Julian Benito-Leon

Summary

Country: Spain

Publications

  1. pmc Cognitive decline in short and long sleepers: a prospective population-based study (NEDICES)
    Julian Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain Department of Medicine, Faculty of Medicine, Complutense University, Madrid, Spain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Madrid, Spain Electronic address
    J Psychiatr Res 47:1998-2003. 2013
  2. pmc LINGO1 rs9652490 and rs11856808 polymorphisms are not associated with risk for multiple sclerosis
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology, University of Extremadura, Caceres, Spain
    BMC Neurol 13:34. 2013
  3. pmc Rate of cognitive decline during the premotor phase of essential tremor: a prospective study
    Julian Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    Neurology 81:60-6. 2013
  4. doi Obesity and impaired cognitive functioning in the elderly: a population-based cross-sectional study (NEDICES)
    J Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    Eur J Neurol 20:899-906, e76-7. 2013
  5. doi Impaired health-related quality of life predicts progression of disability in multiple sclerosis
    J Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    Eur J Neurol 20:79-86. 2013
  6. doi Impact of apathy on health-related quality of life in recently diagnosed Parkinson's disease: the ANIMO study
    Julian Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    Mov Disord 27:211-8. 2012
  7. doi Management of essential tremor, including medical and surgical approaches
    Julian Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Madrid, Spain
    Handb Clin Neurol 100:449-56. 2011
  8. ncbi Isolated CNS Whipple disease: acute onset and relapsing-remitting course
    Julian Benito-Leon
    Department of Neurology, Mostoles General Hospital, Mostoles, Madrid, Spain
    Scand J Infect Dis 39:623-5. 2007
  9. ncbi Impact of fatigue in multiple sclerosis: the Fatigue Impact Scale for Daily Use (D-FIS)
    J Benito-Leon
    Department of Neurology, Mostoles General Hospital, and Gregorio Marañón University, Madrid, Spain
    Mult Scler 13:645-51. 2007
  10. ncbi Clinical update: diagnosis and treatment of essential tremor
    Julian Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, E 28041 Madrid, Spain
    Lancet 369:1152-4. 2007

Detail Information

Publications88

  1. pmc Cognitive decline in short and long sleepers: a prospective population-based study (NEDICES)
    Julian Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain Department of Medicine, Faculty of Medicine, Complutense University, Madrid, Spain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Madrid, Spain Electronic address
    J Psychiatr Res 47:1998-2003. 2013
    ..We assessed cognitive decline as a function of self-reported sleep duration in a prospective population-based cohort (NEDICES)...
  2. pmc LINGO1 rs9652490 and rs11856808 polymorphisms are not associated with risk for multiple sclerosis
    Elena Garcia-Martin
    Department of Biochemistry and Molecular Biology, University of Extremadura, Caceres, Spain
    BMC Neurol 13:34. 2013
    ..These SNPs are linked to several SNPs within the LINGO1 gene, especially in individuals of Oriental or Caucasian descent...
  3. pmc Rate of cognitive decline during the premotor phase of essential tremor: a prospective study
    Julian Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    Neurology 81:60-6. 2013
    ..To characterize the rate of cognitive decline during the premotor phase of essential tremor (ET) in comparison to prevalent ET cases and controls...
  4. doi Obesity and impaired cognitive functioning in the elderly: a population-based cross-sectional study (NEDICES)
    J Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    Eur J Neurol 20:899-906, e76-7. 2013
    ..9 kg/m(2) ) and obese (BMI ≥ 30 kg/m(2) ) community-dwelling elderly participants compared with their counterparts with BMI < 25 kg/m(2) (i.e. controls) living in the same population...
  5. doi Impaired health-related quality of life predicts progression of disability in multiple sclerosis
    J Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    Eur J Neurol 20:79-86. 2013
    ..To determine the value of health-related quality of life (HRQOL) in predicting progression of disability in patients with multiple sclerosis (MS) over a period of 2 years...
  6. doi Impact of apathy on health-related quality of life in recently diagnosed Parkinson's disease: the ANIMO study
    Julian Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    Mov Disord 27:211-8. 2012
    ..It should be one of the primary concerns among clinicians who provide treatment to individuals affected by PD...
  7. doi Management of essential tremor, including medical and surgical approaches
    Julian Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Madrid, Spain
    Handb Clin Neurol 100:449-56. 2011
    ..For severe tremor, deep-brain stimulation of the thalamus may improve function...
