Research Topics
Genomes and GenesSpecies | Francisca I CamachoSummaryCountry: Spain Publications
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Publications
Nodal marginal zone lymphoma: a heterogeneous tumor: a comprehensive analysis of a series of 27 casesFrancisca I Camacho
Lymphoma Group, Molecular Pathology Program, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
Am J Surg Pathol 27:762-71. 2003..Molecular and immunohistochemical data obtained in this study strongly imply that there is significant heterogeneity among the cases included in the category termed nodal marginal zone lymphoma...- Aberrant Bcl6 protein expression in mantle cell lymphomaFrancisca I Camacho
Molecular Pathology Program, Centro Nacional de Investigaciones Oncologicas, C Melchior Fernandez Almagro 3, E 28029 Madrid, Spain
Am J Surg Pathol 28:1051-6. 2004..Chromosomal alterations involving 3q27 seem to be responsible for this increased Bcl6 expression, which needs to be considered when Bcl6 is used in lymphoma diagnosis... 
TCL1A expression delineates biological and clinical variability in B-cell lymphomaMohit Aggarwal
Molecular Pathology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
Mod Pathol 22:206-15. 2009....- Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysisElena Ruiz-Ballesteros
Molecular Pathology Program, Centro Nacional de Investigaciones Oncologicas, C Melchor Fernandez Almagro 3, E 28 029 Madrid, Spain
Blood 106:1831-8. 2005..Shorter survival was associated with CD38 expression, naive IgV(H) genes, and the expression of a set of NF-kappaB pathway genes, including TRAF5, REL, and PKCA... - The molecular signature of mantle cell lymphoma reveals multiple signals favoring cell survivalNerea Martinez
Molecular Pathology Program, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
Cancer Res 63:8226-32. 2003..In conclusion, MCL seems to combine a disease-specific signature and different sets of genes of which the expression is associated with key clinical, molecular, and immunophenotypical events... - Somatic hypermutation signature in B-cell low-grade lymphomasLorraine Tracey
Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
Haematologica 93:1186-94. 2008.... - Functional signatures identified in B-cell non-Hodgkin lymphoma profilesMohit Aggarwal
Lymphoma Group, Molecular Pathology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
Leuk Lymphoma 50:1699-708. 2009..A specific attention was paid to the analysis of BCR and coregulated pathways, defining molecular heterogeneity within multiple B-cell lymphoma types... - Variability in the degree of expression of phosphorylated IkappaBalpha in chronic lymphocytic leukemia cases with nodal involvementAntonia Rodriguez
Molecular Pathology Program, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
Clin Cancer Res 10:6796-806. 2004.... - Peripheral T-cell lymphoma with follicular T-cell markersSocorro Maria Rodriguez-Pinilla
Lymphoma Group, Molecular Pathology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
Am J Surg Pathol 32:1787-99. 2008..The aim of this study was to establish whether other PTCL subgroups also express TFH cell markers... - Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomasSantiago Montes-Moreno
Lymphoma Group, Spanish National Cancer Centre CNIO, Madrid, Spain
Blood 111:351-8. 2008..The results of RNA and protein expression should prompt further investigation into the role of Gcet1 in regulating B-cell survival... - Expression of the NF-kappaB targets BCL2 and BIRC5/Survivin characterizes small B-cell and aggressive B-cell lymphomas, respectivelyLorraine Tracey
, Madrid, Spain
J Pathol 206:123-34. 2005..Meanwhile, in chronic lymphocytic leukaemia (CLL)-derived lymphocytes, NF-kappaB inhibition resulted in a marked decrease in BCL2 expression... - Improved demonstration of immunohistochemical prognostic markers for survival in follicular lymphoma cellsFrancisca I Camacho
Department of Pathology, Hospital Universitario de Getafe, Carretera de Toledo, Getafe, Madrid, Spain
Mod Pathol 24:698-707. 2011..This not only confirms that a group of FL cases may have a very good clinical course, but also indicates that this group can be identified using this integrated clinical and immunohistochemical approach... - Silencing of the p18INK4c gene by promoter hypermethylation in Reed-Sternberg cells in Hodgkin lymphomasAbel Sanchez-Aguilera
Lymphoma Group, Molecular Pathology Program, and the Immunohistochemistry and Histology Unit, Centro Nacional de Investigaciones Oncologicas, E 28029 Madrid, Spain
Blood 103:2351-7. 2004..These findings suggest that p18INK4c may function as a tumor suppressor gene in HL, and its inactivation may contribute to the cell cycle deregulation and defective terminal differentiation characteristic of the RS cells... - Molecular heterogeneity in MCL defined by the use of specific VH genes and the frequency of somatic mutationsFrancisca I Camacho
, Molecular Pathology Program, Madrid, Spain
Blood 101:4042-6. 2003.... - Large B-cell lymphoma presenting in the spleen: identification of different clinicopathologic conditionsManuela Mollejo
Lymphoma Group, Molecular Pathology Program, , Madrid, Spain
Am J Surg Pathol 27:895-902. 2003..Additionally, they provide evidence that clinical presentation as a tumor confined to the spleen and the hilar lymph nodes is associated with lower aggressivity... - Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomasJavier Silva
Department of Medical Oncology, Hospital Universitario Puerta de Hierro, Madrid, Spain
Clin Cancer Res 12:6929-36. 2006..Here, we examine whether these in vitro findings can be extrapolated to the in vivo situation... - Hodgkin and Reed-Sternberg cells harbor alterations in the major tumor suppressor pathways and cell-cycle checkpoints: analyses using tissue microarraysJuan F Garcia
Lymphoma Group, Molecular Pathology Program, and Immunohistochemistry and Histology Unit, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
Blood 101:681-9. 2003..This appears to determine the viability of the tumoral cells and the clinical outcome... 
