J Corral

Summary

Country: Spain

Publications

  1. ncbi Genetic determinants of platelet function in thromboembolic diseases
    J Corral
    University of Murcia, Department of Medicine, Centro Regional de Hemodonacion, Murcia, Spain
    J Biol Regul Homeost Agents 18:166-71. 2004
  2. doi GPI-anchor and GPI-anchored protein expression in PMM2-CDG patients
    María E de la Morena-Barrio
    Centro Regional de Hemodonación Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Universidad de Murcia, Ronda de Garay S N, 30003 Murcia, Spain
    Orphanet J Rare Dis 8:170. 2013
  3. pmc Control of post-translational modifications in antithrombin during murine post-natal development by miR-200a
    Raúl Teruel
    Centro Regional de Hemodonacion, University of Murcia, IMIB, Spain, C Ronda de Garay s n, 30003, Murcia, Spain
    J Biomed Sci 20:29. 2013
  4. pmc Polymorphisms in xenobiotic metabolizing genes (EPHX1, NQO1 and PON1) in lymphoma susceptibility: a case control study
    Pablo Conesa-Zamora
    Pathology Department, Santa Lucía General University Hospital HGUSL, 30202, Cartagena, Spain
    BMC Cancer 13:228. 2013
  5. doi Inherited thrombophilic conditions
    Javier Corral
    Centro Regional de Hemodonacion, University of Murcia, Ronda de Garay S N Murcia 30003, Spain
    Hematology 17:S163-6. 2012
  6. doi Regulatory regions of SERPINC1 gene: identification of the first mutation associated with antithrombin deficiency
    María Eugenia de la Morena-Barrio
    Centro Regional de Hemodonacion, University of Murcia, Spain
    Thromb Haemost 107:430-7. 2012
  7. pmc Role of lipopolysaccharide and cecal ligation and puncture on blood coagulation and inflammation in sensitive and resistant mice models
    Javier Corral
    Department of Medicine, Centro Regional de Hemodonacion, Ronda de Garay S N, Murcia 30003, Spain
    Am J Pathol 166:1089-98. 2005
  8. ncbi Molecular, ultrastructural and functional characterization of a Spanish family with Hermansky-Pudlak syndrome: role of insC974 in platelet function and clinical relevance
    Rocio Gonzalez-Conejero
    Centro Regional de Hemodonación University of Murcia, Murcia, Spain
    Br J Haematol 123:132-8. 2003
  9. ncbi Homozygous deficiency of heparin cofactor II: relevance of P17 glutamate residue in serpins, relationship with conformational diseases, and role in thrombosis
    Javier Corral
    University of Murcia, Centro Regional de Hemodonación de Murcia, Murcia, Spain
    Circulation 110:1303-7. 2004
  10. ncbi Mutation analysis of HPS1, the gene mutated in Hermansky-Pudlak syndrome, in patients with isolated platelet dense-granule deficiency
    Javier Corral
    Universidad de Murcia, Centro Regional de Hemodo nación, Spain
    Haematologica 89:325-9. 2004

Collaborators

Detail Information

Publications78

  1. ncbi Genetic determinants of platelet function in thromboembolic diseases
    J Corral
    University of Murcia, Department of Medicine, Centro Regional de Hemodonacion, Murcia, Spain
    J Biol Regul Homeost Agents 18:166-71. 2004
    ....
  2. doi GPI-anchor and GPI-anchored protein expression in PMM2-CDG patients
    María E de la Morena-Barrio
    Centro Regional de Hemodonación Servicio de Hematología y Oncología Médica, Hospital Universitario Morales Meseguer, Universidad de Murcia, Ronda de Garay S N, 30003 Murcia, Spain
    Orphanet J Rare Dis 8:170. 2013
    ..Mannose-1-phosphate, that is deficient in this disorder, is also implicated in the biosynthesis of glycosylphosphatidyl inositol (GPI) anchors...
  3. pmc Control of post-translational modifications in antithrombin during murine post-natal development by miR-200a
    Raúl Teruel
    Centro Regional de Hemodonacion, University of Murcia, IMIB, Spain, C Ronda de Garay s n, 30003, Murcia, Spain
    J Biomed Sci 20:29. 2013
    ..Developmental haemostatic studies may help identifying new elements involved in the control of key haemostatic proteins like antithrombin, the most relevant endogenous anticoagulant...
