Elias Campo

Summary

Country: Spain

Publications

  1. ncbi request reprint Immunohistochemical profiling of homogeneously treated de novo tumors with nodal presentation on tissue micro-arrays
    Elias Campo
    Department of Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Haematologica 90:292. 2005
  2. pmc The genomic landscape of chronic lymphocytic leukemia: clinical implications
    Victor Quesada
    Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo IUOPA, Oviedo, Spain
    BMC Med 11:124. 2013
  3. doi request reprint Whole genome profiling and other high throughput technologies in lymphoid neoplasms--current contributions and future hopes
    Elias Campo
    Haematopathology Section, Department of Anatomic Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Mod Pathol 26:S97-S110. 2013
  4. doi request reprint New pathogenic mechanisms in Burkitt lymphoma
    Elias Campo
    Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Nat Genet 44:1288-9. 2012
  5. pmc In situ mantle cell lymphoma: clinical implications of an incidental finding with indolent clinical behavior
    Alejandra Carvajal-Cuenca
    Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    Haematologica 97:270-8. 2012
  6. doi request reprint Primary cutaneous small/medium CD4+ T-cell lymphomas: a heterogeneous group of tumors with different clinicopathologic features and outcome
    Adriana Garcia-Herrera
    Hematopathology Section, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
    J Clin Oncol 26:3364-71. 2008
  7. ncbi request reprint Follicular lymphoma in early stages: high risk of relapse and usefulness of the Follicular Lymphoma International Prognostic Index to predict the outcome of patients
    Francisco Plancarte
    Department of Hematology, Hospital Clinic, Barcelona, Spain
    Eur J Haematol 76:58-63. 2006
  8. ncbi request reprint Activation of mitochondrial apoptotic pathway in mantle cell lymphoma: high sensitivity to mitoxantrone in cases with functional DNA-damage response genes
    Ana Ferrer
    Department of Hematology, Hematopathology Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
    Oncogene 23:8941-9. 2004
  9. ncbi request reprint Leukemic involvement is a common feature in mantle cell lymphoma
    Ana Ferrer
    Department of Hematology, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
    Cancer 109:2473-80. 2007
  10. ncbi request reprint CDK4 and MDM2 gene alterations mainly occur in highly proliferative and aggressive mantle cell lymphomas with wild-type INK4a/ARF locus
    Luis Hernandez
    Department of Pathology and Hematology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Cancer Res 65:2199-206. 2005

Detail Information

Publications136 found, 100 shown here

  1. ncbi request reprint Immunohistochemical profiling of homogeneously treated de novo tumors with nodal presentation on tissue micro-arrays
    Elias Campo
    Department of Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Haematologica 90:292. 2005
  2. pmc The genomic landscape of chronic lymphocytic leukemia: clinical implications
    Victor Quesada
    Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo IUOPA, Oviedo, Spain
    BMC Med 11:124. 2013
    ..Herein, we review the recent advances in the definition of the genomic landscape of CLL and the ongoing research to characterize the underlying biochemical events that drive this disease...
  3. doi request reprint Whole genome profiling and other high throughput technologies in lymphoid neoplasms--current contributions and future hopes
    Elias Campo
    Haematopathology Section, Department of Anatomic Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Mod Pathol 26:S97-S110. 2013
    ..The initial results of the NGS studies are also presented...
  4. doi request reprint New pathogenic mechanisms in Burkitt lymphoma
    Elias Campo
    Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Nat Genet 44:1288-9. 2012
    ..Two studies in this issue identify the landscape of somatic mutations in Burkitt lymphoma and highlight the pathogenic and clinical relevance of inactivating mutations of ID3, an inhibitor of the TCF3 transcription factor...
  5. pmc In situ mantle cell lymphoma: clinical implications of an incidental finding with indolent clinical behavior
    Alejandra Carvajal-Cuenca
    Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    Haematologica 97:270-8. 2012
    ..Cyclin D1-positive B cells are occasionally found in the mantle zones of reactive lymphoid follicles, a condition that has been called "in situ mantle cell lymphoma". The clinical significance of this lesion remains uncertain...
  6. doi request reprint Primary cutaneous small/medium CD4+ T-cell lymphomas: a heterogeneous group of tumors with different clinicopathologic features and outcome
    Adriana Garcia-Herrera
    Hematopathology Section, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
    J Clin Oncol 26:3364-71. 2008
    ..To define the clinical and pathologic characteristics of primary cutaneous small/medium CD4(+) T-cell lymphoma (PCSM-TCL) and identify parameters of prognostic significance...
  7. ncbi request reprint Follicular lymphoma in early stages: high risk of relapse and usefulness of the Follicular Lymphoma International Prognostic Index to predict the outcome of patients
    Francisco Plancarte
    Department of Hematology, Hospital Clinic, Barcelona, Spain
    Eur J Haematol 76:58-63. 2006
    ..The objective of this study was to analyze the clinical features and the outcome of a series of patients with FL in early stages with a long follow-up...
  8. ncbi request reprint Activation of mitochondrial apoptotic pathway in mantle cell lymphoma: high sensitivity to mitoxantrone in cases with functional DNA-damage response genes
    Ana Ferrer
    Department of Hematology, Hematopathology Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
    Oncogene 23:8941-9. 2004
    ..These results support that mitoxantrone can be effective in the treatment of MCL but that this activity requires the integrity of functional DNA-damage response genes...
