Benedicto Crespo-Facorro

Summary

Country: Spain

Publications

  1. ncbi request reprint A practical clinical trial comparing haloperidol, risperidone, and olanzapine for the acute treatment of first-episode nonaffective psychosis
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, Department of Psychiatry, Santander, Spain
    J Clin Psychiatry 67:1511-21. 2006
  2. ncbi request reprint Reduced thalamic volume in first-episode non-affective psychosis: correlations with clinical variables, symptomatology and cognitive functioning
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, Department of Psychiatry, Planta 2 a, Edificio 2 de Noviembre Avda, Valdecilla s n, 39008, Santander, Spain
    Neuroimage 35:1613-23. 2007
  3. ncbi request reprint Neurocognitive effectiveness of haloperidol, risperidone, and olanzapine in first-episode psychosis: a randomized, controlled 1-year follow-up comparison
    Benedicto Crespo-Facorro
    Department of Psychiatry, CIBERSAM, School of Medicine, University Hospital Marques de Valdecilla, University of Cantabria, Santander, Spain
    J Clin Psychiatry 70:717-29. 2009
  4. doi request reprint First-episode schizophrenia patients neuropsychologically within the normal limits: evidence of deterioration in speed of processing
    Cesar Gonzalez-Blanch
    Psychiatry Research Unit of Cantabria, IFIMAV, CIBERSAM, University Hospital Marques de Valdecilla, Santander, Spain
    Schizophr Res 119:18-26. 2010
  5. doi request reprint White matter integrity and cognitive impairment in first-episode psychosis
    Rocio Perez-Iglesias
    Department of Psychiatry, Marques de Valdecilla University Hospital, Spain
    Am J Psychiatry 167:451-8. 2010
  6. doi request reprint Aripiprazole, Ziprasidone and Quetiapine in the treatment of first-episode nonaffective psychosis: a 12-week randomized, flexible-dose, open-label trial
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Schizophr Res 147:375-82. 2013
  7. doi request reprint Prediction of acute clinical response following a first episode of non affective psychosis: results of a cohort of 375 patients from the Spanish PAFIP study
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 44:162-7. 2013
  8. doi request reprint Aripiprazole, ziprasidone, and quetiapine in the treatment of first-episode nonaffective psychosis: results of a 6-week, randomized, flexible-dose, open-label comparison
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    J Clin Psychopharmacol 33:215-20. 2013
  9. ncbi request reprint Gene-environment interactions underlying the effect of cannabis in first episode psychosis
    Jose Maria Pelayo-Teran
    Hospital Universitario Marques de Valdecilla, Department of Psychiatry, planta 2a, Edificio 2 de Noviembre Avda Valdecilla s n, 39008, Santander, Spain
    Curr Pharm Des 18:5024-35. 2012
  10. pmc Clinical usefulness of the screen for cognitive impairment in psychiatry (SCIP-S) scale in patients with type I bipolar disorder
    Georgina Guilera
    Department of Methodology, Faculty of Psychology, University of Barcelona, Barcelona, Spain
    Health Qual Life Outcomes 7:28. 2009

Collaborators

Detail Information

Publications80

  1. ncbi request reprint A practical clinical trial comparing haloperidol, risperidone, and olanzapine for the acute treatment of first-episode nonaffective psychosis
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, Department of Psychiatry, Santander, Spain
    J Clin Psychiatry 67:1511-21. 2006
    ....
  2. ncbi request reprint Reduced thalamic volume in first-episode non-affective psychosis: correlations with clinical variables, symptomatology and cognitive functioning
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, Department of Psychiatry, Planta 2 a, Edificio 2 de Noviembre Avda, Valdecilla s n, 39008, Santander, Spain
    Neuroimage 35:1613-23. 2007
    ..However, further investigations are warranted to fully clarify the relationship between those structural anomalies and clinical and cognitive outcomes...
  3. ncbi request reprint Neurocognitive effectiveness of haloperidol, risperidone, and olanzapine in first-episode psychosis: a randomized, controlled 1-year follow-up comparison
    Benedicto Crespo-Facorro
    Department of Psychiatry, CIBERSAM, School of Medicine, University Hospital Marques de Valdecilla, University of Cantabria, Santander, Spain
    J Clin Psychiatry 70:717-29. 2009
    ..To investigate the neurocognitive effectiveness of haloperidol, risperidone, and olanzapine in first-episode schizophrenia-spectrum disorders...
  4. doi request reprint First-episode schizophrenia patients neuropsychologically within the normal limits: evidence of deterioration in speed of processing
    Cesar Gonzalez-Blanch
    Psychiatry Research Unit of Cantabria, IFIMAV, CIBERSAM, University Hospital Marques de Valdecilla, Santander, Spain
    Schizophr Res 119:18-26. 2010
    ....
