Affiliation: Centro Nacional de Investigaciones Cardiovasculares
Muñoz Martín N, Sierra R, Schimmang T, Villa del Campo C, Torres M. Myc is dispensable for cardiomyocyte development but rescues Mycn-deficient hearts through functional replacement and cell competition. Development. 2019;146: pubmed publisher
Marcos S, GonzÃ¡lez LÃ¡zaro M, Beccari L, Carramolino L, Martín Bermejo M, Amarie O, et al
. Meis1 coordinates a network of genes implicated in eye development and microphthalmia. Development. 2015;142:3009-20 pubmed publisher
..We propose that Meis1 is at the core of a genetic network implicated in eye patterning/microphthalmia, and represents an additional candidate for syndromic cases of these ocular malformations. ..
Claveria C, Torres M. Cell Competition: Mechanisms and Physiological Roles. Annu Rev Cell Dev Biol. 2016;32:411-439 pubmed
..Cell competition plays essential roles in quality control, homeostasis, and repair of developing and adult tissues, and depending on the context, it may function as a tumor-suppressing or tumor-promoting mechanism. ..
Villa del Campo C, ClaverÃa C, Sierra R, Torres M. Cell competition promotes phenotypically silent cardiomyocyte replacement in the mammalian heart. Cell Rep. 2014;8:1741-1751 pubmed publisher
..These results show that the capacity for cell competition in mammals is not restricted to stem cell populations and suggest that stimulated cell competition has potential as a cardiomyocyte-replacement strategy. ..
Delgado I, Torres M. Gradients, waves and timers, an overview of limb patterning models. Semin Cell Dev Biol. 2016;49:109-15 pubmed publisher
..Here we concentrate on reviewing patterning mechanisms along the P-D and A-P axes, in which different mechanisms converge and interact to pattern segmented structures. ..
Ivanovitch K, Esteban I, Torres M. Growth and Morphogenesis during Early Heart Development in Amniotes. J Cardiovasc Dev Dis. 2017;4: pubmed publisher
Delgado I, Torres M. Coordination of limb development by crosstalk among axial patterning pathways. Dev Biol. 2017;429:382-386 pubmed publisher
..We review here the main interactions described between the three axial systems of the developing limb and discuss their relevance to proper limb growth and patterning. ..
Díaz Díaz C, Fernandez de Manuel L, Jimenez Carretero D, Montoya M, Claveria C, Torres M. Pluripotency Surveillance by Myc-Driven Competitive Elimination of Differentiating Cells. Dev Cell. 2017;42:585-599.e4 pubmed publisher
..In the mouse embryo, cell competition promotes pluripotency maintenance by elimination of primed lineages before gastrulation. The mechanism described here is relevant to mammalian embryo development and induced pluripotency. ..