T Kekarainen

Summary

Affiliation: Centre de Recerca en Sanitat Animal
Country: Spain

Publications

  1. doi request reprint Porcine circovirus type 2 (PCV2) viral components immunomodulate recall antigen responses
    Tuija Kekarainen
    Centre de Recerca en Sanitat Animal CReSA, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet Immunol Immunopathol 124:41-9. 2008
  2. doi request reprint Torque teno virus infection in the pig and its potential role as a model of human infection
    Tuija Kekarainen
    Centre de Recerca en Sanitat Animal CReSA, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet J 180:163-8. 2009
  3. doi request reprint Porcine circovirus type 2-induced interleukin-10 modulates recall antigen responses
    Tuija Kekarainen
    Centre de Recerca en Sanitat Animal, Bellaterra, Barcelona, Spain
    J Gen Virol 89:760-5. 2008
  4. doi request reprint Immune responses and vaccine-induced immunity against Porcine circovirus type 2
    T Kekarainen
    Centre de Recerca en Sanitat Animal CReSA, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet Immunol Immunopathol 136:185-93. 2010
  5. doi request reprint Swine torque teno virus detection in pig commercial vaccines, enzymes for laboratory use and human drugs containing components of porcine origin
    Tuija Kekarainen
    Centre de Recerca en Sanitat Animal CReSA, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    J Gen Virol 90:648-53. 2009
  6. pmc Optimization of immunomagnetic separation for cord blood-derived hematopoietic stem cells
    Tuija Kekarainen
    Finnish Red Cross Blood Service, Helsinki, Finland
    BMC Cell Biol 7:30. 2006
  7. ncbi request reprint Prevalence of swine Torque teno virus in post-weaning multisystemic wasting syndrome (PMWS)-affected and non-PMWS-affected pigs in Spain
    Tuija Kekarainen
    Centre de Recerca en Sanitat Animal CReSA, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    J Gen Virol 87:833-7. 2006
  8. ncbi request reprint Swine torque teno virus (TTV) infection and excretion dynamics in conventional pig farms
    M Sibila
    Centre de Recerca en Sanitat Animal, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet Microbiol 139:213-8. 2009
  9. doi request reprint Lack of effect of piglet vaccination against Porcine circovirus type 2 (PCV2) on serum viral loads of Torque teno sus virus 2 (TTSuV2)
    D Nieto
    Centre de Recerca en Sanitat Animal CReSA, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet Microbiol 157:8-12. 2012
  10. ncbi request reprint Exploratory study of Torque teno sus viruses in pulmonary inflammatory lesions in pigs
    M Aramouni
    Centre de Recerca en Sanitat Animal, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet Microbiol 162:338-44. 2013

