Research Topics
Genomes and GenesSpecies | Benedicto Crespo-FacorroSummaryCountry: Spain Publications
| Collaborators
|
Detail Information
Publications
Reduced thalamic volume in first-episode non-affective psychosis: correlations with clinical variables, symptomatology and cognitive functioningBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, Department of Psychiatry, Planta 2 a, Edificio 2 de Noviembre Avda, Valdecilla s n, 39008, Santander, Spain
Neuroimage 35:1613-23. 2007..However, further investigations are warranted to fully clarify the relationship between those structural anomalies and clinical and cognitive outcomes...- A practical clinical trial comparing haloperidol, risperidone, and olanzapine for the acute treatment of first-episode nonaffective psychosisBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, Department of Psychiatry, Santander, Spain
J Clin Psychiatry 67:1511-21. 2006.... 
Neurocognitive effectiveness of haloperidol, risperidone, and olanzapine in first-episode psychosis: a randomized, controlled 1-year follow-up comparisonBenedicto Crespo-Facorro
Department of Psychiatry, CIBERSAM, School of Medicine, University Hospital Marques de Valdecilla, University of Cantabria, Santander, Spain
J Clin Psychiatry 70:717-29. 2009..To investigate the neurocognitive effectiveness of haloperidol, risperidone, and olanzapine in first-episode schizophrenia-spectrum disorders...- First-episode schizophrenia patients neuropsychologically within the normal limits: evidence of deterioration in speed of processingCesar Gonzalez-Blanch
Psychiatry Research Unit of Cantabria, IFIMAV, CIBERSAM, University Hospital Marques de Valdecilla, Santander, Spain
Schizophr Res 119:18-26. 2010.... - White matter integrity and cognitive impairment in first-episode psychosisRocio Perez-Iglesias
Department of Psychiatry, Marques de Valdecilla University Hospital, Spain
Am J Psychiatry 167:451-8. 2010..However, a significant proportion of patients do not show any cognitive deficits. The aim of this study was to assess if there were differences in white matter integrity between patients with and without cognitive impairment... - Prediction of acute clinical response following a first episode of non affective psychosis: Results of a cohort of 375 patients from the Spanish PAFIP studyBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Madrid, Spain Electronic address
Prog Neuropsychopharmacol Biol Psychiatry 44:162-7. 2013..We aimed to investigate sociodemographic, premorbid and clinical predictors of response to antipsychotic treatment after a first episode of non-affective psychosis... - Aripiprazole, ziprasidone, and quetiapine in the treatment of first-episode nonaffective psychosis: results of a 6-week, randomized, flexible-dose, open-label comparisonBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
J Clin Psychopharmacol 33:215-20. 2013..Differences in effectiveness between second-generation antipsychotics would determine their position in everyday clinical practice and could help physicians choose the more efficacious antipsychotics... - Gene-environment interactions underlying the effect of cannabis in first episode psychosisJose Maria Pelayo-Teran
Hospital Universitario Marques de Valdecilla, Department of Psychiatry, planta 2a, Edificio 2 de Noviembre Avda Valdecilla s n, 39008, Santander, Spain
Curr Pharm Des 18:5024-35. 2012..The most promising genetic variants in this field are COMT, CNR1, BDNF, AKT1 and NRG1. Additionally, the interaction with other environmental factors and possible gene-gene interactions are considered in the etiological model... 