  8. ncbi Isolated CNS Whipple disease: acute onset and relapsing-remitting course
    Julian Benito-Leon
    Department of Neurology, Mostoles General Hospital, Mostoles, Madrid, Spain
    Scand J Infect Dis 39:623-5. 2007
    ..We describe 2 patients with isolated CNS WD who presented unusually with an acute onset followed by a relapsing-remitting course. Neither was diagnosed with WD until they had had several relapses...
  9. ncbi Impact of fatigue in multiple sclerosis: the Fatigue Impact Scale for Daily Use (D-FIS)
    J Benito-Leon
    Department of Neurology, Mostoles General Hospital, and Gregorio Marañón University, Madrid, Spain
    Mult Scler 13:645-51. 2007
    ..The Fatigue Impact Scale for Daily Use (D-FIS) is an eight-item instrument designed to measure subjective daily experience of fatigue. This study sought to determine the metric properties of the D-FIS in multiple sclerosis (MS) patients...
  10. ncbi Clinical update: diagnosis and treatment of essential tremor
    Julian Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, E 28041 Madrid, Spain
    Lancet 369:1152-4. 2007
  11. ncbi Essential tremor: emerging views of a common disorder
    Julian Benito-Leon
    Department of Neurology, Mostoles General Hospital, Madrid, Spain
    Nat Clin Pract Neurol 2:666-78; quiz 2p following 691. 2006
    ..In addition, recent investigations of environmental toxicants that might be linked to ET open the way towards primary disease prevention through a reduction in exposure to these factors...
  12. ncbi Elderly-onset essential tremor is associated with dementia
    Julian Benito-Leon
    Department of Neurology, Mostoles General Hospital, Madrid, Spain
    Neurology 66:1500-5. 2006
    ..To determine whether essential tremor (ET) is associated with prevalent dementia...
  13. ncbi [Prophylactic treatment of migraine]
    Julian Benito-Leon
    Servicio de Neurologia, Hospital General de Mostoles, Mostoles, Madrid, Spain
    Med Clin (Barc) 126:467-72. 2006
  14. doi Risk of incident Parkinson's disease and parkinsonism in essential tremor: a population based study
    J Benito-Leon
    Department of Neurology, University Hospital, Madrid, Spain
    J Neurol Neurosurg Psychiatry 80:423-5. 2009
    ..A longstanding literature suggests an association between essential tremor (ET) and Parkinson's disease (PD). However, the risk of incident PD has not been quantified in cases of ET compared with controls...
  15. doi Elderly-onset essential tremor and mild cognitive impairment: a population-based study (NEDICES)
    Julian Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    J Alzheimers Dis 23:727-35. 2011
    ..73, 95% CI = 0.34 to 1.57, p = 0.43). In this study, older-onset ET was associated with MCI. This finding supports the hypothesis that cognitive disturbances are one of the core non-motor symptoms of ET...
  16. ncbi Population-based case-control study of cigarette smoking and essential tremor
    Julian Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    Mov Disord 23:246-52. 2008
    ..22-0.69, P = 0.001). We demonstrated an inverse association between ever smoking and ET. Additional studies are needed to reproduce these findings and assess whether this association is due to a biologically protective effect...
  17. doi Brain structural changes in essential tremor: voxel-based morphometry at 3-Tesla
    Julian Benito-Leon
    Departamento de Neurologia, Hospital Universitario 12 de Octubre, Madrid, Spain
    J Neurol Sci 287:138-42. 2009
    ..Two voxel-based morphometry (VBM) studies, each using a 1.5-T magnet, evaluated ET patients, leading to contradictory results. Using a 3-T magnet, we assessed whether white or gray matter changes occurred in ET patients vs. controls...
  18. doi Population-based case-control study of morale in Parkinson's disease
    J Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    Eur J Neurol 16:330-6. 2009
    ..Parkinson's disease (PD) is associated with cognitive, psychiatric, and motor features. Each could contribute to a poor sense of well-being and low morale. A systematic study of morale in community-dwelling PD cases has not been performed...
  19. pmc Low morale is associated with increased risk of mortality in the elderly: a population-based prospective study (NEDICES)
    Julian Benito-Leon
    The Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    Age Ageing 39:366-73. 2010
    ..the study aimed to assess the association between morale and mortality...