Collaborators

Detail Information

Publications26

  1. doi request reprint Porcine circovirus type 2 (PCV2) viral components immunomodulate recall antigen responses
    Tuija Kekarainen
    Centre de Recerca en Sanitat Animal CReSA, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet Immunol Immunopathol 124:41-9. 2008
    ..Thus, the final immune response upon PCV2 infection seems to depend on the fine balance between the regulatory elements present in viral DNA and structural protein within the host immune system...
  2. doi request reprint Torque teno virus infection in the pig and its potential role as a model of human infection
    Tuija Kekarainen
    Centre de Recerca en Sanitat Animal CReSA, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet J 180:163-8. 2009
    ..The present review summarises research on animal TTV infection, focussing in particular on TTV infection in the pig, and considers how a porcine experimental infection model might assist in the study of human TTV infection...
  3. doi request reprint Porcine circovirus type 2-induced interleukin-10 modulates recall antigen responses
    Tuija Kekarainen
    Centre de Recerca en Sanitat Animal, Bellaterra, Barcelona, Spain
    J Gen Virol 89:760-5. 2008
    ..The ability of PCV2 to hamper the development of immune responses may contribute to the Th1 suppressed responses, immune suppression and co-infections...
  4. doi request reprint Immune responses and vaccine-induced immunity against Porcine circovirus type 2
    T Kekarainen
    Centre de Recerca en Sanitat Animal CReSA, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet Immunol Immunopathol 136:185-93. 2010
    ..This review focuses on the recent research on immunological aspects during PCV2 infections and summarizes what is currently known about the vaccine-induced immunity...
  5. doi request reprint Swine torque teno virus detection in pig commercial vaccines, enzymes for laboratory use and human drugs containing components of porcine origin
    Tuija Kekarainen
    Centre de Recerca en Sanitat Animal CReSA, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    J Gen Virol 90:648-53. 2009
    ..These results show that swine TTVs are contaminants not only of swine vaccines but also of human drugs containing porcine components and enzymes for laboratory use...
  6. pmc Optimization of immunomagnetic separation for cord blood-derived hematopoietic stem cells
    Tuija Kekarainen
    Finnish Red Cross Blood Service, Helsinki, Finland
    BMC Cell Biol 7:30. 2006
    ..Protocols developed for the enrichment of peripheral blood-derived stem cells have been found to be suboptimal for cord blood...
  7. ncbi request reprint Prevalence of swine Torque teno virus in post-weaning multisystemic wasting syndrome (PMWS)-affected and non-PMWS-affected pigs in Spain
    Tuija Kekarainen
    Centre de Recerca en Sanitat Animal CReSA, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    J Gen Virol 87:833-7. 2006
    ..These results indicate a high prevalence of both swine TTV genogroups in Spain, being present more frequently in PMWS-affected animals than in non-PMWS-affected animals...
  8. ncbi request reprint Swine torque teno virus (TTV) infection and excretion dynamics in conventional pig farms
    M Sibila
    Centre de Recerca en Sanitat Animal, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet Microbiol 139:213-8. 2009
    ..Moreover, results indicate that both swine TTV genogroups are able to establish persistent infections in a number of pigs...
  9. doi request reprint Lack of effect of piglet vaccination against Porcine circovirus type 2 (PCV2) on serum viral loads of Torque teno sus virus 2 (TTSuV2)
    D Nieto
    Centre de Recerca en Sanitat Animal CReSA, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet Microbiol 157:8-12. 2012
    ..Therefore, vaccination of PCV2 subclinically infected pigs did not modify the outcome of TTSuV2 infection...
  10. ncbi request reprint Exploratory study of Torque teno sus viruses in pulmonary inflammatory lesions in pigs
    M Aramouni
    Centre de Recerca en Sanitat Animal, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet Microbiol 162:338-44. 2013
    ..This result suggests a possible role of TTSuV2 in the pathogenic mechanism of inflammatory lesions of lungs compatible with viral infection...
  11. doi request reprint Dynamics of Torque teno sus virus 1 (TTSuV1) and 2 (TTSuV2) DNA loads in serum of healthy and postweaning multisystemic wasting syndrome (PMWS) affected pigs
    D Nieto
    Centre de Recerca en Sanitat Animal CReSA, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet Microbiol 152:284-90. 2011
    ..On the contrary, TTSuV2 DNA loads in PMWS affected pigs increased throughout the sampling period. It seems that TTSuV species differ in the in vivo infection dynamics in PMWS affected animals...
  12. doi request reprint Torque teno sus virus 1 and 2 viral loads in postweaning multisystemic wasting syndrome (PMWS) and porcine dermatitis and nephropathy syndrome (PDNS) affected pigs
    M Aramouni
    Centre de Recerca en Sanitat Animal CReSA, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet Microbiol 153:377-81. 2011
    ..TTSuV2 viral loads were significantly higher in PMWS affected animals, further supporting the previously suggested association between TTSuV2 and PMWS. On the contrary, TTSuV1 prevalence and loads were not related with the studied PCVDs...
  13. doi request reprint Torque teno sus virus (TTV) detection in aborted and slaughterhouse collected foetuses
    L Martínez-Guinó
    Centre de Recerca en Sanitat Animal CReSA, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, Barcelona, Spain
    Theriogenology 74:277-81. 2010
