A Cano

Summary

Country: Spain

Publications

  1. ncbi request reprint Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition
    Gema Moreno-Bueno
    Breast and Gynecological Cancer Group, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Cancer Res 66:9543-56. 2006
  2. doi request reprint LOXL2 in epithelial cell plasticity and tumor progression
    Amparo Cano
    Departamento de Bioquimica, UAM, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, IdiPAZ, Arzobispo Morcillo, 2, 28029 Madrid, Spain
    Future Oncol 8:1095-108. 2012
  3. pmc PAI-1 and functional blockade of SNAI1 in breast cancer cell migration
    Elizabeth Fabre-Guillevin
    DYNAMIC Team, IBISC FRE 3190 CNRS Université d Evry Val d Essonne, Genopole, Evry 91000, France
    Breast Cancer Res 10:R100. 2008
  4. pmc Functional characterization of E- and P-cadherin in invasive breast cancer cells
    David Sarrio
    Department of Biochemistry UAM, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Madrid, Spain
    BMC Cancer 9:74. 2009
  5. doi request reprint Non-coding RNAs take centre stage in epithelial-to-mesenchymal transition
    Amparo Cano
    Departamento de Bioquimica UAM, Instituto de Investigaciones Biomédicas Alberto Sols CSIC UAM Arturo Duperier 4, 28029 Madrid, Spain
    Trends Cell Biol 18:357-9. 2008
  6. ncbi request reprint The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    A Cano
    Instituto de Investigaciones Biomedicas, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Cell Biol 2:76-83. 2000
  7. pmc An emerging role for class I bHLH E2-2 proteins in EMT regulation and tumor progression
    Amparo Cano
    Departmento de Bioquimica, Universidad Autonoma de Madrid UAM, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Madrid, Spain
    Cell Adh Migr 4:56-60. 2010
  8. ncbi request reprint Suppression of the metastatic phenotype of a mouse skin carcinoma cell line independent of E-cadherin expression and correlated with reduced Ha-ras oncogene products
    C Caulin
    Instituto de Investigaciones Biomédicas del Consejo Sperior de Investigaciones Cientificas, Departamento de Bioquimica UAM, Madrid, Spain
    Mol Carcinog 15:104-14. 1996
  9. ncbi request reprint Expression of simple epithelial cytokeratins in mouse epidermal keratinocytes harboring Harvey ras gene alterations
    M Diaz-Guerra
    Dept Bioquimica Facultad de Medicina UAM, Madrid, Spain
    Cancer Res 52:680-7. 1992
  10. pmc E-cadherin expression in basal cell carcinoma
    A Pizarro
    Servicio de Dermatologia, Hospital La Paz, Madrid, Spain
    Br J Cancer 69:157-62. 1994

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition
    Gema Moreno-Bueno
    Breast and Gynecological Cancer Group, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Cancer Res 66:9543-56. 2006
    ..These results indicate that Snail, Slug, and E47 transcription factors induce common and specific genetic programs, supporting a differential role of the factors in tumor progression and invasion...
  2. doi request reprint LOXL2 in epithelial cell plasticity and tumor progression
    Amparo Cano
    Departamento de Bioquimica, UAM, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, IdiPAZ, Arzobispo Morcillo, 2, 28029 Madrid, Spain
    Future Oncol 8:1095-108. 2012
    ..These recent findings open new avenues for the therapeutic utility of LOXL2...
  3. pmc PAI-1 and functional blockade of SNAI1 in breast cancer cell migration
    Elizabeth Fabre-Guillevin
    DYNAMIC Team, IBISC FRE 3190 CNRS Université d Evry Val d Essonne, Genopole, Evry 91000, France
    Breast Cancer Res 10:R100. 2008
    ..In this study we aimed to determine if the activity of SNAI1 (a member of the Snail family) is correlated with expression of the PA system components and how this correlation can influence tumoural cell migration...