  9. ncbi request reprint Leukemic involvement is a common feature in mantle cell lymphoma
    Ana Ferrer
    Department of Hematology, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
    Cancer 109:2473-80. 2007
    ..The aim of the study was to analyze the prevalence and the biologic and clinical significance of leukemic involvement in a series of patients with MCL...
  10. ncbi request reprint CDK4 and MDM2 gene alterations mainly occur in highly proliferative and aggressive mantle cell lymphomas with wild-type INK4a/ARF locus
    Luis Hernandez
    Department of Pathology and Hematology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Cancer Res 65:2199-206. 2005
    ..These findings indicate that CDK4 and MDM2 gene alterations mainly occur in MCL with a wild-type INK4a/ARF locus and may contribute to the higher proliferation and more aggressive behavior of the tumors...
  11. ncbi request reprint Incidence and clinical significance of bcl-2/IgH rearrangements in follicular lymphoma
    Silvia Montoto
    Hematology Department, Institute of Hematology and Oncology, Postgraduate School of Hematology Farrers Valenti Institut d Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Leuk Lymphoma 44:71-6. 2003
    ..In our series bcl-2/IgH rearrangement at MBR or mcr, which was found in 67% of the patients, was not correlated with response to treatment, survival nor time-to-treatment-failure...
  12. ncbi request reprint The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak
    Patricia Perez-Galan
    Hematopathology Unit, Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
    Blood 109:4441-9. 2007
    ..All these findings suggest that GX15-070 alone or in combination with bortezomib represents a new attractive therapeutic approach for MCL treatment...
  13. ncbi request reprint Gene expression profiling of acute myeloid leukemia with translocation t(8;16)(p11;p13) and MYST3-CREBBP rearrangement reveals a distinctive signature with a specific pattern of HOX gene expression
    Mireia Camos
    Hematopathology Unit, Hematology Department, Hospital Clinic, IDIBAPS, University of Barcelona, Spain
    Cancer Res 66:6947-54. 2006
    ..In summary, this study shows the distinctive gene expression profile of MYST3-CREBBP AML, with overexpression of RET and PRL and a specific pattern of HOX gene expression...
  14. ncbi request reprint Analysis of Aurora-A and hMPS1 mitotic kinases in mantle cell lymphoma
    Emma Camacho
    Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Int J Cancer 118:357-63. 2006
    ..Although the Aurora-A P31I polymorphic variant is not directly involved in a genetic predisposition to these lymphomas, it may modulate the clinical presentation of these tumors...
  15. ncbi request reprint Allogeneic stem-cell transplantation may overcome the adverse prognosis of unmutated VH gene in patients with chronic lymphocytic leukemia
    Carol Moreno
    Department of Hematology, Institute of Hematology and Oncology, Hospital Clinic, Villarroel, 170, 08036 Barcelona, Spain
    J Clin Oncol 23:3433-8. 2005
    ..To investigate whether allogeneic stem-cell transplantation (allo-SCT) may overcome the negative impact of unmutated VH genes in the outcome of patients with chronic lymphocytic leukemia (CLL)...
  16. doi request reprint Gene expression profile and genomic changes in disease progression of early-stage chronic lymphocytic leukemia
    Veronica Fernandez
    Hematopathology Section, Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Haematologica 93:132-6. 2008
    ..Gene expression profile analysis showed a significant modulation of 58 genes with a particular downregulation of genes that are inhibitors of cell adhesion and motility...
  17. ncbi request reprint Clinical impact of the differentiation profile assessed by immunophenotyping in patients with diffuse large B-cell lymphoma
    Lluis Colomo
    Department of Pathology, Hospital Clinic, Institut de Recerca Biomèdica August Pi i Sunyer, University of Barcelona, Spain
    Blood 101:78-84. 2003
    ..In conclusion, differentiation profile was associated with particular clinicopathological features but was not essential to predicting outcome in DLBCL patients...
  18. pmc The expression of the endoplasmic reticulum stress sensor BiP/GRP78 predicts response to chemotherapy and determines the efficacy of proteasome inhibitors in diffuse large b-cell lymphoma
    Ana Mozos
    Department of Hematopathology, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    Am J Pathol 179:2601-10. 2011
    ..Moreover, this study provides preclinical evidence that the germinal center B-cell-like subtype DLBCL is sensitive to bortezomib combined with immunochemotherapy...
  19. pmc Identification of methylated genes associated with aggressive clinicopathological features in mantle cell lymphoma
    Anna Enjuanes
    Hematopathology Section, Department of Anatomic Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    PLoS ONE 6:e19736. 2011
    ..The contribution of DNA methylation to MCL lymphomagenesis is not well known. We sought to identify epigenetically silenced genes in these tumours that might have clinical relevance...
  20. ncbi request reprint Fluorescence in situ hybridization studies using BAC clones of the EVI1 locus in hematological malignancies with 3q rearrangements
    Irene Madrigal
    IDIBAPS, Hospital Clinic, Barcelona, Catalonia, Spain
    Cancer Genet Cytogenet 170:115-20. 2006
    ..FISH analysis with BAC clones was a useful tool for identifying the chromosome breakpoints affecting the EVI1 locus in patients with 3q26 rearrangements...
