Cristina Fillat

Summary

Affiliation: Center for Genomic Regulation
Country: Spain

Publications

  1. ncbi request reprint Insights from mouse models to understand neurodegeneration in Down syndrome
    Cristina Fillat
    Centre de Regulacio Genomica, UPF, Parc de Recerca Biomedica de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Raras, Spain
    CNS Neurol Disord Drug Targets 9:429-38. 2010
  2. ncbi request reprint Suicide gene therapy mediated by the Herpes Simplex virus thymidine kinase gene/Ganciclovir system: fifteen years of application
    C Fillat
    Programa Gens i Malaltia, Centre de Regulacio Genomica, Barcelona, Spain
    Curr Gene Ther 3:13-26. 2003
  3. doi request reprint Positive selection of gene-modified cells increases the efficacy of pancreatic cancer suicide gene therapy
    Jordi Martinez-Quintanilla
    Gene and Viral Therapy Group, IDIBELL Catalan Institute of Oncology ICO, L Hospitalet de Llobregat, UPF, Parc de Recerca Biomédica de Barcelona and Centro de Investigación Biomédica en Red de Enfermedades Raras CIBERER ISCIII, Barcelona, Spain
    Mol Cancer Ther 8:3098-107. 2009
  4. ncbi request reprint Targeting the CYP2B 1/cyclophosphamide suicide system to fibroblast growth factor receptors results in a potent antitumoral response in pancreatic cancer models
    Meritxell Huch
    Programa Gens i Malaltia, Centre de Regulació Genòmica Universitat Pompeu Fabra, 08003 Barcelona, Spain
    Hum Gene Ther 17:1187-200. 2006
  5. pmc Intraductal delivery of adenoviruses targets pancreatic tumors in transgenic Ela-myc mice and orthotopic xenografts
    Anabel José
    Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Oncotarget 4:94-105. 2013
  6. doi request reprint Cell cycle control pathways act as conditioning factors for TK/GCV sensitivity in pancreatic cancer cells
    Daniel Abate-Daga
    Programa Gens i Malaltia, Parc de Recerca Biomedica de Barcelona, Barcelona, Spain
    Biochim Biophys Acta 1803:1175-85. 2010
  7. pmc Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome
    Jon Ortiz-Abalia
    Programa Gens i Malaltia Centre de Regulació Genòmica CRG, UPF, Parc de Recerca Biomédica de Barcelona PRBB, Barcelona 08003, Spain
    Am J Hum Genet 83:479-88. 2008
  8. pmc Oncolytic adenoviruses armed with thymidine kinase can be traced by PET imaging and show potent antitumoural effects by ganciclovir dosing
    Daniel Abate-Daga
    Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    PLoS ONE 6:e26142. 2011
  9. ncbi request reprint Tat8-TK/GCV suicide gene therapy induces pancreatic tumor regression in vivo
    Anna Cascante
    Programa Gens i Malaltia, Centre de Regulació Genòmica CRG UPF, 08003 Barcelona, Spain
    Hum Gene Ther 16:1377-88. 2005
  10. doi request reprint Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome
    Xavier Altafaj
    Centre for Biomedical Network Research on Rare Diseases, Barcelona, Spain
    Neurobiol Dis 52:117-27. 2013