  20. doi Association between multiple sclerosis and Candida species: evidence from a case-control study
    J Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    Eur J Clin Microbiol Infect Dis 29:1139-45. 2010
    ..0 (1.5-6.1, p = 0.002) for Candida glabrata. The results were similar after excluding ten patients on immunosuppressants. The results of this single study suggest that Candida species infection may be associated with increased odds of MS...
  21. doi Isolated central nervous system Whipple's disease causing reversible frontotemporal-like dementia
    Julian Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    Clin Neurol Neurosurg 110:747-9. 2008
    ..Because Whipple's disease is treatable, it should be considered in the workup of patients with a FTD-like behavioural and cognitive syndrome...
  22. doi The CAREQOL-MS was a useful instrument to measure caregiver quality of life in multiple sclerosis
    Julian Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    J Clin Epidemiol 64:675-86. 2011
    ..To develop and test the first specific instrument for assessing caregiver health-related quality of life (HRQOL) in multiple sclerosis (MS) (CAREQOL-MS)...
  23. pmc Reported hearing impairment in essential tremor: a population-based case-control study
    Julian Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    Neuroepidemiology 29:213-7. 2007
    ..3; 95% confidence interval 1.01-1.7; p = 0.04). ET seemed to be associated with reported hearing impairment. The basis for this finding, which has been noted in several studies, deserves further exploration...
  24. doi Total daily sleep duration and the risk of dementia: a prospective population-based study
    J Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    Eur J Neurol 16:990-7. 2009
    ..We determined in a population-based study whether sleep duration was associated with an increased risk of incident dementia...
  25. ncbi Population-based case-control study of cognitive function in essential tremor
    Julian Benito-Leon
    Department of Neurology, Mostoles General Hospital, Mostoles, Madrid, Spain
    Neurology 66:69-74. 2006
    ..To determine whether patients with essential tremor (ET) have cognitive deficits when compared with controls and whether the types of cognitive deficits reported previously are also found in this large sampling of patients with ET...
  26. doi A population-based study of cognitive function in older people with subjective memory complaints
    Julian Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    J Alzheimers Dis 22:159-70. 2010
    ..Predictors of SMC may differ in those with versus without MCI and those with versus without depressive symptoms...
  27. ncbi [Ischemic stroke in children]
    J Benito-Leon
    Servicio de Neurologia Infantil, Hospital Universitario 12 de Octubre, Madrid, Espana
    Rev Neurol 27:631-4; discussion 634-5. 1998
    ..Ischemic stroke in children and infants is a rare condition. We present a series of 23 pediatric patients of ischemic stroke...
  28. ncbi [Backache as the initial symptom of adrenomyeloneuropathy]
    J Benito-Leon
    Servicio de Neurologia, Hospital General de Mostoles, Mostoles, Madrid, Espana
    Rev Neurol 31:1167-70. 2000
    ..We describe a patient with adrenomyeloneuropathy in whom the presenting symptom was lumbago...
  29. ncbi Prevalence of PD and other types of parkinsonism in three elderly populations of central Spain
    Julian Benito-Leon
    Department of Neurology, Mostoles General Hospital, Mostoles, Madrid, Spain
    Mov Disord 18:267-74. 2003
    ..Despite improvement in access to health services, an important proportion of PD patients may never seek neurological attention...
  30. ncbi [Intracranial hypotension syndrome]
    J Benito-Leon
    Servicios de Neurologia, Hospital General de Mostoles, Mostoles, Madrid, Spain
    Neurologia 16:418-26. 2001
    ..In this article, we review the clinical and neuroimaging findings, pathophysiology, and treatment of this syndrome...
  31. ncbi Health-related quality of life and its relationship to cognitive and emotional functioning in multiple sclerosis patients
    J Benito-Leon
    Department of Neurology, Mostoles General Hospital, Madrid, Spain
    Eur J Neurol 9:497-502. 2002
    ..Furthermore, we also found significant correlations between cognitive and emotional functioning tests and HRQoL dimensions. Thus, the worse cognitive functioning and the higher depressive and anxiety symptoms score the lower the HRQoL...
  32. doi Statins and cognitive functioning in the elderly: a population-based study
    Juliín Benito-León
    The Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    J Alzheimers Dis 21:95-102. 2010
    ..In this population-based sample, elderly participants treated with statins and untreated controls performed similarly in all tested cognitive areas. These results do not support a positive benefit of statins on cognition...
