Mara Dierssen

Summary

Affiliation: Center for Genomic Regulation
Country: Spain

Publications

  1. pmc Reduced Mid1 Expression and Delayed Neuromotor Development in daDREAM Transgenic Mice
    Mara Dierssen
    Genomic Regulation Center, Parc de Recerca Biomedica de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Raras Barcelona, Spain
    Front Mol Neurosci 5:58. 2012
  2. pmc Increased opioid dependence in a mouse model of panic disorder
    Xavier Gallego
    Genes and Disease Program, Genomic Regulation Center CRG, Barcelona Biomedical Research Park PRBB and CIBER de Enfermedades Raras Barcelona, Catalonia, Spain
    Front Behav Neurosci 3:60. 2010
  3. pmc Impaired spatial learning strategies and novel object recognition in mice haploinsufficient for the dual specificity tyrosine-regulated kinase-1A (Dyrk1A)
    Gloria Arqué
    Genes and Disease Program, Genomic Regulation Center CRG, Pompeu Fabra University, Barcelona, Spain
    PLoS ONE 3:e2575. 2008
  4. doi request reprint Down syndrome: the brain in trisomic mode
    Mara Dierssen
    Genes and Disease Programme, Centre for Genomic Regulation CRG, Universitat Pompeu Fabra, Centro de Investigación Biomédica en Red de Enfermedades Raras, E 08003 Barcelona, Spain
    Nat Rev Neurosci 13:844-58. 2012
  5. pmc Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1
    Mara Dierssen
    Centre for Genomic Regulation, Barcelona Biomedical Research Park, and CIBER de Enfermedades Raras, Barcelona, Catalonia, Spain
    PLoS ONE 6:e17010. 2011
  6. doi request reprint Aneuploidy: from a physiological mechanism of variance to Down syndrome
    Mara Dierssen
    Genes and Disease Program, Genomic Regulation Center CRG, Pompeu Fabra University, Barcelona Biomedical Research Park, Dr Aiguader 88, PRBB building E, Barcelona 08003, Catalonia, Spain
    Physiol Rev 89:887-920. 2009
  7. ncbi request reprint DYRK1A (dual-specificity tyrosine-phosphorylated and -regulated kinase 1A): a gene with dosage effect during development and neurogenesis
    M Dierssen
    Genes and Disease Program, Genomic Regulation Center, Barcelona Biomedical Research Park, 08003 Barcelona, Spain
    ScientificWorldJournal 6:1911-22. 2006
  8. ncbi request reprint Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction
    Mara Dierssen
    Genes and Disease Program, Genomic Regulation Center CRG UPF, Barcelona, Biomedical Research Park, E 08003 Barcelona, Catalonia, Spain
    Neurobiol Dis 24:403-18. 2006
  9. ncbi request reprint Dendritic pathology in mental retardation: from molecular genetics to neurobiology
    M Dierssen
    Neurobehavioral Analysis Laboratory, Genes and Disease Program, Center for Genomic Regulation, CRG UPF PRBB, 08003 Barcelona, Spain
    Genes Brain Behav 5:48-60. 2006
  10. ncbi request reprint Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of environmental enrichment
    M Dierssen
    Program in Genes and Disease, Genomic Regulation Center, Passeif Maritim 32 49, 08003 Barcelona, Spain
    Cereb Cortex 13:758-64. 2003

Collaborators

Detail Information

Publications51

  1. pmc Reduced Mid1 Expression and Delayed Neuromotor Development in daDREAM Transgenic Mice
    Mara Dierssen
    Genomic Regulation Center, Parc de Recerca Biomedica de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Raras Barcelona, Spain
    Front Mol Neurosci 5:58. 2012
    ..As a consequence, daDREAM mice exhibit a significant shortening of the rostro-caudal axis of the cerebellum and a delay in neuromotor development early after birth. Our results indicate a role for DREAM in cerebellar function...
  2. pmc Increased opioid dependence in a mouse model of panic disorder
    Xavier Gallego
    Genes and Disease Program, Genomic Regulation Center CRG, Barcelona Biomedical Research Park PRBB and CIBER de Enfermedades Raras Barcelona, Catalonia, Spain
    Front Behav Neurosci 3:60. 2010
    ....