Identification of novel candidate target genes in amplicons of Glioblastoma multiforme tumors detected by expression and CGH microarray profilingYolanda Ruano
Genetics Department, Hospital Virgen de la Salud, Avda, Barber 30, 45004 Toledo, Spain
Mol Cancer 5:39. 2006..However, the limited resolution of these techniques has precluded the precise identification of detailed specific gene copy number alterations...- Identification of survival-related genes of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma multiformeYolanda Ruano
Genetics Department, Virgen de la Salud Hospital, Toledo, Spain
Cancer 112:1575-84. 2008.... - Comparative genome profiling across subtypes of low-grade B-cell lymphoma identifies type-specific and common aberrations that target genes with a role in B-cell neoplasiaBibiana I Ferreira
Molecular Cytogenetics Group, Centro Nacional Investigaciones Oncologicas CNIO, Melchor Fernandez Almagro, 3, 28029 Madrid, Spain
Haematologica 93:670-9. 2008..Our objective was to search for genomic features that allow a better molecular identification of the different types of lymphoma studied... - Nuclear bcl10 expression characterizes a group of ocular adnexa MALT lymphomas with shorter failure-free survivalRenato Franco
Pathology Unit, National Cancer Institute Giovanni Pascale, Naples, Italy
Mod Pathol 19:1055-67. 2006..Moreover, patients with tumoral bcl10 nuclear expression showed shorter failure-free survival... - Clonal proliferation of cyclin D1-positive mantle lymphocytes in an asymptomatic patient: an early-stage event in the development or an indolent form of a mantle cell lymphoma?Blanca Espinet
Servei de Patologia Laboratori de Citogenetica i Biologia Molecular, Laboratori de Citologia Hematologica, Laboratori de Patologia, Hospital del Mar, IMAS, URNHE, PRBB, Barcelona 08003, Spain
Hum Pathol 36:1232-7. 2005..The existence of such asymptomatic patients with an indolent clinical course should induce a strict clinical judgment in terms of therapeutic decisions... - IgV(H) and bcl6 somatic mutation analysis reveals the heterogeneity of cutaneous B-cell lymphoma, and indicates the presence of undisclosed local antigensRenato Franco
Istituto dei Tumori G Pascale, Napoli, Italy
Mod Pathol 17:623-30. 2004..The biased usage of V(H)2-70, the low rate of replacement mutation in the FR, and the presence of ongoing mutation imply that local antigens could modulate the growth of primary cutaneous BCL... - Nodal and splenic marginal zone B cell lymphomasManuela Mollejo
Department of Genetics and Pathology, Hospital Virgen de la Salud, Toledo, Spain
Hematol Oncol 23:108-18. 2005..Specific therapeutic protocols and prognostic factors are required to more precisely define this tumour... - The presence of STAT1-positive tumor-associated macrophages and their relation to outcome in patients with follicular lymphomaTomas Alvaro
Department of Pathology, Hospital de Tortosa Verge de la Cinta, C Esplanetes n 14, 43500 Tortosa, Spain
Haematologica 91:1605-12. 2006..The aim of this study was to determine the extent to which macrophages are present in FL and to investigate the expression of STAT1 in these cells...