L Corzo

Summary

Country: Spain

Publications

  1. ncbi request reprint Citicoline protects hippocampal neurons against apoptosis induced by brain beta-amyloid deposits plus cerebral hypoperfusion in rats
    X A Alvarez
    EuroEspes Biomedical Research Center, A Coruna, Spain
    Methods Find Exp Clin Pharmacol 21:535-40. 1999
  2. ncbi request reprint Blood levels of histamine, IL-1 beta, and TNF-alpha in patients with mild to moderate Alzheimer disease
    X A Alvarez
    EuroEspes Research Center, Santa Marta de Babío, A Coruna, Spain
    Mol Chem Neuropathol 29:237-52. 1996
  3. ncbi request reprint Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer's disease patients. Effects on cognitive performance, brain bioelectrical activity and cerebral perfusion
    X A Alvarez
    EuroEspes Biomedical Research Center, A Coruna, Barcelona, Spain
    Methods Find Exp Clin Pharmacol 21:633-44. 1999
  4. ncbi request reprint Effects of Cerebrolysin on in vitro primary microglial and astrocyte rat cell cultures
    V R Lombardi
    Biotechnology Division, EuroEspes, Basic and Clinical Neurosciences Research Center, La Coruna, Spain
    Methods Find Exp Clin Pharmacol 21:331-8. 1999
  5. ncbi request reprint Characterization of cytokine production, screening of lymphocyte subset patterns and in vitro apoptosis in healthy and Alzheimer's Disease (AD) individuals
    V R Lombardi
    Biotechnology Division, EuroEspes, Basic and Clinical Neurosciences Research Center, Bergondo La Coruña, Spain
    J Neuroimmunol 97:163-71. 1999
  6. ncbi request reprint 19/20 kDa low molecular weight serum protein pattern: a novel potential biochemical prognostic marker for different types of dementia
    V R Lombardi
    Department of Biotechnology, EuroEspes, Biomedical Research Center, La Coruna, Spain
    Neurosci Lett 260:61-4. 1999
  7. ncbi request reprint Microglial activation induced by factor(s) contained in sera from Alzheimer-related ApoE genotypes
    V R Lombardi
    EuroEspes Biomedical Research Center, Division of Biotechnology, Santa Marta de Babío, La Coruna, Spain
    J Neurosci Res 54:539-53. 1998
  8. ncbi request reprint Neuroprotective role of S12024 against neurodegeneration in the rat dentate gyrus
    J J Miguel-Hidalgo
    Department of Basic Neuroscience, EuroEspes Biomedical Research Center, Santa Marta de Babío, La Coruna, Spain
    Eur Neuropsychopharmacol 8:203-8. 1998
  9. ncbi request reprint APOE-induced microglial activation: an in vitro assay to screen sera from Alzheimer's disease patients and novel therapeutic compounds
    V R Lombardi
    EuroEspes Biomedical Research Center, Division of Biotechnology, Bergondo, La Coruna, Spain
    Methods Find Exp Clin Pharmacol 20:377-86. 1998
  10. ncbi request reprint Plasticity of Congo red staining displayed by subpopulations of neurons within the rat central nervous system
    J J Miguel-Hidalgo
    Department of Basic Neuroscience, EuroEspes Biomedical Research Center, Santa Marta de Babío, E 15166 Bergondo, La Coruna, Spain
    Cell Tissue Res 293:75-86. 1998

Collaborators

  • J J Miguel-Hidalgo
  • M Windisch
  • Y Kubota
  • J J Secades
  • A Alvarez
  • R Cacabelos
  • X A Alvarez
  • V R Lombardi
  • L Fernandez-Novoa
  • C Sampedro
  • M Laredo
  • M Garcia
  • H Moessler
  • V Pichel
  • R Lozano
  • M Varela
  • C Linares
  • M Vargas
  • E Granizo
  • M Aleixandre
  • D Muresanu
  • V Couceiro
  • T H Crook
  • V Lombardi
  • P Perez
  • R Mouzo
  • R Zas
  • M Alcaraz
  • L Rey
  • R Cacabelow
  • A Franco