  4. pmc Polymorphisms in xenobiotic metabolizing genes (EPHX1, NQO1 and PON1) in lymphoma susceptibility: a case control study
    Pablo Conesa-Zamora
    Pathology Department, Santa Lucía General University Hospital HGUSL, 30202, Cartagena, Spain
    BMC Cancer 13:228. 2013
    ..EPHX1, NQO1 and PON1 are three genes encoding proteins directly involved in the detoxification of potential carcinogens...
  5. doi Inherited thrombophilic conditions
    Javier Corral
    Centro Regional de Hemodonacion, University of Murcia, Ronda de Garay S N Murcia 30003, Spain
    Hematology 17:S163-6. 2012
    ..It is time to analyze carefully, without any pressure, the real state of the art and to moderate the conclusions, separating clinical use and research of inherited thrombophilic conditions...
  6. doi Regulatory regions of SERPINC1 gene: identification of the first mutation associated with antithrombin deficiency
    María Eugenia de la Morena-Barrio
    Centro Regional de Hemodonacion, University of Murcia, Spain
    Thromb Haemost 107:430-7. 2012
    ..Our results strongly sustain the inclusion of the promoter region of SERPINC1 in the molecular analysis of patients with antithrombin deficiency...
  7. pmc Role of lipopolysaccharide and cecal ligation and puncture on blood coagulation and inflammation in sensitive and resistant mice models
    Javier Corral
    Department of Medicine, Centro Regional de Hemodonacion, Ronda de Garay S N, Murcia 30003, Spain
    Am J Pathol 166:1089-98. 2005
    ..Our results suggest that activation of coagulation by endotoxemia is severe and independent of the inflammatory response. However, such activation may act with fibrin deposition to have a minor influence on survival in sepsis...
  8. ncbi Molecular, ultrastructural and functional characterization of a Spanish family with Hermansky-Pudlak syndrome: role of insC974 in platelet function and clinical relevance
    Rocio Gonzalez-Conejero
    Centro Regional de Hemodonación University of Murcia, Murcia, Spain
    Br J Haematol 123:132-8. 2003
    ..However, these functional defects were not of a great enough magnitude to have clinical significance and, thus, these subjects were clinically asymptomatic...
  9. ncbi Homozygous deficiency of heparin cofactor II: relevance of P17 glutamate residue in serpins, relationship with conformational diseases, and role in thrombosis
    Javier Corral
    University of Murcia, Centro Regional de Hemodonación de Murcia, Murcia, Spain
    Circulation 110:1303-7. 2004
    ..Recent data obtained in mice lacking HCII suggest that this serpin might inhibit thrombosis in the arterial circulation. However, the clinical relevance and molecular mechanisms associated with deficiency of HCII in humans are unclear...
  10. ncbi Mutation analysis of HPS1, the gene mutated in Hermansky-Pudlak syndrome, in patients with isolated platelet dense-granule deficiency
    Javier Corral
    Universidad de Murcia, Centro Regional de Hemodo nación, Spain
    Haematologica 89:325-9. 2004
    ..This suggested that HPS1 mutations could be involved in isolated PDG deficiency...
  11. ncbi Protein Z/Z-dependent protease inhibitor (PZ/ZPI) anticoagulant system and thrombosis
    Javier Corral
    Universidad de Murcia, Centro Regional de Hemodonacion, Murcia, Spain
    Br J Haematol 137:99-108. 2007
    ..This system could play a redundant role in haemostasis that explains the conflicting results on its thrombotic potential, which might be exacerbated in combination with other prothrombotic factors...
  12. pmc A nonsense polymorphism in the protein Z-dependent protease inhibitor increases the risk for venous thrombosis
    Javier Corral
    Centro Regional de Hemodonacion, Universidad de Murcia, Murcia, Spain
    Blood 108:177-83. 2006
    ..Although further studies are required, all available data support that the ZPI is a candidate to play a significant role in thrombosis and should be evaluated in thrombophilic studies...
  13. doi Influence of the F12 -4 C>T polymorphism on hemostatic tests
    Javier Corral
    Servicio de Hematología y Oncología Médica HU Morales Meseguer, Centro Regional de Hemodonacion, Universidad de Murcia, Murcia, Spain
    Blood Coagul Fibrinolysis 21:632-9. 2010
    ..Our study reveals a significant effect of the F12 -4 C>T polymorphism on hemostatic tests widely used in routine clinical practice...