Clinical usefulness of the screen for cognitive impairment in psychiatry (SCIP-S) scale in patients with type I bipolar disorderGeorgina Guilera
Department of Methodology, Faculty of Psychology, University of Barcelona, Barcelona, Spain
Health Qual Life Outcomes 7:28. 2009..This investigation assessed the psychometric properties of the Spanish version of the Screen for Cognitive Impairment in Psychiatry (SCIP-S) for the detection of cognitive impairment in BD...- Low-activity allele of Catechol-O-Methyltransferase (COMTL) is associated with increased lateral ventricles in patients with first episode non-affective psychosisBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
Prog Neuropsychopharmacol Biol Psychiatry 31:1514-8. 2007..We hypothesized that the low activity-COMT (COMT(L)) allele would be associated with the presence of structural brain changes as assessed by quantitative magnetic resonance imaging (MRI)... - Caudate nucleus volume and its clinical and cognitive correlations in first episode schizophreniaBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
Schizophr Res 91:87-96. 2007..The purpose of this study is to examine the relationship between caudate nucleus volumes and clinical and cognitive features of schizophrenic patients in an early phase of their illness... - Neuropsychological functioning and brain structure in schizophreniaBenedicto Crespo-Facorro
Department of Psychiatry, School of Medicine, University Hospital Marques de Valdecilla, Avenida aldecilla s n, 39008 Santander, Spain
Int Rev Psychiatry 19:325-36. 2007..Therefore, there is still a great need for more methodologically stringent investigations that would help in the advance of our understanding of the cognition/brain structure relationships in schizophrenia... - Specific brain structural abnormalities in first-episode schizophrenia. A comparative study with patients with schizophreniform disorder, non-schizophrenic non-affective psychoses and healthy volunteersBenedicto Crespo-Facorro
Department of Psychiatry, University Hospital Marques de Valdecilla, CIBERSAM, School of Medicine, University of Cantabria, Santander, Spain
Schizophr Res 115:191-201. 2009..The brain changes found in patients with a first episode of schizophrenia spectrum disorders are robustly associated with the diagnoses of schizophrenia and schizophreniform disorder and are independent of relevant intervening variables... - Insular cortex morphometry in first-episode schizophrenia-spectrum patients: Diagnostic specificity and clinical correlationsBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, CIBERSAM, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
J Psychiatr Res 44:314-20. 2010..Contrary to our initial hypotheses, we were unable to demonstrate significant morphometric anomalies in a large and heterogeneous sample of patients with a first-episode of schizophrenia-spectrum disorders... - Interleukin-12 plasma levels in drug-naïve patients with a first episode of psychosis: effects of antipsychotic drugsBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
Psychiatry Res 158:206-16. 2008..Thus, patients with a first episode of psychosis have inflammatory-like immunological function during early phases of the illness that it is independent of the antipsychotic treatment used... - Effect of antipsychotic drugs on brain morphometry. A randomized controlled one-year follow-up study of haloperidol, risperidone and olanzapineBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
Prog Neuropsychopharmacol Biol Psychiatry 32:1936-43. 2008..Here we investigate the effects of risperidone, olanzapine and low doses of haloperidol on cortical and subcortical morphometry in first episode drug naïve patients with non-affective psychosis... - Global and regional cortical thinning in first-episode psychosis patients: relationships with clinical and cognitive featuresB Crespo-Facorro
University Hospital Marques de Valdecilla, CIBERSAM, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
Psychol Med 41:1449-60. 2011..We aimed to explore whether first episode schizophrenia patients already show a significant cortical thinning and whether cortical thickness anomalies may significantly influence clinical and cognitive features... - Long-term (3-year) effectiveness of haloperidol, risperidone and olanzapine: results of a randomized, flexible-dose, open-label comparison in first-episode nonaffective psychosisBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Planta 2ª, Edificio 2 de Noviembre Avda Valdecilla s n, 39008 Santander, Spain