  3. pmc Impaired spatial learning strategies and novel object recognition in mice haploinsufficient for the dual specificity tyrosine-regulated kinase-1A (Dyrk1A)
    Gloria Arqué
    Genes and Disease Program, Genomic Regulation Center CRG, Pompeu Fabra University, Barcelona, Spain
    PLoS ONE 3:e2575. 2008
    ..It encodes a dual-specificity kinase involved in neuronal development and in adult brain physiology, but its possible role as critical haploinsufficient gene in cognitive function has not been explored...
  4. doi request reprint Down syndrome: the brain in trisomic mode
    Mara Dierssen
    Genes and Disease Programme, Centre for Genomic Regulation CRG, Universitat Pompeu Fabra, Centro de Investigación Biomédica en Red de Enfermedades Raras, E 08003 Barcelona, Spain
    Nat Rev Neurosci 13:844-58. 2012
    ..These advances hold promise for the development of treatments for intellectual disability...
  5. pmc Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1
    Mara Dierssen
    Centre for Genomic Regulation, Barcelona Biomedical Research Park, and CIBER de Enfermedades Raras, Barcelona, Catalonia, Spain
    PLoS ONE 6:e17010. 2011
    ....
  6. doi request reprint Aneuploidy: from a physiological mechanism of variance to Down syndrome
    Mara Dierssen
    Genes and Disease Program, Genomic Regulation Center CRG, Pompeu Fabra University, Barcelona Biomedical Research Park, Dr Aiguader 88, PRBB building E, Barcelona 08003, Catalonia, Spain
    Physiol Rev 89:887-920. 2009
    ..We also review the potential that genetically engineered mouse models of DS bring into the understanding of the molecular biology of human learning disorders...
  7. ncbi request reprint DYRK1A (dual-specificity tyrosine-phosphorylated and -regulated kinase 1A): a gene with dosage effect during development and neurogenesis
    M Dierssen
    Genes and Disease Program, Genomic Regulation Center, Barcelona Biomedical Research Park, 08003 Barcelona, Spain
    ScientificWorldJournal 6:1911-22. 2006
    ..This review focuses on the functional role that DYRK1A plays in brain development...
  8. ncbi request reprint Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction
    Mara Dierssen
    Genes and Disease Program, Genomic Regulation Center CRG UPF, Barcelona, Biomedical Research Park, E 08003 Barcelona, Catalonia, Spain
    Neurobiol Dis 24:403-18. 2006
    ..Our results demonstrate that the elevated NT3-TrkC tone via overexpression of TrkC in the brain may constitute a molecular mechanism for the expression of anxiety and anxiety...
  9. ncbi request reprint Dendritic pathology in mental retardation: from molecular genetics to neurobiology
    M Dierssen
    Neurobehavioral Analysis Laboratory, Genes and Disease Program, Center for Genomic Regulation, CRG UPF PRBB, 08003 Barcelona, Spain
    Genes Brain Behav 5:48-60. 2006
    ..In this review, we discuss the neurobiology underlying MR, with a focus on FraX and DS...
  10. ncbi request reprint Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of environmental enrichment
    M Dierssen
    Program in Genes and Disease, Genomic Regulation Center, Passeif Maritim 32 49, 08003 Barcelona, Spain
    Cereb Cortex 13:758-64. 2003
    ..The present results suggest that behavioral deficits demonstrated in the Ts65Dn model could be attributed to abnormal circuit development...
  11. doi request reprint Overexpression of the CHRNA5/A3/B4 genomic cluster in mice increases the sensitivity to nicotine and modifies its reinforcing effects
    Xavier Gallego
    Genes and Disease Program, Center for Genomic Regulation, Barcelona Biomedical Research Park, 08003 Barcelona, Catalonia, Spain
    Amino Acids 43:897-909. 2012
    ....
  12. pmc Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome
    Jon Ortiz-Abalia
    Programa Gens i Malaltia Centre de Regulació Genòmica CRG, UPF, Parc de Recerca Biomédica de Barcelona PRBB, Barcelona 08003, Spain
    Am J Hum Genet 83:479-88. 2008
    ..Furthermore, these results identify Dyrk1A as a potential target for therapy in DS...