  21. ncbi request reprint High-risk cervical epithelial neoplasia grade 1 treated by loop electrosurgical excision: follow-up and value of HPV testing
    Immaculada Alonso
    Department of Obstetrics and Gynecology, University of Barcelona School of Medicine, IDIBAPS Hospital Clinic, Barcelona, Spain
    Am J Obstet Gynecol 197:359.e1-6. 2007
    ....
  22. doi request reprint Genomic and gene expression profiling defines indolent forms of mantle cell lymphoma
    Veronica Fernandez
    Hematopathology Section, Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer and Department of Hematology, Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain
    Cancer Res 70:1408-18. 2010
    ....
  23. ncbi request reprint Diffuse large B-cell lymphomas with plasmablastic differentiation represent a heterogeneous group of disease entities
    Lluis Colomo
    Hematopathology Section, Laboratory of Pathology, and Department of Hematology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Am J Surg Pathol 28:736-47. 2004
    ..In conclusion, DLBCLs with plasmablastic differentiation are a heterogeneous group of neoplasms with different clinicopathological characteristics that may correspond to different entities...
  24. ncbi request reprint Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics
    Pedro Jares
    Haematopathology Section, Laboratory of Pathology, and Genomics Unit, Hospital Clinic, Institut de Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Nat Rev Cancer 7:750-62. 2007
    ....
  25. doi request reprint Multiple recurrent chromosomal breakpoints in mantle cell lymphoma revealed by a combination of molecular cytogenetic techniques
    Itziar Salaverria
    Department of Pathology, Hematopathology Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Genes Chromosomes Cancer 47:1086-97. 2008
    ..Furthermore, most MCL harbor complex karyotypes with a high number of both structural and numerical alterations affecting several common breakpoints, leading to various balanced and unbalanced translocations...
  26. pmc Activation of the endoplasmic reticulum stress-associated transcription factor x box-binding protein-1 occurs in a subset of normal germinal-center B cells and in aggressive B-cell lymphomas with prognostic implications
    Olga Balague
    Hematopathology Section, Hospital Clinic, Villarroel 170, 08036 Barcelona, Barcelona, Spain
    Am J Pathol 174:2337-46. 2009
    ..These findings suggest that Xbp-1 activation may play a role in the pathogenesis of aggressive B-cell lymphomas...
  27. doi request reprint Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM
    Roberto Alonso
    Hematopathology Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Blood 114:1563-75. 2009
    ..In conclusion, forodesine induces apoptosis of CLL cells bypassing the DNA-damage/ATM/p53 pathway and might represent a novel chemotherapeutic approach that deserves clinical investigation...
  28. ncbi request reprint Comparative genomic hybridisation identifies two variants of smoldering multiple myeloma
    Laura Rosinol
    Haematology Department, Institute of Haematology and Oncology, Institut d Investigacions Biomèdiques Agustí Pi i Sunyer, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Br J Haematol 130:729-32. 2005
    ..Evolving SMM showed cytogenetic changes consistent with those found in de novo symptomatic MM (1q gains, chromosome 13 deletions) while the non-evolving variant showed no 1q gains and deletions were uncommon...
  29. ncbi request reprint Immunohistochemical analysis of ZAP-70 expression in B-cell lymphoid neoplasms
    Joaquim Carreras
    Haemopathology Unit, Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    J Pathol 205:507-13. 2005
    ....
  30. pmc Nuclear survivin expression in mantle cell lymphoma is associated with cell proliferation and survival
    Antonio Martinez
    Hematopathology Unit, Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Am J Pathol 164:501-10. 2004
    ..The expression levels are strongly associated with the proliferative activity of the tumors and the survival of the patients, suggesting a potential role in cell cycle regulation and tumor progression...
  31. ncbi request reprint Unbalanced expression of licensing DNA replication factors occurs in a subset of mantle cell lymphomas with genomic instability
    Magda Pinyol
    Genomics Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Int J Cancer 119:2768-74. 2006
    ..These results suggest that an unbalanced mRNA expression of licensing regulatory genes may play a role in the pathogenesis of the chromosomal instability of a subset of MCL with inactivation of the p53/p14(ARF) pathway...
  32. doi request reprint Sorafenib inhibits cell migration and stroma-mediated bortezomib resistance by interfering B-cell receptor signaling and protein translation in mantle cell lymphoma
    Sílvia Xargay-Torrent
    Hematopathology Unit, Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Clin Cancer Res 19:586-97. 2013
    ..We evaluated the antitumoral properties of the multikinase inhibitor sorafenib in mantle cell lymphoma (MCL), an aggressive B lymphoma for which current therapies have shown limited efficacy...
  33. ncbi request reprint Familial lymphoid neoplasms in patients with mantle cell lymphoma
    Frederic Tort
    Hematopathology Unit, Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
    Haematologica 89:314-9. 2004
    ..However, no familial association has been previously recognized in MCL...
  34. pmc Co-regulation analysis of closely linked genes identifies a highly recurrent gain on chromosome 17q25.3 in prostate cancer
    Raquel Bermudo
    Department of Molecular and Cell Biology, Instituto de Biologia Molecular de Barcelona, Consejo Superior de Investigaciones Cientificas, Barcelona, Spain
    BMC Cancer 8:315. 2008
    ..Here we describe transcriptional signatures identifying distinct normal and tumoral prostate tissue compartments, and the inference and demonstration of a new, highly recurrent copy number gain on chromosome 17q25.3...
