Miguel Blanca

Summary

Country: Spain

Publications

  1. ncbi Specificities of B cell reactions to drugs. The penicillin model
    Miguel Blanca
    Allergy Service and Research Unit for Allergic Diseases, Carlos Haya Hospital, Plaza del Hospital Civil s n, 29009 Malaga, Spain
    Toxicology 209:181-4. 2005
  2. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
  3. ncbi Continued need of appropriate betalactam-derived skin test reagents for the management of allergy to betalactams
    M Blanca
    Allergy Service, Carlos Haya Hospital, Malaga, Spain
    Clin Exp Allergy 37:166-73. 2007
  4. pmc Synergistic effect between amoxicillin and TLR ligands on dendritic cells from amoxicillin-delayed allergic patients
    Maria J Sanchez-Quintero
    Research Laboratory, Carlos Haya Hospital IBIMA, Malaga, Spain
    PLoS ONE 8:e74198. 2013
  5. pmc Antigenic proteins involved in occupational rhinitis and asthma caused by obeche wood (Triplochiton scleroxylon)
    Ana Aranda
    Allergy Research Laboratory, Carlos Haya Hospital, Malaga, Spain
    PLoS ONE 8:e53926. 2013
  6. doi Effect of Pru p 3 on dendritic cell maturation and T-lymphocyte proliferation in peach allergic patients
    Enrique Gomez
    Research Laboratory for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
    Ann Allergy Asthma Immunol 109:52-8. 2012
  7. ncbi Follow-up study in local allergic rhinitis shows a consistent entity not evolving to systemic allergic rhinitis
    Carmen Rondon
    Allergy Service, Carlos Haya Hospital, Malaga, Spain Electronic address
    J Allergy Clin Immunol 133:1026-31. 2014
  8. doi Nasal inflammatory mediators and specific IgE production after nasal challenge with grass pollen in local allergic rhinitis
    Carmen Rondon
    Allergy Service, Carlos Haya Hospital, Malaga, Spain
    J Allergy Clin Immunol 124:1005-11.e1. 2009
  9. ncbi Prediction of hypersensitivity to antibiotics: what factors need to be considered?
    Adriana Ariza
    Research Laboratory for Allergic Diseases, Hospital Regional Universitario de Málaga IBIMA, Malaga, Spain
    Expert Rev Clin Immunol 9:1279-88. 2013
  10. ncbi Basophil activation after nonsteroidal anti-inflammatory drugs stimulation in patients with immediate hypersensitivity reactions to these drugs
    Adriana Ariza
    Research Laboratory, Instituto de Investigación Biomédica de Málaga Ibima, Hospital Universitario Regional de Málaga, UMA, Malaga, Spain
    Cytometry A 85:400-7. 2014

Collaborators

Detail Information

Publications48

  1. ncbi Specificities of B cell reactions to drugs. The penicillin model
    Miguel Blanca
    Allergy Service and Research Unit for Allergic Diseases, Carlos Haya Hospital, Plaza del Hospital Civil s n, 29009 Malaga, Spain
    Toxicology 209:181-4. 2005
    ....
  2. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
    ..Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein...
  3. ncbi Continued need of appropriate betalactam-derived skin test reagents for the management of allergy to betalactams
    M Blanca
    Allergy Service, Carlos Haya Hospital, Malaga, Spain
    Clin Exp Allergy 37:166-73. 2007
    ..Furthermore, skin tests are the most readily available form of allergy testing for physicians. This paper reviews the results of skin tests in BL allergy and provides evidence for their continued need...
  4. pmc Synergistic effect between amoxicillin and TLR ligands on dendritic cells from amoxicillin-delayed allergic patients
    Maria J Sanchez-Quintero
    Research Laboratory, Carlos Haya Hospital IBIMA, Malaga, Spain
    PLoS ONE 8:e74198. 2013
    ....
  5. pmc Antigenic proteins involved in occupational rhinitis and asthma caused by obeche wood (Triplochiton scleroxylon)
    Ana Aranda
    Allergy Research Laboratory, Carlos Haya Hospital, Malaga, Spain
    PLoS ONE 8:e53926. 2013
    ..Obeche wood dust is a known cause of occupational asthma where an IgE-mediated mechanism has been demonstrated...