  4. pmc Functional characterization of E- and P-cadherin in invasive breast cancer cells
    David Sarrio
    Department of Biochemistry UAM, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Madrid, Spain
    BMC Cancer 9:74. 2009
    ..Alterations in the cadherin-catenin adhesion complexes are involved in tumor initiation, progression and metastasis. However, the functional implication of distinct cadherin types in breast cancer biology is still poorly understood...
  5. doi request reprint Non-coding RNAs take centre stage in epithelial-to-mesenchymal transition
    Amparo Cano
    Departamento de Bioquimica UAM, Instituto de Investigaciones Biomédicas Alberto Sols CSIC UAM Arturo Duperier 4, 28029 Madrid, Spain
    Trends Cell Biol 18:357-9. 2008
    ..These findings open new avenues for understanding the modulation of the epithelial-to-mesenchymal transition in physiological and pathological situations...
  6. ncbi request reprint The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    A Cano
    Instituto de Investigaciones Biomedicas, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Cell Biol 2:76-83. 2000
    ..Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs...
  7. pmc An emerging role for class I bHLH E2-2 proteins in EMT regulation and tumor progression
    Amparo Cano
    Departmento de Bioquimica, Universidad Autonoma de Madrid UAM, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Madrid, Spain
    Cell Adh Migr 4:56-60. 2010
    ..Emerging evidence supporting the participation of TCF4 in human malignancies is also discussed. Thus, increasing understanding of EMT and its regulators is providing meaningful insights into the present knowledge on tumor progression...
  8. ncbi request reprint Suppression of the metastatic phenotype of a mouse skin carcinoma cell line independent of E-cadherin expression and correlated with reduced Ha-ras oncogene products
    C Caulin
    Instituto de Investigaciones Biomédicas del Consejo Sperior de Investigaciones Cientificas, Departamento de Bioquimica UAM, Madrid, Spain
    Mol Carcinog 15:104-14. 1996
    ..These results suggest that suppression of the metastatic phenotype in E24 cells occurs independently of E-CD expression and correlates with decreased levels of the oncogenic ras p21 protein...
  9. ncbi request reprint Expression of simple epithelial cytokeratins in mouse epidermal keratinocytes harboring Harvey ras gene alterations
    M Diaz-Guerra
    Dept Bioquimica Facultad de Medicina UAM, Madrid, Spain
    Cancer Res 52:680-7. 1992
    ..Our results suggest that activation of a H-ras gene can alter the normal differentiation program of epidermal cells and that the ability to synthesize CK8 and CK18 could be related to tumor progression...
  10. pmc E-cadherin expression in basal cell carcinoma
    A Pizarro
    Servicio de Dermatologia, Hospital La Paz, Madrid, Spain
    Br J Cancer 69:157-62. 1994
    ..These results suggest that E-CD might be related to the growth pattern and the local aggressive behaviour of BCC, and support the idea that E-CD might play a role as an invasion-suppressor molecule in vivo...
  11. pmc Differential patterns of placental and epithelial cadherin expression in basal cell carcinoma and in the epidermis overlying tumours
    A Pizarro
    Department of Pathology, Hospital La Paz, Madrid, Spain
    Br J Cancer 72:327-32. 1995
    ..This phenomenon was significantly associated with the presence of keratinocytic atypia, which suggests that disturbed cadherin expression could be a marker of premalignant changes and/or hyperproliferative activity in human epidermis...
  12. ncbi request reprint A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions
    M A Perez-Moreno
    Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier, 4, Madrid 28029, Spain
    J Biol Chem 276:27424-31. 2001
    ..These results implicate E12/E47 as a repressor of E-cadherin expression during both development and tumor progression and indicate its involvement in the acquisition and/or maintenance of the mesenchymal phenotype...
  13. doi request reprint Snai1 and Snai2 collaborate on tumor growth and metastasis properties of mouse skin carcinoma cell lines
    D Olmeda
    Departamento de Bioquimica, UAM, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Madrid, Spain
    Oncogene 27:4690-701. 2008
    ..These data also indicate that Snai1 is the major regulator of local invasion, supporting a hierarchical participation of both factors in the metastatic process...
