Pedro Carvalho

Summary

Affiliation: Center for Genomic Regulation
Country: Spain

Publications

  1. ncbi Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p
    Pedro Carvalho
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Cell 143:579-91. 2010
  2. ncbi Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins
    Pedro Carvalho
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Cell 126:361-73. 2006
  3. ncbi The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p
    Veit Goder
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    FEBS Lett 582:1575-80. 2008
  4. ncbi Recognition of an ERAD-L substrate analyzed by site-specific in vivo photocrosslinking
    Ann Marie Stanley
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    FEBS Lett 585:1281-6. 2011
  5. ncbi Cell cycle control of kinesin-mediated transport of Bik1 (CLIP-170) regulates microtubule stability and dynein activation
    Pedro Carvalho
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Division of Hematology Oncology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 6:815-29. 2004
  6. ncbi Plus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle
    Mohan L Gupta
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Division of Hematology Oncology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Nat Cell Biol 8:913-23. 2006
  7. ncbi Mitotic spindle: laser microsurgery in yeast cells
    Pedro Carvalho
    Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 14:R748-50. 2004
  8. ncbi Determinants of S. cerevisiae dynein localization and activation: implications for the mechanism of spindle positioning
    Brina Sheeman
    Department of Pediatric Oncology, The Dana Farber Cancer Institute, The Children s Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Curr Biol 13:364-72. 2003
  9. ncbi Surfing on microtubule ends
    Pedro Carvalho
    Departments of Pediatric Oncology, Dana-Farber Cancer Institute and Pediatric Hematology/Oncology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA
    Trends Cell Biol 13:229-37. 2003

Collaborators

Detail Information

Publications9

  1. ncbi Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p
    Pedro Carvalho
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Cell 143:579-91. 2010
    ..Our results suggest a model for how Hrd1p promotes polypeptide movement through the ER membrane...
  2. ncbi Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins
    Pedro Carvalho
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Cell 126:361-73. 2006
    ..All three pathways converge at the Cdc48p ATPase complex. These results lead to a unifying concept for ERAD that may also apply to mammalian cells...
  3. ncbi The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p
    Veit Goder
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    FEBS Lett 582:1575-80. 2008
    ..These data suggest distinct functions for the Der1p and Dfm1p complexes...
  4. ncbi Recognition of an ERAD-L substrate analyzed by site-specific in vivo photocrosslinking
    Ann Marie Stanley
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    FEBS Lett 585:1281-6. 2011
    ..Hrd3p may thus be the first substrate-recognizing component. Der1p appears to have a role in a pathway that is parallel to that involving Hrd3p...
  5. ncbi Cell cycle control of kinesin-mediated transport of Bik1 (CLIP-170) regulates microtubule stability and dynein activation
    Pedro Carvalho
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Division of Hematology Oncology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 6:815-29. 2004
    ..As with Bik1, the targeting of dynein to the microtubule plus end requires Kip2. These findings reveal a central role for Kip2-dependent transport in the cell cycle control of microtubule dynamics and dynein-dependent motility...
  6. ncbi Plus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle
    Mohan L Gupta
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Division of Hematology Oncology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Nat Cell Biol 8:913-23. 2006
    ..These findings explain the role of Kip3p in positioning the mitotic spindle in budding yeast and potentially other processes controlled by kinesin-8 family members...
  7. ncbi Mitotic spindle: laser microsurgery in yeast cells
    Pedro Carvalho
    Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 14:R748-50. 2004
    ..Two recent studies have shown that this classical technology can now be employed with small yeast cells. This advance will enable regional ablation to be combined with facile genetic manipulation in a eukaryotic cell...
  8. ncbi Determinants of S. cerevisiae dynein localization and activation: implications for the mechanism of spindle positioning
    Brina Sheeman
    Department of Pediatric Oncology, The Dana Farber Cancer Institute, The Children s Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Curr Biol 13:364-72. 2003
    ..The mechanism of dynein-dependent spindle positioning is thought to involve recruitment of dynein to the cell cortex followed by capture of astral microtubules (aMTs)...
  9. ncbi Surfing on microtubule ends
    Pedro Carvalho
    Departments of Pediatric Oncology, Dana-Farber Cancer Institute and Pediatric Hematology/Oncology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA
    Trends Cell Biol 13:229-37. 2003
    ..We also consider the possibility that, by studying +TIPs, we might learn more about the dynamic structural changes at the microtubule ends that are at the heart of dynamic instability...