  14. ncbi Antithrombin Cambridge II (A384S): an underestimated genetic risk factor for venous thrombosis
    Javier Corral
    Centro Regional de Hemodonacion, Universidad de Murcia, Murcia, Spain
    Blood 109:4258-63. 2007
    ..75 (95% CI, 2.2-42.5). This is the first study supporting that antithrombin A384S mutation is a prevalent genetic risk factor for venous thrombosis and is the most frequent cause of antithrombin deficiency in white populations...
  15. ncbi Latent and polymeric antithrombin: clearance and potential thrombotic risk
    Javier Corral
    University of Murcia, Centro Regional de Hemodonacion, Ronda de Garay S N, Murcia 30003, Spain
    Exp Biol Med (Maywood) 232:219-26. 2007
    ..Moreover, the suggested antiangiogenic role of latent antithrombin, together with its stability in plasma and its negligible thrombogenicity raises the possibility of its use as a new antiangiogenic drug...
  16. ncbi Polymorphisms of clotting factors modify the risk for primary intracranial hemorrhage
    J Corral
    The Neurology Division and the Hematology and Medical Oncology Service, Hospital General Universitario, Murcia, Spain
    Blood 97:2979-82. 2001
    ....
  17. ncbi Mutations in the shutter region of antithrombin result in formation of disulfide-linked dimers and severe venous thrombosis
    J Corral
    Department of Medicine, University of Murcia, Murcia, Spain
    J Thromb Haemost 2:931-9. 2004
    ..However, there are few data about conformational consequences of mutations affecting antithrombin, the main hemostatic serpin...
  18. ncbi Genetic variants of the extra-large stimulatory Gs protein alpha-subunit and risk of thrombotic and haemorrhagic disorders
    R Gonzalez-Conejero
    Department of Medicine, University of Murcia, Murcia, Spain
    Br J Haematol 125:621-8. 2004
    ..Thus, our study suggests a minor functional role of XLalphas polymorphism in thrombotic or in haemorrhagic disorders...
  19. doi Pharmacogenetics of acenocoumarol in patients with extreme dose requirements
    V Pérez-Andreu
    University of Murcia, Centro de Hemodonación, Murcia, Spain
    J Thromb Haemost 8:1012-7. 2010
    ..Recently, it has been suggested that the greatest benefit of pharmacogenetic algorithms is observed in patients with extreme dose requirements...
  20. ncbi Binding of recombinant apolipoprotein(a) to human platelets and effect on platelet aggregation
    C Martinez
    Unit of Hematology and Clinical Oncology, University General Hospital, Murcia, Spain
    Thromb Haemost 85:686-93. 2001
    ..These results suggest that the prothrombotic action of Lp(a) may be in part mediated by modulating the platelet function through the interaction of its apo(a) subunit with a specific receptor at the platelet surface...
  21. doi Rare homozygous status of P43 β1-tubulin polymorphism causes alterations in platelet ultrastructure
    L Navarro-Núñez
    Centro Regional de Hemodonacion, University of Murcia, Spain
    Thromb Haemost 105:855-63. 2011
    ..TUBB1 Q43P polymorphism in homozygosity mildly affects platelet ultrastructure and our data further suggest that high levels of β1-tubulin might not be critical to sustain platelet discoid shape...
  22. ncbi Polymorphisms of P-selectin glycoprotein ligand-1 are associated with neutrophil-platelet adhesion and with ischaemic cerebrovascular disease
    M L Lozano
    The Unit of Haematology and Clinical Oncology, University General Hospital and School of Medicine, 30003 Murcia, Spain
    Br J Haematol 115:969-76. 2001
    ..008) but not to be related to CHD or DVT. In conclusion, polymorphisms of the PSGL-1 receptor may influence the neutrophil-platelet binding, and represent a risk factor for CVD...
  23. ncbi Platelet aggregation through prothrombinase activation induced by non-aggregant doses of platelet agonists
    J Corral
    Unit of Hematology and Medical Oncology, Hospital General Universitario Morales Meseguer, Murcia, Spain
    Blood Coagul Fibrinolysis 13:95-103. 2002
    ..These results may suggest that activation of the prothrombinase complex could be a common step of the platelet response to distinct agonists, which may be achieved at low levels of platelet stimulation...
  24. doi Dexamethasone induces a heat-stress response that ameliorates the conformational consequences on antithrombin of L-asparaginase treatment
    D Hernandez-Espinosa
    Centro Regional de Hemodonacion, University of Murcia, Murcia, Spain
    J Thromb Haemost 7:1128-33. 2009
    ..Interestingly, co-administration of dexamethasone with L-ASP seems to reduce the risk of thrombosis...