  5. doi request reprint White matter integrity and cognitive impairment in first-episode psychosis
    Rocio Perez-Iglesias
    Department of Psychiatry, Marques de Valdecilla University Hospital, Spain
    Am J Psychiatry 167:451-8. 2010
    ..However, a significant proportion of patients do not show any cognitive deficits. The aim of this study was to assess if there were differences in white matter integrity between patients with and without cognitive impairment...
  6. doi request reprint Aripiprazole, Ziprasidone and Quetiapine in the treatment of first-episode nonaffective psychosis: a 12-week randomized, flexible-dose, open-label trial
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Schizophr Res 147:375-82. 2013
    ..We aimed to compare the clinical effectiveness in the short-term of Aripiprazole, Ziprasidone and Quetiapine in the treatment of first-episode schizophrenia-spectrum disorders...
  7. doi request reprint Prediction of acute clinical response following a first episode of non affective psychosis: results of a cohort of 375 patients from the Spanish PAFIP study
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 44:162-7. 2013
    ..We aimed to investigate sociodemographic, premorbid and clinical predictors of response to antipsychotic treatment after a first episode of non-affective psychosis...
  8. doi request reprint Aripiprazole, ziprasidone, and quetiapine in the treatment of first-episode nonaffective psychosis: results of a 6-week, randomized, flexible-dose, open-label comparison
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    J Clin Psychopharmacol 33:215-20. 2013
    ..Differences in effectiveness between second-generation antipsychotics would determine their position in everyday clinical practice and could help physicians choose the more efficacious antipsychotics...
  9. ncbi request reprint Gene-environment interactions underlying the effect of cannabis in first episode psychosis
    Jose Maria Pelayo-Teran
    Hospital Universitario Marques de Valdecilla, Department of Psychiatry, planta 2a, Edificio 2 de Noviembre Avda Valdecilla s n, 39008, Santander, Spain
    Curr Pharm Des 18:5024-35. 2012
    ..The most promising genetic variants in this field are COMT, CNR1, BDNF, AKT1 and NRG1. Additionally, the interaction with other environmental factors and possible gene-gene interactions are considered in the etiological model...
  10. pmc Clinical usefulness of the screen for cognitive impairment in psychiatry (SCIP-S) scale in patients with type I bipolar disorder
    Georgina Guilera
    Department of Methodology, Faculty of Psychology, University of Barcelona, Barcelona, Spain
    Health Qual Life Outcomes 7:28. 2009
    ..This investigation assessed the psychometric properties of the Spanish version of the Screen for Cognitive Impairment in Psychiatry (SCIP-S) for the detection of cognitive impairment in BD...
  11. ncbi request reprint Low-activity allele of Catechol-O-Methyltransferase (COMTL) is associated with increased lateral ventricles in patients with first episode non-affective psychosis
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 31:1514-8. 2007
    ..We hypothesized that the low activity-COMT (COMT(L)) allele would be associated with the presence of structural brain changes as assessed by quantitative magnetic resonance imaging (MRI)...
  12. ncbi request reprint Neuropsychological functioning and brain structure in schizophrenia
    Benedicto Crespo-Facorro
    Department of Psychiatry, School of Medicine, University Hospital Marques de Valdecilla, Avenida aldecilla s n, 39008 Santander, Spain
    Int Rev Psychiatry 19:325-36. 2007
    ..Therefore, there is still a great need for more methodologically stringent investigations that would help in the advance of our understanding of the cognition/brain structure relationships in schizophrenia...
  13. doi request reprint Insular cortex morphometry in first-episode schizophrenia-spectrum patients: Diagnostic specificity and clinical correlations
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, CIBERSAM, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    J Psychiatr Res 44:314-20. 2010
    ..Contrary to our initial hypotheses, we were unable to demonstrate significant morphometric anomalies in a large and heterogeneous sample of patients with a first-episode of schizophrenia-spectrum disorders...
  14. doi request reprint Effectiveness of haloperidol, risperidone and olanzapine in the treatment of first-episode non-affective psychosis: results of a randomized, flexible-dose, open-label 1-year follow-up comparison
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    J Psychopharmacol 25:744-54. 2011
    ..Specific clinical programmes and the use of second-generation antipsychotics may enhance the effectiveness of antipsychotic treatments...
  15. pmc Sex-specific variation of MRI-based cortical morphometry in adult healthy volunteers: the effect on cognitive functioning
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, CIBERSAM, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 35:616-23. 2011
    ..In conclusion, our findings do not support the notion of sexual dimorphism in cortical mantle morphology. The results also suggest that variability in cortical thickness may affect cognitive functioning in females but not in males...