  6. doi Effect of Pru p 3 on dendritic cell maturation and T-lymphocyte proliferation in peach allergic patients
    Enrique Gomez
    Research Laboratory for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
    Ann Allergy Asthma Immunol 109:52-8. 2012
    ..Pru p 3 is the major peach allergen and the most frequent cause of food allergy in adults in the Mediterranean area. Although its allergenicity is well characterized, its ability to generate a T-cell response is not completely known...
  7. ncbi Follow-up study in local allergic rhinitis shows a consistent entity not evolving to systemic allergic rhinitis
    Carmen Rondon
    Allergy Service, Carlos Haya Hospital, Malaga, Spain Electronic address
    J Allergy Clin Immunol 133:1026-31. 2014
    ..Whether LAR is the first step in the natural history of allergic rhinitis (AR) with systemic atopy or a consistent entity is unknown...
  8. doi Nasal inflammatory mediators and specific IgE production after nasal challenge with grass pollen in local allergic rhinitis
    Carmen Rondon
    Allergy Service, Carlos Haya Hospital, Malaga, Spain
    J Allergy Clin Immunol 124:1005-11.e1. 2009
    ..However, the immunologic mechanisms involved are still poorly understood...
  9. ncbi Prediction of hypersensitivity to antibiotics: what factors need to be considered?
    Adriana Ariza
    Research Laboratory for Allergic Diseases, Hospital Regional Universitario de Málaga IBIMA, Malaga, Spain
    Expert Rev Clin Immunol 9:1279-88. 2013
    ..These include the chemical properties, molecular weight and administration route of the drug and the age, gender, concomitant diseases and genetic factors of the patient...
  10. ncbi Basophil activation after nonsteroidal anti-inflammatory drugs stimulation in patients with immediate hypersensitivity reactions to these drugs
    Adriana Ariza
    Research Laboratory, Instituto de Investigación Biomédica de Málaga Ibima, Hospital Universitario Regional de Málaga, UMA, Malaga, Spain
    Cytometry A 85:400-7. 2014
    ....
  11. ncbi Immediate allergic reactions to cephalosporins: evaluation of cross-reactivity with a panel of penicillins and cephalosporins
    Cristina Antunez
    Research Laboratory for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
    J Allergy Clin Immunol 117:404-10. 2006
    ..The problem of studying cross-reactivity in subjects primarily sensitized to cephalosporins and potentially allergic to penicillins has not been sufficiently addressed...
  12. doi Drug provocation tests in the diagnosis of hypersensitivity reactions to non-steroidal anti-inflammatory drugs in children
    Maria A Zambonino
    Pediatric Service, Carlos Haya Hospital, Malaga, Spain
    Pediatr Allergy Immunol 24:151-9. 2013
    ....
  13. doi Induction of accelerated reactions to amoxicillin by T-cell effector mechanisms
    Enrique Gomez
    Research Laboratory for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
    Ann Allergy Asthma Immunol 110:267-73. 2013
    ..Although allergic drug reactions have been considered to be immediate (IgE mediated) or delayed (T-cell effector mechanisms), accelerated reactions have also been defined; however, they have not been sufficiently studied...
  14. doi Immunological mechanisms underlying delayed-type hypersensitivity reactions to glatiramer acetate
    Cristobalina Mayorga
    Pediatrics Service, Carlos Haya Hospital, Malaga, Spain
    Ann Allergy Asthma Immunol 109:47-51. 2012
    ..Delayed-type hypersensitivity to glatiramer acetate is rare, and the underlying immunological mechanisms are not completely understood...
  15. ncbi Nonimmediate reactions to betalactams
    Soledad Lopez
    Research Laboratory, Carlos Haya Hospital Fundacion IMABIS, Malaga, Spain
    Curr Opin Allergy Clin Immunol 7:310-6. 2007
    ..Nonimmediate reactions to beta-lactams include several clinical entities, from maculopapular rash to severe reactions such as Steven-Johnson syndrome. Toxic epidermal necrolysis and organ-specific reactions may also occur...
  16. doi Food allergy: management, diagnosis and treatment strategies
    Enrique Gomez
    Research Laboratory for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
    Immunotherapy 5:755-68. 2013
    ..Other treatments such as anti-IgE monoclonal antibody therapy, adjuvant therapy and Chinese herbs will also be described. ..
