Herrero D, Cañon S, Albericio G, Carmona R, Aguilar S, Manes S, et al
. Age-related oxidative stress confines damage-responsive Bmi1+ cells to perivascular regions in the murine adult heart. Redox Biol. 2019;22:101156 pubmed publisher
..Thus, we identify cardiac perivascular regions as low-stress microenvironments that favor the maintenance of adult damage-responsive cells. ..
Torán J, Lopez J, Gomes Alves P, Aguilar S, Torroja C, Trevisan Herraz M, et al
. Definition of a cell surface signature for human cardiac progenitor cells after comprehensive comparative transcriptomic and proteomic characterization. Sci Rep. 2019;9:4647 pubmed publisher
..Among them, GPR4 demonstrated the highest discrimination capacity between all cell lineages analyzed. ..
Herrero D, Cañon S, Pelacho B, Salvador Bernáldez M, Aguilar S, Pogontke C, et al
. Bmi1-Progenitor Cell Ablation Impairs the Angiogenic Response to Myocardial Infarction. Arterioscler Thromb Vasc Biol. 2018;: pubmed publisher
Valiente Alandi I, Albo Castellanos C, Herrero D, Arza E, Garcia Gomez M, Segovia J, et al
. Cardiac Bmi1(+) cells contribute to myocardial renewal in the murine adult heart. Stem Cell Res Ther. 2015;6:205 pubmed publisher
..High Bmi1 expression identifies a non-cardiomyocyte resident cardiac population (B-CPC) that contributes to the main lineages of the heart in vitro and in vivo. ..
Valiente Alandi I, Albo Castellanos C, Herrero D, Sanchez I, Bernad A. Bmi1 (+) cardiac progenitor cells contribute to myocardial repair following acute injury. Stem Cell Res Ther. 2016;7:100 pubmed publisher
..Cardiac Bmi1 progenitor cells respond to cardiac injury, contributing to the generation of de novo CM in the adult mouse heart. ..
Herrero D, Tomé M, Cañon S, Cruz F, Carmona R, Fuster E, et al
. Redox-dependent BMI1 activity drives in vivo adult cardiac progenitor cell differentiation. Cell Death Differ. 2018;25:807-820 pubmed publisher
..These findings demonstrate how redox status influences the cardiac progenitor response, and identify redox-mediated BMI1 regulation with implications in maintenance of cellular identity in vivo. ..
Izarra A, Moscoso I, Levent E, CaÃ±Ã³n S, Cerrada I, DÃez Juan A, et al
. miR-133a enhances the protective capacity of cardiac progenitors cells after myocardial infarction. Stem Cell Reports. 2014;3:1029-42 pubmed publisher
..Finally, an inÂ vitro heart muscle model confirmed the antiapoptotic effects of miR-133a-CPCs, favoring the structuration and contractile functionality of the artificial tissue. ..
Gómez Mauricio G, Moscoso I, Martín Cancho M, Crisostomo V, Prat Vidal C, Báez Díaz C, et al
. Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model. Stem Cell Res Ther. 2016;7:94 pubmed publisher
Cañon S, Caballero R, Herraiz Martínez A, Pérez Hernández M, López B, Atienza F, et al
. miR-208b upregulation interferes with calcium handling in HL-1 atrial myocytes: Implications in human chronic atrial fibrillation. J Mol Cell Cardiol. 2016;99:162-173 pubmed publisher
..These findings clearly pointed to CAF-specific upregulated miR-208b as an important mediator in Ca2+ handling impairment during atrial remodeling. ..