  33. ncbi [Health-related quality of life in multiple sclerosis]
    J Benito-Leon
    Seccion de Neurologia, Hospital General de Mostoles, Mostoles, Spain
    Neurologia 18:210-7. 2003
    ..In fact, HRQoL measurements in MS are becoming important in assessing the effect of treatment and progression of the disease. This article will provide a review of the most significant studies on HRQoL in MS...
  34. ncbi Incidence of Parkinson disease and parkinsonism in three elderly populations of central Spain
    J Benito-Leon
    Department of Neurology, Mostoles General Hospital, Ministry of Labor and Social Affairs, Madrid, Spain
    Neurology 62:734-41. 2004
    ..The scarcity of statistics on the incidence of PD and other types of parkinsonism using this methodology led the authors to estimate them in three elderly populations...
  35. ncbi Update on essential tremor
    J Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    Minerva Med 102:417-40. 2011
    ..For severe, medically refractory ET, thalamic ventralis intermedius nucleus deep brain stimulation may lessen tremor and improve function...
  36. ncbi Guillain-Barré-like syndrome associated with olanzapine hypersensitivity reaction
    Julian Benito-Leon
    Department of Neurology, Mostoles General Hospital, Madrid, Spain
    Clin Neuropharmacol 28:150-1. 2005
    ..The presence of progressive numbness, motor weakness, or pain in the limbs of patients receiving olanzapine should raise suspicion of Guillain-Barré syndrome...
  37. ncbi Incidence of essential tremor in three elderly populations of central Spain
    Julian Benito-Leon
    Department of Neurology, Mostoles General Hospital, Mostoles, Madrid, Spain
    Neurology 64:1721-5. 2005
    ..To estimate the incidence of essential tremor (ET) in three populations in central Spain using data from the Neurologic Disorders in Central Spain (NEDICES), a population-based survey of elderly subjects (65 years and older)...
  38. doi Population-based case-control study of cognitive function in early Parkinson's disease (NEDICES)
    Julian Benito-Leon
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    J Neurol Sci 310:176-82. 2011
    ..Population-based assessments of cognitive function in patients with early Parkinson's disease (PD) are rare. We examined whether patients with early PD have cognitive deficits when compared with matched controls..
  39. ncbi Neurosyphilis masquerading as corticobasal degeneration
    J Benito-Leon
    Department of Neurology, Mostoles General Hospital, Mostoles, Madrid, Spain
    Mov Disord 19:1367-70. 2004
    ..Syphilis, "the great imitator," may also masquerade as CBD. Because neurosyphilis is treatable, it should be considered in the workup of patients with cognitive impairment and motor signs of CBD...
  40. ncbi Rapidly deteriorating polyneuropathy associated with osteosclerotic myeloma responsive to intravenous immunoglobulin and radiotherapy
    J Benito-Leon
    Department of Neurology, Universitary Hospital 12 de Octubre, Madrid, Spain
    J Neurol Sci 158:113-7. 1998
    ..We describe a 49-year-old patient with rapidly deteriorating polyneuropathy associated with osteosclerotic myeloma, who responded favorably to a combination of intravenous immunoglobulin and radiotherapy...
  41. ncbi Combined quinacrine and chlorpromazine therapy in fatal familial insomnia
    Julian Benito-Leon
    Service of Neurology, Mostoles General Hospital, Mostoles, Madrid, Spain
    Clin Neuropharmacol 27:201-3. 2004
    ..The objective of this paper was to report on 2 fatal familial insomnia patients whose overall condition worsened despite quinacrine and chlorpromazine treatment...
  42. doi Premotor cognitive status in a cohort of incident Parkinson disease patients (NEDICES)
    Alvaro Sánchez-Ferro
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    J Neurol Sci 310:211-5. 2011
    ..We examined whether patients with incident PD had had global cognitive function disturbances three years prior to diagnosis when compared with matched controls in a cohort of community-dwelling subjects...
  43. doi Dementia-associated mortality at thirteen years in the NEDICES Cohort Study
    Alberto Villarejo
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    J Alzheimers Dis 26:543-51. 2011
    ..Age, gender, and co-morbidity are associated with higher mortality in dementia patients. Almost one third of deaths in persons over 85 years-old could be attributable to dementia...