  25. doi Heparin affinity of factor VIIa: implications on the physiological inhibition by antithrombin and clearance of recombinant factor VIIa
    I MARTINEZ-MARTINEZ
    University of Murcia, Centro Regional de Hemodonacion, Spain
    Thromb Res 127:154-60. 2011
    ..This process may also play an important role in the clearance of recombinant FVIIa administered to patients...
  26. doi Effects of acrolein, a natural occurring aldehyde, on the anticoagulant serpin antithrombin
    I MARTINEZ-MARTINEZ
    Centro Regional de Hemodonacion, Universidad de Murcia, Ronda de Garay S N, Murcia 30003, Spain
    FEBS Lett 583:3165-70. 2009
    ..However, higher concentrations of acrolein and long incubations are required to cause mild functional effects on plasma antithrombin and mice...
  27. doi Genotype-phenotype relationship for six common polymorphisms in genes affecting platelet function from 286 healthy subjects and 160 patients with mucocutaneous bleeding of unknown cause
    Constantino Martinez
    University of Murcia, Centro Regional de Hemodonacion, Murcia, Spain
    Br J Haematol 146:95-103. 2009
    ..Thus, our study demonstrated that polymorphisms in genes affecting platelet function do not influence significantly major platelet functions and appear irrelevant in the pathogenesis of bleeding disorders...
  28. doi Type II antithrombin deficiency caused by a large in-frame insertion: structural, functional and pathological relevance
    I MARTINEZ-MARTINEZ
    Centro Regional de Hemodonacion, University of Murcia, Regional Campus of International Excellence Campus Mare Nostrum, Murcia, Spain
    J Thromb Haemost 10:1859-66. 2012
    ..The metastable native conformation of serpins is required for their protease inhibition mechanism, but also renders them vulnerable to missense mutations that promote protein misfolding with pathological consequences...
  29. doi Identification of miRNAs as potential modulators of tissue factor expression in patients with systemic lupus erythematosus and antiphospholipid syndrome
    R Teruel
    Centro Regional de Hemodonacion, University of Murcia, Murcia, Spain
    J Thromb Haemost 9:1985-92. 2011
    ..Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are autoimmune diseases characterized by a high TF expression in monocytes...
  30. ncbi Evaluation of refrigerated platelet concentrates supplemented with low doses of second messenger effectors
    E Perez-Ceballos
    Centro Regional de Hemodonación and Unit of Hematology and Clinical Oncology of the Hospital Morales Meseguer, Murcia, Spain
    Clin Lab Haematol 26:275-86. 2004
    ..The reduced pharmacological load with the identified solution compared with ThromboSol is an argument in favour of the potential use of these agents when designing strategies to improve PC storage...
  31. doi Effect of citrullination on the function and conformation of antithrombin
    A Ordonez
    Centro Regional de Hemodonacion, University of Murcia, Murcia, Spain
    FEBS J 276:6763-72. 2009
    ..The observation that these polymers, like heat-generated polymers, are cleaved by AspN in helix I is compatible with their linkage by domain swapping from strand 5 to strand 4 of beta-sheet A...
  32. ncbi Effect of cold-storage in the accumulation of bioreactive substances in platelet concentrates treated with second messenger effects
    F Ferrer
    Hematology and Medical Oncology Unit, School of Medicine Los Arcos, Ronda de Garay S N, 30003 Murcia, Spain
    Haematologica 86:530-6. 2001
    ..This study further investigates this storage approach by comparing the accumulation of bioactive compounds in standard and refrigerated PCs...
  33. doi In silico discovery of a compound with nanomolar affinity to antithrombin causing partial activation and increased heparin affinity
    J Navarro-Fernandez
    Servicio de Hematologia y Oncologia Medica, H U Morales Meseguer, Centro Regional de Hemodonacion, University of Murcia, Spain
    J Med Chem 55:6403-12. 2012
    ..The functional consequences of this interaction were experimentally characterized and suggest potential anticoagulant therapeutic applications...
  34. ncbi Polymorphisms of platelet adhesive receptors: do they play a role in primary intracerebral hemorrhage?
    Juan A Iniesta
    Neurosurgery Division, Hospital Virgen de la Arrixaca, Murcia, Spain
    Cerebrovasc Dis 15:51-5. 2003
    ..The aim of this study was to evaluate the role of frequent polymorphisms affecting platelet GPs in primary intracerebral hemorrhage (PIH), the third most frequent cause of cerebrovascular disorder...