Collaborators

  • Mara Dierssen
  • Xavier Estivill
  • Ramon Alemany
  • Eduardo D Martin
  • Marçal Pastor-Anglada
  • Luis Martinez-Lostao
  • Nuria Matamoros
  • Lauro Sumoy
  • Antoni Ivorra
  • Francisco X Real
  • Isidre Ferrer
  • Frances J D Smith
  • Miguel Martin
  • Eulalia Marti
  • W H Irwin McLean
  • Carmen Martinez Cue
  • Nuria Andreu
  • Anabel José
  • Meritxell Huch
  • Daniel Abate-Daga
  • Anna Cascante
  • Adela Mazo
  • Xavier Altafaj
  • Laura Garcia-Rodríguez
  • Jon Ortiz-Abalia
  • Juan Ramon Gonzalez
  • Manel Cascallo
  • I Herrero-Fresneda
  • M Franquesa
  • Meritxell Carrio
  • Luciano Sobrevals
  • Josep Maria Roig
  • Victor Volpini
  • Jordi Martinez-Quintanilla
  • Alena Gros
  • Judit Pujal
  • A Cascante
  • J Segura
  • M Carrio
  • J Torras
  • J M Cruzado
  • N Lloberas
  • J M Grinyo
  • Joaquim Calbo
  • R Benavides-Piccione
  • Aitana Valderrama
  • Juan Miguel Camacho-Sánchez
  • Eduard Ayuso
  • Cristina Lao-Peregrín
  • Pilar Navarro
  • A Mazo
  • E Mercade
  • Juan Camacho-Sánchez
  • Olga Millán
  • Ignacio Garcia-Ribas
  • Raul Herance
  • Sandra Pérez-Torras
  • Alba Duch
  • Ibane Abasolo
  • Annie Rodolosse
  • Luis Sánchez-Palazón
  • Ignasi Sahún
  • J D Gispert
  • J A Pascual
  • L García-Rodriguez
  • R Castelo
  • Z Nikolovski
  • N Andreu
  • D Andreu
  • V Gomez
  • J Llop
  • D Abate-Daga
  • A Pinyot
  • J R Gonzalez
  • Josep M Aran
  • B G de la Torre
  • Antonio Escudero
  • O Millan
  • Joan Fabregat
  • A Vidal
  • Ignacio J Molina
  • Maricruz García-Rodríguez
  • Cecilia Frecha
  • Gumersindo Fontan
  • Barbara Sosnowski
  • Laura Garcia Rodríguez
  • Lauren Costantini
  • Gabriel Capella
  • N Bolanos
  • I Rama

