A Cascon

Summary

Country: Spain

Publications

  1. doi request reprint MAX and MYC: a heritable breakup
    Alberto Cascon
    Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre, Madrid, Spain
    Cancer Res 72:3119-24. 2012
  2. ncbi request reprint Identification of novel SDHD mutations in patients with phaeochromocytoma and/or paraganglioma
    Alberto Cascon
    Department of Human Genetics, Spanish National Cancer Center CNIO, Madrid, Spain
    Eur J Hum Genet 10:457-61. 2002
  3. pmc Genetic and epigenetic profile of sporadic pheochromocytomas
    A Cascon
    Hereditary Endocrine Cancer Group, Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    J Med Genet 41:e30. 2004
  4. pmc SDHB mutation analysis in familial and sporadic phaeochromocytoma identifies a novel mutation
    A Cascon
    Department of Human Genetics, Spanish National Cancer Center CNIO, Madrid, Spain
    J Med Genet 39:E64. 2002
  5. doi request reprint Rationalization of genetic testing in patients with apparently sporadic pheochromocytoma/paraganglioma
    A Cascon
    Spanish National Cancer Research Centre CNIO, Hereditary Endocrine Cancer Group, Madrid, Spain
    Horm Metab Res 41:672-5. 2009
  6. pmc Mutational and gross deletion study of the MEN1 gene and correlation with clinical features in Spanish patients
    A Cebrian
    Hereditary Endocrine Cancer Group, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    J Med Genet 40:e72. 2003
  7. doi request reprint Polymorphisms in cytochromes P450 2C8 and 3A5 are associated with paclitaxel neurotoxicity
    S Leskela
    Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Pharmacogenomics J 11:121-9. 2011
  8. ncbi request reprint Cellular senescence bypass screen identifies new putative tumor suppressor genes
    J F M Leal
    Experimental Therapeutics Programme, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    Oncogene 27:1961-70. 2008
  9. ncbi request reprint Cytochrome P450 3A5 is highly expressed in normal prostate cells but absent in prostate cancer
    S Leskela
    Hereditary Endocrine Cancer Group, Spanish National Cancer Center, Madrid, Spain
    Endocr Relat Cancer 14:645-54. 2007
  10. ncbi request reprint Epigenetic analysis of HIC1, CASP8, FLIP, TSP1, DCR1, DCR2, DR4, DR5, KvDMR1, H19 and preferential 11p15.5 maternal-allele loss in von Hippel-Lindau and sporadic phaeochromocytomas
    C D E Margetts
    Section of Medical and Molecular Genetics, Department of Paediatrics and Child Health, University of Birmingham, The Medical School, Edgbaston, Birmingham B15 2TT, UK
    Endocr Relat Cancer 12:161-72. 2005

Collaborators

Detail Information

Publications10

  1. doi request reprint MAX and MYC: a heritable breakup
    Alberto Cascon
    Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre, Madrid, Spain
    Cancer Res 72:3119-24. 2012
    ..Finally, the likely malignant behavior of tumors with mutations in MAX points to MYC as a candidate therapeutic target in the treatment of metastatic pheochromocytoma...
  2. ncbi request reprint Identification of novel SDHD mutations in patients with phaeochromocytoma and/or paraganglioma
    Alberto Cascon
    Department of Human Genetics, Spanish National Cancer Center CNIO, Madrid, Spain
    Eur J Hum Genet 10:457-61. 2002
    ..The involvement of SDHD mutations in familial phaeochromocytoma and/or paraganglioma predisposition is of considerable interest since other studies have shown these alterations to be associated with highly expressed angiogenic factors...
  3. pmc Genetic and epigenetic profile of sporadic pheochromocytomas
    A Cascon
    Hereditary Endocrine Cancer Group, Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    J Med Genet 41:e30. 2004
  4. pmc SDHB mutation analysis in familial and sporadic phaeochromocytoma identifies a novel mutation
    A Cascon
    Department of Human Genetics, Spanish National Cancer Center CNIO, Madrid, Spain
    J Med Genet 39:E64. 2002
  5. doi request reprint Rationalization of genetic testing in patients with apparently sporadic pheochromocytoma/paraganglioma
    A Cascon
    Spanish National Cancer Research Centre CNIO, Hereditary Endocrine Cancer Group, Madrid, Spain
    Horm Metab Res 41:672-5. 2009
    ..Finally, the analysis of SDHB should always be performed because of its association to malignancy and the low penetrance of mutations affecting this gene...
  6. pmc Mutational and gross deletion study of the MEN1 gene and correlation with clinical features in Spanish patients
    A Cebrian
    Hereditary Endocrine Cancer Group, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    J Med Genet 40:e72. 2003
  7. doi request reprint Polymorphisms in cytochromes P450 2C8 and 3A5 are associated with paclitaxel neurotoxicity
    S Leskela
    Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Pharmacogenomics J 11:121-9. 2011
    ..The incorporation of this genetic data in treatment selection could help to reduce neurotoxicity events, thereby individualizing paclitaxel pharmacotherapy. These results warrant validation in independent series...
  8. ncbi request reprint Cellular senescence bypass screen identifies new putative tumor suppressor genes
    J F M Leal
    Experimental Therapeutics Programme, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    Oncogene 27:1961-70. 2008
    ..Our data suggest that the three genes identified in the genome-wide loss-of-function genetic screen are putative tumor suppressors located at 15q21.2; 7q35 and 14q32.33...
  9. ncbi request reprint Cytochrome P450 3A5 is highly expressed in normal prostate cells but absent in prostate cancer
    S Leskela
    Hereditary Endocrine Cancer Group, Spanish National Cancer Center, Madrid, Spain
    Endocr Relat Cancer 14:645-54. 2007
    ....
  10. ncbi request reprint Epigenetic analysis of HIC1, CASP8, FLIP, TSP1, DCR1, DCR2, DR4, DR5, KvDMR1, H19 and preferential 11p15.5 maternal-allele loss in von Hippel-Lindau and sporadic phaeochromocytomas
    C D E Margetts
    Section of Medical and Molecular Genetics, Department of Paediatrics and Child Health, University of Birmingham, The Medical School, Edgbaston, Birmingham B15 2TT, UK
    Endocr Relat Cancer 12:161-72. 2005
    ..001). This suggests that 11p15.5-imprinted genes may be implicated in the pathogenesis of both familial (germline VHL and SDHD mutations) and sporadic phaeochromocytomas...