  44. doi Rate of cognitive decline in premotor Parkinson's disease: a prospective study (NEDICES)
    Alvaro Sánchez-Ferro
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    Mov Disord 28:161-8. 2013
    ..The rate of cognitive decline in premotor PD and controls was similar. Our data suggest that a decline in global cognitive function does not occur in premotor PD...
  45. doi Mortality from Parkinson's disease: a population-based prospective study (NEDICES)
    Ignacio J Posada
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    Mov Disord 26:2522-9. 2011
    ..40-4.90; P < .001). In this prospective population-based study, Parkinson's disease was an independent predictor of mortality in the elderly. Parkinson's disease patients with dementia had particularly high risks of mortality...
  46. ncbi Prevalence of essential tremor in three elderly populations of central Spain
    Julian Benito-Leon
    Department of Neurology, Mostoles General Hospital, Mostoles, Madrid, Spain
    Mov Disord 18:389-94. 2003
    ..Despite the variability in worldwide data, ET is a frequently encountered disorder in elderly people. Furthermore, as ET may be seen as a relatively benign condition, a large proportion of patients may never seek neurological attention...
  47. ncbi Impact of fatigue in Parkinson's disease: the Fatigue Impact Scale for Daily Use (D-FIS)
    Pablo Martinez-Martin
    Unit of Neuroepidemiology, National Centre for Epidemiology, ISCIII, Madrid, The Spanish Network HOHSR, Spain
    Qual Life Res 15:597-606. 2006
    ..In PD, D-FIS is a consistent and valid measure for fatigue, a frequent symptom previously found to impair patients' HRQoL. Fatigue was also linked to depression and disability in this study...
  48. ncbi Patients', doctors', and caregivers' assessment of disability using the UPDRS-ADL section: are these ratings interchangeable?
    Pablo Martinez-Martin
    National Center for Epidemiology, Carlos III Institute of Public Health, Madrid, Spain
    Mov Disord 18:985-92. 2003
    ..In PD, UPDRS-section 2-based assessment of disability by patients themselves and caregivers is a valid and reliable outcome...
  49. ncbi [Essential tremor and Parkinson's disease: are they associated?]
    Andrés Labiano-Fontcuberta
    Servicio de Neurologia, Hospital Universitario 12 de Octubre, Madrid, Espana
    Rev Neurol 55:479-89. 2012
    ..There is now growing evidence that essential tremor and Parkinson's disease are related...
  50. pmc Clinical correlates of apathy in patients recently diagnosed with Parkinson's disease: the ANIMO study
    Esther Cubo
    Department of Neurology, Complejo Asistencial Universitario, Burgos, Spain
    Neuroepidemiology 38:48-55. 2012
    ..Little is known about apathy in the early stages of Parkinson's disease (PD). We determined the clinical correlates of apathy in a large representative sample of patients recently diagnosed with PD (ANIMO study)...
  51. ncbi Health-related quality of life evaluation by proxy in Parkinson's disease: approach using PDQ-8 and EuroQoL-5D
    Pablo Martinez-Martin
    Neuroepidemiology Unit, National Centre for Epidemiology, Carlos III Institute of Public Health, Madrid, Spain
    Mov Disord 19:312-8. 2004
    ..The degree of agreement varied for individual dimensions. Proxy evaluation of PD patients' HRQoL showed limitations mainly with assessments using the EuroQoL and especially in patients with severe disease and depression...
  52. ncbi Risk of incident dementia in essential tremor: a population-based study
    Felix Bermejo-Pareja
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    Mov Disord 22:1573-80. 2007
    ..The basis for this dementia, which is not known, requires additional study...
  53. ncbi A review about the impact of multiple sclerosis on health-related quality of life
    Julian Benito-Leon
    tment of Neurology, Mostoles General Hospital, Madrid, Spain
    Disabil Rehabil 25:1291-303. 2003
    ..This development is likely to lead to increasing recognition of neuropsychiatric complications of MS in clinical practice and better quantification of treatment responses in clinical trials...
  54. doi Memory impairment in a simple recall task increases mortality at 10 years in non-demented elderly
    Alberto Villarejo
    Department of Neurology, Hospital Universitario 12 de Octubre, Madrid, Spain
    Int J Geriatr Psychiatry 26:182-7. 2011
    ..To evaluate whether memory impairment detected in the three-word delayed recall task of the Mini-Mental State Examination (MMSE) increases the risk of mortality...