  16. doi request reprint Specific brain structural abnormalities in first-episode schizophrenia. A comparative study with patients with schizophreniform disorder, non-schizophrenic non-affective psychoses and healthy volunteers
    Benedicto Crespo-Facorro
    Department of Psychiatry, University Hospital Marques de Valdecilla, CIBERSAM, School of Medicine, University of Cantabria, Santander, Spain
    Schizophr Res 115:191-201. 2009
    ..The brain changes found in patients with a first episode of schizophrenia spectrum disorders are robustly associated with the diagnoses of schizophrenia and schizophreniform disorder and are independent of relevant intervening variables...
  17. doi request reprint Relapse prevention and remission attainment in first-episode non-affective psychosis. A randomized, controlled 1-year follow-up comparison of haloperidol, risperidone and olanzapine
    Benedicto Crespo-Facorro
    Department of Psychiatry, University of Cantabria IFIMAV, Santander 39008, Spain
    J Psychiatr Res 45:763-9. 2011
    ..We conclude that haloperidol, olanzapine and risperidone show a similar effectiveness in relapse prevention or in remission attainment during the first year of treatment...
  18. doi request reprint Global and regional cortical thinning in first-episode psychosis patients: relationships with clinical and cognitive features
    B Crespo-Facorro
    University Hospital Marques de Valdecilla, CIBERSAM, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Psychol Med 41:1449-60. 2011
    ..We aimed to explore whether first episode schizophrenia patients already show a significant cortical thinning and whether cortical thickness anomalies may significantly influence clinical and cognitive features...
  19. ncbi request reprint Caudate nucleus volume and its clinical and cognitive correlations in first episode schizophrenia
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Schizophr Res 91:87-96. 2007
    ..The purpose of this study is to examine the relationship between caudate nucleus volumes and clinical and cognitive features of schizophrenic patients in an early phase of their illness...
  20. ncbi request reprint Treatment of the first episode of schizophrenia: an update on pharmacologic and psychological interventions
    Benedicto Crespo-Facorro
    Department of Psychiatry, Hospital Universitario Marques de Valdecilla, Avda Valdecilla s n 39008, Santander, Spain
    Curr Psychiatry Rep 10:202-9. 2008
    ..Cognitive-behavioral therapy and family interventions seem to be effective adjunctive treatments in early phases of schizophrenia in some patients...
  21. ncbi request reprint Temporal pole morphology and psychopathology in males with schizophrenia
    Benedicto Crespo-Facorro
    Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
    Psychiatry Res 132:107-15. 2004
    ..Interestingly, a reduction in the TP volume, a higher-order multimodal association cortex, was associated with the severity of disorganized and psychotic symptoms...
  22. ncbi request reprint Predictors of acute treatment response in patients with a first episode of non-affective psychosis: sociodemographics, premorbid and clinical variables
    Benedicto Crespo-Facorro
    Hospital Universitario Marques de Valdecilla, Department of Psychiatry, School of Medicine, planta 2a, Edificio 2 de Noviembre, Avda Valdecilla s n, 39008, Santander, Spain
    J Psychiatr Res 41:659-66. 2007
    ..Helping clinicians to identify non-responders is meant as a first step to optimise therapeutic effort to benefit individuals in this vulnerable group...
  23. doi request reprint Effect of antipsychotic drugs on brain morphometry. A randomized controlled one-year follow-up study of haloperidol, risperidone and olanzapine
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 32:1936-43. 2008
    ..Here we investigate the effects of risperidone, olanzapine and low doses of haloperidol on cortical and subcortical morphometry in first episode drug naïve patients with non-affective psychosis...
  24. doi request reprint Long-term (3-year) effectiveness of haloperidol, risperidone and olanzapine: results of a randomized, flexible-dose, open-label comparison in first-episode nonaffective psychosis
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Planta 2ª, Edificio 2 de Noviembre Avda Valdecilla s n, 39008 Santander, Spain
    Psychopharmacology (Berl) 219:225-33. 2012
    ..To enhance the effectiveness of antipsychotics in first-episode psychosis is crucial in order to achieve the most favourable prognosis. Difference in effectiveness between antipsychotics is still under debate...
  25. doi request reprint Interleukin-12 plasma levels in drug-naïve patients with a first episode of psychosis: effects of antipsychotic drugs
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Psychiatry Res 158:206-16. 2008
    ..Thus, patients with a first episode of psychosis have inflammatory-like immunological function during early phases of the illness that it is independent of the antipsychotic treatment used...
  26. ncbi request reprint Lack of influence of COMT Val158Met genotype on cognition in first-episode non-affective psychosis
    Ignacio Mata
    University Hospital Marques de Valdecilla, Department of Psychiatry, Santander Cantabria, Spain
    Schizophr Res 102:206-9. 2008
    ..We found no significant differences in any cognitive measure according to COMT genotype. These findings, together with previously published research, put the relationship between COMT genotype and cognitive performance in doubt...
