P Bovolenta

Summary

Country: Spain

Publications

  1. ncbi SFRP1 modulates retina cell differentiation through a beta-catenin-independent mechanism
    Pilar Esteve
    Departamento de Neurobiologia del Desarrollo, Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    J Cell Sci 116:2471-81. 2003
  2. doi Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease
    Paola Bovolenta
    Departamento de Neurobiología Molecular, Celular y del Desarrollo, Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    J Cell Sci 121:737-46. 2008
  3. pmc The Netrin-related domain of Sfrp1 interacts with Wnt ligands and antagonizes their activity in the anterior neural plate
    Javier Lopez-Rios
    Departamento de Neurobiología Molecular Celular y del Desarrollo, Instituto Cajal, CSIC, Dr Arce 37, Madrid, 28002, Spain
    Neural Dev 3:19. 2008
  4. pmc Comprehensive characterization of the cis-regulatory code responsible for the spatio-temporal expression of olSix3.2 in the developing medaka forebrain
    Ivan Conte
    Departamento de Neurobiología Celular, Molecular y del Desarrollo, Instituto Cajal, CSIC, Dr Arce, Madrid 28002, Spain
    Genome Biol 8:R137. 2007
  5. ncbi Morphogen signaling at the vertebrate growth cone: a few cases or a general strategy?
    Paola Bovolenta
    Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    J Neurobiol 64:405-16. 2005
  6. ncbi Expression pattern of cSix3, a member of the Six/sine oculis family of transcription factors
    P Bovolenta
    Unidad de Neurobiologia del Desarollo, Instituto Cajal, Madrid, Spain
    Mech Dev 70:201-3. 1998
  7. ncbi Frizzled/RYK mediated signalling in axon guidance
    Paola Bovolenta
    Departamento de Neurobiologia del Desarrollo, Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    Development 133:4399-408. 2006
  8. ncbi Nervous system proteoglycans as modulators of neurite outgrowth
    P Bovolenta
    Departamento de Neurobiologia del Desarrollo, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Dr Arce 37, 28002, Madrid, Spain
    Prog Neurobiol 61:113-32. 2000
  9. ncbi Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies
    M E Gallardo
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Velazquez 144, Madrid, 28006, Spain
    Genomics 61:82-91. 1999
  10. ncbi Six9 (Optx2), a new member of the six gene family of transcription factors, is expressed at early stages of vertebrate ocular and pituitary development
    J Lopez-Rios
    Departamento de Neurobiologia del Desarrollo, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Dr Arce 37, E28002, Madrid, Spain
    Mech Dev 83:155-9. 1999

Collaborators

  • A Mallamaci
  • Isabel Rodrigo
  • Pilar Esteve
  • R Sanz
  • C Ramos
  • Javier Lopez-Rios
  • A Simeone
  • L Puelles
  • E Marti
  • E Boncinelli
  • J M Frade
  • Christine Weinl
  • Felix Loosli
  • M Hammerschmidt
  • Juan Ramon Martinez-Morales
  • Cristina Sánchez-Camacho
  • Ivan Conte
  • Jose Maria Ruiz
  • Josana Rodriguez
  • Julian Morcillo
  • Françoise Trousse
  • F Trousse
  • Leonardo Beccari
  • Elsa Cisneros
  • Beatriz Cubelos
  • Araceli del Arco
  • J R Martinez-Morales
  • Paloma Merchan
  • Yasmin Fermin
  • Maria Garcia-Hoyos
  • B Granadino
  • M E Gallardo
  • Milagros Ramos
  • Jorgina Satrustegui
  • Anna Maria Barbieri
  • Alvaro Sebastián-Serrano
  • Christopher A Walsh
  • Raquel Marco-Ferreres
  • Maria Elisa Calcagnotto
  • Juan Miguel Redondo
  • Seonhee Kim
  • Ana Dopazo
  • Noemí Tabanera
  • Marta Nieto
  • Manuel Alvarez-Dolado
  • S Rodriguez De Cordoba
  • C Ayuso
  • Ana Bribian
  • Fernando De Castro
  • Melissa Lezameta
  • Jane C Sowden
  • Gabriela Nica
  • Asha Dwivedy
  • Joachim Wittbrodt
  • Filippo Del Bene
  • Christine Holt
  • Carolina Arroyo
  • Maria Jose Trujillo
  • Diego Cantalapiedra
  • Rosa Riveiro
  • Carmen Ayuso
  • Beatriz Pardo
  • Simon Saule
  • Vincent Dolez
  • Keiko Kobayashi
  • Elena Bogónez
  • Takeyori Saheki
  • Laurence Leconte
  • Tomotsugu Yasuda
  • Raffaella Zaccarini
  • Alberto Martinez-Serrano
  • Carmen Galián
  • Vania Broccoli
  • Anna Marchitiello
  • Alessandro Bulfone
  • Andrea Ballabio
  • Sandro Banfi
  • Cristina Mocchetti
  • Vera Martos
  • Giovanna Alfano
  • Luca Crippa
  • Valeria Marigo
  • D Acampora
  • P Gruss
  • M Torres
  • M Signore
  • I Fernaud-Espinosa
  • H G Brunner
  • M J Seller
  • D Edgar