Detail Information

Publications32

  1. ncbi request reprint Insights from mouse models to understand neurodegeneration in Down syndrome
    Cristina Fillat
    Centre de Regulacio Genomica, UPF, Parc de Recerca Biomedica de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Raras, Spain
    CNS Neurol Disord Drug Targets 9:429-38. 2010
    ..In addition, these models might allow to define and evaluate potential drug targets and to develop therapeutic strategies that may interfere or delay the onset of AD...
  2. ncbi request reprint Suicide gene therapy mediated by the Herpes Simplex virus thymidine kinase gene/Ganciclovir system: fifteen years of application
    C Fillat
    Programa Gens i Malaltia, Centre de Regulacio Genomica, Barcelona, Spain
    Curr Gene Ther 3:13-26. 2003
    ..The present review describes the current state of preclinical research and summarizes the results of the clinical trials undertaken...
  3. doi request reprint Positive selection of gene-modified cells increases the efficacy of pancreatic cancer suicide gene therapy
    Jordi Martinez-Quintanilla
    Gene and Viral Therapy Group, IDIBELL Catalan Institute of Oncology ICO, L Hospitalet de Llobregat, UPF, Parc de Recerca Biomédica de Barcelona and Centro de Investigación Biomédica en Red de Enfermedades Raras CIBERER ISCIII, Barcelona, Spain
    Mol Cancer Ther 8:3098-107. 2009
    ....
  4. ncbi request reprint Targeting the CYP2B 1/cyclophosphamide suicide system to fibroblast growth factor receptors results in a potent antitumoral response in pancreatic cancer models
    Meritxell Huch
    Programa Gens i Malaltia, Centre de Regulació Genòmica Universitat Pompeu Fabra, 08003 Barcelona, Spain
    Hum Gene Ther 17:1187-200. 2006
    ..Consequently, it may constitute a promising approach to the treatment of patients with pancreatic tumors, in which a high proportion of FGF receptors precisely localize to the plasma membrane...
  5. pmc Intraductal delivery of adenoviruses targets pancreatic tumors in transgenic Ela-myc mice and orthotopic xenografts
    Anabel José
    Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Oncotarget 4:94-105. 2013
    ..In summary our data show that cytotoxic adenoviruses retrogradelly injected to the pancreas can be a feasible approach to treat localized pancreatic tumors...
  6. doi request reprint Cell cycle control pathways act as conditioning factors for TK/GCV sensitivity in pancreatic cancer cells
    Daniel Abate-Daga
    Programa Gens i Malaltia, Parc de Recerca Biomedica de Barcelona, Barcelona, Spain
    Biochim Biophys Acta 1803:1175-85. 2010
    ..Moreover it points out, for the first time at Chk1 activation as a key factor to mediate TK/GCV cytotoxicity...
  7. pmc Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome
    Jon Ortiz-Abalia
    Programa Gens i Malaltia Centre de Regulació Genòmica CRG, UPF, Parc de Recerca Biomédica de Barcelona PRBB, Barcelona 08003, Spain
    Am J Hum Genet 83:479-88. 2008
    ..Furthermore, these results identify Dyrk1A as a potential target for therapy in DS...
  8. pmc Oncolytic adenoviruses armed with thymidine kinase can be traced by PET imaging and show potent antitumoural effects by ganciclovir dosing
    Daniel Abate-Daga
    Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    PLoS ONE 6:e26142. 2011
    ..Thus, TK-expressing oncolytic adenoviruses can be traced by PET imaging providing real time information on the activity of the virus and its antitumoral potency can be optimized by GCV dosing...
  9. ncbi request reprint Tat8-TK/GCV suicide gene therapy induces pancreatic tumor regression in vivo
    Anna Cascante
    Programa Gens i Malaltia, Centre de Regulació Genòmica CRG UPF, 08003 Barcelona, Spain
    Hum Gene Ther 16:1377-88. 2005
    ..Therefore, our results suggest that fusion of TK to the Tat8 peptide enhances TK/GCV suicide gene therapy...
  10. doi request reprint Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome
    Xavier Altafaj
    Centre for Biomedical Network Research on Rare Diseases, Barcelona, Spain
    Neurobiol Dis 52:117-27. 2013
    ..Taken together, these results show Dyrk1A as a critical player in the pathophysiology of DS and define Dyrk1A as a therapeutic target in adult trisomic mice...
  11. doi request reprint Connexin-26 is a key factor mediating gemcitabine bystander effect
    Laura Garcia-Rodríguez
    Programa Gens i Malaltia, Centre de Regulació Genòmica Dr Aiguader, 88 08003 Barcelona, Spain
    Mol Cancer Ther 10:505-17. 2011