Psychopharmacology (Berl) 219:225-33. 2012..To enhance the effectiveness of antipsychotics in first-episode psychosis is crucial in order to achieve the most favourable prognosis. Difference in effectiveness between antipsychotics is still under debate... - Temporal pole morphology and psychopathology in males with schizophreniaBenedicto Crespo-Facorro
Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
Psychiatry Res 132:107-15. 2004..Interestingly, a reduction in the TP volume, a higher-order multimodal association cortex, was associated with the severity of disorganized and psychotic symptoms... - Effectiveness of haloperidol, risperidone and olanzapine in the treatment of first-episode non-affective psychosis: results of a randomized, flexible-dose, open-label 1-year follow-up comparisonBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
J Psychopharmacol 25:744-54. 2011..Specific clinical programmes and the use of second-generation antipsychotics may enhance the effectiveness of antipsychotic treatments... - Predictors of acute treatment response in patients with a first episode of non-affective psychosis: sociodemographics, premorbid and clinical variablesBenedicto Crespo-Facorro
Hospital Universitario Marques de Valdecilla, Department of Psychiatry, School of Medicine, planta 2a, Edificio 2 de Noviembre, Avda Valdecilla s n, 39008, Santander, Spain
J Psychiatr Res 41:659-66. 2007..Helping clinicians to identify non-responders is meant as a first step to optimise therapeutic effort to benefit individuals in this vulnerable group... - Treatment of the first episode of schizophrenia: an update on pharmacologic and psychological interventionsBenedicto Crespo-Facorro
Department of Psychiatry, Hospital Universitario Marques de Valdecilla, Avda Valdecilla s n 39008, Santander, Spain
Curr Psychiatry Rep 10:202-9. 2008..Cognitive-behavioral therapy and family interventions seem to be effective adjunctive treatments in early phases of schizophrenia in some patients... - Sex-specific variation of MRI-based cortical morphometry in adult healthy volunteers: the effect on cognitive functioningBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, CIBERSAM, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
Prog Neuropsychopharmacol Biol Psychiatry 35:616-23. 2011..In conclusion, our findings do not support the notion of sexual dimorphism in cortical mantle morphology. The results also suggest that variability in cortical thickness may affect cognitive functioning in females but not in males... - Relapse prevention and remission attainment in first-episode non-affective psychosis. A randomized, controlled 1-year follow-up comparison of haloperidol, risperidone and olanzapineBenedicto Crespo-Facorro
Department of Psychiatry, University of Cantabria IFIMAV, Santander 39008, Spain
J Psychiatr Res 45:763-9. 2011..We conclude that haloperidol, olanzapine and risperidone show a similar effectiveness in relapse prevention or in remission attainment during the first year of treatment... - Lack of influence of COMT Val158Met genotype on cognition in first-episode non-affective psychosisIgnacio Mata
University Hospital Marques de Valdecilla, Department of Psychiatry, Santander Cantabria, Spain
Schizophr Res 102:206-9. 2008..We found no significant differences in any cognitive measure according to COMT genotype. These findings, together with previously published research, put the relationship between COMT genotype and cognitive performance in doubt... - Effect of antipsychotic drugs on cortical thickness. A randomized controlled one-year follow-up study of haloperidol, risperidone and olanzapineRoberto Roiz-Santiáñez
University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
Schizophr Res 141:22-8. 2012..We aimed to investigate the effects of low doses of haloperidol, risperidone and olanzapine on cortical thickness... - Effect of antipsychotics on peptides involved in energy balance in drug-naive psychotic patients after 1 year of treatmentRocio Perez-Iglesias
Department of Psychiatry, Marques de Valdecilla University Hospital, University of Cantabria, Cantabria, Spain
J Clin Psychopharmacol 28:289-95. 2008..The unexpected increase in ghrelin levels might be related with the causal mechanism of weight gain induced by antipsychotics. Finally, the 3 antipsychotics had similar effects in all parameters evaluated... - Cognitive dimensions in first-episode schizophrenia spectrum disordersCesar Gonzalez-Blanch
Hospital Universitario Marques de Valdecilla, Department of Psychiatry, School of Medicine, Santander, Spain
J Psychiatr Res 41:968-77. 2007..We aimed to characterize the basic cognitive functioning of a representative sample of patients with a first-episode schizophrenia spectrum disorders... - Catechol-O-methyltransferase Val158Met polymorphism and negative symptoms after acute antipsychotic treatment in first-episode non-affective psychosisJose Maria Pelayo-Teran
