of association between blood pressure variability and left ventricular hypertrophy in essential hypertension]
    Elisenda Gómez Angelats
    Unidad de Hipertension, Servicio de Medicina Interna, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona IDIBAPS, Barcelona, Spain
    Med Clin (Barc) 123:731-4. 2004
    ..The aim of the present study was to analyze the association between BP variability, defined through different instrument measures, and LVH in a group of essential hypertensive patients...
  67. ncbi request reprint [Use of antihypertensive drug therapy and risk of development of congestive heart failure]
    Javier Sobrino
    Unidad de Hipertension, Hospital de lEsperit Sant, Santa Coloma de Gramenet, Barcelona, Spain
    Med Clin (Barc) 123:328-31. 2004
    ..The aim of the present study was to evaluate such a possible association in patients who had a new diagnosis of congestive heart failure...
  68. ncbi request reprint [Ambulatory blood pressure monitoring (CABPM): clinical characteristics of 31,530 patients]
    Cristina Sierra
    Unidad de Hipertension, Servicio de Medicina Interna, Hospital Clinic, Barcelona, Espana
    Med Clin (Barc) 129:1-5. 2007
    ..Ambulatory blood pressure monitoring (ABPM) is a useful diagnostic and therapeutic tool in hypertensive patients. This study reports the clinical characteristics of 31,530 patients included in the Spanish Registry of ABPM...
  69. doi request reprint Resistant hypertension: patient characteristics, risk factors, co-morbidities and outcomes
    A Oliveras
    Department of Nephrology, Hospital del Mar, Barcelona, Spain
    J Hum Hypertens 28:213-7. 2014
    ....
  70. ncbi request reprint New developments in the diagnosis and management of resistant hypertension
    A Oliveras
    Hypertension Unit, Department of Nephrology, Hospital del Mar, Barcelona, Spain
    Curr Med Chem 19:1210-8. 2012
    ....
  71. doi request reprint [Prevention of progression and regression of target organ damage. Future strategies]
    A de la Sierra
    Unidad de Hipertension, Servicio de Medicina Interna, Hospital Mutua Terrassa, Universidad de Barcelona, Barcelona, Spain
    Rev Clin Esp 211:8-14. 2011
    ....
  72. ncbi request reprint Blood pressure as a therapeutic target in stroke
    Pedro Armario
    Unit of Hypertension and Vascular Risk, Department of Internal Medicine, Hospital General de L Hospitalet, University of Barcelona, Spain
    Curr Top Med Chem 9:1278-84. 2009
    ....
  73. ncbi request reprint Putative endothelial progenitor cells are associated with flow-mediated dilation in refractory hypertensives
    Anna Oliveras
    Hypertension Unit, Nephrology Department, Hospital Universitari del Mar, Universitat Autonoma de Barcelona, Medicine Department, Barcelona, Spain
    Blood Press 17:298-305. 2008
    ..Hypertension has been related to endothelial dysfunction. Patients with refractory hypertension (RH) have a reduced number of endothelial progenitor cells (EPCs)...
  74. ncbi request reprint Association of the G protein beta3 subunit T allele with insulin resistance in essential hypertension
    Esteban Poch
    Servicio de Nefrologia, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Universidad de Barcelona, Spain
    Clin Exp Hypertens 24:345-53. 2002
    ..386, p = 0.022). These results suggest a relationship between the 825T allele of GNB3 and insulin resistance in the essential hypertensive patients studied, which seems to be independent of BMI...
  75. ncbi request reprint [Finapres and Portapres devices]
    C Sierra
    Unidad de Hipertension, IDIBAPS, Hospital Clinic, Universidad de Barcelona
    Nefrologia 22:12-5. 2002
  76. ncbi request reprint [Accuracy of the automated oscillometric device Lohmeier B-606, for blood pressure measurement in hospitals]
    Dolors Estrada
    Unidad de Hipertension, Servicio de Medicina Interna, Hospital Clinic, Barcelona, Espana
    Med Clin (Barc) 119:492-4. 2002
    ..The aim of the present study was to evaluate the accuracy of an automated oscillometric device, Lohmeier B-606, for clinical use in hospitals, according to there commendations of the European Society of Hypertension...
  77. doi request reprint Introduction: The pharmacological profile of eprosartan--implications for cerebrovascular and cardiovascular risk reduction
    Alejandro de la Sierra
    Curr Med Res Opin 23:S1-3. 2007
    ..Eprosartan, therefore, represents a useful therapeutic option in the management of patients with hypertension, including those with a history of stroke or with co-morbid type 2 diabetes mellitus...
  78. ncbi request reprint [Genetic polymorphisms of the renin-angiotensin system and essential hypertension]
    Esteban Poch
    Unidad de Hipertensión Servicios de Nefrología y Medicina Interna Hospital Clínic IDIBAPS Barcelona Spain
    Med Clin (Barc) 118:575-9. 2002
    ....
  79. ncbi request reprint Effectiveness of blood pressure control outside the medical setting
    Jose R Banegas
    Department of Preventive Medicine and Public Health, Autonomous University of Madrid, Madrid, Spain
    Hypertension 49:62-8. 2007
    ..However, the burden of underestimation and overestimation of BP control at the office is still remarkable. Physicians should be aware that the likelihood of misestimating BP control is higher in some hypertensive subjects...
  80. ncbi request reprint Undiagnosed obesity in hypertension: clinical and therapeutic implications
    Ramon Romero
    Department of Nephrology, Hospital Germans Trias i Pujol, Universidad Autonoma de Barcelona, Carretera del Canyet, 08916 Badalona, Spain
    Blood Press 16:347-53. 2007
    ..The aim of this study was to determine the prevalence of obesity in patients with hypertension and to evaluate the relationship between obesity, metabolic syndrome (MetS) and blood pressure (BP) control...
  81. ncbi request reprint [Renin inhibitors]
    Alejandro de la Sierra
    Med Clin (Barc) 128:214-5. 2007
  82. ncbi request reprint [Pulse pressure and cardiovascular risk: from epidemiology to pathophysiology]
    Alejandro de la Sierra
    Med Clin (Barc) 130:374-5. 2008
  83. ncbi request reprint [Prognostic value of high blood pressure in diabetic patients]
    Alejandro de la Sierra
    Med Clin (Barc) 128:495-7. 2007