Genomes and Genes
Juan Carlos Ramirez
Affiliation: Centro Nacional de Investigaciones Cardiovasculares
- A chemokine targets the nucleus: Cxcl12-gamma isoform localizes to the nucleolus in adult mouse heartRaul Torres
Viral Vector Facility, Technical Unit of Gene Targeting, Fundacion CNIC National Centre for Cardiovascular Research, Madrid, Spain
PLoS ONE 4:e7570. 2009..Our results provide an example of genome economy even for essential and highly conserved genes such as Cxcl12, and suggest that chemokines can exert tissue specific functions unrelated to cell-to-cell communication...
- Non-integrative lentivirus drives high-frequency cre-mediated cassette exchange in human cellsRaul Torres
Viral Vector Technical Unit, Fundación Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain
PLoS ONE 6:e19794. 2011..Safety, efficiency, and simplicity are the major advantages of our system, which can be applied in low-to-medium throughput strategies for screening of cDNAs, non-coding RNAs during functional genomic studies, and drug screening...
- Tissue-derived mesenchymal stromal cells used as vehicles for anti-tumor therapy exert different in vivo effects on migration capacity and tumor growthCarolina Belmar-Lopez
Instituto Aragones de Ciencias de la Salud IIS Aragon, Zaragoza, Spain
BMC Med 11:139. 2013....
- Hematologic β-tubulin VI isoform exhibits genetic variability that influences paclitaxel toxicityLuis J Leandro-García
Hereditary Endocrine Cancer Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain
Cancer Res 72:4744-52. 2012..A polymorphism found in a tubulin isoform expressed only in hemapoietic cells may contribute to the patient variation in myelosuppression that occurs after treatment with microtubule-binding drugs...