Department of Psychiatry, CIBERSAM, University Hospital Marqués de Valdecilla IFIMAV, School of Medicine, University of Cantabria, Santander, Spain
Psychiatry Res 185:286-9. 2011..Val homozygote patients showed higher negative symptoms than Met homozygote patients. The COMT Val158 genotype seems to be related to the severity of negative symptoms rather than to clinical response... - Cognitive functioning in the early course of first-episode schizophrenia spectrum disorders: timing and patternsCesar Gonzalez-Blanch
Hospital Universitario Marques de Valdecilla, Department of Psychiatry, planta 2a, Edificio 2 de Noviembre, Avda Valdecilla s n, 39008, Santander, Spain
Eur Arch Psychiatry Clin Neurosci 256:364-71. 2006..The aim of this study was to examine possible cognitive changes throughout the early course of schizophrenia spectrum disorders... - Insight dimensions in first-episode psychosis patients: clinical, cognitive, pre-morbid and socio-demographic correlatesRosa Ayesa-Arriola
University Hospital Marqués de Valdecilla IFIMAV CIBERSAM, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
Early Interv Psychiatry 5:140-9. 2011..To investigate pre-morbid, socio-demographic, clinical and cognitive variables as predictors of insight in a large and representative sample of first-episode psychosis patients... - Lack of association between clinical and cognitive change in first-episode psychosis: the first 6 weeks of treatmentCesar Gonzalez-Blanch
Mental Health Centre, University Hospital Marques de Valdecilla, University of Cantabria, Santander, Spain
Can J Psychiatry 53:839-47. 2008.... - Association between the interleukin-1 receptor antagonist gene and negative symptom improvement during antipsychotic treatmentIgnacio Mata
Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain
Am J Med Genet B Neuropsychiatr Genet 141:939-43. 2006..These results suggest that the VNTR polymorphism in the IL-1RN gene may be a useful predictor of negative symptom improvement in schizophrenic patients treated with antipsychotic drugs... - A 12-week randomized clinical trial to evaluate metabolic changes in drug-naive, first-episode psychosis patients treated with haloperidol, olanzapine, or risperidoneRocio Perez Iglesias
Department of Psychiatry, Marques de Valdecilla University Hospital, University of Cantabria, Santander, Spain
J Clin Psychiatry 68:1733-40. 2007..This study examined the main metabolic side effects induced by antipsychotic treatment in a cohort of first-episode drug-naive subjects... - Preserved orbitofrontal function in first-episode schizophrenia: further evidence from the object alternation paradigmCesar Gonzalez-Blanch
Psychiatry Research Unit of Cantabria, Department of Psychiatry, School of Medicine, University Hospital Marques de Valdecilla, Santander, Spain
J Nerv Ment Dis 196:67-70. 2008..There were no significant differences between patients and control subjects with respect to the OAT. This finding suggests that the OFC function, as measured by decision-making tasks, is preserved in the early phases of schizophrenia... - Effect of FTO, SH2B1, LEP, and LEPR polymorphisms on weight gain associated with antipsychotic treatmentRocio Perez-Iglesias
Department of Psychiatry, Marques de Valdecilla University Hospital, Planta 2 a, Edificio 2 de Noviembre, Avda Valdecilla s n, 39008 Santander, Spain
J Clin Psychopharmacol 30:661-6. 2010..None of the other single nucleotide polymorphisms evaluated were associated with weight gain during the first 12 months of antipsychotic therapy... - Insular cortex thinning in first episode schizophrenia patientsRoberto Roiz-Santiáñez
University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
Psychiatry Res 182:216-22. 2010..The fact that insular thinning is already present at early phases of the illness and is independent of intervening variables offers evidence for the potential of these changes to be a biological marker of the illness... - Catechol-O-methyltransferase Val158Met polymorphism and clinical characteristics in first episode non-affective psychosisJose Maria Pelayo-Teran
Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain
Am J Med Genet B Neuropsychiatr Genet 147:550-6. 2008..These data would indicate that COMT genotype may have a role in the etiological model for schizophrenia and other psychotic disorders... - Interleukin-1 receptor antagonist genotype and brain morphometry in first-episode non-affective psychosisRoberto Roiz-Santiáñez
University Hospital Marques de Valdecilla, Department of Psychiatry School of Medicine, University of Cantabria, Santander, Spain