Detail Information

Publications14

  1. ncbi request reprint Citicoline protects hippocampal neurons against apoptosis induced by brain beta-amyloid deposits plus cerebral hypoperfusion in rats
    X A Alvarez
    EuroEspes Biomedical Research Center, A Coruna, Spain
    Methods Find Exp Clin Pharmacol 21:535-40. 1999
    ..01 vs. CDP0) in a dose-related manner. Based on these results, it was concluded that citicoline exerts antiapoptotic, neuroprotective and antiamnesic effects in conditions of neurodegeneration induced by A beta 4 plus hypoperfusion...
  2. ncbi request reprint Blood levels of histamine, IL-1 beta, and TNF-alpha in patients with mild to moderate Alzheimer disease
    X A Alvarez
    EuroEspes Research Center, Santa Marta de Babío, A Coruna, Spain
    Mol Chem Neuropathol 29:237-52. 1996
    ..63, p < 0.01). These data suggest a dysfunction in cytokine and histamine regulation in AD, probably indicating changes associated with inflammatory processes...
  3. ncbi request reprint Double-blind placebo-controlled study with citicoline in APOE genotyped Alzheimer's disease patients. Effects on cognitive performance, brain bioelectrical activity and cerebral perfusion
    X A Alvarez
    EuroEspes Biomedical Research Center, A Coruna, Barcelona, Spain
    Methods Find Exp Clin Pharmacol 21:633-44. 1999
    ....
  4. ncbi request reprint Effects of Cerebrolysin on in vitro primary microglial and astrocyte rat cell cultures
    V R Lombardi
    Biotechnology Division, EuroEspes, Basic and Clinical Neurosciences Research Center, La Coruna, Spain
    Methods Find Exp Clin Pharmacol 21:331-8. 1999
    ....
  5. ncbi request reprint Characterization of cytokine production, screening of lymphocyte subset patterns and in vitro apoptosis in healthy and Alzheimer's Disease (AD) individuals
    V R Lombardi
    Biotechnology Division, EuroEspes, Basic and Clinical Neurosciences Research Center, Bergondo La Coruña, Spain
    J Neuroimmunol 97:163-71. 1999
    ....
  6. ncbi request reprint 19/20 kDa low molecular weight serum protein pattern: a novel potential biochemical prognostic marker for different types of dementia
    V R Lombardi
    Department of Biotechnology, EuroEspes, Biomedical Research Center, La Coruna, Spain
    Neurosci Lett 260:61-4. 1999
    ..The findings suggest that two proteins of 19 and 20kDa molecular weight, respectively, might be associated with disease progression in different types of dementia...
  7. ncbi request reprint Microglial activation induced by factor(s) contained in sera from Alzheimer-related ApoE genotypes
    V R Lombardi
    EuroEspes Biomedical Research Center, Division of Biotechnology, Santa Marta de Babío, La Coruna, Spain
    J Neurosci Res 54:539-53. 1998
    ..These results strongly suggest that primary in vitro microglial cell cultures can be used as a screening model to test human sera as well as the effect of new potential drugs aimed at down-regulating microglia activation...
  8. ncbi request reprint Neuroprotective role of S12024 against neurodegeneration in the rat dentate gyrus
    J J Miguel-Hidalgo
    Department of Basic Neuroscience, EuroEspes Biomedical Research Center, Santa Marta de Babío, La Coruna, Spain
    Eur Neuropsychopharmacol 8:203-8. 1998
    ....
  9. ncbi request reprint APOE-induced microglial activation: an in vitro assay to screen sera from Alzheimer's disease patients and novel therapeutic compounds
    V R Lombardi
    EuroEspes Biomedical Research Center, Division of Biotechnology, Bergondo, La Coruna, Spain
    Methods Find Exp Clin Pharmacol 20:377-86. 1998
    ....
  10. ncbi request reprint Plasticity of Congo red staining displayed by subpopulations of neurons within the rat central nervous system
    J J Miguel-Hidalgo
    Department of Basic Neuroscience, EuroEspes Biomedical Research Center, Santa Marta de Babío, E 15166 Bergondo, La Coruna, Spain
    Cell Tissue Res 293:75-86. 1998
    ..Therefore, it is proposed that neurons labelled with the present Congo red technique might be in a reversible degenerative state or represent a particular physiological state in some areas of the central nervous system...
  11. ncbi request reprint Beta-amyloid(1-40)-induced neurodegeneration in the rat hippocampal neurons of the CA1 subfield
    J J Miguel-Hidalgo
    Department of Basic Neuroscience, EuroEspes Biomedical Research Center, Santa Marta de Babío, Bergondo, La Coruna, Spain
    Acta Neuropathol 95:455-65. 1998
    ....
  12. ncbi request reprint Neuropeptide dietary supplement N-PEP-12 enhances cognitive function and activates brain bioelectrical activity in healthy elderly subjects
    X A Alvarez
    Department of Neuropharmacology, EuroEspes Biomedical Research Center, Santa Marta de Babío, Bergonodo, A Coruna, Spain
    Methods Find Exp Clin Pharmacol 27:483-7. 2005
    ..Taken together, these data suggest that N-PEP-12 might be a reliable dietary supplement to be investigated for improving and, perhaps, maintaining brain function among healthy older adults...
  13. ncbi request reprint A 24-week, double-blind, placebo-controlled study of three dosages of Cerebrolysin in patients with mild to moderate Alzheimer's disease
    X A Alvarez
    Euroespes Biomedical Research Centre, Santa Maria de Babio, Bergondo, La Coruna, Spain
    Eur J Neurol 13:43-54. 2006
    ..The percentage of patients reporting adverse events was similar across all study groups. Cere treatment was well tolerated and led to significant, dose-dependent improvement of cognition and global clinical impression...
  14. ncbi request reprint Genomics and phenotypic profiles in dementia: implications for pharmacological treatment
    R Cacabelos
    EuroEspes Biomedical Research Center, Institute for CNS Disorders, EuroEspes Biotechnology EBIOTEC, Coruna, Spain
    Methods Find Exp Clin Pharmacol 26:421-44. 2004
    ....