Richard Cervera

Summary

Country: Spain

Publications

  1. ncbi request reprint Lessons from the "Euro-Lupus Cohort"
    Ricard Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain
    Ann Med Interne (Paris) 153:530-6. 2002
  2. ncbi request reprint Systemic lupus erythematosus in Europe at the change of the millennium: lessons from the "Euro-Lupus Project"
    Ricard Cervera
    Department of Autoimmune Diseases, Servei de Malalties Autoimmunes, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Autoimmun Rev 5:180-6. 2006
  3. ncbi request reprint European Working Party on Systemic Lupus Erythematosus: a 15-year report
    Ricard Cervera
    Department of Autoimmune Diseases, Institut Clínic de Medicina i Dermatologia ICMiD, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Catalonia, Spain
    Autoimmun Rev 5:549-53. 2006
  4. doi request reprint European Forum On Antiphospholipid Antibodies: brief history report and governance document
    R Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain
    Lupus 21:699-703. 2012
  5. doi request reprint CAPS Registry
    R Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain
    Lupus 21:755-7. 2012
  6. doi request reprint Update on the catastrophic antiphospholipid syndrome and the "CAPS Registry"
    Ricard Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Villaroel 170, Barcelona, Catalonia, Spain
    Semin Thromb Hemost 38:333-8. 2012
  7. pmc Antiphospholipid syndrome
    Gerard Espinosa
    Department of Autoimmune Diseases, Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Barcelona, Catalonia, Spain
    Arthritis Res Ther 10:230. 2008
  8. ncbi request reprint Intestinal involvement secondary to the antiphospholipid syndrome (APS): clinical and immunologic characteristics of 97 patients: comparison of classic and catastrophic APS
    Ricard Cervera
    Department of Autoimmune Diseases, Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Catalonia, Spain
    Semin Arthritis Rheum 36:287-96. 2007
  9. pmc Antiphospholipid syndrome associated with infections: clinical and microbiological characteristics of 100 patients
    R Cervera
    Servei de Malalties Autoimmunes, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Ann Rheum Dis 63:1312-7. 2004
  10. ncbi request reprint Dementia associated with the antiphospholipid syndrome: clinical and radiological characteristics of 30 patients
    J A Gomez-Puerta
    Servei de Malalties Autoimmunes, Hospital Clinic, Villarroel, 170, 08036 Barcelona, Catalonia, Spain
    Rheumatology (Oxford) 44:95-9. 2005

Detail Information

Publications76

  1. ncbi request reprint Lessons from the "Euro-Lupus Cohort"
    Ricard Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain
    Ann Med Interne (Paris) 153:530-6. 2002
    ..The "Euro-Lupus Cohort" provides an updated information on the SLE morbidity and mortality characteristics in the present decade as well as defines several clinical and immunological prognostic factors...
  2. ncbi request reprint Systemic lupus erythematosus in Europe at the change of the millennium: lessons from the "Euro-Lupus Project"
    Ricard Cervera
    Department of Autoimmune Diseases, Servei de Malalties Autoimmunes, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Autoimmun Rev 5:180-6. 2006
    ..The "Euro-Lupus Cohort" provides an updated information on the SLE morbidity and mortality characteristics in the present decade as well as defines several clinical and immunological prognostic factors...
  3. ncbi request reprint European Working Party on Systemic Lupus Erythematosus: a 15-year report
    Ricard Cervera
    Department of Autoimmune Diseases, Institut Clínic de Medicina i Dermatologia ICMiD, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Catalonia, Spain
    Autoimmun Rev 5:549-53. 2006
    ..Nowadays, more than 50 European centres are collaborating in this venture, 9 large multicentre studies are ongoing and 10 workshops have been organized...
  4. doi request reprint European Forum On Antiphospholipid Antibodies: brief history report and governance document
    R Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain
    Lupus 21:699-703. 2012
    ..In this way, the wide exchange of information could also favour the introduction and evaluation of new tests...
  5. doi request reprint CAPS Registry
    R Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain
    Lupus 21:755-7. 2012
    ..The analysis of this registry has allowed the characterization of the clinical and laboratory features of the catastrophic APS as well as the establishment of preliminary criteria for its classification and guidelines for its management...