  35. ncbi request reprint Lack of methylthioadenosine phosphorylase expression in mantle cell lymphoma is associated with shorter survival: implications for a potential targeted therapy
    Silvia Marcé
    Pathology Department, Hematopathology Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Clin Cancer Res 12:3754-61. 2006
    ....
  36. pmc IG/MYC rearrangements are the main cytogenetic alteration in plasmablastic lymphomas
    Alexandra Valera
    Hematopathology Section, Laboratory of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Am J Surg Pathol 34:1686-94. 2010
    ..The oncogenic activation of MYC in these lymphomas may be an important pathogenetic element associated with EBV infection...
  37. doi request reprint Different distribution of NOTCH1 mutations in chronic lymphocytic leukemia with isolated trisomy 12 or associated with other chromosomal alterations
    Cristina Lopez
    Hematopathology Unit, Pathology Department, Hospital Clinic, Institut d Investigacions Biomèdiques Agustí Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Genes Chromosomes Cancer 51:881-9. 2012
    ..001). These findings indicate that the distribution of NOTCH1 mutations in CLL with trisomy 12 is heterogeneous and that the presence of additional chromosomal abnormalities such as trisomy 18 could change the prognosis of these patients...
  38. pmc Expanded and highly active proliferation centers identify a histological subtype of chronic lymphocytic leukemia ("accelerated" chronic lymphocytic leukemia) with aggressive clinical behavior
    Eva Gine
    Department of Hematology, Hospital Clínic Villarroel n masculine 170, 08036 Barcelona, Spain
    Haematologica 95:1526-33. 2010
    ..However, neither histological criteria to define this form of chronic lymphocytic leukemia nor its clinical correlates and prognostic impact have been formally defined in large series of patients...
  39. doi request reprint MicroRNA expression, chromosomal alterations, and immunoglobulin variable heavy chain hypermutations in Mantle cell lymphomas
    Alba Navarro
    Department of Pathology Hematopathology Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona
    Cancer Res 69:7071-8. 2009
    ..In conclusion, the miR expression pattern of MCL is deregulated in comparison with normal lymphoid cells and distinguishes two subgroups of tumors with different biological features...
  40. ncbi request reprint The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status
    Patricia Perez-Galan
    Hematopathology Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
    Blood 107:257-64. 2006
    ..These findings should be useful to extend the therapeutic strategies in MCL patients and to improve their prognosis...
  41. doi request reprint High numbers of tumor-infiltrating programmed cell death 1-positive regulatory lymphocytes are associated with improved overall survival in follicular lymphoma
    Joaquim Carreras
    Hematopathology Section, Department of Pathology, Hospital Clinic, Institut d Investigacions Biomèdiques August Pi Sunyer, University of Barcelona, Spain
    J Clin Oncol 27:1470-6. 2009
    ..The aim of this study was to determine the impact of programmed cell death 1 (PD-1) -positive inhibitory immunoregulatory lymphoid cells in the clinicobiologic features and outcome of patients with FL...
  42. ncbi request reprint Studies of complex Ph translocations in cases with chronic myelogenous leukemia and one with acute lymphoblastic leukemia
    Dolors Costa
    Hematopathology Unit, Hospital Clinic Villarroel, 170, 08036, Barcelona, Catalonia, Spain
    Cancer Genet Cytogenet 166:89-93. 2006
    ..In conclusion, FISH studies have been useful in the detection of the BCR/ABL rearrangements and 9q34 deletions, and to identify complex rearrangements that differ from the ones previously established by conventional cytogenetics...
  43. doi request reprint Bendamustine is effective in p53-deficient B-cell neoplasms and requires oxidative stress and caspase-independent signaling
    Gaël Roué
    Hematopathology Unit, Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Clin Cancer Res 14:6907-15. 2008
    ..Our aim was to analyze the apoptotic pathways activated by bendamustine in CLL and MCL together with the relevance of p53 mutation in determining the response to this drug...
  44. pmc Uniparental disomies, homozygous deletions, amplifications, and target genes in mantle cell lymphoma revealed by integrative high-resolution whole-genome profiling
    Silvia Bea
    Hematopathology Unit, Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Blood 113:3059-69. 2009
    ..This integrative genomic analysis has revealed target genes that may be potentially relevant in MCL pathogenesis...
  45. pmc SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype
    Ana Mozos
    Hematopathology Section, Department of Pathology and Hematology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Spain
    Haematologica 94:1555-62. 2009
    ..The aim of this study was to determine whether this gene is expressed in cyclin D1-negative mantle cell lymphoma and whether its detection may be useful to identify these tumors...
  46. pmc Landscape of somatic mutations and clonal evolution in mantle cell lymphoma
    Silvia Bea
    Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Universitat de Barcelona, 08036 Barcelona, Spain
    Proc Natl Acad Sci U S A 110:18250-5. 2013
    ..Our study identifies molecular mechanisms contributing to MCL pathogenesis and offers potential targets for therapeutic intervention. ..
  47. doi request reprint Genome-wide methylation analyses identify a subset of mantle cell lymphoma with a high number of methylated CpGs and aggressive clinicopathological features
    Anna Enjuanes
    Genomics Unit, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Int J Cancer 133:2852-63. 2013
    ....
  48. ncbi request reprint Clinical significance of minimal residual disease, as assessed by different techniques, after stem cell transplantation for chronic lymphocytic leukemia
    Carol Moreno
    Department of Hematology, University of Barcelona, Villarroel, 170, 08036 Barcelona, Spain
    Blood 107:4563-9. 2006
    ..These results might be useful to investigate treatments aimed at preventing relapse in patients with CLL who have received an autograft...