  17. doi The complex clinical picture of beta-lactam hypersensitivity: penicillins, cephalosporins, monobactams, carbapenems, and clavams
    Maria J Torres
    Allergy Service, Plaza del Hospital Civil, Pabellón 5 Sótano, Carlos Haya Hospital, Pabellon C, Malaga 29009, Spain
    Med Clin North Am 94:805-20, xii. 2010
    ..The natural history of IgE-mediated reactions indicates that the count of specific IgE antibodies decreases over time and that results of diagnostic tests can become negative...
  18. ncbi Hypersensitivity reactions to non-steroidal anti-inflammatory drugs
    Jose Antonio Cornejo-Garcia
    Research Group of Allergic Diseases, Research Laboratory, IMABIS Foundation Carlos Haya Hospital, Malaga, Spain
    Curr Drug Metab 10:971-80. 2009
    ..In this work we review current knowledge on hypersensitivity reactions to NSAIDs, including diagnostic approach and genetic studies...
  19. doi Nasal allergen provocation test with multiple aeroallergens detects polysensitization in local allergic rhinitis
    Carmen Rondon
    Allergy Service, Carlos Haya Hospital, Malaga, Spain
    J Allergy Clin Immunol 128:1192-7. 2011
    ..Patients previously given a diagnosis of nonallergic rhinitis (NAR) might have a new form of local allergic rhinitis (LAR) with local production of specific IgE antibodies and a positive response to a nasal allergen provocation test (NAPT)...
  20. doi Diagnostic evaluation of hypersensitivity reactions to beta-lactam antibiotics in a large population of children
    Maria A Zambonino
    Paediatric Service, Carlos Haya Hospital, Malaga, Spain
    Pediatr Allergy Immunol 25:80-7. 2014
    ..Although many of these children are considered to be allergic, a careful evaluation only confirms a low percentage...
  21. doi Evolution of patients with nonallergic rhinitis supports conversion to allergic rhinitis
    Carmen Rondon
    Allergy Service, Carlos Haya Hospital, Malaga, Spain
    J Allergy Clin Immunol 123:1098-102. 2009
    ..Once allergy has been ruled out, most of these patients are not usually followed up in allergy clinics, despite the persistence of rhinitis symptoms. Thus few data are available concerning the natural evolution of these patients...
  22. doi Fluoroquinolone photodegradation influences specific basophil activation
    Cristobalina Mayorga
    Research Laboratory, Carlos Haya Hospital, Malaga, Spain
    Int Arch Allergy Immunol 160:377-82. 2013
    ..4% in both conditions). We can conclude that light exposure is a critical factor in BAT results when photolabile drugs like MOX are used. Therefore, light is important when interpreting in vitro results...
  23. doi Methodologies to anchor dendrimeric nanoconjugates to solid phase: toward an efficient in vitro detection of allergy to β-lactam antibiotics
    Maria I Montañez
    Research Laboratory, IMABIS Foundation Carlos Haya Hospital, Malaga, Spain
    Nanomedicine 7:682-5. 2011
    ..Selective and specific IgE recognition was observed in the different activated disks, though those activated with haloalkanoyl halides presented better sensitivity...
  24. ncbi Work-related sensitization and respiratory symptoms in carpentry apprentices exposed to wood dust and diisocyanates
    Paloma Campo
    Allergy Department, Carlos Haya Hospital, Malaga, Spain
    Ann Allergy Asthma Immunol 105:24-30. 2010
    ..Exposure to certain substances in the workplace may lead to sensitization and increased respiratory symptoms...
  25. ncbi Hypersensitivity reactions to beta-lactams
    Maria J Torres
    Allergy Service, Pabellón 6, primera planta, IBIMA, Carlos Haya Hospital Pabellon C, Plaza del Hospital Civil, 29009, Malaga, Spain
    EXS 104:165-84. 2014
    ..A Th1 pattern is observed in both CD4(+) and CD8(+) peripheral T cells in non-immediate reactions, whereas a Th2 pattern is expressed in CD4(+) T cells in immediate reactions. ..