  27. doi request reprint Predictors of neurocognitive impairment at 3 years after a first episode non-affective psychosis
    Rosa Ayesa-Arriola
    Department of Psychiatry, Marques de Valdecilla University Hospital, IFIMAV, School of Medicine, University of Cantabria, Santander, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 43:23-8. 2013
    ..However, patients show great variability in the level and course of deficits. The goal of the present longitudinal study was to identify predictors of neurocognitive impairment in first episode psychosis patients...
  28. doi request reprint Predictors of clinical remission following a first episode of non-affective psychosis: sociodemographics, premorbid and clinical variables
    Ignacio Diaz
    University Hospital La Fe, Department of Psychiatry, Valencia, Spain
    Psychiatry Res 206:181-7. 2013
    ....
  29. ncbi request reprint A 12-week randomized clinical trial to evaluate metabolic changes in drug-naive, first-episode psychosis patients treated with haloperidol, olanzapine, or risperidone
    Rocio Perez-Iglesias
    Department of Psychiatry, Marques de Valdecilla University Hospital, University of Cantabria, Santander, Spain
    J Clin Psychiatry 68:1733-40. 2007
    ..This study examined the main metabolic side effects induced by antipsychotic treatment in a cohort of first-episode drug-naive subjects...
  30. ncbi request reprint Effect of antipsychotic drugs on cortical thickness. A randomized controlled one-year follow-up study of haloperidol, risperidone and olanzapine
    Roberto Roiz-Santiáñez
    University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Schizophr Res 141:22-8. 2012
    ..We aimed to investigate the effects of low doses of haloperidol, risperidone and olanzapine on cortical thickness...
  31. doi request reprint Catechol-O-methyltransferase Val158Met polymorphism and negative symptoms after acute antipsychotic treatment in first-episode non-affective psychosis
    Jose Maria Pelayo-Teran
    Department of Psychiatry, CIBERSAM, University Hospital Marqués de Valdecilla IFIMAV, School of Medicine, University of Cantabria, Santander, Spain
    Psychiatry Res 185:286-9. 2011
    ..Val homozygote patients showed higher negative symptoms than Met homozygote patients. The COMT Val158 genotype seems to be related to the severity of negative symptoms rather than to clinical response...
  32. ncbi request reprint Course of cognitive deficits in first episode of non-affective psychosis: a 3-year follow-up study
    Jose Manuel Rodríguez-Sánchez
    University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Madrid, Spain Electronic address
    Schizophr Res 150:121-8. 2013
    ..However, patients whose cognitive performance demonstrated a declining trend may present with a poorer progression in terms of clinical and disability variables...
  33. ncbi request reprint Association between the interleukin-1 receptor antagonist gene and negative symptom improvement during antipsychotic treatment
    Ignacio Mata
    Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain
    Am J Med Genet B Neuropsychiatr Genet 141:939-43. 2006
    ..These results suggest that the VNTR polymorphism in the IL-1RN gene may be a useful predictor of negative symptom improvement in schizophrenic patients treated with antipsychotic drugs...
  34. doi request reprint Insight dimensions in first-episode psychosis patients: clinical, cognitive, pre-morbid and socio-demographic correlates
    Rosa Ayesa-Arriola
    University Hospital Marqués de Valdecilla IFIMAV CIBERSAM, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Early Interv Psychiatry 5:140-9. 2011
    ..To investigate pre-morbid, socio-demographic, clinical and cognitive variables as predictors of insight in a large and representative sample of first-episode psychosis patients...
  35. ncbi request reprint Lack of association between clinical and cognitive change in first-episode psychosis: the first 6 weeks of treatment
    Cesar Gonzalez-Blanch
    Mental Health Centre, University Hospital Marques de Valdecilla, University of Cantabria, Santander, Spain
    Can J Psychiatry 53:839-47. 2008
    ....
  36. ncbi request reprint The relevance of cognitive, clinical and premorbid variables in predicting functional outcome for individuals with first-episode psychosis: a 3 year longitudinal study
    Rosa Ayesa-Arriola
    Department of Psychiatry, Marques de Valdecilla University Hospital, IFIMAV, School of Medicine, University of Cantabria, Santander, Spain CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Madrid, Spain Electronic address
    Psychiatry Res 209:302-8. 2013
    ..The data support the notion that premorbid social adjustment is an important aspect in functional outcome over the course of the illness. ..
  37. doi request reprint Predicting relapse after a first episode of non-affective psychosis: a three-year follow-up study
    Olalla Caseiro
    Marques de Valdecilla University Hospital, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    J Psychiatr Res 46:1099-105. 2012
    ..A better understanding and improvement in factors which influence relapse should diminish the risk of relapse and consequently improve the outcome of the illness...