  6. doi request reprint Update on the catastrophic antiphospholipid syndrome and the "CAPS Registry"
    Ricard Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Villaroel 170, Barcelona, Catalonia, Spain
    Semin Thromb Hemost 38:333-8. 2012
    ..med.ub.es/MIMMUN/FORUM/CAPS.HTM). Currently, this database documents the entire clinical, laboratory, and therapeutic data of more than 350 fully registered patients...
  7. pmc Antiphospholipid syndrome
    Gerard Espinosa
    Department of Autoimmune Diseases, Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Barcelona, Catalonia, Spain
    Arthritis Res Ther 10:230. 2008
    ..The knowledge of these new pathogenic approaches might identify novel therapeutic targets and therefore may improve the management of these patients...
  8. ncbi request reprint Intestinal involvement secondary to the antiphospholipid syndrome (APS): clinical and immunologic characteristics of 97 patients: comparison of classic and catastrophic APS
    Ricard Cervera
    Department of Autoimmune Diseases, Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Catalonia, Spain
    Semin Arthritis Rheum 36:287-96. 2007
    ..To analyze the clinical and laboratory characteristics of 97 patients with intestinal involvement secondary to the antiphospholipid syndrome (APS) (37 patients with classic APS and 60 with catastrophic APS)...
  9. pmc Antiphospholipid syndrome associated with infections: clinical and microbiological characteristics of 100 patients
    R Cervera
    Servei de Malalties Autoimmunes, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Ann Rheum Dis 63:1312-7. 2004
    ..To describe and analyse the clinical characteristics of 100 patients with antiphospholipid syndrome (APS) associated with infections...
  10. ncbi request reprint Dementia associated with the antiphospholipid syndrome: clinical and radiological characteristics of 30 patients
    J A Gomez-Puerta
    Servei de Malalties Autoimmunes, Hospital Clinic, Villarroel, 170, 08036 Barcelona, Catalonia, Spain
    Rheumatology (Oxford) 44:95-9. 2005
    ..To analyse the clinical and radiological characteristics of patients with dementia associated with the antiphospholipid syndrome (APS)...
  11. ncbi request reprint The management of pregnant patients with antiphospholipid syndrome
    R Cervera
    Department of Autoimmune Diseases, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Catalonia, Spain
    Lupus 13:683-7. 2004
    ..Interventions with these drug therapies and monitored pregnancy have increased fetal survival...
  12. ncbi request reprint Coronary and valvular syndromes and antiphospholipid antibodies
    Ricard Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Villarroel, 170, 08036 Barcelona, Catalonia, Spain
    Thromb Res 114:501-7. 2004
    ..In this review article, the focus will be on the main cardiac features related to the presence of antiphospholipid antibodies (aPLs), which may be of interest to clinicians...
  13. pmc Validation of the preliminary criteria for the classification of catastrophic antiphospholipid syndrome
    R Cervera
    Servei de Malalties Autoimmunes, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Ann Rheum Dis 64:1205-9. 2005
    ....
  14. doi request reprint Lessons from the "Euro-Phospholipid" project
    Ricard Cervera
    Department of Autoimmune Diseases, Institut Clínic of Medicine and Dermatology, Hospital Clinic, Barcelona, Catalonia, Spain
    Autoimmun Rev 7:174-8. 2008
    ....
  15. doi request reprint Morbidity and mortality in the antiphospholipid syndrome during a 5-year period: a multicentre prospective study of 1000 patients
    R Cervera
    Servei de Malalties Autoimmunes, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Ann Rheum Dis 68:1428-32. 2009
    ..To identify the main causes of morbidity and mortality in patients with antiphospholipid syndrome (APS) during a 5-year period and to determine clinical and immunological parameters with prognostic significance...
  16. doi request reprint Bidirectional effects on autoimmunity and reproduction
    Ricard Cervera
    Department of Autoimmune Diseases, Institut Clínic of Medicine and Dermatology, Faculty of Medicine, University of Barcelona, Hospital Clínic Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Catalonia, Spain
    Hum Reprod Update 14:359-66. 2008
    ..This review addresses the impact of abnormal autoimmunity on female fertility, premature ovarian failure (POF) and recurrent pregnancy loss, as well as the influence of pregnancy in systemic lupus erythematosus (SLE)...