  26. doi Molecular mechanisms of maculopapular exanthema
    Tahia D Fernandez
    Research Laboratory for Allergic Diseases, Carlos Haya Hospital Fundacion IMABIS, Malaga, Spain
    Curr Opin Infect Dis 22:272-8. 2009
    ..In spite of its high frequency, knowledge of the molecular mechanisms involved remains scarce...
  27. pmc Variants of CEP68 gene are associated with acute urticaria/angioedema induced by multiple non-steroidal anti-inflammatory drugs
    Jose Antonio Cornejo-Garcia
    Research Laboratory, IBIMA Málaga University General Hospital, Malaga, Spain
    PLoS ONE 9:e90966. 2014
    ....
  28. pmc Study of protein haptenation by amoxicillin through the use of a biotinylated antibiotic
    Adriana Ariza
    Department of Chemical and Physical Biology, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain Research Laboratory Carlos Haya Hospital IBIMA, Malaga, Spain
    PLoS ONE 9:e90891. 2014
    ..Thus, AX-B may constitute a valuable tool for the identification of AX targets with high sensitivity as well as for the elucidation of the mechanisms involved in allergy towards β-lactams. ..
  29. ncbi Cytokine production, activation marker, and skin homing receptor in children with atopic dermatitis and bronchial asthma
    Cristina Antunez
    Research Unit for Allergic Diseases, Allergic Service, Carlos Haya Hospital, Malaga, Spain
    Pediatr Allergy Immunol 17:166-74. 2006
    ..Moreover, the subpopulations (CLA+ vs. CLA-) expressing these changes were different, indicating that the underlying mechanisms in the two diseases are not exactly the same...
  30. ncbi Local IgE production and positive nasal provocation test in patients with persistent nonallergic rhinitis
    Carmen Rondon
    Allergy Service Carlos Haya Hospital, Malaga, Spain
    J Allergy Clin Immunol 119:899-905. 2007
    ..Despite suggestive symptoms of allergic rhinitis, some patients have a negative diagnostic test for atopy...
  31. ncbi Local allergic rhinitis: concept, pathophysiology, and management
    Carmen Rondon
    Allergy Service, Carlos Haya Hospital, Malaga, Spain
    J Allergy Clin Immunol 129:1460-7. 2012
    ..Further studies are needed for examine the prevalence of this phenomenon in different areas, to improve the diagnostic methods to better identify these patients, and to develop therapeutic approaches, including the use of immunotherapy...
  32. doi Local allergic rhinitis: a new entity, characterization and further studies
    Carmen Rondon
    Carlos Haya Hospital, Malaga, Spain
    Curr Opin Allergy Clin Immunol 10:1-7. 2010
    ....
  33. ncbi Potential involvement of dendritic cells in delayed-type hypersensitivity reactions to beta-lactams
    Rebeca Rodriguez-Pena
    Research Laboratory Carlos Haya Hospital Fundacion IMABIS, Spain
    J Allergy Clin Immunol 118:949-56. 2006
    ..Dendritic cells (DCs) are professional antigen-presenting cells essential for initiating T-cell responses. Their ability is regulated in a process known as maturation, by which they modulate the effector immune response...
  34. ncbi Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations
    Jose Antonio Cornejo-Garcia
    Research Laboratory, UGC Allergy, Málaga General Hospital, Malaga, Spain
    Pharmacogenomics 14:1857-69. 2013
    ..In this work, we conducted a genome-wide association study in Spanish and Han Chinese patients suffering from NSAID-induced AUA...
  35. pmc Immunologic evaluation of drug allergy
    Enrique Gomez
    Research Laboratory, Carlos Haya Hospital, Malaga, Spain
    Allergy Asthma Immunol Res 4:251-63. 2012
    ..The monitorization of the acute response of the reactions has given clues for understanding these reactions and has promising results for the future of the immunological evaluation of HDR...
  36. ncbi Cephalosporin chemical reactivity and its immunological implications
    Ezequiel Perez-Inestrosa
    Organic Chemistry Department, University of Malaga, Carlos Haya Hospital, Malaga, Spain
    Curr Opin Allergy Clin Immunol 5:323-30. 2005
    ..The aim of this article is to analyze the chemical reactivity of cephalosporins resulting in the epitope responsible for recognition by IgE antibodies and to establish the basis of the allergenicity...