Psychiatry Res 162:167-71. 2008..We did not find evidence for association between genetic variation in the IL-1RN gene and brain morphometry at early phases of the illness... - Weight gain induced by haloperidol, risperidone and olanzapine after 1 year: findings of a randomized clinical trial in a drug-naïve populationRocio Perez-Iglesias
Department of Psychiatry, Marques de Valdecilla University Hospital, Avda Valdecilla s n, 39008, University of Cantabria, Spain
Schizophr Res 99:13-22. 2008..There is little information about weight gain induced by antipsychotics at long-term... - One year longitudinal study of the straight gyrus morphometry in first-episode schizophrenia-spectrum patientsRoberto Roiz-Santiáñez
Department of Psychiatry, University of Cantabria, Santander, Spain
Psychiatry Res 202:80-3. 2012..We did not find a differential pattern of volumetric change between the two groups... - Straight gyrus morphology in first-episode schizophrenia-spectrum patientsRoberto Roiz-Santiáñez
Department of Psychiatry, School of Medicine, University of Cantabria, University Hospital Marques de Valdecilla, IFIMAV, Santander, Spain
Prog Neuropsychopharmacol Biol Psychiatry 35:84-90. 2011..Our results, based on a large and representative sample, do not confirm the presence of significant straight gyrus morphometric anomalies in schizophrenia-spectrum disorders, after controlling for potential confounding variables... - Cannabis use and cognitive functioning in first-episode schizophrenia patientsJose Manuel Rodríguez-Sánchez
Department of Psychiatry, CIBERSAM, University Hospital Marques de Valdecilla, IFIMAV, Santander, Spain
Schizophr Res 124:142-51. 2010..Cannabis user patients appear to comprise a subgroup of patients with a better premorbid adjustment and premorbid frontal cognitive functions... - Cognitive functioning and negative symptoms in first episode schizophrenia: different patterns of correlatesJose Manuel Rodríguez-Sánchez
University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
Neurotox Res 14:227-35. 2008..The widely described relationship between negative symptoms and executive impairments in schizophrenia appears to be mediated by likely dysfunctions in the speed of processing instead of by working memory impairment... - Predicting relapse after a first episode of non-affective psychosis: a three-year follow-up studyOlalla Caseiro
Marques de Valdecilla University Hospital, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
J Psychiatr Res 46:1099-105. 2012..A better understanding and improvement in factors which influence relapse should diminish the risk of relapse and consequently improve the outcome of the illness... - Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in first-episode non-affective psychosis: clinical-onset implicationsJose Maria Pelayo-Teran
Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain
Psychiatry Res 179:291-6. 2010..Based on these results, the use of cannabis could exert a modulator effect on the genotype, suppressing the delay effect for the age of onset in the case of the Met allele patients... - Additive effect of NRG1 and DISC1 genes on lateral ventricle enlargement in first episode schizophreniaIgnacio Mata
Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain, CIBERSAM
Neuroimage 53:1016-22. 2010..Our findings suggest that NRG1 and DISC1 genes may be associated with brain abnormalities in schizophrenia through their influence on related pathways of brain development... - Glucose and lipid disturbances after 1 year of antipsychotic treatment in a drug-naïve populationRocio Perez-Iglesias
Department of Psychiatry, Marques de Valdecilla University Hospital, Avda Valdecilla s n, 39008, University of Cantabria, Spain
Schizophr Res 107:115-21. 2009..This study examined the main metabolic side effects induced by antipsychotic treatment in a cohort of first episode drug-naïve subjects after the first year of treatment... - Temporal pole morphology in first-episode schizophrenia patients: clinical correlationsRoberto Roiz-Santiáñez
University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
Psychiatry Res 184:189-91. 2010..Patients did not significantly differ from controls in the TP morphometric variables evaluated. Clinical variables were not significantly related to the TP... - 1-year follow-up study of cognitive function in first-episode non-affective psychosisJosé M Rodríguez-Sánchez
University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
Schizophr Res 104:165-74. 2008..Further investigations are warranted to discern the variability in patterns of specific cognitive deficits over time... - Homocysteine and cognition in first-episode psychosis patientsRosa Ayesa-Arriola