  14. ncbi request reprint Differential spatiotemporal expression of E- and P-cadherin during mouse tooth development
    J Palacios
    Departamento de Anatomia Patologica, Hospital La Paz, Madrid, Spain
    Int J Dev Biol 39:663-6. 1995
    ....
  15. ncbi request reprint Regulation of E-cadherin gene expression during tumor progression: the role of a new Ets-binding site and the E-pal element
    I Rodrigo
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Arturo Duperier, 4, Madrid, 28029, Spain
    Exp Cell Res 248:358-71. 1999
    ....
  16. doi request reprint Transcriptional regulation of cell polarity in EMT and cancer
    G Moreno-Bueno
    Departamento de Bioquimica, Universidad Autonoma de Madrid, Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Oncogene 27:6958-69. 2008
    ..These recent observations provide new insights into the relationship between alterations in cell polarity components and EMT in cancer, opening new avenues for their potential use as therapeutic targets to prevent tumour progression...
  17. ncbi request reprint Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin
    P Navarro
    Departamento de Bioquimica, Facultad de Medicina, UAM, Madrid, Spain
    J Cell Sci 105:923-34. 1993
    ..The presence of plakoglobin could be required for the proper organization of E-cadherin in the transfectant cells in order to acquire an epithelioid phenotype...
  18. pmc H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of beta-catenin in epidermal keratinocytes
    J Espada
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, 28029 Madrid, Spain
    J Cell Biol 146:967-80. 1999
    ..These results indicate that H-Ras activation induces the relocalization and cytoplasmic stabilization of beta-catenin by a mechanism involving its interaction with PI3K...
  19. ncbi request reprint Snail silencing effectively suppresses tumour growth and invasiveness
    D Olmeda
    Departamento de Bioquimica, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, C Arturo Duperier, Madrid, Spain
    Oncogene 26:1862-74. 2007
    ..These results indicate that use of RNA interference can be an effective tool for blocking Snail function, opening the way for its application in new antiinvasive therapies...
  20. ncbi request reprint Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
    Hector Peinado
    Departamento de Bioquimica, Facultad de Medicina, Universidad Autonoma de Madrid UAM, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Rev Cancer 7:415-28. 2007
    ....
  21. ncbi request reprint Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels
    F Larcher
    Department of Cell and Molecular Biology, CIEMAT, Madrid, Spain
    Cancer Res 56:5391-6. 1996
    ....
  22. ncbi request reprint The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors
    Victoria Bolós
    Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier, 4, 28029 Madrid, Spain
    J Cell Sci 116:499-511. 2003
    ....
  23. ncbi request reprint New potential therapeutic targets to combat epithelial tumor invasion
    H Peinado
    Departamento de Bioquimica, Facultad de Medicina, Instituto de Investigaciones Biomedicas Alberto Sols, CSIC UAM Madrid Spain
    Clin Transl Oncol 8:851-7. 2006
    ..Recent advances in our understanding of this process is generating a wide range of molecules that could be potentially considered as new therapeutic targets for drug design to block metastatic spreading...
  24. doi request reprint The class I bHLH factors E2-2A and E2-2B regulate EMT
    Veronica R Sobrado
    Departamento de Bioquimica, Facultad de Medicina, Universidad Autonoma de Madrid UAM, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, 28029 Madrid, Spain
    J Cell Sci 122:1014-24. 2009
    ....
  25. doi request reprint Oncogenic H-Ras and PI3K signaling can inhibit E-cadherin-dependent apoptosis and promote cell survival after photodynamic therapy in mouse keratinocytes
    Jesus Espada
    Instituto de Investigaciones Biomedicas Alberto Sols, CSIC Departamento de Bioquímica, Facultad de Medicina, Universidad Autonoma de Madrid, Madrid, Spain
    J Cell Physiol 219:84-93. 2009
    ..Taken together, these results indicate that H-Ras/PI3K/Akt signaling plays a key role in cell survival mediated by E-cadherin cell-cell contacts...