Detail Information

Publications42

  1. ncbi SFRP1 modulates retina cell differentiation through a beta-catenin-independent mechanism
    Pilar Esteve
    Departamento de Neurobiologia del Desarrollo, Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    J Cell Sci 116:2471-81. 2003
    ..Furthermore, retroviral mediated expression of a dominant-negative form of GSK3beta induced a retina phenotype similar to that observed after Sfrp1 overexpression, suggesting a possible involvement of this kinase in SFRP1 function...
  2. doi Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease
    Paola Bovolenta
    Departamento de Neurobiología Molecular, Celular y del Desarrollo, Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    J Cell Sci 121:737-46. 2008
    ..Here we review some of the debated aspects of SFRP-Wnt interactions and discuss the new and emerging roles of SFRPs...
  3. pmc The Netrin-related domain of Sfrp1 interacts with Wnt ligands and antagonizes their activity in the anterior neural plate
    Javier Lopez-Rios
    Departamento de Neurobiología Molecular Celular y del Desarrollo, Instituto Cajal, CSIC, Dr Arce 37, Madrid, 28002, Spain
    Neural Dev 3:19. 2008
    ..Due to its structural relationship with Fz, it is believed that SfrpCRD interferes with Wnt signalling by binding and sequestering the ligand. In contrast, the functional relevance of the SfrpNTR has been barely addressed...
  4. pmc Comprehensive characterization of the cis-regulatory code responsible for the spatio-temporal expression of olSix3.2 in the developing medaka forebrain
    Ivan Conte
    Departamento de Neurobiología Celular, Molecular y del Desarrollo, Instituto Cajal, CSIC, Dr Arce, Madrid 28002, Spain
    Genome Biol 8:R137. 2007
    ..To address this issue, we have focused on Six3, an important regulator of vertebrate forebrain development...
  5. ncbi Morphogen signaling at the vertebrate growth cone: a few cases or a general strategy?
    Paola Bovolenta
    Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    J Neurobiol 64:405-16. 2005
    ..The data that support this conclusion will be summarized and how morphogens may signal at the growth cone will be discussed...
  6. ncbi Expression pattern of cSix3, a member of the Six/sine oculis family of transcription factors
    P Bovolenta
    Unidad de Neurobiologia del Desarollo, Instituto Cajal, Madrid, Spain
    Mech Dev 70:201-3. 1998
    ..In the developing neural retina, cSix3 is expressed in the entire undifferentiated neuroepithelium but is rapidly downregulated, first in the postmitotic photoreceptors and later in the majority of retinal ganglion cells...
  7. ncbi Frizzled/RYK mediated signalling in axon guidance
    Paola Bovolenta
    Departamento de Neurobiologia del Desarrollo, Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    Development 133:4399-408. 2006
  8. ncbi Nervous system proteoglycans as modulators of neurite outgrowth
    P Bovolenta
    Departamento de Neurobiologia del Desarrollo, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Dr Arce 37, 28002, Madrid, Spain
    Prog Neurobiol 61:113-32. 2000
    ..Special emphasis will be placed on those studies that have shown that proteoglycans of certain subtypes inhibit neurite extension either during the development and/or the regeneration of the vertebrate Central Nervous System...
  9. ncbi Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies
    M E Gallardo
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Velazquez 144, Madrid, 28006, Spain
    Genomics 61:82-91. 1999
    ..3-q23 with bilateral anophthalmia and pituitary anomalies. Genomic analyses of one of these cases demonstrated SIX6 hemizygosity, strongly suggesting that SIX6 haploinsufficiency is responsible for these developmental disorders...
  10. ncbi Six9 (Optx2), a new member of the six gene family of transcription factors, is expressed at early stages of vertebrate ocular and pituitary development
    J Lopez-Rios
    Departamento de Neurobiologia del Desarrollo, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Dr Arce 37, E28002, Madrid, Spain