  38. doi request reprint Effect of antipsychotics on peptides involved in energy balance in drug-naive psychotic patients after 1 year of treatment
    Rocio Perez-Iglesias
    Department of Psychiatry, Marques de Valdecilla University Hospital, University of Cantabria, Cantabria, Spain
    J Clin Psychopharmacol 28:289-95. 2008
    ..The unexpected increase in ghrelin levels might be related with the causal mechanism of weight gain induced by antipsychotics. Finally, the 3 antipsychotics had similar effects in all parameters evaluated...
  39. ncbi request reprint Weight gain induced by haloperidol, risperidone and olanzapine after 1 year: findings of a randomized clinical trial in a drug-naïve population
    Rocio Perez-Iglesias
    Department of Psychiatry, Marques de Valdecilla University Hospital, Avda Valdecilla s n, 39008, University of Cantabria, Spain
    Schizophr Res 99:13-22. 2008
    ..There is little information about weight gain induced by antipsychotics at long-term...
  40. doi request reprint Insular cortex thinning in first episode schizophrenia patients
    Roberto Roiz-Santiáñez
    University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Psychiatry Res 182:216-22. 2010
    ..The fact that insular thinning is already present at early phases of the illness and is independent of intervening variables offers evidence for the potential of these changes to be a biological marker of the illness...
  41. ncbi request reprint Effect of FTO, SH2B1, LEP, and LEPR polymorphisms on weight gain associated with antipsychotic treatment
    Rocio Perez-Iglesias
    Department of Psychiatry, Marques de Valdecilla University Hospital, Planta 2 a, Edificio 2 de Noviembre, Avda Valdecilla s n, 39008 Santander, Spain
    J Clin Psychopharmacol 30:661-6. 2010
    ..None of the other single nucleotide polymorphisms evaluated were associated with weight gain during the first 12 months of antipsychotic therapy...
  42. doi request reprint Long-term (3-year) neurocognitive effectiveness of antipsychotic medications in first-episode non-affective psychosis: a randomized comparison of haloperidol, olanzapine, and risperidone
    Rosa Ayesa-Arriola
    Department of Psychiatry, Marques de Valdecilla University Hospital, IFIMAV, School of Medicine, University of Cantabria, Avda Valdecilla s n, 39008 Santander, Spain
    Psychopharmacology (Berl) 227:615-25. 2013
    ..The initially postulated superior neurocognitive effectiveness of second-generation antipsychotics is currently under debate...
  43. doi request reprint Interleukin-1 receptor antagonist genotype and brain morphometry in first-episode non-affective psychosis
    Roberto Roiz-Santiáñez
    University Hospital Marques de Valdecilla, Department of Psychiatry School of Medicine, University of Cantabria, Santander, Spain
    Psychiatry Res 162:167-71. 2008
    ..We did not find evidence for association between genetic variation in the IL-1RN gene and brain morphometry at early phases of the illness...
  44. ncbi request reprint Cognitive dimensions in first-episode schizophrenia spectrum disorders
    Cesar Gonzalez-Blanch
    Hospital Universitario Marques de Valdecilla, Department of Psychiatry, School of Medicine, Santander, Spain
    J Psychiatr Res 41:968-77. 2007
    ..We aimed to characterize the basic cognitive functioning of a representative sample of patients with a first-episode schizophrenia spectrum disorders...
  45. doi request reprint One year longitudinal study of the straight gyrus morphometry in first-episode schizophrenia-spectrum patients
    Roberto Roiz-Santiáñez
    Department of Psychiatry, University of Cantabria, Santander, Spain
    Psychiatry Res 202:80-3. 2012
    ..We did not find a differential pattern of volumetric change between the two groups...
  46. doi request reprint Straight gyrus morphology in first-episode schizophrenia-spectrum patients
    Roberto Roiz-Santiáñez
    Department of Psychiatry, School of Medicine, University of Cantabria, University Hospital Marques de Valdecilla, IFIMAV, Santander, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 35:84-90. 2011
    ..Our results, based on a large and representative sample, do not confirm the presence of significant straight gyrus morphometric anomalies in schizophrenia-spectrum disorders, after controlling for potential confounding variables...
  47. doi request reprint Cannabis use and cognitive functioning in first-episode schizophrenia patients
    Jose Manuel Rodríguez-Sánchez
    Department of Psychiatry, CIBERSAM, University Hospital Marques de Valdecilla, IFIMAV, Santander, Spain
    Schizophr Res 124:142-51. 2010
    ..Cannabis user patients appear to comprise a subgroup of patients with a better premorbid adjustment and premorbid frontal cognitive functions...