  35. ncbi Prothrombotic genetic risk factors in patients with coexisting migraine and ischemic cerebrovascular disease
    J A Iniesta
    General University Hospital, Murcia, Spain
    Headache 39:486-9. 1999
    ..6%; and HPA-1b, 35.3%) was similar to that obtained in all other groups. We can conclude that the studied polymorphisms do not seem to be associated with the development of ischemic cerebrovascular disease in those patients with migraine...
  36. ncbi Role of factor XIII Val 34 Leu polymorphism in patients with migraine
    J A Iniesta
    Neurology Services, Hospital General Universitario, Murcia, Spain
    Cephalalgia 21:837-41. 2001
    ..These data suggest that the factor XIII Leu 34 allele does not play a protective role against these disorders in our population...
  37. ncbi In vivo effects of hyperthermia on the functional and conformational characteristics of antithrombin
    D Hernandez-Espinosa
    Department of Medicine, Centro Regional de Hemodonacion, Hospital Vigen de la Arrixaca, Univeristy of Murcia, Murcia, Spain
    J Thromb Haemost 5:963-70. 2007
    ..Accordingly, high body temperatures might contribute in vivo to conformational changes in antithrombin associated with increased thrombotic risk...
  38. ncbi The prothrombin gene variant 20210A in venous and arterial thromboembolism
    V Vicente
    Centro Regional de Hemodonacion, Ronda de Garay S N, 30003 Murcia, Spain
    Haematologica 84:356-62. 1999
    ..The role of this procoagulant mutation in arterial vascular disease is, however, unclear...
  39. ncbi The genetic interaction between VKORC1 c1173t and calumenin a29809g modulates the anticoagulant response of acenocoumarol
    R Gonzalez-Conejero
    Centro Regional de Hemodonacion, University of Murcia, Murcia, Spain
    J Thromb Haemost 5:1701-6. 2007
    ..The efficacy of oral anticoagulant therapy is largely conditioned by both environmental and genetic factors. Objectives: To attempt to define the genetic profile involved in the response to this treatment...
  40. doi Increased levels of citrullinated antithrombin in plasma of patients with rheumatoid arthritis and colorectal adenocarcinoma determined by a newly developed ELISA using a specific monoclonal antibody
    Adriana Ordonez
    Centro Regional de Hemodonacion, University of Murcia, Spain
    Thromb Haemost 104:1143-9. 2010
    ..This result explains the absence of association of this marker with an increased risk of thrombosis in patients with colorectal adenocarcinoma...
  41. ncbi The association of the beta1-tubulin Q43P polymorphism with intracerebral hemorrhage in men
    Leyre Navarro-Nuñez
    Centro Regional de Hemodonacion, University of Murcia, Murcia, Spain
    Haematologica 92:513-8. 2007
    ..The potential effect of this variant in the pathogenesis of hemorrhagic stroke has not yet been investigated...
  42. doi Proteomic analysis of platelet N-glycoproteins in PMM2-CDG patients
    M E de la Morena-Barrio
    Centro Regional de Hemodonacion, Servicio de Hematologia y Oncologia Medica, Hospital Universitario Morales Meseguer, University of Murcia, Murcia, Spain
    Thromb Res 133:412-7. 2014
    ..Our findings suggest that platelet proteins are not significantly affected in PMM2-CDG patients. Further studies are still warranted to unravel the mechanism(s) that increase(s) the risk of thrombosis in these patients. ..
  43. doi Congenital disorder of glycosylation (PMM2-CDG) in a patient with antithrombin deficiency and severe thrombophilia
    M E de la Morena-Barrio
    Centro Regional de Hemodonacion, University of Murcia, Regional Campus of International Excellence Campus Mare Nostrum, Murcia, Spain Department of Hematology, Centro Hospitalar de Coimbra, Portugal Center for Metabolic Diseases, Universitair Ziekenhuis Gasthuisberg, Leuven, Belgium
    J Thromb Haemost 10:2625-7. 2012
    ..Congenital disorder of glycosylation (PMM2-CDG) in a patient with antithrombin deficiency and severe thrombophilia. J Thromb Haemost 2012; 10: 2625-7...
  44. ncbi Biological assessment of aspirin efficacy on healthy individuals: heterogeneous response or aspirin failure?