    Mech Dev 83:155-9. 1999
    ....
  11. ncbi Otx genes are required for tissue specification in the developing eye
    J R Martinez-Morales
    Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    Development 128:2019-30. 2001
    ....
  12. ncbi Bmp4 mediates apoptotic cell death in the developing chick eye
    F Trousse
    Departamento de Neurobiologia del Desarollo, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    J Neurosci 21:1292-301. 2001
    ..These results provide evidence that BMP4 contributes to eye development by promoting cell proliferation and programmed cell death...
  13. ncbi Control of early cell death by BDNF in the chick retina
    J M Frade
    Instituto Cajal de Neurobiologia, CSIC, Madrid, Spain
    Development 124:3313-20. 1997
    ..Our data indicate that early cell death is an important process in the neurogenesis of retinal ganglion cells and is regulated by locally produced BDNF...
  14. ncbi Early and dynamic expression of cSfrp1 during chick embryo development
    P Esteve
    Departamento de Neurobiologia del Desarrollo, Instituto Cajal, CSIC, Dr Arce 37, 28002, Madrid, Spain
    Mech Dev 97:217-21. 2000
    ....
  15. ncbi Control of retinal ganglion cell axon growth: a new role for Sonic hedgehog
    F Trousse
    Instituto Cajal, CSIC, Av. Doctor Arce 37, 28002 Madrid, Spain
    Development 128:3927-36. 2001
    ..Based on these findings, we propose that Shh expression at the chiasm border defines a constrained pathway within the ventral midline which serves to guide the progression of RGC axons...
  16. ncbi Morphogens as growth cone signalling molecules
    Cristina Sánchez-Camacho
    Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    Brain Res Brain Res Rev 49:242-52. 2005
    ..Here, we have summarised the evidence for this novel idea with a particular emphasis on those related to Shh and Wnt signalling-the object of some works in our laboratory...
  17. ncbi OTX2 activates the molecular network underlying retina pigment epithelium differentiation
    Juan Ramon Martinez-Morales
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Dr Arce 37, Madrid 28002, Spain
    J Biol Chem 278:21721-31. 2003
    ..Collectively, these data suggest that both transcription factors operate at the same hierarchical level to establish the identity of the RPE...
  18. ncbi cSix4, a member of the six gene family of transcription factors, is expressed during placode and somite development
    P Esteve
    Unidad de Neurobiologia del Desarrollo, Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    Mech Dev 85:161-5. 1999
    ....
  19. ncbi Genomic cloning, structure, expression pattern, and chromosomal location of the human SIX3 gene
    B Granadino
    Departamento de Inmunologia, Centro de Investigaciones Biologicas Consejo Superior de Investigaciones Cientificas, Velazquez 144, Madrid, 28006, Spain
    Genomics 55:100-5. 1999
    ..Interestingly, the map position of human SIX3 overlaps the locations of two dominant disorders with ocular phenotypes that have been assigned to this chromosomal region, holoprosencephaly type 2 and Malattia Leventinese...
  20. ncbi Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH
    Julian Morcillo
    Departamento de Neurobiologia del Desarrollo, Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    Development 133:3179-90. 2006
    ..Collectively, these data indicate that BMP7 is required for retinal fissure formation and that its activity is needed, before SHH signalling, for the generation of PAX2-positive cells at the optic disc...
  21. ncbi SFRP1 regulates the growth of retinal ganglion cell axons through the Fz2 receptor
    Josana Rodriguez
    Departamento de Neurobiologia del Desarrollo, Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    Nat Neurosci 8:1301-9. 2005
    ....
  22. ncbi Sonic hedgehog in CNS development: one signal, multiple outputs
    Elisa Marti
    Instituto de Biología Molecular de Barcelona CID CSIC, Jordi Girona 18, 08034, Barcelona, Spain