    ..This study shows that Cx26 participates in the gap junction-mediated bystander cytoxic effect of gemcitabine and provides evidence that upregulation of Cx26 improves gemcitabine anticancer efficacy...
  12. pmc Urokinase-type plasminogen activator receptor transcriptionally controlled adenoviruses eradicate pancreatic tumors and liver metastasis in mouse models
    Meritxell Huch
    Programa Gens i Malaltia, Centre de Regulacio Genomica CRG, UPF, Parc de Recerca Biomédica de Barcelona PRBB, Barcelona, Spain
    Neoplasia 11:518-28, 4 p following 528. 2009
    ..43 x 10(-5)). The antitumoral selective activity of AduPARE1A shows the potential of uPAR promoter-based therapies in pancreatic cancer treatment...
  13. ncbi request reprint Two novel mutations identified in the Wiskott-Aldrich syndrome protein gene cause Wiskott-Aldrich syndrome and thrombocytopenia
    Nuria Andreu
    Programa Gens i Malaltia, Centre de Regulació Genòmica CRG UPF, Barcelona, Spain
    Int J Mol Med 19:777-82. 2007
    ..As a consequence, there was no WASP expression...
  14. ncbi request reprint A novel Wiskott-Aldrich syndrome protein (WASP) complex mutation identified in a WAS patient results in an aberrant product at the C-terminus from two transcripts with unusual polyA signals
    Nuria Andreu
    Programa Gens i Malaltia, Centre de Regulació Genòmica CRG UPF, Passeig Maritim, 37 49, 08003 Barcelona, Spain
    J Hum Genet 51:92-7. 2006
    ..We demonstrate that these two transcripts differ in the 3' UTR region, and result from the use of two alternative polyadenylation signals. The severe phenotype of the patient correlates with the presence of an aberrant protein...
  15. ncbi request reprint Enhancement of gemcitabine-induced apoptosis by restoration of p53 function in human pancreatic tumors
    Manel Cascallo
    Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain
    Oncology 68:179-89. 2005
    ..It may constitute a useful step towards a better clinical treatment of patients harboring pancreatic cancer...
  16. doi request reprint Keratin 7 promoter selectively targets transgene expression to normal and neoplastic pancreatic ductal cells in vitro and in vivo
    Judit Pujal
    Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Parc de Recerca Biomedica de Barcelona, Barcelona, Spain
    FASEB J 23:1366-75. 2009
    ..In conclusion, the krt7 promoter is useful to target pancreatic ductal adenocarcinoma cells in vitro and in vivo...
  17. doi request reprint Irreversible electroporation shows efficacy against pancreatic carcinoma without systemic toxicity in mouse models
    Anabel José
    Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Cancer Lett 317:16-23. 2012
    ..Animals had transient increases in transaminases, amylase and lipase enzymes that normalized at 24h post-IRE. These results suggest that IRE could be an effective treatment for locally advanced pancreatic tumors...
  18. doi request reprint Gene therapy for Down syndrome
    Cristina Fillat
    Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Prog Brain Res 197:237-47. 2012
    ..Attempts toward gene-based treatment approaches in mouse models will be discussed as new opportunities to ameliorate DS alterations...
  19. ncbi request reprint Adenovirus-mediated retinoblastoma 94 gene transfer induces human pancreatic tumor regression in a mouse xenograft model
    Josep Maria Roig
    Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain
    Clin Cancer Res 10:1454-62. 2004
    ..For this purpose, preclinical studies aimed to evaluate the therapeutic potential of RB94 gene transfer in pancreatic cancer were carried out...
  20. ncbi request reprint Wiskott-Aldrich syndrome in a female with skewed X-chromosome inactivation
    Nuria Andreu
    Programa Gens i Malaltia, Centre de Regulacio Genomica, Passeig Maritim 37 49, Barcelona 08003, Spain
    Blood Cells Mol Dis 31:332-7. 2003
    ..Moreover the results alert us to the fact that particular females, with a family history of WAS, may develop certain signs of the disease...
  21. ncbi request reprint Novel membrane cell projection defects in Wiskott-Aldrich syndrome B cells
    Nuria Andreu
    Programa Gens i Malaltia, Centre de Regulació Genòmica CRG UPF, Parc de Recerca Biomèdica PRBB, 08003 Barcelona, Spain
    Int J Mol Med 20:445-50. 2007
    ..Such alterations most probably result from a WASP dysfunction, given that a retroviral gene transfer of a corrected form of the WASP gene was able to rescue the abnormal phenotypes...
  22. ncbi request reprint GCV modulates the antitumoural efficacy of a replicative adenovirus expressing the Tat8-TK as a late gene in a pancreatic tumour model