  26. ncbi request reprint Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions
    Hector Peinado
    Instituto de Investigaciones Biomédicas Alberto Sols CSIC UAM and Departamento de Bioquímica UAM, Arturo Duperier 4, 28029 Madrid, Spain
    J Biol Chem 278:21113-23. 2003
    ..These data support that MAPK and phosphatidylinositol 3-kinase signaling pathways are implicated in TGFbeta1-mediated induction of Snail promoter, probably through Ras activation and its downstream effectors...
  27. ncbi request reprint Direct metabolic regulation of beta-catenin activity by the p85alpha regulatory subunit of phosphoinositide 3-OH kinase
    Jesus Espada
    Centro Nacional de Investigaciones Oncologicas, Instituto de Salud Carlos III, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Exp Cell Res 305:409-17. 2005
    ..These findings suggest that p85alpha can act as a direct metabolic regulator of beta-catenin activity...
  28. ncbi request reprint Snail and E47 repressors of E-cadherin induce distinct invasive and angiogenic properties in vivo
    Hector Peinado
    Departamento de Bioquimica, UAM Instituto de Investigaciones Biomédicas Alberto Sols CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    J Cell Sci 117:2827-39. 2004
    ....
  29. pmc A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression
    Hector Peinado
    Departamento de Bioquimica, Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Arturo Duperier, Madrid, Spain
    EMBO J 24:3446-58. 2005
    ..Taken together, these results establish a direct link between LOXL2 and Snail in carcinoma progression...
  30. pmc Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex
    Hector Peinado
    Departamento de Bioquimica, Instituto de Investigaciones Biomedicas Alberto Sols, Madrid, Spain
    Mol Cell Biol 24:306-19. 2004
    ..Our results establish a direct causal relationship between Snail-dependent repression of E-cadherin and the modification of chromatin at its promoter...
  31. ncbi request reprint The 5' flanking sequences of the mouse P-cadherin gene. Homologies to 5' sequences of the E-cadherin gene and identification of a first 215 base-pair intron
    M L Faraldo
    CSIC, Departamento de Bioquimica, Facultad de Medicina UAM, Madrid, Spain
    J Mol Biol 231:935-41. 1993
    ..These results indicate that, in contrast to a previous report, the mouse E and P-cadherin genes exhibit a similar genomic organization both containing 15 introns and a similar size for the first two exons...
  32. pmc Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A
    Matthew Reid MacPherson
    Departamento de Bioquimica, UAM, Instituto de Investigaciones Biomedicas Alberto Sols, CSIC UAM, 28029 Madrid, Spain
    Mol Biol Cell 21:244-53. 2010
    ..These results highlight serines 11 and 92 as new players in Snail1 regulation and suggest the participation of CK2 and PKA in the modulation of Snail1 functionality...
  33. pmc Anomalous expression of P-cadherin in breast carcinoma. Correlation with E-cadherin expression and pathological features
    J Palacios
    Department of Pathology, La Paz Hospital, Madrid, Spain
    Am J Pathol 146:605-12. 1995
    ..The distinct patterns of P- and E-cadherin expression observed in this study strongly suggest a differential role for these cadherins in human breast carcinogenesis...
  34. doi request reprint Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype
    David Sarrio
    Breast and Gynecological Cancer Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Cancer Res 68:989-97. 2008
    ....
  35. ncbi request reprint Switching on-off Snail: LOXL2 versus GSK3beta
    Hector Peinado
    Departamento de Bioquimica, Universidad Autonoma de Madrid, Instituto de Investigaciones Biomódicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Cell Cycle 4:1749-52. 2005
    ..Interestingly, LOXL2 seems to attenuate the GSK3beta-dependent Snail degradation. Here, we discuss the relevance of this new potential mechanism of regulation and the role of LOXL2 during carcinoma progression...