  55. pmc The ability of self-rated health to predict mortality among community-dwelling elderly individuals differs according to the specific cause of death: data from the NEDICES cohort
    Mario Fernández-Ruiz
    Department of Internal Medicine, Hospital Universitario 12 de Octubre, Instituto de Investigación Hospital 12 de Octubre I 12, Universidad Complutense, Madrid, Spain
    Gerontology 59:368-77. 2013
    ..The biomedical and psychosocial mechanisms underlying the relationship between self-rated health (SRH) and mortality in elderly individuals remain unclear...
  56. pmc Prevalence of dementia and major dementia subtypes in Spanish populations: a reanalysis of dementia prevalence surveys, 1990-2008
    Jesus de Pedro-Cuesta
    National Centre for Epidemiology, CIBERNED and Alzheimer Disease Research Unit, Carlos III Institute of Public Health, Madrid, Spain
    BMC Neurol 9:55. 2009
    ..This study describes the prevalence of dementia and major dementia subtypes in Spanish elderly...
  57. doi Risk of incident dementia in drug-untreated arterial hypertension: a population-based study
    Felix Bermejo-Pareja
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    J Alzheimers Dis 22:949-58. 2010
    ..38, 95% CI =1.32–4.29, p=0.004). Results were similar for risk of AD. Our results suggest that drug-untreated hypertension may be an independent risk factor for dementia and AD in the elderly...
  58. doi Cerebrovascular disease incidence in central Spain (NEDICES): a population-based prospective study
    Antonio Martinez-Salio
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    J Neurol Sci 298:85-90. 2010
    ....
  59. doi Retinal nerve fiber layer thinning in dementia associated with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease
    Teresa Moreno-Ramos
    Department of Neurology, University Clinic Hospital San Carlos, Madrid, Spain
    J Alzheimers Dis 34:659-64. 2013
    ..The findings from this study show that retinal involvement measured by optical coherence tomography may also be present in non-AD dementias...
  60. ncbi Caregiver burden in Parkinson's disease
    Pablo Martinez-Martin
    Neuroepidemiology Unit, National Center for Epidemiology, Carlos III Institute of Public Health, Madrid, Spain
    Mov Disord 22:924-31; quiz 1060. 2007
    ..This study underscores the need to consider the impact of PD on caregivers' well-being...
  61. ncbi Quality of life of caregivers in Parkinson's disease
    Pablo Martinez-Martin
    National Center for Epidemiology, Carlos III Institute of Public Health, Madrid, Spain
    Qual Life Res 14:463-72. 2005
    ..To assess the impact of PD on informal caregivers of patients and identify the main factors related to caregiver strain...
  62. doi [Neuropsychiatric disturbances in essential tremor]
    Andrés Labiano-Fontcuberta
    Servicio de Neurologia, Hospital Universitario 12 de Octubre, Madrid, Espana
    Med Clin (Barc) 138:171-6. 2012
    ....
  63. doi Prevalence of tics in schoolchildren in central Spain: a population-based study
    Esther Cubo
    Department of Neurology, Hospital General Yague, Burgos, Spain
    Pediatr Neurol 45:100-8. 2011
    ..The most frequent diagnoses involved chronic motor tics (6.07%) and Tourette syndrome (5.26%). Tic disorders are common in childhood, and the use or nonuse of impairment criteria exerts a significant impact on tic prevalence estimates...
  64. pmc Methods and design of the baseline survey of the neurological disorders in Salamanca (NEDISA) cohort: a population-based study in Central-Western Spain
    Jesus Cacho
    Department of Neurology, Salamanca University Hospital, Salamanca, Spain
    Neuroepidemiology 36:62-8. 2011
    ..We assessed the epidemiology of stroke, cognitive disorders, essential tremor (ET), Parkinson's disease (PD) and restless legs syndrome...
  65. ncbi Anger in Parkinson's disease: a case-control study
    Yolanda Macías
    Parkinson s Disease Association of Móstoles, Mostoles, Madrid, Spain
    Mov Disord 23:195-9. 2008
    ..Conclusions: PD patients showed lower levels of external expression of anger and higher levels of control of anger. Our results demonstrate another dimension to the stoic personality trait seen in PD...