  17. ncbi request reprint Catastrophic antiphospholipid syndrome
    Richard Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain
    Pathophysiol Haemost Thromb 35:181-6. 2006
    ..The combination of high doses of intravenous (iv) heparin, iv steroids, iv gamma globulins and/or repeated plasma exchanges is the basic treatment of choice for all patients with this severe condition...
  18. ncbi request reprint Catastrophic antiphospholipid syndrome
    Ricard Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Rheum Dis Clin North Am 32:575-90. 2006
    ..Additionally, preventive measures in patients with APS may be effective if the development of the catastrophic APS is to be avoided...
  19. ncbi request reprint Catastrophic antiphospholipid syndrome: lessons from the "CAPS Registry"--a tribute to the late Josep Font
    Ricard Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain
    Ann N Y Acad Sci 1108:448-56. 2007
    ..This registry can be freely consulted at the Internet (www.med.ub.es/MIMMUN/FORUM/CAPS.HTM) and it is expected that the periodical analysis of these data will allow us to increase our knowledge of this condition...
  20. ncbi request reprint Lessons from the catastrophic antiphospholipid syndrome (CAPS) registry
    Ricard Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain
    Autoimmun Rev 6:81-4. 2006
    ..This registry can be freely consulted at the Internet (www.med.ub.es/MIMMUN/FORUM/CAPS.HTM) and it is expected that the periodical analysis of these data will allow us to increase our knowledge of this condition...
  21. doi request reprint Update on the diagnosis, treatment, and prognosis of the catastrophic antiphospholipid syndrome
    Ricard Cervera
    Department of Autoimmune Diseases, Servei de Malalties Autoimmunes, Hospital Clinic, Villarroel 170, Barcelona, Catalonia, 08036, Spain
    Curr Rheumatol Rep 12:70-6. 2010
    ..However, once patients with catastrophic APS have recovered, they usually follow a stable course with continued anticoagulation and few patients present with a relapse of the catastrophic episode...
  22. ncbi request reprint V meeting of the European forum on antiphospholipid antibodies
    Ricard Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain
    Autoimmun Rev 5:499-507. 2006
    ..This report summarizes the main studies and new research projects presented during this Forum Meeting...
  23. ncbi request reprint Catastrophic antiphospholipid syndrome: therapeutic developments
    Ricard Cervera
    Head, Servei de Malalties Autoimmunes, , Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Expert Rev Clin Immunol 3:277-85. 2007
    ..The combination of high doses of intravenous heparin, steroids, gamma-globulins and/or repeated plasma exchanges are the basic treatment of choice for all patients with this severe condition...
  24. ncbi request reprint Pregnancy outcome in systemic lupus erythematosus: good news for the new millennium
    Ricard Cervera
    Department of Autoimmune Diseases, Institut Clínic of Infections and Immunology, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Autoimmun Rev 1:354-9. 2002
    ....
  25. doi request reprint Task Force on Catastrophic Antiphospholipid Syndrome (APS) and Non-criteria APS Manifestations (I): catastrophic APS, APS nephropathy and heart valve lesions
    R Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain
    Lupus 20:165-73. 2011
    ..This article summarizes the studies analysed on the catastrophic APS, APS nephropathy and heart valve lesions, and presents the recommendations elaborated by the Task Force after this analysis...
  26. doi request reprint Task Force on Catastrophic Antiphospholipid Syndrome (APS) and Non-criteria APS Manifestations (II): thrombocytopenia and skin manifestations
    R Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain
    Lupus 20:174-81. 2011
    ..This article summarizes the studies analyzed on thrombocytopenia and skin manifestations, and presents the recommendations elaborated by the Task Force after this analysis...
  27. ncbi request reprint Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients
    Ricard Cervera
    Institut Clínic d Infeccions i Immunologia ICII, Hospital Clinic, and Institut d Investigacions Biomè diques August Pi i Sunyer IDIBAPS, Barcelona, Catalonia, Spain
    Arthritis Rheum 46:1019-27. 2002
    ..To analyze the clinical and immunologic manifestations of antiphospholipid syndrome (APS) in a large cohort of patients and to define patterns of disease expression...