    Rocio Gonzalez-Conejero
    University of Murcia, Centro Regional de Hemodonacion, Ronda de Garay S N, 30003, Murcia, Spain
    Stroke 36:276-80. 2005
    ..The widespread use of aspirin requires clarification of the aspirin resistance phenomenon. Most studies on this field are focused on patients which may affect the action of aspirin...
  45. ncbi Intracellular retention of hepatic serpins caused by severe hyperlipidemia
    David Hernandez-Espinosa
    Department of Medicine, Centro Regional de Hemodonacion, University of Murcia, Murcia, Spain
    Liver Int 26:708-15. 2006
    ..The conformational flexibility of antithrombin renders it susceptible to both, genetic and posttranslational modifications. Thus, mutations and environmental factors have been shown to alter this molecule...
  46. doi Inhibition of proteasome by bortezomib causes intracellular aggregation of hepatic serpins and increases the latent circulating form of antithrombin
    David Hernandez-Espinosa
    Department of Medicine, Centro Regional de Hemodonacion, Murcia, Spain
    Lab Invest 88:306-17. 2008
    ....
  47. ncbi Factors with conformational effects on haemostatic serpins: implications in thrombosis
    David Hernandez-Espinosa
    Department of Medicine, Centro Regional de Hemodonacion, University of Murcia, Murcia, Spain
    Thromb Haemost 98:557-63. 2007
    ..In this study, we review the causes of deficiency of haemostatic serpins that may be explained by conformational mechanisms, and their association with an increased risk of venous thrombosis...
  48. doi Study of 18 functional hemostatic polymorphisms in mucocutaneous bleeding disorders
    Ana I Anton
    Centro Regional de Hemodonacion, University of Murcia, Ronda de Garay S N, Murcia, Spain
    Ann Hematol 89:1147-54. 2010
    ..24; 95% CI, 0.11-0.52), supporting the polygenic nature of MCB. Our data suggest that some common polymorphisms affecting hemostasis-related genes could protect from bleeding...
  49. ncbi Coexistence of three genetic risk factors in a Spanish thrombophilic family: Factor V Leiden, prothrombin 20210 and a new type I antithrombin deficiency
    Adriana Ordonez
    Centro Regional de Hemodonacion, University of Murcia, Spain
    Thromb Haemost 97:153-5. 2007
  50. ncbi Synergistic association between hypercholesterolemia and the C46T factor XII polymorphism for developing premature myocardial infarction
    Vanessa Roldan
    Centro Regional de Hemodonacion, University of Murcia, Murcia, Spain
    Thromb Haemost 94:1294-9. 2005
    ..This effect could be associated with an increased pro-inflammatory state, as the 46T allele associates with high levels of CRP...
  51. pmc L-asparaginase-induced antithrombin type I deficiency: implications for conformational diseases
    David Hernandez-Espinosa
    Centro Regional de Hemodonacion, Universidad de Murcia, Murcia 30003, Spain
    Am J Pathol 169:142-53. 2006
    ..l-Asparaginase treatment induces severe, acquired, and transient type I deficiency of antithrombin (and alpha1-antitrypsin) with intracellular accumulation of the nascent molecule, increasing the risk of thrombosis...
  52. ncbi Human platelet antigen systems in allogeneic peripheral blood progenitor cell transplantation: effect of human platelet antigen mismatch on platelet engraftment and graft-versus-host disease
    M D García-Malo
    University of Murcia, Department of Medicine, Murcia, Spain
    Transfusion 44:771-6. 2004
    ..Thus, HPA mismatch in HLA-identical ASCT could play a potential role in PLT engraftment and GVHD...
  53. ncbi Detection of conformational transformation of antithrombin in blood with crossed immunoelectrophoresis: new application for a classical method
    Javier Corral
    Hematology and Clinical Oncology Service, Department of Medicine, Hospital General Universitario, Centro Regional de Hemodonacion, Universidad de Murcia, Spain
    J Lab Clin Med 142:298-305. 2003
    ..Our results support a role for small changes in temperature in nonmutated antithrombin, suggesting that fever is a general risk factor for thrombosis...
  54. ncbi Role of fibrinogen levels and factor XIII V34L polymorphism in thrombolytic therapy in stroke patients
    Rocio Gonzalez-Conejero
    Centro Regional de Hemodonacion, Universidad de Murcia, Murcia, Spain
    Stroke 37:2288-93. 2006
    ..The identification of genetic and environmental factors that could improve the benefit/risk ratio of thrombolytic therapy in patients with ischemic stroke is crucial...