  49. doi request reprint Gene-expression profiling and not immunophenotypic algorithms predicts prognosis in patients with diffuse large B-cell lymphoma treated with immunochemotherapy
    Gonzalo Gutierrez-García
    Department of Hematology and Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Blood 117:4836-43. 2011
    ..In conclusion, stratification based on immunostaining algorithms should be used with caution in guiding therapy, even in clinical trials...
  50. ncbi request reprint Frequent polymorphic changes but not mutations of TRAIL receptors DR4 and DR5 in mantle cell lymphoma and other B-cell lymphoid neoplasms
    Veronica Fernandez
    Hematopathology Section, Laboratory of Pathology, Hematology Department, Hospital Clinic, Institut d Investigacions Biomèdiques August Pi iSunyer, University of Barcelona, Barcelona, Spain
    Haematologica 89:1322-31. 2004
    ..Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) receptors DR4 and DR5 have been mapped to chromosome 8p21-22, a region frequently deleted in different lymphoid neoplasms...
  51. doi request reprint SOX11 regulates PAX5 expression and blocks terminal B-cell differentiation in aggressive mantle cell lymphoma
    Maria Carmela Vegliante
    Hematopathology Unit, Pathology Department, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Blood 121:2175-85. 2013
    ....
  52. ncbi request reprint Diffuse large B-cell lymphoma: clinical and biological characterization and outcome according to the nodal or extranodal primary origin
    Armando Lopez-Guillermo
    Department of Hematology, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
    J Clin Oncol 23:2797-804. 2005
    ..To study the main clinicobiologic features, response, and outcome of patients with diffuse large B-cell lymphoma (DLBCL) according to the primary site, lymph node, or different extranodal organs of the disease...
  53. doi request reprint Incidence and prognostic impact of secondary cytogenetic aberrations in a series of 145 patients with mantle cell lymphoma
    Blanca Espinet
    Laboratori de Citogenètica Molecular, Laboratori de Citologia Hematologica, Servei de Patologia, Servei d Hematologia Clinica, GRETNHE, IMIM Hospital del Mar, Barcelona, Spain
    Genes Chromosomes Cancer 49:439-51. 2010
    ..Additionally, we observed that 3q gains and 17p losses detected by conventional cytogenetics are proliferation-independent prognostic markers indicating poor outcome...
  54. doi request reprint Genomic profiling reveals different genetic aberrations in systemic ALK-positive and ALK-negative anaplastic large cell lymphomas
    Itziar Salaverria
    Haematopathology Section, Department of Pathology, Hospital Clinic, Istitute d Inverstigacions Biomèdiques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Br J Haematol 140:516-26. 2008
    ..However no specific chromosomal alterations were associated with survival. In conclusion, ALK-positive and negative ALCL have different secondary genomic aberrations, suggesting they correspond to different genetic entities...
  55. doi request reprint Identification of TIGAR in the equilibrative nucleoside transporter 2-mediated response to fludarabine in chronic lymphocytic leukemia cells
    Mónica López-Guerra
    Unitat d Hematopatologia, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    Haematologica 93:1843-51. 2008
    ....
  56. ncbi request reprint ZAP-70 expression in normal pro/pre B cells, mature B cells, and in B-cell acute lymphoblastic leukemia
    Marta Crespo
    Department of Hematology, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Clin Cancer Res 12:726-34. 2006
    ..The purpose was to investigate the presence of ZAP-70 in normal pro/pre B cells and mature B cells and in tumoral cells from B-acute lymphoblastic leukemias (B-ALL)...
  57. doi request reprint p65 activity and ZAP-70 status predict the sensitivity of chronic lymphocytic leukemia cells to the selective IkappaB kinase inhibitor BMS-345541
    Mónica López-Guerra
    Authors Affiliations Hematopathology Unit, Department of Pathology and Department of Hematology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Clin Cancer Res 15:2767-76. 2009
    ..Our purpose was to characterize the molecular mechanisms underlying for the selective IkappaB kinase inhibitor BMS-345541 in CLL cells together with the analysis of its combination with several antineoplasic drugs...
  58. doi request reprint Clinico-biological characterization and outcome of primary nodal and extranodal diffuse large B-cell lymphoma in the rituximab era
    Gonzalo Gutierrez-García
    Department of Hematology, Hospital Clinic, Institut de Recerca Biomèdica August Pi i Sunyer, Barcelona, Spain
    Leuk Lymphoma 51:1225-32. 2010
    ....
  59. ncbi request reprint Epstein-Barr virus negative clonal plasma cell proliferations and lymphomas in peripheral T-cell lymphomas: a phenomenon with distinctive clinicopathologic features
    Olga Balague
    Hematopathology Section, Laboratory of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Am J Surg Pathol 31:1310-22. 2007
    ..The distinctive features of these patients suggest that these lesions represent a specific phenomenon in PTCL...
  60. doi request reprint High clinical and molecular response rates with fludarabine, cyclophosphamide and mitoxantrone in previously untreated patients with advanced stage follicular lymphoma
    Silvia Montoto
    Department of Hematology, Hospital Clinic, IDIBAPS, Barcelona, Spain
    Haematologica 93:207-14. 2008
    ..The aim of this study was to analyze the efficacy and toxicity of a fludarabine combination as first-line treatment in patients with advanced-stage disease...