  36. doi request reprint The morphological and molecular features of the epithelial-to-mesenchymal transition
    Gema Moreno-Bueno
    Departamento de Bioquimica, Universidad Autonoma de Madrid, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Madrid, Spain
    Nat Protoc 4:1591-613. 2009
    ..Once the methodology is established, the time required to complete the protocol may vary from 3 to 4 weeks (monolayer cultures) and up to 6-8 weeks if including 3D cultures...
  37. ncbi request reprint Expression of alpha 6 beta 4 integrin increases during malignant conversion of mouse epidermal keratinocytes: association of beta 4 subunit to the cytokeratin fraction
    M Gomez
    Instituto de Investigaciones Biomedicas, CSIC, Madrid, Spain
    Exp Cell Res 201:250-61. 1992
    ..These results, together with those regarding the organization of both cellular components in drug-treated cells, support the existence of a close association between alpha 6 beta 4 and the intermediate filaments of the cytoskeleton...
  38. doi request reprint Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas
    Hector Peinado
    Departamento de Bioquimica, Instituto de Investigaciones Biomédicas Alberto Sols Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Universidad Autonoma de Madrid, Madrid, Spain
    Cancer Res 68:4541-50. 2008
    ..Altogether, our results show that LOXL2 can be used as a new poor prognosis indicator in human squamous cell carcinomas promoting malignant transformation by both SNAI1-dependent and SNAI1-independent pathways...
  39. ncbi request reprint Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions
    David Sarrio
    Molecular Pathology Program, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    Oncogene 23:3272-83. 2004
    ..Consequently, p120 may be an important mediator of the oncogenic effects derived from E-CD inactivation, including enhanced motility and invasion, in lobular breast cancer...
  40. ncbi request reprint Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
    Mario F Fraga
    Cancer Epigenetics Laboratory, Molecular Pathology Program, Spanish National Cancer Center, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Nat Genet 37:391-400. 2005
    ..Our data suggest that the global loss of monoacetylation and trimethylation of histone H4 is a common hallmark of human tumor cells...
  41. ncbi request reprint SNAI1 is required for tumor growth and lymph node metastasis of human breast carcinoma MDA-MB-231 cells
    David Olmeda
    Departamento de Bioquimica, Facultad de Medicina, Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Cancer Res 67:11721-31. 2007
    ..Remarkably, analysis of cell lines derived from lymph node metastasis indicates that SNAI1 expression is required for metastatic dissemination...
  42. ncbi request reprint DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells
    Andreas Eger
    Max F Perutz Laboratories, University Department at the Vienna Biocenter, Department of Medical Biochemistry, Medical University Vienna, Vienna, Austria
    Oncogene 24:2375-85. 2005
    ..RNA interference-mediated downregulation of deltaEF1 in cancer cells was sufficient to derepress E-cadherin expression and restore cell to cell adhesion, suggesting that deltaEF1 is a key player in late stage carcinogenesis...
  43. pmc The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells
    Ofelia M Martinez-Estrada
    Departament de Biologia Cellular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Biochem J 394:449-57. 2006
    ..Taken together, these results support the hypothesis that Claudin-1 is a direct downstream target gene of Snail family factors in epithelial cells...
  44. ncbi request reprint SPARC represses E-cadherin and induces mesenchymal transition during melanoma development
    Guillaume Robert
    INSERM Unité 597, Biologie et Pathologies des cellules mélanocytaires, Faculte de Medecine, Universite de Nice Sophia Antipolis, 28 Avenue de Valombrose, 06107 Nice Cedex 2, France
    Cancer Res 66:7516-23. 2006
    ..Our findings provide evidence for the role of SPARC in early transformation of melanocytes and identify a novel mechanism, whereby tumor-derived SPARC promotes tumorigenesis by mediating Snail induction and E-cadherin suppression...