  13. doi request reprint Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome
    Xavier Altafaj
    Centre for Biomedical Network Research on Rare Diseases, Barcelona, Spain
    Neurobiol Dis 52:117-27. 2013
    ..Taken together, these results show Dyrk1A as a critical player in the pathophysiology of DS and define Dyrk1A as a therapeutic target in adult trisomic mice...
  14. doi request reprint Susceptibility to stress in transgenic mice overexpressing TrkC, a model of panic disorder
    Alejandro Amador-Arjona
    Genes and Disease Program, Centre for Genomic Regulation, Universidad Pompeu Fabra, Barcelona Biomedical Research Park PRBB, Dr Aiguader 88, Barcelona E 08003, Spain
    J Psychiatr Res 44:157-67. 2010
    ....
  15. doi request reprint Hippocampal hyperexcitability underlies enhanced fear memories in TgNTRK3, a panic disorder mouse model
    Monica Santos
    Systems Biology Programme, Centre for Genomic Regulation, E 08003 Barcelona, Spain, Universitat Pompeu Fabra, E 08003 Barcelona, Spain, Centro de Investigación Biomédica en Red de Enfermedades Raras, E 08003 Barcelona, Spain, Department of Stem Cells and Regeneration, Sanford Burnham Medical Research Institute, La Jolla, California 92037, and Institute of Biology, Otto von Guericke University Magdeburg, and Center for Behavioral Brain Sciences, D39120 Magdeburg, Germany
    J Neurosci 33:15259-71. 2013
    ..The fearful phenotype appears to be the result of hippocampal hyperexcitability and aberrant fear circuit activation. We conclude that NTRK3 plays a role in PAND by regulating hippocampus-dependent fear memories. ..
  16. doi request reprint Overexpression of α3/α5/β4 nicotinic receptor subunits modifies impulsive-like behavior
    Xavier Viñals
    Laboratory of Neuropharmacology, Pompeu Fabra University, PRBB, Barcelona, Spain
    Drug Alcohol Depend 122:247-52. 2012
    ..These results reveal the involvement of α3/α5/β4 nicotinic receptor subunits in working memory and impulsivity, two behavioral traits directly related to the vulnerability to develop nicotine dependence...
  17. pmc Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice
    Vassiliki Fotaki
    Medical and Molecular Genetics Center, Institut de Recerca Oncologica, 08907 L Hospitalet de Llobregat, Barcelona, Spain
    Mol Cell Biol 22:6636-47. 2002
    ..These data provide evidence about the nonredundant, vital role of Dyrk1A and suggest a conserved mode of action that determines normal growth and brain size in both mice and flies...
  18. ncbi request reprint Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system
    Eulalia Marti
    Program in Genes and Disease, Centre de Regulacio Genomica CRG, Passeig Maritim 37 49, 08003, Barcelona, Spain
    Brain Res 964:250-63. 2003
    ....
  19. ncbi request reprint Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice
    Gloria Arqué
    Genes and Disease Program, Center for Genomic Regulation CRG, Pompeu Fabra University, Barcelona Biomedical Research Park PRBB and CIBER de Enfermedades Raras CIBERER, Barcelona, Spain
    Neurobiol Dis 36:312-9. 2009
    ....
  20. ncbi request reprint Dissociation between CA3-CA1 synaptic plasticity and associative learning in TgNTRK3 transgenic mice
    Ignasi Sahún
    Genes and Disease Program, Genomic Regulation Center, Universidad Pompeu Fabra, Barcelona Biomedical Research Park, 08003 Barcelona, Spain
    J Neurosci 27:2253-60. 2007
    ..No changes of AMPA and kainate subunits were detected. Results indicate that the NT-3/TrkC cascade could regulate synaptic transmission and plasticity through modulation of glutamatergic transmission at the CA3-CA1 synapse...
  21. doi request reprint Aberrant brain microRNA target and miRISC gene expression in the anx/anx anorexia mouse model
    Josep M Mercader
    Center for Genomic Regulation, Barcelona, Catalonia, Spain
    Gene 497:181-90. 2012
    ....
  22. doi request reprint Hypothalamus transcriptome profile suggests an anorexia-cachexia syndrome in the anx/anx mouse model
    Josep Maria Mercader
    Genes and Disease Program, Center for Genomic Regulation CRG UPF, Barcelona, Catalonia, Spain
    Physiol Genomics 35:341-50. 2008
    ....