  61. pmc Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature
    Itziar Salaverria
    Department of Pathology and Hematology, Hospital Clinic, University of Barcelona, Barcelona, Spain
    J Clin Oncol 25:1216-22. 2007
    ....
  62. pmc CCND2 rearrangements are the most frequent genetic events in cyclin D1(-) mantle cell lymphoma
    Itziar Salaverria
    Department of Pathology, Hematopathology Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Blood 121:1394-402. 2013
    ....
  63. pmc Nonhepatosplenic γδ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation
    Adriana Garcia-Herrera
    Department of Pathology, Hospital Clinic, IDIBAPS, Barcelona, Spain
    Am J Surg Pathol 35:1214-25. 2011
    ..However, non-HSTL γδ TCL do not seem to represent a single entity. The relationship of these tumors with either HSTL or PCGD-TCL requires further study...
  64. doi request reprint A new genetic abnormality leading to TP53 gene deletion in chronic lymphocytic leukaemia
    Cristina Lopez
    Fundació Clínic per a la Recerca Biomèdica, Barcelona, Spain
    Br J Haematol 156:612-8. 2012
    ..Larger series are needed to better evaluate the clinical impact of this chromosomal aberration during the course of the disease...
  65. pmc Epigenetic activation of SOX11 in lymphoid neoplasms by histone modifications
    Maria Carmela Vegliante
    Hematopathology Section, Laboratory of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    PLoS ONE 6:e21382. 2011
    ..In contrast, the pathogenic role of SOX11 is associated with its de novo expression in some aggressive lymphoid malignancies, which is mediated by a shift from inactivating to activating histone modifications...
  66. ncbi request reprint Heterogeneity of genomic breakpoints in MSN-ALK translocations in anaplastic large cell lymphoma
    Frederic Tort
    Laboratory of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
    Hum Pathol 35:1038-41. 2004
    ....
  67. doi request reprint Vorinostat-induced apoptosis in mantle cell lymphoma is mediated by acetylation of proapoptotic BH3-only gene promoters
    Sílvia Xargay-Torrent
    Hematopathology Unit, Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Catalonia, Spain
    Clin Cancer Res 17:3956-68. 2011
    ..Our purpose was to describe the molecular mechanism whereby vorinostat induces apoptosis in MCL with particular emphasis on the role of proapoptotic BH3-only proteins...
  68. doi request reprint The Hsp90 inhibitor IPI-504 overcomes bortezomib resistance in mantle cell lymphoma in vitro and in vivo by down-regulation of the prosurvival ER chaperone BiP/Grp78
    Gaël Roué
    Hematopathology Unit, Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Blood 117:1270-9. 2011
    ..These results suggest that targeting unfolded protein response activation by the inhibition of Hsp90 may be an attractive model for the design of a new bortezomib-based combination therapy for MCL...
  69. doi request reprint Initial features and outcome of cutaneous and non-cutaneous primary extranodal follicular lymphoma
    Carlos Fernández de Larrea
    Departments of Haematology Pathology Dermatology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Br J Haematol 153:334-40. 2011
    ..In conclusion, extranodal FLs, particularly cutaneous, have particular clinico-biological features, which differentiate them from nodal cases. Nevertheless, primary site of the disease is not the main issue to predict outcome...
  70. pmc High microvessel density determines a poor outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus chemotherapy
    Teresa M Cardesa-Salzmann
    Hospital Clinic, University of Barcelona, Barcelona, Spain
    Haematologica 96:996-1001. 2011
    ..The purpose of this study is to assess the prognostic impact of histopathological microvessel density in two independent series of patients with diffuse large B-cell lymphoma treated with immunochemotherapy...
  71. doi request reprint Do we need to do fluorescence in situ hybridization analysis in myelodysplastic syndromes as often as we do?
    Dolors Costa
    Hematopathology Section, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Leuk Res 34:1437-41. 2010
    ..These results indicate that FISH studies provide relevant information in MSD in which the conventional cytogenetic analysis was unsuccessful but add little value to a normal katyotype in conventional cytogenetic analysis...
  72. doi request reprint Refining the diagnosis and prognostic categorization of acute myeloid leukemia patients with an integrated use of cytogenetic and molecular studies
    Dolors Costa
    Hematopathology Section, Hospital Clinic, Barcelona, Catalonia, Spain
    Acta Haematol 129:65-71. 2013
    ..Our results demonstrate that molecular biology and FISH studies provide relevant information in AML and should be routinely performed...
  73. ncbi request reprint Clinicopathologic significance and prognostic value of chromosomal imbalances in diffuse large B-cell lymphomas
    Silvia Bea
    Laboratory of Pathology and Hematology Department, Hospital Clinic, Institut d Investigactions Biomediques August Pi I Sunyer, University of Barcelona, Spain
    J Clin Oncol 22:3498-506. 2004
    ..To determine the clinicopathologic significance and prognostic value of chromosomal imbalances in diffuse large B-cell lymphomas (DLBCL)...
  74. doi request reprint Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia
    Anna Enjuanes
    Department of Anatomic Pathology, Hematopathology Section, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Cancer Res 68:10178-86. 2008
    ..This study suggests that common genetic variation in apoptosis- and immunoregulation-related genes is associated with the CLL risk...