    ..Results obtained confirm that vertical transmission is an important route of TTVs dissemination. In addition, data obtained suggest that swine TTVs should not be considered as infectious agents responsible for abortion occurrence...
  14. ncbi request reprint Increased viral load and prevalence of Torque teno sus virus 2 (TTSuV2) in pigs experimentally infected with classical swine fever virus (CSFV)
    M Aramouni
    Centre de Recerca en Sanitat Animal CReSA, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Cerdanyola del Valles, Barcelona, Spain
    Virus Res 172:81-4. 2013
    ..Therefore, this study emphasizes the different behaviour of both TTSuVs, as already found in the PMWS background, and further supports the association of TTSuV2 with disease occurrence...
  15. doi request reprint Evidence of Torque teno virus (TTV) vertical transmission in swine
    L Martínez-Guinó
    Centre de Recerca en Sanitat Animal CReSA, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Theriogenology 71:1390-5. 2009
    ..This study represents the first description of swine TTV presence in colostrum and stillborn piglets...
  16. doi request reprint Age-related tissue distribution of swine Torque teno sus virus 1 and 2
    M Aramouni
    Centre de Recerca en Sanitat Animal CReSA, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet Microbiol 146:350-3. 2010
    ..Both swine TTV species were present in high levels in almost all older animals, while viral negative tissues were only found in 5-week-old and 5-day-old pigs, and foetuses...
  17. ncbi request reprint Torque teno virus (TTV) is highly prevalent in the European wild boar (Sus scrofa)
    Laura Martinez
    Centre de Recerca en Sanitat Animal CReSA, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
    Vet Microbiol 118:223-9. 2006
    ..The results indicate that TTV is apparently ubiquitous in European wild boar populations...
  18. ncbi request reprint Detection of swine Torque teno virus genogroups 1 and 2 in boar sera and semen
    T Kekarainen
    Centre de Recerca en Sanitat Animal CReSA, Facultat de Veterinaria, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Theriogenology 68:966-71. 2007
    ..It is presently unknown if this potential vertical transmission of swine TTV implies any effect on female reproductive tract. This study also represents the first description of swine TTV presence in semen...
  19. doi request reprint Retrospective study on swine Torque teno virus genogroups 1 and 2 infection from 1985 to 2005 in Spain
    Joaquim Segales
    Centre de Recerca en Sanitat Animal, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet Microbiol 134:199-207. 2009
    ..This study represents the earliest evidence of TTV infection in pigs to date, 14 years before the initial description of this virus. Moreover, this is also the earliest evidence of TTV infection in any species...
  20. doi request reprint Torque teno virus (TTV) infection in sows and suckling piglets
    M Sibila
    Centre de Recerca en Sanitat Animal CReSA, UAB IRTA, Campus de la Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Vet Microbiol 137:354-8. 2009
    ..Results of the present study showed that the TTV infection occurs early in the production system and that these viruses may be transmitted from sow-to-piglet but also from piglet-to-piglet in farrowing facilities...
  21. ncbi request reprint Construction and biological activity of a full-length molecular clone of human Torque teno virus (TTV) genotype 6
    Laura Kakkola
    Department of Virology, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Finland
    FEBS J 274:4719-30. 2007
    ..The replicating full-length clone, the cell lines found to support TTV replication, and the methods presented here will facilitate the elucidation of the molecular biology and the life cycle of this recently identified human virus...
  22. ncbi request reprint Umbilical cord blood-derived progenitor cells enhance muscle regeneration in mouse hindlimb ischemia model
    Jonna K Koponen
    Department of Molecular Medicine, A I Virtanen Institute, University of Kuopio, Kuopio, Finland
    Mol Ther 15:2172-7. 2007
    ..However, VEGF-D gene transfer of progenitor cells did not improve the therapeutic effect in ischemic muscles...
  23. ncbi request reprint A novel insertion site inside the potyvirus P1 cistron allows expression of heterologous proteins and suggests some P1 functions
    Minna Liisa Rajamäki
    Department of Applied Biology, PO Box 27, FIN 00014 University of Helsinki, Finland
    Virology 342:88-101. 2005
    ..This heterologous protein expression site is the first within a protein-encoding cistron and the third in the genome of potyviruses...
  24. ncbi request reprint P16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cells
    Igor Oruetxebarria
    Gene Regulation Laboratory and Center for Biomedical Genetics, Leiden University Medical Center, The Netherlands
    J Biol Chem 279:3807-16. 2004
    ..Collectively, these results indicate that in human MRT cells, the p16(INK4a)/pRb, rather than the p14(ARF)/p53 pathway, mediates hSNF5-induced cellular senescence...
  25. ncbi request reprint Mapping of viral genomic regions important in cross-protection between strains of a potyvirus
    Jari P T Valkonen
    Department of Plant Biology, Genetics Centre, SLU, Uppsala, Sweden
    Mol Plant Microbe Interact 15:683-92. 2002
    ....
  26. pmc Functional genomics on potato virus A: virus genome-wide map of sites essential for virus propagation
    Tuija Kekarainen
    Department of Plant Biology, Swedish University of Agricultural Sciences SLU, S 75007 Uppsala, Sweden
    Genome Res 12:584-94. 2002
    ..The methodology described is applicable to a detailed functional analysis of any viral nucleic acid cloned as DNA and can be used to address many different processes during viral infection cycles...