  66. doi Gait disorders of unknown cause in the elderly: Clinical and MRI findings
    Oriol Franch
    Department of Neurology, Hospital Ruber Internacional, Madrid, Spain
    J Neurol Sci 280:84-6. 2009
    ..Disequilibrium of unknown cause in older people has been associated with white matter lesions on neuroimaging studies...
  67. ncbi Incidence and subtypes of dementia in three elderly populations of central Spain
    F Bermejo-Pareja
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    J Neurol Sci 264:63-72. 2008
    ..To assess age-, gender, and subtype-specific incidence rates of dementia in three populations in central Spain using data from the Neurological Disorders in Central Spain (NEDICES), a population-based survey of elderly participants...
  68. doi Association of tic disorders with poor academic performance in central Spain: a population-based study
    Esther Cubo
    Department of Neurology, Yagüe General Hospital, Burgos, Spain
    J Pediatr 163:217-23.e1-3. 2013
    ..To analyze the association between tic disorders and poor academic performance in school-aged children...
  69. doi Does the combination of the MMSE and clock drawing test (mini-clock) improve the detection of mild Alzheimer's disease and mild cognitive impairment?
    Jesus Cacho
    Department of Neurology, University Hospital of Salamanca, University of Salamanca, Salamanca, Spain
    J Alzheimers Dis 22:889-96. 2010
    ..It has a high interrater and test-retest reliability, can be quickly administered, and does not require major training...
  70. doi Consistency of clinical diagnosis of dementia in NEDICES: A population-based longitudinal study in Spain
    F Bermejo-Pareja
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    J Geriatr Psychiatry Neurol 22:246-55. 2009
    ..We evaluated the consistency of the clinical diagnosis of dementia over a period of 3 years of follow-up in a population-based, cohort study of older people in central Spain...
  71. pmc A review of the potential therapeutic role of statins in the treatment of Alzheimer's disease: current research and opinion
    Alvaro Sánchez-Ferro
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain Department of Medicine, Complutense University, Madrid, Spain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Madrid, Spain Instituto de Salud Carlos III, Madrid, Spain
    Neuropsychiatr Dis Treat 9:55-63. 2013
    ..Therefore, the role of statins as a therapy in this disorder may be of great interest. The aim of the present review is to summarize of the role of statins in the treatment of Alzheimer's disease...
  72. doi Multifocal myoclonus induced by haloperidol
    Cristina Domínguez
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    Neurol Sci 30:385-6. 2009
    ..We report the first case of a patient with severe Alzheimer's disease who presented with non-epileptic myoclonus just after haloperidol treatment was initiated...
  73. ncbi Changes at the CYP2C locus and disruption of CYP2C8/9 linkage disequilibrium in patients with essential tremor
    Carmen Martinez
    Department of Pharmacology and Psychiatry, Medical School, University of Extremadura, Badajoz, and Department of Medicine Neurology, Principe de Asturias Hospital, Alcala de Henares, Madrid, Spain
    Neuromolecular Med 9:195-204. 2007
    ..0001). These findings were independent of gender, age, age of onset, or clinical symptoms. These results suggest that alterations at the CYP2C gene locus are associated with the risk for ET...
  74. ncbi Methods and demographic findings of the baseline survey of the NEDICES cohort: a door-to-door survey of neurological disorders in three communities from Central Spain
    J M Morales
    Department of Research, Ministry of Labour and Social Affairs, Madrid, Spain
    Public Health 118:426-33. 2004
    ..The survey was designed to study dementia, essential tremor, Parkinson's disease and stroke...
  75. doi A variant of WEBINO syndrome after top of the basilar artery stroke
    Fernando Sierra-Hidalgo
    Department of Neurology, Hospital Universitario 12 de Octubre, Madrid, Spain
    Clin Neurol Neurosurg 112:801-4. 2010
    ....
  76. doi Widespread urticaria due to intramuscular interferon beta-1a therapy for multiple sclerosis
    Cristina Guijarro
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    Neurol Sci 32:309-11. 2011
    ..Widespread urticaria complicating intramuscular INF-β-1a therapy in multiple sclerosis should be therefore added to the list of dermatological lesions associated with interferon therapy...
  77. doi Cognitive dysfunction in multiple sclerosis: methods and prevalence from the GEDMA Study
    J Olazaran
    Neurology Clinic, Hermanos Sangro Specialist Medical Centre, Madrid, Spain
    Eur Neurol 61:87-93. 2009
    ..Its prevalence varies due to disease heterogeneity and methodological issues. A neuropsychological battery of intermediate size was designed for and explored in the screening of cognitive dysfunction in MS patients...