  28. doi request reprint Catastrophic antiphospholipid syndrome (CAPS): update from the 'CAPS Registry'
    R Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Catalonia, Spain
    Lupus 19:412-8. 2010
    ..med.ub.es/MIMMUN/FORUM/CAPS.HTM). Currently, it documents the entire clinical, laboratory and therapeutic data of more than 300 patients whose data has been fully registered...
  29. doi request reprint Autoimmunity and recurrent pregnancy losses
    Ricard Cervera
    Department of Autoimmune Diseases, Institut Clínic of Medicine and Dermatology, Faculty of Medicine University of Barcelona, Hospital Clínic Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Catalonia, Spain
    Clin Rev Allergy Immunol 39:148-52. 2010
    ..Well-designed diagnostic studies are needed to estimate the true association between other specific autoantibodies and recurrent miscarriage...
  30. doi request reprint The Euro-Phospholipid project: epidemiology of the antiphospholipid syndrome in Europe
    R Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain
    Lupus 18:889-93. 2009
    ..Childhood onset patients presented more episodes of chorea and jugular vein thrombosis, whereas older onset patients were more frequently male and had more strokes and angina pectoris, but less frequently livedo reticularis...
  31. doi request reprint The Euro-lupus project: epidemiology of systemic lupus erythematosus in Europe
    R Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain
    Lupus 18:869-74. 2009
    ....
  32. doi request reprint Catastrophic antiphospholipid syndrome (CAPS): descriptive analysis of a series of 280 patients from the "CAPS Registry"
    Ricard Cervera
    Department of Autoimmune Diseases, Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Barcelona, Catalonia, Spain
    J Autoimmun 32:240-5. 2009
    ..To describe the clinical and laboratory features, as well as the precipitating factors, treatment and outcome of patients with catastrophic antiphospholipid syndrome (APS)...
  33. pmc Anti-chromatin antibodies in systemic lupus erythematosus: a useful marker for lupus nephropathy
    R Cervera
    Department of Autoimmune Diseases, Institut Clinic d Infeccions i Immunologia, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Catalonia, Spain
    Ann Rheum Dis 62:431-4. 2003
    ..Anti-chromatin antibodies have recently been described in patients with systemic lupus erythematosus (SLE) and it has been suggested that their presence is associated with lupus nephritis...
  34. doi request reprint Morbidity and mortality in the catastrophic antiphospholipid syndrome: pathophysiology, causes of death, and prognostic factors
    Gerard Espinosa
    Department of Autoimmune Diseases, Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Barcelona, Catalonia, Spain
    Semin Thromb Hemost 34:290-4. 2008
    ..The only identified prognostic factor for a higher mortality rate is the presence of systemic lupus erythematosus...
  35. ncbi request reprint Adrenal involvement in the antiphospholipid syndrome: clinical and immunologic characteristics of 86 patients
    Gerard Espinosa
    Department of Autoimmune Diseases, Institut Clinic d Infeccions i Immunologia, Institut d Investigacions Biomèdiques August Pi Sunyer, Hospital Clinic, Barcelona, Catalonia, Spain
    Medicine (Baltimore) 82:106-18. 2003
    ..An initial screening for hypoadrenalism is mandatory in any antiphospholipid antibody-positive patient who complains of abdominal pain and undue weakness or asthenia...
  36. ncbi request reprint Catastrophic antiphospholipid (Asherson's) syndrome
    Ricard Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain
    Br J Hosp Med (Lond) 69:384-7. 2008
    ..Knowledge of its treatment is vital as the outcome can be lethal...
  37. pmc Catastrophic antiphospholipid syndrome during pregnancy and puerperium: maternal and fetal characteristics of 15 cases
    José A Gómez-Puerta
    Servei de Malalties Autoimmunes, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Ann Rheum Dis 66:740-6. 2007
    ..The catastrophic variant of the antiphospholipid syndrome (APS) is a life-threatening form of presentation of this syndrome that can be triggered by several factors...