  45. ncbi request reprint Upregulation of MMP-9 in MDCK epithelial cell line in response to expression of the Snail transcription factor
    Mireia Jorda
    Centre d Oncologia Molecular, IDIBELL Institut de Recerca Oncologica, Barcelona, Spain
    J Cell Sci 118:3371-85. 2005
    ..Altogether, these results indicate that MMP-9 transcription is activated in response to Snail expression and that it might explain, at least in part, the invasive properties of the Snail-expressing cells...
  46. ncbi request reprint Correlation of Snail expression with histological grade and lymph node status in breast carcinomas
    Maria J Blanco
    Instituto Cajal, CSIC, Doctor Arce 37, 28002 Madrid, Spain
    Oncogene 21:3241-6. 2002
    ....
  47. pmc VE-cadherin expression and clustering maintain low levels of survivin in endothelial cells
    Monica Iurlaro
    Italian Foundation for Cancer Research, Institute of Molecular Oncology, Milan, Italy
    Am J Pathol 165:181-9. 2004
    ..Consistently, in epidermal and pancreatic cell lines or ovarian tumors, epithelial-cadherin (E-cadherin) and survivin expression is inversely related, suggesting a non-cell-specific role of cadherins in reducing survivin synthesis...
  48. ncbi request reprint Transcriptional regulation of cadherins during development and carcinogenesis
    Hector Peinado
    Department of Biochemistry, Faculty of Medicine, Universidad Autonoma de Madrid, Instituto de Investigaciones Biomedicas Alberto Sols, CSIC UAM, 28029 Madrid Spain
    Int J Dev Biol 48:365-75. 2004
    ....
  49. ncbi request reprint beta-Catenin regulates P-cadherin expression in mammary basal epithelial cells
    Marisa M Faraldo
    UMR 144, CNRS Institut Curie, Section de Recherche, 26, rue d Ulm, 75248 Paris, Cedex 05, France
    FEBS Lett 581:831-6. 2007
    ..These data suggest that beta-catenin-dependent modulation of P-cadherin expression can contribute to the establishment of the basal phenotype...
  50. ncbi request reprint Id-1 is induced in MDCK epithelial cells by activated Erk/MAPK pathway in response to expression of the Snail and E47 transcription factors
    Mireia Jorda
    IDIBELL Institut de Recerca Oncologica, Centre d Oncologia Molecular, Barcelona, Spain
    Exp Cell Res 313:2389-403. 2007
    ..Our results provide new insights into how some target genes are activated during and/or as a consequence of the EMT triggered by both E47 and Snail transcription factors...
  51. pmc Beta-catenin regulation during the cell cycle: implications in G2/M and apoptosis
    David Olmeda
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, 28029 Madrid, Spain
    Mol Biol Cell 14:2844-60. 2003
    ..These results support a role for beta-catenin in the control of cell cycle and apoptosis at G2/M in normal and transformed epidermal keratinocytes...
  52. ncbi request reprint Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis
    Olga Millán
    Instituto de Bioquimica, CSIC UCM, 28040 Madrid, Spain
    Carcinogenesis 27:328-36. 2006
    ..These effects mediated by 15dPGJ2 might contribute to understand the role of COX-2 metabolites in carcinogenesis, leading to an increase of cell viability after mutagenic injury and therefore in the progression of tumors...
  53. ncbi request reprint Inducible expression of Snail selectively increases paracellular ion permeability and differentially modulates tight junction proteins
    Fabio Carrozzino
    Department of Cell Physiology and Metabolism, University of Geneva Medical Center, Rue Michel Servet 1, CH 1211 Geneva 4, Switzerland
    Am J Physiol Cell Physiol 289:C1002-14. 2005
    ..Together, these results suggest that induction of mSnail selectively increases the ionic permeability of TJs by differentially modulating the expression of specific claudins...
  54. doi request reprint A hypoxic twist in metastasis
    Hector Peinado
    Nat Cell Biol 10:253-4. 2008