  48. ncbi request reprint Cognitive functioning and negative symptoms in first episode schizophrenia: different patterns of correlates
    Jose Manuel Rodríguez-Sánchez
    University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Neurotox Res 14:227-35. 2008
    ..The widely described relationship between negative symptoms and executive impairments in schizophrenia appears to be mediated by likely dysfunctions in the speed of processing instead of by working memory impairment...
  49. ncbi request reprint Cognitive functioning in the early course of first-episode schizophrenia spectrum disorders: timing and patterns
    Cesar Gonzalez-Blanch
    Hospital Universitario Marques de Valdecilla, Department of Psychiatry, planta 2a, Edificio 2 de Noviembre, Avda Valdecilla s n, 39008, Santander, Spain
    Eur Arch Psychiatry Clin Neurosci 256:364-71. 2006
    ..The aim of this study was to examine possible cognitive changes throughout the early course of schizophrenia spectrum disorders...
  50. doi request reprint 1-year follow-up study of cognitive function in first-episode non-affective psychosis
    José M Rodríguez-Sánchez
    University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Schizophr Res 104:165-74. 2008
    ..Further investigations are warranted to discern the variability in patterns of specific cognitive deficits over time...
  51. doi request reprint Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in first-episode non-affective psychosis: clinical-onset implications
    Jose Maria Pelayo-Teran
    Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain
    Psychiatry Res 179:291-6. 2010
    ..Based on these results, the use of cannabis could exert a modulator effect on the genotype, suppressing the delay effect for the age of onset in the case of the Met allele patients...
  52. doi request reprint Temporal pole morphology in first-episode schizophrenia patients: clinical correlations
    Roberto Roiz-Santiáñez
    University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Psychiatry Res 184:189-91. 2010
    ..Patients did not significantly differ from controls in the TP morphometric variables evaluated. Clinical variables were not significantly related to the TP...
  53. doi request reprint Additive effect of NRG1 and DISC1 genes on lateral ventricle enlargement in first episode schizophrenia
    Ignacio Mata
    Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain, CIBERSAM
    Neuroimage 53:1016-22. 2010
    ..Our findings suggest that NRG1 and DISC1 genes may be associated with brain abnormalities in schizophrenia through their influence on related pathways of brain development...
  54. doi request reprint Preserved orbitofrontal function in first-episode schizophrenia: further evidence from the object alternation paradigm
    Cesar Gonzalez-Blanch
    Psychiatry Research Unit of Cantabria, Department of Psychiatry, School of Medicine, University Hospital Marques de Valdecilla, Santander, Spain
    J Nerv Ment Dis 196:67-70. 2008
    ..There were no significant differences between patients and control subjects with respect to the OAT. This finding suggests that the OFC function, as measured by decision-making tasks, is preserved in the early phases of schizophrenia...
  55. ncbi request reprint Catechol-O-methyltransferase Val158Met polymorphism and clinical characteristics in first episode non-affective psychosis
    Jose Maria Pelayo-Teran
    Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain
    Am J Med Genet B Neuropsychiatr Genet 147:550-6. 2008
    ..These data would indicate that COMT genotype may have a role in the etiological model for schizophrenia and other psychotic disorders...
  56. doi request reprint Glucose and lipid disturbances after 1 year of antipsychotic treatment in a drug-naïve population
    Rocio Perez-Iglesias
    Department of Psychiatry, Marques de Valdecilla University Hospital, Avda Valdecilla s n, 39008, University of Cantabria, Spain
    Schizophr Res 107:115-21. 2009
    ..This study examined the main metabolic side effects induced by antipsychotic treatment in a cohort of first episode drug-naïve subjects after the first year of treatment...
  57. doi request reprint Neurocognitive diagnosis and cut-off scores of the Screen for Cognitive Impairment in Psychiatry (SCIP-S)
    Emilio Rojo
    Department of Psychiatry, Benito Menni CASM, Granollers Hospital General, Granollers, Barcelona, Spain
    Schizophr Res 116:243-51. 2010
    ....
  58. doi request reprint Homocysteine and cognition in first-episode psychosis patients
    Rosa Ayesa-Arriola
    Department of Psychiatry, Marques de Valdecilla University Hospital, IFIMAV, School of Medicine, University of Cantabria, Santander, Spain
    Eur Arch Psychiatry Clin Neurosci 262:557-64. 2012
    ..However, no relationship between homocysteine levels and cognitive impairment was detected. These results suggest the need for further studies to clarify the role of homocysteine in the etiology and prognosis of psychosis...
  59. doi request reprint Serotonin transporter polymorphisms and early response to antipsychotic treatment in first episode of psychosis
    Javier Vázquez-Bourgon
    Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain
    Psychiatry Res 175:189-94. 2010
    ..Our results suggest a minor contribution to antipsychotic drug response of genetic alterations in the 5-HTT gene...