  38. ncbi request reprint Antiphospholipid syndrome associated with infections: clinical and microbiological characteristics
    Ricard Cervera
    Department of Autoimmune Diseases, Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Villaroel, 170, 08036 Barcelona, Catalonia, Spain
    Immunobiology 210:735-41. 2005
    ..Since then, many infections have been found to be associated with aPL positivity, although a pathogenic role for these antibodies was not usually obvious except in a few isolated cases...
  39. doi request reprint Proliferative lupus nephritis in a patient with systemic lupus erythematosus and longstanding secondary amyloid nephropathy
    José A Gómez-Puerta
    Department of Rheumatology, Hospital Clinic, Barcelona, Spain
    Clin Rheumatol 28:95-7. 2009
    ..The patient was treated with mycophenolate mofetil (1.5 g/day) with a significant improvement in proteinuria...
  40. doi request reprint Transverse myelitis affecting more than 4 spinal segments associated with systemic lupus erythematosus: clinical, immunological, and radiological characteristics of 22 patients
    Gerard Espinosa
    Department of Autoimmune Diseases, Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Barcelona, Catalonia, Spain
    Semin Arthritis Rheum 39:246-56. 2010
    ..To analyze the clinical and laboratory characteristics and outcomes of patients with transverse myelitis affecting more than 4 spinal segments secondary to systemic lupus erythematosus (SLE)...
  41. doi request reprint Catastrophic antiphospholipid syndrome: treatment, prognosis, and the risk of relapse
    Silvia Bucciarelli
    Department of Autoimmune Diseases, Hospital Clinic, Catalonia, Spain
    Clin Rev Allergy Immunol 36:80-4. 2009
    ..A detailed description of the clinical and laboratory features of the syndrome can be found in the other articles of this issue...
  42. ncbi request reprint Thromboprophylaxis and obstetric management of the antiphospholipid syndrome
    Gerard Espinosa
    Hospital Clinic, Institut Clinic de Medicina i Dermatologia, Department of Autoimmune Diseases, Barcelona, Catalonia, Spain
    Expert Opin Pharmacother 10:601-14. 2009
    ....
  43. ncbi request reprint Sarcoidosis in patients with chronic hepatitis C virus infection: analysis of 68 cases
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, School of Medicine, University of Barcelona, Barcelona, Spain
    Medicine (Baltimore) 84:69-80. 2005
    ..Clinicians should be aware of the possibility that sarcoidosis may initially manifest or be reactivated during or shortly after treatment with antiviral therapy in patients with chronic HCV infection...
  44. ncbi request reprint Severe valvular regurgitation and antiphospholipid antibodies in systemic lupus erythematosus: a prospective, long-term, followup study
    Felix Perez-Villa
    Hospital Clinic, IDIBAPS, Barcelona, Spain
    Arthritis Rheum 53:460-7. 2005
    ..To assess whether the presence of antiphospholipid antibodies is related to the incidence and progression of severe valvular dysfunction and the need for valve replacement in patients with systemic lupus erythematosus (SLE)...
  45. ncbi request reprint Clusters of clinical and immunologic features in systemic lupus erythematosus: analysis of 600 patients from a single center
    Josep Font
    Department of Autoimmune Diseases, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, School of Medicine, University of Barcelona, Spain
    Semin Arthritis Rheum 33:217-30. 2004
    ....
  46. ncbi request reprint Th1/Th2 cytokine imbalance in patients with Sjögren syndrome secondary to hepatitis C virus infection
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain
    Semin Arthritis Rheum 32:56-63. 2002
    ..To investigate if the serum immunologic profile, as delineated by serum circulating levels of Th1/Th2 cytokines and autoantibodies, is different in patients with Sjögren syndrome (SS) with and without hepatitis C virus (HCV) infection...
  47. ncbi request reprint Primary Sjögren syndrome: hematologic patterns of disease expression
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Clinical Institute of Infections and Immunology, Barcelona, Spain
    Medicine (Baltimore) 81:281-92. 2002
  48. ncbi request reprint Viral etiopathogenesis of Sjögren's syndrome: role of the hepatitis C virus
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, C Villaroel 170, Hospital Clinic, Institut Clinic d Infeccions i Immunologia, 08036 Barcelona, Catalonia, Spain
    Autoimmun Rev 1:238-43. 2002
    ..Thus, HCV patients with sicca symptomatology and positive autoantibodies could be misdiagnosed as a 'primary' SS. Nevertheless, there are several clinical and immunologic features that could help us differentiate both processes...