  55. ncbi Prothrombin A19911G and G20210A polymorphisms' role in thrombosis
    Elena Perez-Ceballos
    Hematology Services, Hospital General Universitario, Murcia, Spain
    Br J Haematol 118:610-4. 2002
    ..34 vs 5.86), supporting that the prothrombin 19911 polymorphism could modulate the risk of the G20210A polymorphism in developing DVT...
  56. ncbi Platelet GP IIIa polymorphism HPA-1 (PlA) protects against subarachnoid hemorrhage
    Juan A Iniesta
    Hematology and Oncology Service, Centro Regional de Hemodonacion, Universidad de Murcia, Spain
    Stroke 35:2282-6. 2004
    ..Few genetic modifications have been identified to be associated with subarachnoid hemorrhage (SAH), most of them playing a role in the formation or size of aneurysms...
  57. doi Hyperglycaemia impairs antithrombin secretion: possible contribution to the thrombotic risk of diabetes
    David Hernandez-Espinosa
    Centro Regional de Hemodonacion, University of Murcia, Murcia, Spain
    Thromb Res 124:483-9. 2009
    ..Our data further support that diabetes has conformational effects on structurally sensitive proteins. These effects on antithrombin, the main natural anticoagulant, might contribute to the hypercoagulable status of diabetic patients...
  58. ncbi Antithrombin Cambridge II (A384S) supports a role for antithrombin deficiency in arterial thrombosis
    Vanessa Roldan
    Centro Regional de Hemodonacion, C Ronda de Garay s n, Murcia 30002, Spain
    Thromb Haemost 101:483-6. 2009
    ..These results suggest that deficiency of antithrombin may be an independent risk factor for MI that has been underestimated, but larger studies are needed to confirm the relevance of inhibitors of thrombin in arterial thrombosis...
  59. ncbi Poly(ADP-ribose) polymerase-1 inhibition increases expression of heat shock proteins and attenuates heat stroke-induced liver injury
    Ruben A Mota
    Department of Surgery, Hospital Virgen de la Arrixaca, CIBERehd, Murcia, Spain
    Crit Care Med 36:526-34. 2008
    ..Therefore, we set out to investigate whether inhibition of PARP activity might affect the heat stroke-induced injury...
  60. doi Factor VII -323 decanucleotide D/I polymorphism in atrial fibrillation: implications for the prothrombotic state and stroke risk
    Vanessa Roldan
    Centro de Hemodonación, Universidad de Murcia, Murcia, Spain
    Ann Med 40:553-9. 2008
    ..Other functional polymorphisms were also tested...
  61. pmc Novel loci involved in platelet function and platelet count identified by a genome-wide study performed in children
    Jose A Guerrero
    University of Murcia, Centro Regional de Hemodonacion, Murcia, Spain
    Haematologica 96:1335-43. 2011
    ..e., acquired and environmental factors, such as smoking, physical activity, diet, and drug or hormone intake, which are particularly important in platelet function...
  62. doi Pharmacogenetic relevance of CYP4F2 V433M polymorphism on acenocoumarol therapy
    Virginia Pérez-Andreu
    University of Murcia, Centro Regional de Hemodonacion, Spain
    Blood 113:4977-9. 2009
    ..14) and dose requirements (R(2) = 0.19). Our data underline the relevant role of CYP4F2 V433M polymorphism in the pharmacogenetics of coumarin anticoagulants...
  63. ncbi Role of factor XIII Val34Leu polymorphism in patients <45 years of age with acute myocardial infarction
    Vanessa Roldan
    Hematology Unit, Hospital de San Vicente, Alicante, Spain
    Am J Cardiol 91:1242-5. 2003
  64. ncbi Five prothrombotic polymorphisms and the prevalence of premature myocardial infarction
    Vanessa Roldan
    Haematologica 90:421-3. 2005
    ..028). Moreover, combinations of factor V Leiden with prothrombin, and factor XII with prothrombin polymorphisms were only identified in patients. Our results support the relevance of gene-gene interactions in myocardial infarction...
  65. ncbi A common polymorphism in the annexin V Kozak sequence (-1C>T) increases translation efficiency and plasma levels of annexin V, and decreases the risk of myocardial infarction in young patients
    Rocio Gonzalez-Conejero
    Hematology and Neurology Services, Hospital General Universitario, 30003 Murcia, Spain
    Blood 100:2081-6. 2002
    ..006; odds ratio, 0.51; 95% confidence interval, 0.30-0.85)...