Department of Psychiatry, Marques de Valdecilla University Hospital, IFIMAV, School of Medicine, University of Cantabria, Santander, Spain
Eur Arch Psychiatry Clin Neurosci 262:557-64. 2012..However, no relationship between homocysteine levels and cognitive impairment was detected. These results suggest the need for further studies to clarify the role of homocysteine in the etiology and prognosis of psychosis... - Epidemiological factors associated with treated incidence of first-episode non-affective psychosis in Cantabria: insights from the Clinical Programme on Early Phases of PsychosisJose M Pelayo-Teran
Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain
Early Interv Psychiatry 2:178-87. 2008..The aim of the study was to analyse the treated incidence of schizophrenia in Cantabria (Northern Spain) and the sociodemographic risk factors associated with the illness onset... - White matter defects in first episode psychosis patients: a voxelwise analysis of diffusion tensor imagingRocio Perez-Iglesias
Department of Psychiatry, Marques de Valdecilla University Hospital, Avenida Valdecilla s n, University of Cantabria, Spain
Neuroimage 49:199-204. 2010.... - Serotonin transporter polymorphisms and early response to antipsychotic treatment in first episode of psychosisJavier Vázquez-Bourgon
Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain
Psychiatry Res 175:189-94. 2010..Our results suggest a minor contribution to antipsychotic drug response of genetic alterations in the 5-HTT gene... - A digit symbol coding task as a screening instrument for cognitive impairment in first-episode psychosisCesar Gonzalez-Blanch
Psychiatry Research Unit of Cantabria, IFIMAV, CIBERSAM, University Hospital Marques de Valdecilla, Santander, Spain
Arch Clin Neuropsychol 26:48-58. 2011..The processing speed, as measured by Digit Symbol, may be particularly good in capturing the generalized dysfunction which may be causing the widespread cognitive failures in schizophrenia spectrum disorders... - Prefrontal cognitive functions in stabilized first-episode patients with schizophrenia spectrum disorders: a dissociation between dorsolateral and orbitofrontal functioningJose Manuel Rodríguez-Sánchez
Hospital Universitario Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Planta 2 a, Edificio 2 de Noviembre Avda Valdecilla s n, 39008 Santander, Spain
Schizophr Res 77:279-88. 2005..The OFC functions are unimpaired at the early phases of psychosis and in contrast there is a significant deficit in DLPFC functions in first-episode of schizophrenia... - Effects of family psychoeducation on expressed emotion and burden of care in first-episode psychosis: a prospective observational studyCesar Gonzalez-Blanch
Hospital Universitario Marques de Valdecilla, Unidad de Investigación en Psiquiatría de Cantabria, Avda Valdecilla s n Edificio 2 de Noviembre, planta 2a, 39008 Santander, Cantabria, Spain
Span J Psychol 13:389-95. 2010..Brief psychoeducational groups may not be sufficient to reduce FB and EE associated to the experience of caregiving for a family member with a first-episode psychotic disorder... - Morphometry of the superior temporal plane in schizophrenia: relationship to clinical correlatesBenedicto Crespo-Facorro
Mental Health-Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
J Neuropsychiatry Clin Neurosci 16:284-94. 2004.... - Major depression following traumatic brain injuryRicardo E Jorge
Department of Psychiatry, University of Iowa, 500 Newton Road, Iowa City, IA 52242, USA
Arch Gen Psychiatry 61:42-50. 2004..Major depression is a frequent psychiatric complication among patients with traumatic brain injury (TBI). To our knowledge, however, the clinical correlates of major depression have not been extensively studied... - Identifying attentional deficits in people with first-episode psychosis with the Scale for the Assessment of Negative Symptoms attention subscale: is it possible?Cesar Gonzalez-Blanch
Psychiatry Research Unit of Cantabria, CIBERSAM, University Hospital Marques de Valdecilla, Santander, Spain
Compr Psychiatry 53:701-5. 2012.... - Prevention of antipsychotic-induced weight gain with early behavioural intervention in first-episode psychosis: 2-year results of a randomized controlled trialMario Alvarez-Jimenez
Marques de Valdecilla Public Foundation Research Institute FMV IFIMAV, Santander, Spain
Schizophr Res 116:16-9. 2010..Weight-management interventions may need to be offered for longer periods to maintain preventative effects. Alternatively, booster sessions may need to be regularly delivered after intervention completion... - Cognitive dysfunction in first-episode psychosis: the processing speed hypothesisJose Manuel Rodríguez Sánchez