  49. doi request reprint Recent trends in the management of antiphospholipid syndrome (Hughes syndrome)
    Gerard Espinosa
    Department of Autoimmune Diseases, Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Barcelona, Spain
    Drugs Today (Barc) 46:39-47. 2010
    ..However, the knowledge of new pathogenic mechanisms might identify novel therapeutic targets and, therefore, may improve the management of these patients...
  50. ncbi request reprint Pure sensory neuropathy in primary Sjögren's syndrome. Longterm prospective followup and review of the literature
    Josep Font
    Department of Autoimmune Diseases, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    J Rheumatol 30:1552-7. 2003
    ..To study the clinical course, response to therapy, and longterm outcome of pure sensory neuropathy (PSN) in a series of patients with primary Sjögren's syndrome (SS) followed prospectively in our referral centers...
  51. ncbi request reprint Triple association between hepatitis C virus infection, systemic autoimmune diseases, and B cell lymphoma
    Manuel Ramos-Casals
    Departments of Autoimmune Diseases and Hematology, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
    J Rheumatol 31:495-9. 2004
    ..To analyze the clinical characteristics of patients from a Department of Autoimmune Diseases presenting chronic hepatitis C virus (HCV) infection, systemic autoimmune disease, and B cell lymphoma...
  52. ncbi request reprint Clinical features related to antiphospholipid syndrome in patients with chronic viral infections (hepatitis C virus/HIV infection): description of 82 cases
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, School of Medicine, University of Barcelona, Spain
    Clin Infect Dis 38:1009-16. 2004
    ..These viruses might act in some patients as chronic triggering agents that induce a heterogeneous, atypical presentation of APS...
  53. doi request reprint Antiphospholipid antibodies may impair factor XIIa-dependent activation of fibrinolysis in pregnancy: in vitro evidence with human endothelial cells in culture and monoclonal anticardiolipin antibodies
    Isabel Lázaro
    Faculty of Medicine, Institut Clínic of Ginecology, Obstetrics and Neonatology, University of Barcelona, Barcelona, Spain
    Am J Obstet Gynecol 201:87.e1-6. 2009
    ..The purpose of this study was to analyze the in vitro activation of the contact complex with the use of human umbilical vein endothelial cells (HUVEC) in culture and monoclonal anticardiolipin antibodies (MaCL)...
  54. ncbi request reprint True anti-anionic phospholipid immunoglobulin M antibodies can exert lupus anticoagulant activity
    Teresa Gallart
    Service of Immunology, Hospital Clinic Universitari, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona University School of Medicine, Barcelona, Spain
    Br J Haematol 116:875-86. 2002
    ..These findings demonstrate unequivocally that true anti-anionic PL IgM antibodies can exert LA and indicate this anti-PL type does not involve thrombophilia...
  55. ncbi request reprint Mortality in the catastrophic antiphospholipid syndrome: causes of death and prognostic factors
    Silvia Bucciarelli
    Department of Autoimmune Diseases, Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Barcelona, Catalonia, Spain
    Autoimmun Rev 6:72-5. 2006
    ..According to the results of this analysis, anticoagulation plus steroids plus plasma exchange should be the first line of therapy in patients with catastrophic APS...
  56. doi request reprint Thrombin activatable fibrinolysis inhibitor and clot lysis time in pregnant patients with antiphospholipid syndrome: relationship with pregnancy outcome and thrombosis
    Maria Angeles Martinez-Zamora
    Institut Clinic of Gynecology, Obstetrics and Neonatology, Hospital Clínic Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Villarroel, 170 08036 Barcelona, Spain
    Am J Reprod Immunol 62:381-9. 2009
    ..This study evaluated Thrombin Activatable Fibrinolysis Inhibitor (TAFI) levels, TAFI gene polymorphisms and Clot Lysis Time (CLT) in pregnant patients with APS in relation to pregnancy outcome and thrombosis...