  23. ncbi request reprint Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A
    Meritxell Pons-Espinal
    Systems Biology Program, Centre for Genomic Regulation CRG, Dr Aiguader 88, E 08003 Barcelona, Spain Universitat Pompeu Fabra UPF, Dr Aiguader 88, E 08003 Barcelona, Spain Centro de Investigación Biomédica en Red de Enfermedades Raras CIBERER, Dr Aiguader 88, E 08003 Barcelona, Spain
    Neurobiol Dis 60:18-31. 2013
    ....
  24. ncbi request reprint Pitfalls and hopes in Down syndrome therapeutic approaches: in the search for evidence-based treatments
    Mara Dierssen
    Genes and Disease Program, Genomic Regulation Center, CRG UPF, Barcelona Biomedical Research Park, Spain
    Behav Genet 36:454-68. 2006
    ..We describe some of the most recent developments in the field and give a sense of the prospects for future prevention and therapy...
  25. ncbi request reprint Insights from mouse models to understand neurodegeneration in Down syndrome
    Cristina Fillat
    Centre de Regulacio Genomica, UPF, Parc de Recerca Biomedica de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Raras, Spain
    CNS Neurol Disord Drug Targets 9:429-38. 2010
    ..In addition, these models might allow to define and evaluate potential drug targets and to develop therapeutic strategies that may interfere or delay the onset of AD...
  26. pmc Overexpression of Reelin prevents the manifestation of behavioral phenotypes related to schizophrenia and bipolar disorder
    Cátia M Teixeira
    Developmental Neurobiology and Regeneration Unit, Institute for Research in Biomedicine, Parc Cientific de Barcelona, University of Barcelona, Barcelona, Spain
    Neuropsychopharmacology 36:2395-405. 2011
    ..Together, these results point to the Reelin signaling pathway as a relevant drug target for the treatment of a range of psychiatric disorders...
  27. doi request reprint Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders
    Josep Maria Mercader
    Genes and Disease Program, Center for Genomic Regulation, 08003 Barcelona, Catalonia, Spain
    Hum Mol Genet 17:1234-44. 2008
    ..The reported data, in addition to the previous reported findings for BDNF and NTRK2, point neurotrophin signaling genes as key regulators of eating behavior and their altered cross-regulation as susceptibility factors for EDs...
  28. ncbi request reprint Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction
    M Martinez de Lagran
    Programme of Genes and Disease, Center for Genomic Regulation, 08003 Barcelona, Spain
    Neurobiol Dis 15:132-42. 2004
    ..These results confirm and extend previous data and provide further insight to the functional domains that might be altered in TgDyrk1a mice and underlying molecular mechanisms of DS motor dysfunction...
  29. pmc Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice
    Mireia Garriga-Canut
    EMBL CRG Systems Biology Research Unit, Centre for Genomic Regulation CRG, Dr Aiguader 88, 08003 Barcelona, Spain
    Proc Natl Acad Sci U S A 109:E3136-45. 2012
    ....
  30. ncbi request reprint Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome
    X Altafaj
    Down Syndrome Research Group, Medical and Molecular Genetics Center, IRO, Hospital Duran i Reynals, Gran Via s n, Km 2 7, 08907 L Hospitalet de Llobregat, Barcelona, Catalonia, Spain
    Hum Mol Genet 10:1915-23. 2001
    ..These alterations are comparable with those found in the partial trisomy chromosome 16 murine models of DS and suggest a causative role of DYRK1A in mental retardation and in motor anomalies of DS...
  31. doi request reprint Functional implications of hippocampal adult neurogenesis in intellectual disabilities
    Meritxell Pons-Espinal
    Systems Biology Program, Centre for Genomic Regulation CRG, Dr Aiguader 88, 08003 Barcelona, Spain
    Amino Acids 45:113-31. 2013
    ..We review the process of generating functional neurons from precursors in the adult brain and its implications in intellectual disability disorders...
  32. pmc Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: possible role in Down syndrome
    Gloria Arqué
    Genes and Disease Program, Center for Genomic Regulation CRG, Pompeu Fabra University, Barcelona Biomedical Research Park PRBB and CIBER de Enfermedades Raras CIBERER, Barcelona, Spain
    PLoS ONE 8:e54285. 2013
    ....