    A Cascante
    Programa Gens i Malaltia, Centre de Regulacio Genomica CRG, UPF, Parc de Recerca Biomédica de Barcelona PRBB, Barcelona, Spain
    Gene Ther 14:1471-80. 2007
    ..Thus, our results show that the combination therapy of a replicative adenovirus and the Tat8-TK/GCV suicide system can prove beneficial, when the appropriate regimen of virus and GCV is applied...
  23. ncbi request reprint Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction
    Mara Dierssen
    Genes and Disease Program, Genomic Regulation Center CRG UPF, Barcelona, Biomedical Research Park, E 08003 Barcelona, Catalonia, Spain
    Neurobiol Dis 24:403-18. 2006
    ..Our results demonstrate that the elevated NT3-TrkC tone via overexpression of TrkC in the brain may constitute a molecular mechanism for the expression of anxiety and anxiety...
  24. pmc Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1
    Mara Dierssen
    Centre for Genomic Regulation, Barcelona Biomedical Research Park, and CIBER de Enfermedades Raras, Barcelona, Catalonia, Spain
    PLoS ONE 6:e17010. 2011
    ....
  25. ncbi request reprint Intratumoral activation of cyclophosphamide by retroviral transfer of the cytochrome P450 2B1 in a pancreatic tumor model. Combination with the HSVtk/GCV system
    Meritxell Carrio
    Centre de Genètica Mèdica i Molecular, Institut de Recerca Oncològica IRO, Barcelona, Spain
    J Gene Med 4:141-9. 2002
    ..The use of pro-drug-activating genes is a possible approach for cancer gene therapy...
  26. ncbi request reprint Identification and characterization of a novel splice-site mutation in a patient with Wiskott-Aldrich syndrome
    Nuria Andreu
    Programa Gens i Malaltia, Centre de Regulacio Genomica, 37 49 Passeig Marítim, 08003, Barcelona, Spain
    J Hum Genet 48:590-3. 2003
    ..The translation of such aberrant mRNA will produce a truncated protein with a premature stop at codon 190. Thus, a novel splice-site mutation is reported in a patient with a mild WAS phenotype...
  27. ncbi request reprint Direct electrotransfer of hHGF gene into kidney ameliorates ischemic acute renal failure
    M Franquesa
    Laboratory of Experimental Nephrology, Department of Medicine, University of Barcelona, L Hospitalet, Barcelona, Spain
    Gene Ther 12:1551-8. 2005
    ..Kidney direct electrotransfer was shown to be more efficient not only in pharmacokinetic but also in therapeutic terms, so it may become a clinically practical alternative in renal transplantation...
  28. ncbi request reprint Monitoring gene therapy by external imaging of mRNA: pilot study on murine erythropoietin
    J Segura
    Institut Municipal d Investigació Mèdica IMIM Hospital del Mar, Barcelona, Spain
    Ther Drug Monit 29:612-8. 2007
    ..The extension of the approach to more sensitive methods for whole-body external detection such as positron emission tomography appears feasible...
  29. ncbi request reprint HGF gene therapy attenuates renal allograft scarring by preventing the profibrotic inflammatory-induced mechanisms
    I Herrero-Fresneda
    Laboratory of Experimental Nephrology, Department of Medicine, IDIBELL Hospital Universitari de Bellvitge, Barcelona, Spain
    Kidney Int 70:265-74. 2006
    ..The effectiveness of HGF-gene therapy in the prevention of renal allograft scarring is related with the halt of profibrotic inflammatory-induced mechanisms...
  30. ncbi request reprint Treatment based on a combination of the CYP2B1/cyclophosphamide system and p53 delivery enhances tumour regression in human pancreatic cancer
    E Mercade
    Department of Microbiology, University of Barcelona, Barcelona, Spain
    Ann Oncol 12:379-88. 2001
    ..The in situ bioactivation of cyclophosphamide by cytochrome p450-2B1 and subsequent p53 delivery were examined...
  31. ncbi request reprint Retrovirus-mediated transfer of the herpes simplex virus thymidine kinase and connexin26 genes in pancreatic cells results in variable efficiency on the bystander killing: implications for gene therapy
    M Carrio
    Centre de Genètica Mèdica i Molecular, Institut de Recerca Oncològica IRO, L Hospitalet de Llobregat, 08907 Barcelona, Spain
    Int J Cancer 94:81-8. 2001
    ..Moreover, they indicate that overexpression of the Cx26 gene does not always correspond to an increase in GJIC although they clearly suggest the role of GJIC in mediating the bystander effect...
  32. ncbi request reprint On dendrites in Down syndrome and DS murine models: a spiny way to learn
    R Benavides-Piccione
    Cajal Institute, 28002 Madrid, Spain
    Prog Neurobiol 74:111-26. 2004
    ....