Department of Psychiatry, School of Medicine, Hospital Universitario Marques de Valdecilla, University of Cantabria, planta 2a, Edificio 2 de Noviembre, Avda, Valdecilla s n, 39008, Santander, Spain
Br J Psychiatry Suppl 51:s107-10. 2007..Speed of processing is a cognitive process underlying cognitive dysfunction in people with chronic schizophrenia... - Neurocognitive diagnosis and cut-off scores of the Screen for Cognitive Impairment in Psychiatry (SCIP-S)Emilio Rojo
Department of Psychiatry, Benito Menni CASM, Granollers Hospital General, Granollers, Barcelona, Spain
Schizophr Res 116:243-51. 2010.... - Attenuation of antipsychotic-induced weight gain with early behavioral intervention in drug-naive first-episode psychosis patients: A randomized controlled trialMario Alvarez-Jimenez
University Hospital Marqués de Valdecilla Clinical and Social Psychiatry Research Unit, Department of Psychiatry, Santander, Spain
J Clin Psychiatry 67:1253-60. 2006.... - Gyrification brain abnormalities associated with adolescence and early-adulthood cannabis useIgnacio Mata
Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, IFIMAV, Santander, Spain
Brain Res 1317:297-304. 2010.... - A neuregulin 1 variant is associated with increased lateral ventricle volume in patients with first-episode schizophreniaIgnacio Mata
Department of Psychiatry, School of Medicine, University of Cantabria, University Hospital Marques de Valdecilla, CIBERSAM, Santander, Spain
Biol Psychiatry 65:535-40. 2009..We examined whether variations in this polymorphism influence brain volumes in first-episode schizophrenia subjects... - Spanish version of the Screen for Cognitive Impairment in Psychiatry (SCIP-S): psychometric properties of a brief scale for cognitive evaluation in schizophreniaOscar Pino
Department of Psychiatry, Hospital General Granollers Benito Menni CASM, Granollers, Barcelona, Spain
Schizophr Res 99:139-48. 2008..This study examined the psychometric properties of the Spanish version of the SCIP in a sample of outpatients suffering schizophrenia-spectrum disorders... - Morphology of the ventral frontal cortex in schizophrenia: relationship with social dysfunctionEran Chemerinski
Mental Health-Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242-1057, USA
Biol Psychiatry 52:1-8. 2002..CONCLUSIONS: Morphology of the VFC is directly related to abnormal social function in schizophrenia, including measures of social dysfunction that predate the onset of illness... - Alcohol misuse and mood disorders following traumatic brain injuryRicardo E Jorge
Department of Psychiatry, The University of Iowa, Iowa City, USA
Arch Gen Psychiatry 62:742-9. 2005..Alcohol abuse and/or dependence (AA/D) and mood disturbance are co-occurring conditions among patients who have had a traumatic brain injury (TBI). However, the relationship between these disorders has not been extensively studied... - Emotions in unmedicated patients with schizophrenia during evaluation with positron emission tomographySergio Paradiso
Mental Health Clinical Research Center, Dapartment of Psychiatry, Univeristy of Iowa College of Medicine, Iowa City, IA 52242 1057, USA
Am J Psychiatry 160:1775-83. 2003..The authors measured regional cerebral blood flow (rCBF) during performance of a task that required unmedicated patients to recognize the emotional valence of visual images and to determine whether they were pleasant or unpleasant... - The child and adolescent first-episode psychosis study (CAFEPS): design and baseline resultsJosefina Castro-Fornieles
Department of Child and Adolescent Psychiatry and Psychology, Institut Clinic of Neurosciences, Institut d Investigacions Biomèdiques August Pi Sunyer, Hospital Clinic Universitari of Barcelona, Villarroel, Spain
Schizophr Res 91:226-37. 2007..This paper describes the methods and rationale behind the study and the general characteristics of the sample... - Morphology of the lateral superior temporal gyrus in neuroleptic nai;ve patients with schizophrenia: relationship to symptomsJae Jin Kim
BK21 Human Life Sciences, Seoul National University, Seoul, South Korea
Schizophr Res 60:173-81. 2003..CONCLUSIONS: These findings suggest that abnormalities in the lateral side of the STG may be associated with both psychotic and negative symptoms through different pathophysiological mechanisms... - Antipsychotic-induced weight gain in chronic and first-episode psychotic disorders: a systematic critical reappraisalMario Alvarez-Jimenez
ORYGEN Research Centre, University of Melbourne, Melbourne, Victoria, Australia
CNS Drugs 22:547-62. 2008..Although antipsychotics present idiosyncratic patterns of weight gain, they may also generate similar absolute gains...