  78. ncbi [Serum pro-oxidant and antioxidant factors and risk of Parkinson's disease: population study]
    J A Molina Arjona
    , Hospital 12 de Octubre, Madrid
    Rev Neurol 29:12-5. 1999
    ..CONCLUSIONS: These results confirm the previous findings of classic case-control studies, suggesting the absence of relationship of the studied values with the risk for Parkinson's disease...
  79. ncbi Selective memory impairment on an adapted Mini-Mental State Examination increases risk of future dementia
    J Olazaran
    Neurology Clinic, CEP Hermanos Sangro, Madrid, Spain
    Int J Geriatr Psychiatry 19:1173-80. 2004
    ..To determine whether selective memory impairment (SMI) on an adapted Mini-Mental State Examination (aMMSE) test increases risk of future dementia in a population-based survey of central Spain...
  80. ncbi Cutaneous mucinoses complicating interferon beta-1b therapy
    Julian Benito-Leon
    Department of Neurology, Mostoles General Hospital, Mostoles, Madrid, Spain
    Eur Neurol 47:123-4. 2002
  81. doi Accuracy of MRI criteria for dissemination in space for the diagnosis of multiple sclerosis in patients with clinically isolated syndromes
    Maria Diaz-Sanchez
    Department of Neurology, University Hospital Virgen del Rocio, Seville, Spain
    Mult Scler 16:576-80. 2010
    ..Swanton's criteria are simpler and more sensitive than Barkhof-Tintoré's criteria, with a slight decrease in specificity. These results reinforce their use in multiple sclerosis diagnosis...
  82. doi Driving cost factors in adult outpatients with refractory epilepsy: a daily clinical practice in clinics of neurology in Spain
    Pilar Peña
    Department of Neurology, General University Hospital, Valencia, Spain
    Epilepsy Res 83:133-43. 2009
    ..To explore the association between patient-reported-outcomes measurements and costs in adult outpatients with drug refractory epilepsy (DRE) in Spain...
  83. ncbi [Thalamic dementia due to infarct of the left thalamus and genum of the right internal capsule]
    J Porta-Etessam
    Servicio de Neurologia Hospital Universitario 12 de Octubre, Madrid, 28041, Espana
    Rev Neurol 33:1043-6. 2001
    ..We report a case of dementia of acute onset involving the left thalamus and the genum of the right internal capsule...
  84. ncbi [Differentiation between cerebral abscesses and necrotic or cystic tumours by means of diffusion sequences]
    J Benito Leon
    Servicio de Neuroradiología Hospital Rúber Internacional, Madrid, Espana
    Rev Neurol 32:137-40. 2001
    ..Recently it has been suggested that diffusion sequences may be useful in the differential diagnosis of a necrotic or cystic mass...
  85. ncbi [HTLV-I myelopathy: presentation of a new case]
    J Diaz-Guzman
    Servicio de Neurologia, Hospital Doce de Octubre, Madrid, Espana
    Rev Neurol 25:557-9. 1997
    ..So far five cases of this illness have been detected in Spain, five of them in immigrants. We present a new case in Spain, with a characteristic chronic clinical picture...
  86. doi Prevalence of stroke and transient ischemic attack in three elderly populations of central Spain
    J Diaz-Guzman
    Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain
    Neuroepidemiology 30:247-53. 2008
    ....
  87. ncbi [Paraneoplastic cerebellar degeneration with asymmetrical pan-cerebellar syndrome]
    J Porta-Etessam
    Servicio de Neurologia Hospital Universitario 12 de Octubre, Madrid, Espana
    Rev Neurol 26:1015-7. 1998
    ..Different families of tumours are associated with this, particularly (in view of its frequency) oat cell pulmonary carcinoma, gynecological tumours and Hodgkin's lymphoma...
  88. ncbi [The NEDICES cohort of the elderly. Methodology and main neurological findings]
    F Bermejo-Pareja
    Hospital Universitario 12 de Octubre, Madrid, Espana
    Rev Neurol 46:416-23. 2008
    ..To summarise the methodological aspects and main findings of the NEDICES (Neurological Disorders in Central Spain) cohort study of the elderly population, with over 5000 participants...