    Trends Neurosci 25:89-96. 2002
    ..Therefore, a more precise understanding of the molecular mechanisms that underlie the different responses to SHH signalling is the next step in the study of this molecule and its role in the regulation of neural development...
  23. ncbi Comparative analysis of Six 3 and Six 6 distribution in the developing and adult mouse brain
    Ivan Conte
    Departamento de Neurobiologia del Desarrollo, Instituto Cajal, CSIC, Madrid, Spain
    Dev Dyn 234:718-25. 2005
    ..These distinct patterns support the idea that Six 3 and Six 6 are differentially required during forebrain development...
  24. ncbi Six3 and Six6 activity is modulated by members of the groucho family
    Javier Lopez-Rios
    Instituto Cajal, CSIC, Avenida Doctor Arce 37, 28002 Madrid, Spain
    Development 130:185-95. 2003
    ..These data indicate that both Tle1 and Aes participate in the molecular network that control eye development and are consistent with the view that both Six3 and Six6 act in combination with either Tle1 and/or Aes...
  25. doi Autonomous and non-autonomous Shh signalling mediate the in vivo growth and guidance of mouse retinal ganglion cell axons
    Cristina Sánchez-Camacho
    Departamento de Neurobiología Molecular Celular y del Desarrollo, Instituto Cajal, CSIC and CIBER de Enfermedades Raras CIBERER 37, Madrid 28002, Spain
    Development 135:3531-41. 2008
    ....
  26. pmc Meox homeodomain proteins are required for Bapx1 expression in the sclerotome and activate its transcription by direct binding to its promoter
    Isabel Rodrigo
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    Mol Cell Biol 24:2757-66. 2004
    ..Our data demonstrate that the Meox genes are required for Bapx1 expression in the sclerotome and suggest that the mechanism by which the Meox proteins exert this function is through direct activation of the Bapx1 gene...
  27. ncbi The advantages and disadvantages of sfrp1 and sfrp2 expression in pathological events
    Pilar Esteve
    Departamento de Neurobiología Molecular, Celular y del Desarrollo, Instituto Cajal CSIC, Spain
    Tohoku J Exp Med 221:11-7. 2010
    ..Here, we summarise the evidence that relates Sfrps with these diseases and discuss how the proposed multiple Sfrp interactions with Wnt related and unrelated pathways may explain their implication in such diverse pathologies...
  28. doi Growth and differentiation of the retina and the optic tectum in the medaka fish requires olSfrp5
    Jose Maria Ruiz
    Departamento de Neurobiología Molecular Celular y del Desarrollo, Instituto Cajal, CSIC, Madrid 28002, Spain
    Dev Neurobiol 69:617-32. 2009
    ..The results point to an important role of olSfrp5 in visual system formation and indicate that olSfrp1 and olSfrp5, despite their overlapping expression, have only partially redundant function during eye development...
  29. doi Emerging mechanisms in morphogen-mediated axon guidance
    Cristina Sánchez-Camacho
    Departamento de Neurobiología Molecular, Celular y del Desarrollo, Instituto Cajal, CSIC and CIBER de Enfermedades Raras CIBERER, Madrid, Spain
    Bioessays 31:1013-25. 2009
    ....
  30. ncbi Vitronectin is expressed in the ventral region of the neural tube and promotes the differentiation of motor neurons
    J R Martinez-Morales
    Instituto Cajal de Neurobiologia, CSIC, Madrid, Spain
    Development 124:5139-47. 1997
    ....
  31. doi Proper differentiation of photoreceptors and amacrine cells depends on a regulatory loop between NeuroD and Six6
    Ivan Conte
    Instituto Cajal, CSIC and CIBER de Enfermedades Raras, Madrid, Spain
    Development 137:2307-17. 2010
    ..Together, these results indicate that Six6 and NeuroD control the expression of each other and their functions coordinate amacrine cell generation and photoreceptor terminal differentiation...
  32. ncbi SFRP1 is required for the proper establishment of the eye field in the medaka fish
    Pilar Esteve
    Departamento de Neurobiologia del Desarrollo, Instituto Cajal, CSIC, Avenida Dr Arce 37, Madrid 28002, Spain