  75. ncbi request reprint Cutaneous gamma/delta T-cell lymphoma: a histopathologic mimicker of lupus erythematosus profundus (lupus panniculitis)
    Paula Aguilera
    Department of Dermatology, Hospital Clinic i Provincial de Barcelona, University of Barcelona, Spain
    J Am Acad Dermatol 56:643-7. 2007
    ..Herein, we describe a patient whose initial histopathologic findings ressembled LEP but presented an aggressive clinical course. A new biopsy was performed during the follow-up, and a final diagnosis of CGD-TCL was made...
  76. ncbi request reprint Inactivation of RB1 in mantle-cell lymphoma detected by nonsense-mediated mRNA decay pathway inhibition and microarray analysis
    Magda Pinyol
    Genomics Unit, Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Blood 109:5422-9. 2007
    ..These tumors carried a concomitant inactivation of p53, whereas p16INK4a was wild type. These results indicate for the first time that RB1 may be inactivated in aggressive MCL by intragenic deletions...
  77. ncbi request reprint High levels of chromosomal imbalances in typical and small-cell variants of T-cell prolymphocytic leukemia
    Dolors Costa
    Hematopathology Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Villarroel 170, University of Barcelona, 08036 Barcelona, Catalonia, Spain
    Cancer Genet Cytogenet 147:36-43. 2003
    ..These results indicate that T-PLL carry a high number of chromosomal alterations that are not related to the morphologic variants or the clinical behavior of the disease...
  78. doi request reprint Improving survival in patients with chronic lymphocytic leukemia (1980-2008): the Hospital Clinic of Barcelona experience
    Pau Abrisqueta
    Department of Hematology, Institute of Hematology and Oncology, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Blood 114:2044-50. 2009
    ..These results suggest that newer treatments are changing the prognosis of CLL, particularly in younger patients with advanced disease, whereas no improvement is yet observed in older subjects or those with lower-risk disease...
  79. ncbi request reprint Selective inhibition of IkappaB kinase sensitizes mantle cell lymphoma B cells to TRAIL by decreasing cellular FLIP level
    Gaël Roué
    Hematopathology Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    J Immunol 178:1923-30. 2007
    ..These results present the combination of TRAIL stimulation and IkappaB kinase inhibition as a new approach to MCL therapy...
  80. ncbi request reprint Pre- and post-conization high-risk HPV testing predicts residual/recurrent disease in patients treated for CIN 2-3
    Immaculada Alonso
    Department of Obstetrics and Gynecology, IDIBAPS Hospital Clinic, University of Barcelona School of Medicine, Barcelona, Spain
    Gynecol Oncol 103:631-6. 2006
    ....
  81. ncbi request reprint Type I MOZ/CBP (MYST3/CREBBP) is the most common chimeric transcript in acute myeloid leukemia with t(8;16)(p11;p13) translocation
    Maria Rozman
    Hematopathology Unit, Department of Pathology, Postgraduate School of Hematology Farreras Valenti, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Genes Chromosomes Cancer 40:140-5. 2004
    ..The newly designed single-round PCR provides a simple tool for the molecular confirmation of MOZ/CBP rearrangement...
  82. doi request reprint Most primary adrenal lymphomas are diffuse large B-cell lymphomas with non-germinal center B-cell phenotype, BCL6 gene rearrangement and poor prognosis
    Ana Mozos
    Department of Anatomic Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Mod Pathol 22:1210-7. 2009
    ..We speculate that the poor outcome of primary adrenal lymphoma might be related to the bulky tumor size at presentation, non-germinal center B-cell phenotype, and frequent BCL-6 gene rearrangement...
  83. ncbi request reprint Osteopontin and alphavbeta3 integrin expression in the endometrium of infertile and fertile women
    Gemma Casals
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Barcelona, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Reprod Biomed Online 16:808-16. 2008
    ..It is concluded that the functional significance of the osteopontin:alpha(v)beta(3) integrin complex as a marker of endometrial receptivity and implantation potential in women seems to be untenable...
  84. doi request reprint Advances in the understanding of mantle cell lymphoma
    Pedro Jares
    Haematopathology Section, Laboratory of Pathology, and Genomics Unit, Hospital Clinic, Institut de Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Br J Haematol 142:149-65. 2008
    ....
  85. ncbi request reprint Routine use of immunophenotype by flow cytometry in tissues with suspected hematological malignancies
    Antoni Martinez
    Hematopathology Unit, Department of Pathology, Hospital Clinic, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Cytometry B Clin Cytom 56:8-15. 2003
    ..The aim of this study was to analyze the role of FCM in the diagnosis of biopsies from patients with a suspected hematological disorder...
  86. doi request reprint The complex landscape of genetic alterations in mantle cell lymphoma
    Cristina Royo
    Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Hematopathology Section, Hospital Clinic, 08036 Barcelona, Spain
    Semin Cancer Biol 21:322-34. 2011
    ..The better understanding of genetic alterations of MCL may offer new approaches for more patient-tailored, risk-adapted treatment options...
  87. ncbi request reprint Redistribution of FOXP3-positive regulatory T cells from lymphoid tissues to peripheral blood in HIV-infected patients
    Ana Mozos
    Hematopathology Section, Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    J Acquir Immune Defic Syndr 46:529-37. 2007
    ..Design: Paired samples from lymphoid tissue and peripheral blood were simultaneously obtained from 27 HIV-infected patients (before and after highly active antiretroviral therapy [HAART]) and 6 controls...