  33. doi request reprint Targeting the endocannabinoid system in the treatment of fragile X syndrome
    Arnau Busquets-Garcia
    Departament de Ciències Experimentals i de la Salut DCEXS, Universitat Pompeu Fabra UPF, Barcelona, Spain
    Nat Med 19:603-7. 2013
    ..Some of these traits were also reversed by pharmacological inhibition of mTOR or mGluR5. Thus, blockade of ECS is a potential therapeutic approach to normalize specific alterations in FXS...
  34. pmc Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice
    Xavier Gallego
    Genes and Disease Program, Center for Genomic Regulation, UPF, Barcelona, Spain
    Alcohol 46:205-15. 2012
    ..water) preference test. These results suggest a complex role for this receptor subunit gene cluster in the modulation of ethanol's as well as nicotine's effects...
  35. doi request reprint Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome
    X Altafaj
    Programa Gens i Malatia, Centre de Regulacio Genomica CRG, UPF, Parc de Recerca Biomédica de Barcelona PRBB, Barcelona, Spain
    Neurobiol Dis 32:377-84. 2008
    ..These findings suggest that DYRK1A overexpression might contribute to the dysbalance in the excitatory transmission found in the cerebellum of DS individuals and DS mouse models...
  36. pmc DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease
    Jose V Sanchez-Mut
    1 Cancer Epigenetics and Biology Program PEBC, Bellvitge Biomedical Research Institute IDIBELL, 08908 L Hospitalet, Barcelona, Catalonia, Spain
    Brain 136:3018-27. 2013
    ..These hypermethylation targets indicate that the cyclic AMP response element-binding protein (CREB) activation pathway and the axon initial segment could contribute to the disease. ..
  37. doi request reprint Therapeutic approaches in the improvement of cognitive performance in Down syndrome: past, present, and future
    Rafael de la Torre
    Neurosciences Research Programme, IMIM Hospital del Mar Research Institute and CIBEROBN, Barcelona, Spain
    Prog Brain Res 197:1-14. 2012
    ..Epigallocatechin gallate, a green tea polyphenol, that modulates DYRK1A functioning has already shown preliminarily that this approach may prove useful in therapeutics...
  38. doi request reprint Characterization of a mouse model overexpressing beta-site APP-cleaving enzyme 2 reveals a new role for BACE2
    G Azkona
    Genes and Disease Program, Center for Genomic Regulation CRG, Barcelona Biomedical Research Park PRBB, E 08003 Barcelona, Catalonia, Spain
    Genes Brain Behav 9:160-72. 2010
    ..However, TgBACE2 animals showed increased anxiety-like behaviour along with increased numbers of noradrenergic neurones in locus coeruleus, thus suggesting an unexpected role of BACE2 overexpression...
  39. doi request reprint Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans
    Rafael de la Torre
    Human Pharmacology and Clinical Neurosciences Research Group Neurosciences Program, IMIM Hospital del Mar Research Institute, Barcelona, Spain Cardiovascular Risk and Nutrition Research Group Inflammatory and Cardiovascular Disorders Program, IMIM Hospital del Mar Research Institute, and CIBER of Physiopathology of Obesity and Nutrition CIBEROBN, Barcelona, Spain University Pompeu Fabra, CEXS UPF, Barcelona, Spain
    Mol Nutr Food Res 58:278-88. 2014
    ..Accumulating data suggest that overexpression of the dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A), is a critical pathogenic mechanisms in the intellectual deficit...
  40. ncbi request reprint Murine models for Down syndrome
    M Dierssen
    Down Syndrome Research Group, Medical and Molecular Genetics Center IRO, Hospital Duran i Reynals, Granvia km 2 7, 08907 L Hospitalet de Llobregat, Barcelona, Spain
    Physiol Behav 73:859-71. 2001
    ..Here we review the existing murine models and the relevance of their contribution to DS research...
  41. ncbi request reprint Dopaminergic deficiency in mice with reduced levels of the dual-specificity tyrosine-phosphorylated and regulated kinase 1A, Dyrk1A(+/-)
    M Martinez de Lagran
    Genes and Disease Program, Center for Genomic Regulation, CRG UPF PRBB, Barcelona, Spain
    Genes Brain Behav 6:569-78. 2007
    ..These data indicate that Dyrk1A is essential for a proper function of nigrostriatal dopaminergic neurons and suggest that Dyrk1A(+/-) mice can be used to study the pathogenesis of motor disorders involving dopaminergic dysfunction...