  60. doi request reprint A digit symbol coding task as a screening instrument for cognitive impairment in first-episode psychosis
    Cesar Gonzalez-Blanch
    Psychiatry Research Unit of Cantabria, IFIMAV, CIBERSAM, University Hospital Marques de Valdecilla, Santander, Spain
    Arch Clin Neuropsychol 26:48-58. 2011
    ..The processing speed, as measured by Digit Symbol, may be particularly good in capturing the generalized dysfunction which may be causing the widespread cognitive failures in schizophrenia spectrum disorders...
  61. doi request reprint White matter defects in first episode psychosis patients: a voxelwise analysis of diffusion tensor imaging
    Rocio Perez-Iglesias
    Department of Psychiatry, Marques de Valdecilla University Hospital, Avenida Valdecilla s n, University of Cantabria, Spain
    Neuroimage 49:199-204. 2010
    ....
  62. doi request reprint Epidemiological factors associated with treated incidence of first-episode non-affective psychosis in Cantabria: insights from the Clinical Programme on Early Phases of Psychosis
    Jose M Pelayo-Teran
    Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain
    Early Interv Psychiatry 2:178-87. 2008
    ..The aim of the study was to analyse the treated incidence of schizophrenia in Cantabria (Northern Spain) and the sociodemographic risk factors associated with the illness onset...
  63. doi request reprint Long-term effect of haloperidol, olanzapine, and risperidone on plasma prolactin levels in patients with first-episode psychosis
    Rocio Perez-Iglesias
    Department of Psychiatry, Marques de Valdecilla University Hospital, University of Cantabria, Spain
    J Clin Psychopharmacol 32:804-8. 2012
    ..The main goal of this study was to assess the long-term effect of haloperidol, olanzapine, and risperidone on serum prolactin levels in a naturalistically treated first-episode psychosis population...
  64. ncbi request reprint Prefrontal cognitive functions in stabilized first-episode patients with schizophrenia spectrum disorders: a dissociation between dorsolateral and orbitofrontal functioning
    Jose Manuel Rodríguez-Sánchez
    Hospital Universitario Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Planta 2 a, Edificio 2 de Noviembre Avda Valdecilla s n, 39008 Santander, Spain
    Schizophr Res 77:279-88. 2005
    ..The OFC functions are unimpaired at the early phases of psychosis and in contrast there is a significant deficit in DLPFC functions in first-episode of schizophrenia...
  65. ncbi request reprint Major depression following traumatic brain injury
    Ricardo E Jorge
    Department of Psychiatry, University of Iowa, 500 Newton Road, Iowa City, IA 52242, USA
    Arch Gen Psychiatry 61:42-50. 2004
    ..Major depression is a frequent psychiatric complication among patients with traumatic brain injury (TBI). To our knowledge, however, the clinical correlates of major depression have not been extensively studied...
  66. ncbi request reprint Effects of family psychoeducation on expressed emotion and burden of care in first-episode psychosis: a prospective observational study
    Cesar Gonzalez-Blanch
    Hospital Universitario Marques de Valdecilla, Unidad de Investigación en Psiquiatría de Cantabria, Avda Valdecilla s n Edificio 2 de Noviembre, planta 2a, 39008 Santander, Cantabria, Spain
    Span J Psychol 13:389-95. 2010
    ..Brief psychoeducational groups may not be sufficient to reduce FB and EE associated to the experience of caregiving for a family member with a first-episode psychotic disorder...
  67. ncbi request reprint Morphometry of the superior temporal plane in schizophrenia: relationship to clinical correlates
    Benedicto Crespo-Facorro
    Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    J Neuropsychiatry Clin Neurosci 16:284-94. 2004
    ....
  68. ncbi request reprint Attenuation of antipsychotic-induced weight gain with early behavioral intervention in drug-naive first-episode psychosis patients: A randomized controlled trial
    Mario Alvarez-Jimenez
    University Hospital Marqués de Valdecilla Clinical and Social Psychiatry Research Unit, Department of Psychiatry, Santander, Spain
    J Clin Psychiatry 67:1253-60. 2006
    ....
  69. doi request reprint Identifying attentional deficits in people with first-episode psychosis with the Scale for the Assessment of Negative Symptoms attention subscale: is it possible?
    Cesar Gonzalez-Blanch
    Psychiatry Research Unit of Cantabria, CIBERSAM, University Hospital Marques de Valdecilla, Santander, Spain
    Compr Psychiatry 53:701-5. 2012
    ....