    Mech Dev 121:687-701. 2004
    ..In addition, olSfrp1 may contribute to the control of mesodermal convergence extension movements that take place during gastrulation...
  33. ncbi Evaluation of SFRP1 as a candidate for human retinal dystrophies
    Maria Garcia-Hoyos
    Department of Genetics, Fundacion Jimenez Diaz, Madrid, Spain
    Mol Vis 10:426-31. 2004
    ..Because the genetic causes of many retinal dystrophies still need to be determined, we have asked whether mutations in the SFRP genes might be associated with retinal dystrophies...
  34. ncbi Eye development: a view from the retina pigmented epithelium
    Juan Ramon Martinez-Morales
    Instituto Cajal, CSIC, Madrid, Spain
    Bioessays 26:766-77. 2004
    ..Furthermore, using this information and the data available on the specification of the pigmented cells of primitive chordates, we have ventured some hypotheses on the origin of RPE cells during evolution...
  35. ncbi Secreted inducers in vertebrate eye development: more functions for old morphogens
    Pilar Esteve
    Departamento de Neurobiologia del Desarrollo, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Doctor Arce 37, Madrid 28002, Spain
    Curr Opin Neurobiol 16:13-9. 2006
    ..In addition, later on in development, Fgf controls the onset of retinal neurogenesis and Shh and GDF11 control its feedback regulation...
  36. pmc Cux1 and Cux2 regulate dendritic branching, spine morphology, and synapses of the upper layer neurons of the cortex
    Beatriz Cubelos
    Centro Nacional de Biotecnologia, CSIC, Darwin 3, Campus de Cantoblanco, Madrid 28049, Spain
    Neuron 66:523-35. 2010
    ..These demonstrate critical roles of Cux in dendritogenesis and highlight subclass-specific mechanisms of synapse regulation that contribute to the establishment of cognitive circuits...
  37. ncbi Sonic hedgehog promotes the migration and proliferation of optic nerve oligodendrocyte precursors
    Paloma Merchan
    Grupo de Neurobiología del Desarrollo, Hospital Nacional de Paraplejicos, Finca La Peraleda, S N, E 45071 Toledo, Spain
    Mol Cell Neurosci 36:355-68. 2007
    ..Altogether these data indicate that Shh contributes to OPC proliferation and distribution along the ON, in addition to their specification...
  38. ncbi Differentiation of the vertebrate retina is coordinated by an FGF signaling center
    Juan Ramon Martinez-Morales
    Developmental Biology Programme, EMBL Heidelberg, Meyerhofstrasse 1, 69012 Heidelberg, Germany
    Dev Cell 8:565-74. 2005
    ..The concerted activity of Fgf8 and Fgf3 is both necessary and sufficient to coordinate retinal differentiation independent of the connecting optic stalk...
  39. ncbi Vax2 inactivation in mouse determines alteration of the eye dorsal-ventral axis, misrouting of the optic fibres and eye coloboma
    Anna Maria Barbieri
    Telethon Institute of Genetics and Medicine TIGEM, Via Pietro Castellino 111, Naples, Italy
    Development 129:805-13. 2002
    ....
  40. ncbi Developmental changes in the Ca2+-regulated mitochondrial aspartate-glutamate carrier aralar1 in brain and prominent expression in the spinal cord
    Milagros Ramos
    Departamento de Biologia Molecular, Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Brain Res Dev Brain Res 143:33-46. 2003
    ..The presence of aralar1 could reflect a tonic activity of these neurons, which is met by the combination of high malate-aspartate NADH shuttle and respiratory chain activities...
  41. ncbi Introduction: unexpected roles for morphogens in the development and regeneration of the CNS
    Paola Bovolenta
    J Neurobiol 64:321-3. 2005
  42. ncbi Expression of the aspartate/glutamate mitochondrial carriers aralar1 and citrin during development and in adult rat tissues
    Araceli del Arco
    Departamento de Biologia Molecular, Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Eur J Biochem 269:3313-20. 2002
    ..This explains why citrin deficiency in humans (type II citrullinemia) only affects the liver and suggests that aralar1 may compensate for the lack of citrin in other tissues...