  42. ncbi request reprint Candidate genes for panic disorder: insight from human and mouse genetic studies
    M Gratacos
    Genes and Disease Program, Genomic Regulation Center CRG, Pompeu Fabra University, Barcelona Biomedical Research Park, Barcelona, Catalonia, Spain
    Genes Brain Behav 6:2-23. 2007
    ..The integration of human and animal studies targeting behavioral, systems-level, cellular and molecular levels will most probably help identify new molecules with potential impact on the pathogenetic aspects of the disease...
  43. ncbi request reprint Haploinsufficiency of Dyrk1A in mice leads to specific alterations in the development and regulation of motor activity
    V Fotaki
    Genetics and Disease Program, Genomic Regulation Center, Barcelona, Spain
    Behav Neurosci 118:815-21. 2004
    ..These results are in agreement with the significant expression of Dyrk1A in structures related to motor function and support a role of Dyrk1A in the control of motor function...
  44. ncbi request reprint Differential responses to anxiogenic drugs in a mouse model of panic disorder as revealed by Fos immunocytochemistry in specific areas of the fear circuitry
    I Sahún
    Genes and Disease Program, Center for Genomic Regulation CRG, Barcelona Biomedical Research Park PRBB, Barcelona, Spain
    Amino Acids 33:677-88. 2007
    ....
  45. ncbi request reprint Reduced phospholipase C-beta activity and isoform expression in the cerebellum of TS65Dn mouse: a model of Down syndrome
    I Ruiz de Azua
    Department of Pharmacology, Faculty of Pharmacy, University of the Basque Country, Alava, Spain
    J Neurosci Res 66:540-50. 2001
    ....
  46. ncbi request reprint Down syndrome and the genes of human chromosome 21: current knowledge and future potentials. Report on the Expert workshop on the biology of chromosome 21 genes: towards gene-phenotype correlations in Down syndrome. Washington D.C., September 28-October 1
    M Pritchard
    Monash University, Victoria, Australia
    Cytogenet Genome Res 121:67-77. 2008
    ..A knowledge-based approach to therapeutics also requires the correlation of chromosome 21 gene function with phenotypic features...
  47. ncbi request reprint Alterations in the phenotype of neocortical pyramidal cells in the Dyrk1A+/- mouse
    R Benavides-Piccione
    Cajal Institute, Av Dr Arce, 37, 28002 Madrid, Spain
    Neurobiol Dis 20:115-22. 2005
    ..These results suggest that Dyrk1A influences the size and complexity of pyramidal cells, and thus their capability to integrate information...
  48. ncbi request reprint On dendrites in Down syndrome and DS murine models: a spiny way to learn
    R Benavides-Piccione
    Cajal Institute, 28002 Madrid, Spain
    Prog Neurobiol 74:111-26. 2004
    ....
  49. ncbi request reprint Postnatal handling induces long-term modifications in central beta-noradrenergic signalling in rats
    C Baamonde
    Laboratory of Developmental Neurobiology, Department of Physiology and Pharmacology, Faculty of Medicine, University of Cantabria, Avda Herrera Oria, S N, 39011 Santander, Spain
    Stress 5:137-47. 2002
    ..These results suggest that the long-lasting adaptation of the adenylyl cyclase transduction system, which affects the primary biochemical response of the beta-adrenoceptor, may participate in the effects of this manipulation...
  50. ncbi request reprint Brain G protein-dependent signaling pathways in Down syndrome and Alzheimer's disease
    M Lumbreras
    Department of Physiology and Pharmacology, Faculty of Medicine, University of Cantabria, Santander, Spain
    Amino Acids 31:449-56. 2006
    ..Our results demonstrate that PLC and AC were severely disturbed in the aged DS and AD brains, but the alterations in DS were more severe, and differed to some extent from those observed in AD...
  51. ncbi request reprint Protein expression of BACE1, BACE2 and APP in Down syndrome brains
    M S Cheon
    Department of Pediatrics, Medical University of Vienna, Vienna, Austria
    Amino Acids 35:339-43. 2008
    ..Furthermore, current data indicate that the DS phenotype cannot be fully explained by simple gene dosage effect...