  66. ncbi Genetic polymorphisms of platelet adhesive molecules: association with breast cancer risk and clinical presentation
    Francisco Ayala
    Department of Internal Medicine, Hematology and Medical Oncology Unit, Hospital Morales Meseguer, Spain
    Breast Cancer Res Treat 80:145-54. 2003
    ....
  67. ncbi Thrombosis as a conformational disease
    Javier Corral
    Universidad de Murcia Centro Regional de Hemodonación, Spain
    Haematologica 90:238-46. 2005
    ..The search for other causes is important, as the conformational perturbation of normal antithrombin is likely to be a contributory cause to the sporadic and apparently idiopathic occurrence of venous thrombosis...
  68. ncbi What can Drosophila tell us about serpins, thrombosis and dementia?
    Robin Carrell
    University of Cambridge, Cambridge Institute of Medical Research, Cambridge, UK
    Bioessays 26:1-5. 2004
    ..The findings provide clues as to the unusual severity and variable onset of such conformational diseases and demonstrate the potential of Drosophila as a model for their future study...
  69. ncbi Short alleles of P-selectin glycoprotein ligand-1 protect against premature myocardial infarction
    Vanessa Roldan
    Hematology Unit, Hospital de San Vicente, Alicante, Spain
    Am Heart J 148:602-5. 2004
    ..We sought to evaluate the role of this polymorphism in premature myocardial infarction because genetic risk factors have more relevance in the development of disease in young patients...
  70. ncbi A pharmacogenetic effect of factor XIII valine 34 leucine polymorphism on fibrinolytic therapy for acute myocardial infarction
    Francisco Marin
    Cardiology Department, Hospital General Universitario, Alicante, Spain
    J Am Coll Cardiol 45:25-9. 2005
    ..The aim of this study was to evaluate the pharmacogenetic role of the factor XIII (FXIII) valine 34 leucine (Val34Leu) polymorphism in the fibrinolytic therapy of acute myocardial infarction (MI)...
  71. doi AB0 blood group and risk of venous or arterial thrombosis in carriers of factor V Leiden or prothrombin G20210A polymorphisms
    Antonia Minano
    Centro Regional de Hemodonacion, C Ronda de Garay s n, Murcia 30003 Spain
    Haematologica 93:729-34. 2008
    ....
  72. ncbi Factor XIII Val34Leu polymorphism modulates the prothrombotic and inflammatory state associated with atrial fibrillation
    Francisco Marin
    Cardiology Service, Hospital General Universitario, c Pintor Baeza s n, 03010 Alicante, Spain
    J Mol Cell Cardiol 37:699-704. 2004
    ....
  73. ncbi Protein Z-dependent protease inhibitor W303X mutation in venous thrombosis
    Rocio Gonzalez-Conejero
    Br J Haematol 129:561-2; author reply 562. 2005
  74. ncbi Pharmacogenetics in cardiovascular antithrombotic therapy
    Francisco Marin
    Cardiology Department, Hospital General Universitario, c Pintor Baeza s n, Alicante, Spain
    Curr Med Chem Cardiovasc Hematol Agents 3:357-64. 2005
    ..The present review article explores the genetic influence on antithrombotic drug efficacy, analysing the modulating role of different polymorphisms on individuals' response to drugs commonly used in current day practice...
  75. ncbi [Annexin V levels in survivors of early myocardial infarction]
    Vanessa Roldan
    Unidad de Hematología Hospital de San Vicente Alicante Spain
    Rev Esp Cardiol 55:1230-4. 2002
    ..We studied plasma annexin V levels and analyzed its relationship to risk factors and several blood markers...
  76. ncbi The pharmacogenetics of antiplatelet drugs
    Francisco Marin
    Servicio de Cardiologia, Hospital Universitario Virgen de la Arrixaca, Madrid Cartagen s n El Palmar, Murcia, 30008 Spain
    Curr Opin Investig Drugs 8:213-8. 2007
    ..This review explores the genetic influences on antiplatelet drug efficacy by analyzing the modulating role of different genetic polymorphisms on individual responses to antiplatelet therapy...
  77. ncbi Effect of factor XIII VAL34LEU polymorphism on thrombolytic therapy in premature myocardial infarction
    Vanessa Roldan
    Thromb Haemost 88:354-5. 2002
  78. ncbi [Hereditary thrombophilia: learnt lessons and pending duties]
    Vicente Vicente
    Med Clin (Barc) 128:657-9. 2007