  88. ncbi request reprint FOXP1 status in splenic marginal zone lymphoma: a fluorescence in situ hybridization and immunohistochemistry approach
    Cristina Baro
    Dept Biologia Animal, Vegetal i Ecologia Unitat d Antropologia Biològica Facultat de Biociències Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain
    Histol Histopathol 24:1399-404. 2009
    ..FOXP1 protein expression seemed to be not related to any aberration and IHC studies are not conclusive...
  89. ncbi request reprint Immunoarchitecture of lymphoid tissue in HIV-infection during antiretroviral therapy correlates with viral persistence
    Llucia Alos
    Department of Pathology, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
    Mod Pathol 18:127-36. 2005
    ..However, these parameters studied in lymphoid tissue are not re-established completely, even after 36 months of highly active antiretroviral therapy...
  90. ncbi request reprint Uterine (CD56+) natural killer cells recruitment: association with decidual reaction rather than embryo implantation
    Jaume Ordi
    Department of Anatomical Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Faculty of Medicine, University of Barcelona, Barcelona, Spain
    Am J Reprod Immunol 55:369-77. 2006
    ....
  91. ncbi request reprint Chimeric BCR/ABL gene detected by fluorescence in situ hybridization in three new cases of Philadelphia chromosome-negative chronic myelocytic leukemia
    Dolors Costa
    Unitat Hematopatologia, Hospital del Mar, Barcelona, Spain
    Cancer Genet Cytogenet 141:114-9. 2003
    ..In conclusion, in cases of Ph- CML, FISH studies are of paramount importance since they can detect chromosomal reorganization and its location, and can also provide quantitative follow-up of these patients...
  92. ncbi request reprint Alterations of cell cycle-regulatory genes in prostate cancer
    Pedro L Fernandez
    Department of Anatomical Pathology, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Pathobiology 70:1-10. 2002
    ....
  93. ncbi request reprint Human papillomavirus load in Hybrid Capture II assay: does increasing the cutoff improve the test?
    Jaume Ordi
    Department of Anatomical Pathology, IDIBAPS Hospital Clinic, University of Barcelona, School of Medicine, C Villarroel 170, 08036 Barcelona, Spain
    Gynecol Oncol 99:313-9. 2005
    ....
  94. ncbi request reprint Herpes simplex and Epstein-Barr virus lymphadenitis in a patient with chronic lymphocytic leukemia treated with fludarabine
    Santiago Mercadal
    Department of Hematology, Hospital Clinic, IDIBAPS, University of Barcelona, Spain
    Eur J Haematol 77:442-4. 2006
    ..To the best of our knowledge, this is the first reported case of a multiple human herpes virus infection mimicking Richter syndrome...
  95. ncbi request reprint CHK2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomas
    Frederic Tort
    Laboratory of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Spain
    Blood 100:4602-8. 2002
    ..The high number of chromosomal imbalances in tumors with complete absence of CHK2 protein suggests a role of this gene in chromosomal instability in human lymphomas...
  96. ncbi request reprint Bullous pemphigoid associated with mantle cell lymphoma
    Pilar Iranzo
    Departments of Dermatology and Pathology, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Arch Dermatol 140:1496-9. 2004
    ..Bullous pemphigoid has developed in association with different types of malignant diseases, including a few cases of B-cell lymphoproliferative disorders. However, the paraneoplastic significance of this association is still controversial...
  97. ncbi request reprint Association of CDK4 and CCND1 mRNA overexpression in laryngeal squamous cell carcinomas occurs without CDK4 amplification
    Alfons Nadal
    Anatomia Patologica, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Villarroel 170, Barcelona, Spain
    Virchows Arch 450:161-7. 2007
    ....
  98. pmc Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction
    Silvia Bea
    Department of Pathology and Hematology Hospital Clinic, University of Barcelona, Spain
    Blood 106:3183-90. 2005
    ..In addition, gains involving the chromosomal region 3p11-p12 provided prognostic information that was statistically independent of the previously defined gene-expression-based survival model, thereby improving its predictive power...
  99. ncbi request reprint Identification of anaplastic lymphoma kinase variant translocations using 5'RACE
    Luis Hernandez
    Department of Pathology, Hospital Clinic, University of Barcelona, Spain
    Methods Mol Med 115:295-314. 2005
    ..The reamplification is achieved by using a nested gene-specific primer (ALK3), which anneals 3' to ALK2, and a universal amplification primer, which anneals to the 5' sequence previously introduced by the AAP primer...
  100. ncbi request reprint p16 overexpression identifies HPV-positive vulvar squamous cell carcinomas
    Monica Santos
    Department of Pathology, Hospital Clínic Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Am J Surg Pathol 30:1347-56. 2006
    ..Immunostaining for p16 is a reliable marker for HPV-positive VSSCs, which improves the results of histologic classification...
  101. pmc Genetic imbalances in progressed B-cell chronic lymphocytic leukemia and transformed large-cell lymphoma (Richter's syndrome)
    Silvia Bea
    Hematopathology Section, Laboratory of Anatomic Pathology, Hospital Clinic, University of Barcelona, Spain
    Am J Pathol 161:957-68. 2002
    ..Genetic alterations detected by comparative genomic hybridization may also be of prognostic significance...