  57. ncbi request reprint Mortality in the catastrophic antiphospholipid syndrome: causes of death and prognostic factors in a series of 250 patients
    Silvia Bucciarelli
    Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Barcelona, Catalonia, Spain
    Arthritis Rheum 54:2568-76. 2006
    ..To assess the main causes of death and the prognostic factors that influence mortality in patients with the catastrophic antiphospholipid syndrome (CAPS)...
  58. ncbi request reprint Vasculitis in systemic lupus erythematosus: prevalence and clinical characteristics in 670 patients
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, School of Medicine, University of Barcelona, Barcelona, Spain
    Medicine (Baltimore) 85:95-104. 2006
    ..The presence of vasculitis in our patients with SLE was associated with a higher ECLAM score, livedo reticularis, hematologic parameters (anemia, high ESR), and anti-La/SS-B antibodies...
  59. ncbi request reprint Class III-IV proliferative lupus nephritis and pregnancy: a study of 42 cases
    Francisco Carmona
    Institut Clinic of Gynecology, Obstetrics, and Neonatology, Barcelona, Spain
    Am J Reprod Immunol 53:182-8. 2005
    ..A growing number of women with lupus nephritis wish pregnancy. Our aim was to analyze maternal and fetal outcome in pregnancies with the most severe forms (proliferative or class III-IV) of lupus nephritis...
  60. doi request reprint Morbidity and mortality in the antiphospholipid syndrome
    Gerard Espinosa
    Department of Autoimmune Diseases, Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Barcelona, Catalonia, Spain
    Curr Opin Pulm Med 15:413-7. 2009
    ..There is a growing awareness to determine optimal prognostic markers and therapeutic measures to prevent these important complications in the APS...
  61. ncbi request reprint Hematologic malignancies in patients with cryoglobulinemia: association with autoimmune and chronic viral diseases
    Olga Trejo
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, School of Medicine, University of Barcelona, Barcelona, Spain
    Semin Arthritis Rheum 33:19-28. 2003
    ....
  62. ncbi request reprint Laboratory studies on pathophysiology of the catastrophic antiphospholipid syndrome
    Gerard Espinosa
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain
    Autoimmun Rev 6:68-71. 2006
    ....
  63. ncbi request reprint Antiphospholipid syndrome: pathogenic mechanisms
    Gerard Espinosa
    Department of Autoimmune Diseases, Institut Clinic d Infeccions i Immunologia, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Autoimmun Rev 2:86-93. 2003
    ..Second, aPL may stimulate certain cells thereby altering the expression and secretion of various molecules. In this article, we review the mechanisms by which aPL may develop thrombotic events...
  64. ncbi request reprint Clinical and epidemiological aspects in the antiphospholipid syndrome
    Ricard Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain
    Immunobiology 207:5-11. 2003
    ..Systemic lupus erythematosus (SLE) is the disorder in which an APS is most commonly associated. Less frequently, aPL and, rarely, an APS may also be encountered in other groups of patients (Table 1) (1)...
  65. doi request reprint Antiphospholipid syndrome: frequency, main causes and risk factors of mortality
    Gerard Espinosa
    Department of Autoimmune Diseases, Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Villarroel, Barcelona, Catalonia, Spain
    Nat Rev Rheumatol 6:296-300. 2010
    ..The combined use of anticoagulation, corticosteroids, plasma exchange and intravenous immunoglobulin therapy could result in a dramatic reduction in mortality, by approximately 20%, in patients with catastrophic APS...
  66. ncbi request reprint Raynaud's phenomenon in primary Sjögren's syndrome. Prevalence and clinical characteristics in a series of 320 patients
    Mario Garcia-Carrasco
    Department of Systemic Autoimmune Diseases, Hospital Clinic, Barcelona, Spain
    J Rheumatol 29:726-30. 2002
    ..To determine the prevalence of Raynaud's phenomenon (RP) in a large series of patients with primary Sjögren's syndrome (SS) and to identify the clinical and immunological features related to its presence...