  70. doi request reprint Prevention of antipsychotic-induced weight gain with early behavioural intervention in first-episode psychosis: 2-year results of a randomized controlled trial
    Mario Alvarez-Jimenez
    Marques de Valdecilla Public Foundation Research Institute FMV IFIMAV, Santander, Spain
    Schizophr Res 116:16-9. 2010
    ..Weight-management interventions may need to be offered for longer periods to maintain preventative effects. Alternatively, booster sessions may need to be regularly delivered after intervention completion...
  71. doi request reprint Cognitive dysfunction in first-episode psychosis: the processing speed hypothesis
    Jose Manuel Rodríguez-Sánchez
    Department of Psychiatry, School of Medicine, Hospital Universitario Marques de Valdecilla, University of Cantabria, planta 2a, Edificio 2 de Noviembre, Avda, Valdecilla s n, 39008, Santander, Spain
    Br J Psychiatry Suppl 51:s107-10. 2007
    ..Speed of processing is a cognitive process underlying cognitive dysfunction in people with chronic schizophrenia...
  72. ncbi request reprint A neuregulin 1 variant is associated with increased lateral ventricle volume in patients with first-episode schizophrenia
    Ignacio Mata
    Department of Psychiatry, School of Medicine, University of Cantabria, University Hospital Marques de Valdecilla, CIBERSAM, Santander, Spain
    Biol Psychiatry 65:535-40. 2009
    ..We examined whether variations in this polymorphism influence brain volumes in first-episode schizophrenia subjects...
  73. doi request reprint Gyrification brain abnormalities associated with adolescence and early-adulthood cannabis use
    Ignacio Mata
    Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, IFIMAV, Santander, Spain
    Brain Res 1317:297-304. 2010
    ....
  74. ncbi request reprint Spanish version of the Screen for Cognitive Impairment in Psychiatry (SCIP-S): psychometric properties of a brief scale for cognitive evaluation in schizophrenia
    Oscar Pino
    Department of Psychiatry, Hospital General Granollers Benito Menni CASM, Granollers, Barcelona, Spain
    Schizophr Res 99:139-48. 2008
    ..This study examined the psychometric properties of the Spanish version of the SCIP in a sample of outpatients suffering schizophrenia-spectrum disorders...
  75. ncbi request reprint Morphology of the ventral frontal cortex in schizophrenia: relationship with social dysfunction
    Eran Chemerinski
    Mental Health Clinical Research Center, Department of Psychiatry, College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 1057, USA
    Biol Psychiatry 52:1-8. 2002
    ..This impairment has also been observed to emerge after lesions in the ventral aspect of the frontal cortex (i.e., straight gyrus and orbitofrontal cortex)...
  76. ncbi request reprint Alcohol misuse and mood disorders following traumatic brain injury
    Ricardo E Jorge
    Department of Psychiatry, The University of Iowa, Iowa City, USA
    Arch Gen Psychiatry 62:742-9. 2005
    ..Alcohol abuse and/or dependence (AA/D) and mood disturbance are co-occurring conditions among patients who have had a traumatic brain injury (TBI). However, the relationship between these disorders has not been extensively studied...
  77. ncbi request reprint Emotions in unmedicated patients with schizophrenia during evaluation with positron emission tomography
    Sergio Paradiso
    Mental Health Clinical Research Center, Dapartment of Psychiatry, Univeristy of Iowa College of Medicine, Iowa City, IA 52242 1057, USA
    Am J Psychiatry 160:1775-83. 2003
    ..The authors measured regional cerebral blood flow (rCBF) during performance of a task that required unmedicated patients to recognize the emotional valence of visual images and to determine whether they were pleasant or unpleasant...
  78. ncbi request reprint Morphology of the lateral superior temporal gyrus in neuroleptic nai;ve patients with schizophrenia: relationship to symptoms
    Jae Jin Kim
    BK21 Human Life Sciences, Seoul National University, Seoul, South Korea
    Schizophr Res 60:173-81. 2003
    ..Furthermore, relationships between the morphology of these regions and symptoms of the illness were explored...
  79. ncbi request reprint The child and adolescent first-episode psychosis study (CAFEPS): design and baseline results
    Josefina Castro-Fornieles
    Department of Child and Adolescent Psychiatry and Psychology, Institut Clinic of Neurosciences, Institut d Investigacions Biomèdiques August Pi Sunyer, Hospital Clinic Universitari of Barcelona, Villarroel, Spain
    Schizophr Res 91:226-37. 2007
    ..This paper describes the methods and rationale behind the study and the general characteristics of the sample...
  80. ncbi request reprint Antipsychotic-induced weight gain in chronic and first-episode psychotic disorders: a systematic critical reappraisal
    Mario Alvarez-Jimenez
    ORYGEN Research Centre, University of Melbourne, Melbourne, Victoria, Australia
    CNS Drugs 22:547-62. 2008
    ..Although antipsychotics present idiosyncratic patterns of weight gain, they may also generate similar absolute gains...