  37. ncbi Gene expression levels of cytokine profile and cytotoxic markers in non-immediate reactions to drugs
    Sinforiano J Posadas
    Allergy Service, La Paz Hospital, Madrid, Spain
    Blood Cells Mol Dis 29:179-89. 2002
    ..01). These data demonstrate the complexity of the Th1 phenotype in NIR after drug intake. In patients with mild NIR, cytokines appear to play a closely related role, whereas cytotoxic markers appear more relevant in severe reactions...
  38. ncbi Improvement of toxic epidermal necrolysis after the early administration of a single high dose of intravenous immunoglobulin
    Cristobalina Mayorga
    Research Unit for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
    Ann Allergy Asthma Immunol 91:86-91. 2003
    ..Toxic epidermal necrolysis (TEN) is a severe disease often induced by drugs. Treatment is controversial, although intravenous immunoglobulins (IVIGs) have been effective...
  39. ncbi Delayed reactions to drugs show levels of perforin, granzyme B, and Fas-L to be related to disease severity
    Sinforiano J Posadas
    Allergy Service, La Paz Hospital, Madrid the Research Unit for Allergy Diseases, Carlos Haya Hospital, Malaga, Spain
    J Allergy Clin Immunol 109:155-61. 2002
    ..T lymphocytes produce cytotoxic markers that are responsible for 2 major pathways to cell death: granule-mediated exocytosis (perforin and granzyme B) and Fas/FasL interaction...
  40. ncbi Penicillin allergy is a global problem: the European experience
    Miguel Blanca
    J Allergy Clin Immunol 112:1014-5; author reply 1015-6. 2003
  41. ncbi The contribution of major and minor determinants from benzylpenicillin to the diagnosis of immediate allergy to beta-lactams
    Maria Jose Torres
    J Allergy Clin Immunol 117:220-1; author reply 221. 2006
  42. ncbi Anaphylaxis to Mare's milk
    Silvia Robles
    Ann Allergy Asthma Immunol 98:600-2. 2007
  43. ncbi Cephalosporin allergy
    Cristobalina Mayorga
    N Engl J Med 346:380-1. 2002
  44. ncbi Boosted IgE response after anaphylaxis reaction to cefuroxime with cross-reactivity with cefotaxime
    Blanca Sáenz de San Pedro
    Allergy Unit, Ciudad de Jaén Hospital, Spain
    Ann Allergy Asthma Immunol 89:101-3. 2002
    ..Cefuroxime is a second-generation lactamase-stable cephalosporin. Its use is on the increase, and in recent years several reactions to this compound have been reported...
  45. doi Dendrimerized cellulose as a scaffold for artificial antigens with applications in drug allergy diagnosis
    Maria I Montañez
    Department of Organic Chemistry, Faculty of Sciences, University of Malaga, 29071 Malaga, Spain
    Biomacromolecules 9:1461-6. 2008
    ..The proposed method provides an effective tool for developing clinically testable materials with a view to studying adverse immunological responses to drugs in humans...
  46. ncbi Immediate allergy to tetanus toxoid vaccine: determination of immunoglobulin E and immunoglobulin G antibodies to allergenic proteins
    Cristobalina Mayorga
    Research Unit for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
    Ann Allergy Asthma Immunol 90:238-43. 2003
    ..001%. When TT induces an allergic reaction, the potential causative agents can be TT antigens, thimerosal or aluminum phosphate...
  47. ncbi Anaphylactic reaction to diphtheria-tetanus vaccine in a child: specific IgE/IgG determinations and cross-reactivity studies
    M Flora Martín-Muñoz
    Allergy Service, University Hospital La Paz, Paseo de la Castellana, 261, 28046 Madrid, Spain
    Vaccine 20:3409-12. 2002
    ..We show that simultaneous IgE antibodies to two different toxoids may occur, indicating that after an immediate reaction to DT, a search for IgE antibodies to both tetanus and Dtx should be undertaken...
  48. ncbi Synthesis, characterization and immunochemical evaluation of cephalosporin antigenic determinants
    Francisco Sánchez-Sancho
    Department of Organic Chemistry, Faculty of Science, University of Malaga, Malaga, Spain
    J Mol Recognit 16:148-56. 2003
    ..Thus, these data indicate that recognition is mainly directed to the acyl side chain and to the beta-lactam fragment that remains linked to the carrier protein in the cephalosporin conjugation course...