  67. ncbi request reprint Catastrophic antiphospholipid syndrome
    Ronald A Asherson
    Department of Autoimmune Diseases, Institut Clinic d Infeccions i Immunologia, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Curr Rheumatol Rep 5:395-400. 2003
    ..Regrettably, despite all available therapeutic options at this time, the mortality is still high (greater than 50%)...
  68. ncbi request reprint Pregnancy and puerperium are high susceptibility periods for the development of catastrophic antiphospholipid syndrome
    José A Gómez-Puerta
    Department of Autoimmune Diseases, Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Barcelona, Catalonia, Spain
    Autoimmun Rev 6:85-8. 2006
    ..In around 6% of the cases, the catastrophic APS can appear during pregnancy or puerperium. We review this specific subset of the catastrophic APS and propose a therapeutical approach for this particular situation...
  69. ncbi request reprint Behçet's disease in an HIV-1-infected patient treated with highly active antiretroviral therapy
    José A Gómez-Puerta
    Department of Autoimmune Diseases, Institut Clinic de Medicina i Dermatologia, Hospital Clinic, University of Barcelona, Spain
    Isr Med Assoc J 8:513-4. 2006
  70. doi request reprint Anti-chromatin (anti-nucleosome) antibodies: diagnostic and clinical value
    José A Gómez-Puerta
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain
    Autoimmun Rev 7:606-11. 2008
    ..Recent studies demonstrated the induction of anti-chromatin (anti-nucleosome) antibodies after an anti-tumour necrosis factor (TNF)-alpha agent treatment...
  71. ncbi request reprint Impaired factor XIIa-dependent activation of fibrinolysis in treated antiphospholipid syndrome gestations developing late-pregnancy complications
    Francisco Carmona
    Institut Clinic of Gynecology, Obstetrics, and Neonatology, Barcelona, Spain
    Am J Obstet Gynecol 194:457-65. 2006
    ..The objective of the study was to investigate the potential role of impaired factor XII-dependent activation of fibrinolysis in treated antiphospholipid syndrome gestations developing late-pregnancy complications...
  72. ncbi request reprint [Sarcoidosis as seronegative spondyloarthropathy]
    José A Gómez-Puerta
    Servicio de Reumatologia, Hospital Clinic, Barcelona, Espana
    Biomedica 25:435-8. 2005
    ..These clinical forms of spondyloarthropathy and sarcoidosis were unusual and were compared with similar cases present in the literature...
  73. ncbi request reprint Preclinical vascular disease in systemic lupus erythematosus and primary antiphospholipid syndrome
    Sonia Jimenez
    Servicio de Enfermedades Autoinmunes, ICMiD, Hospital Clinic, C Villaroel 170, 08036 Barcelona, Spain
    Rheumatology (Oxford) 44:756-61. 2005
    ..To determine the prevalence of preclinical vascular disease and associated risk factors in patients with systemic lupus erythematosus (SLE) or primary antiphospholipid syndrome (APS)...
  74. ncbi request reprint The epidemiology of systemic lupus erythematosus
    Sonia Jimenez
    Department of Autoimmune Diseases, Institut Clinic d Infeccions i Immunologia, Hospital Clinic, Barcelona, Catalonia, Spain
    Clin Rev Allergy Immunol 25:3-12. 2003
    ..An important amount of information comes from the data obtained from the "Euro-Lupus Cohort," a series of 1000 patients with SLE from several European countries that have been followed prospectively since 1991...
  75. ncbi request reprint Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1,000 patients
    Ricard Cervera
    Department of Autoimmune Diseases, Institut Clinic d Infeccions i Immunologia, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Barcelona, Catalonia, Spain
    Medicine (Baltimore) 82:299-308. 2003
    ..Meanwhile, a more prominent role of thrombotic events is becoming evident, affecting both morbidity and mortality in SLE...
  76. ncbi request reprint Factor XIII-A subunit Val34Leu polymorphism is associated with the risk of thrombosis in patients with antiphospholipid antibodies and high fibrinogen levels
    Gloria de la Red
    Department of Hemotherapy and Hemostasis, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Thromb Haemost 101:312-6. 2009
    ..20, 95% CI 0.67-2.16). The FXIII-A Leu34 allele seems to have a protective effect on the development of thrombosis in patients with aPL, but only in those with high plasma fibrinogen values...