A Barco

Summary

Country: Spain

Publications

  1. pmc Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition
    Jose P Lopez-Atalaya
    Instituto de Neurociencias de Alicante Universidad Miguel Hernández Consejo Superior de Investigaciones Científicas, Campus de Sant Joan Apt 18 Sant Joan d Alacant, 03550 Alicante, Spain
    Nucleic Acids Res 41:8072-84. 2013
  2. pmc Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses toward morphine--and morphine withdrawal-related cues
    Carles Sanchis-Segura
    Area de Psicobiologia, Universitat Jaume I de Castello Castello, Spain
    Front Behav Neurosci 3:30. 2009
  3. pmc Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders
    Luis M Valor
    Instituto de Neurociencias, Av Santiago Ramon y Cajal s n Sant Joan d Alacant 03550, Alicante, Spain
    Curr Pharm Des 19:5051-64. 2013
  4. doi Genetic approaches to investigate the role of CREB in neuronal plasticity and memory
    Angel Barco
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, Campus de Sant Joan, Apt 18, Sant Joan d Alacant, 03550 Alicante, Spain
    Mol Neurobiol 44:330-49. 2011
  5. doi Synapse-specific stabilization of plasticity processes: the synaptic tagging and capture hypothesis revisited 10 years later
    Angel Barco
    Instituto de Neurociencias de Alicante Universidad Miguel Hernández Consejo Superior de Investigaciones Científicas, Campus de Sant Joan Apt 18, Sant Joan d Alacant, 03550 Alicante, Spain
    Neurosci Biobehav Rev 32:831-51. 2008
  6. ncbi Gene expression profiling of facilitated L-LTP in VP16-CREB mice reveals that BDNF is critical for the maintenance of LTP and its synaptic capture
    Angel Barco
    Center for Neurobiology and Behavior, Columbia University, 1051 Riverside Drive, New York, New York 10032, USA
    Neuron 48:123-37. 2005
  7. ncbi The Rubinstein-Taybi syndrome: modeling mental impairment in the mouse
    A Barco
    Instituto de Neurociencias de Alicante UMH CSIC, Campus de Sant Joan, Sant Joan d Alacant, Spain
    Genes Brain Behav 6:32-9. 2007
  8. ncbi Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture
    Angel Barco
    Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Cell 108:689-703. 2002
  9. doi Histone acetylation deficits in lymphoblastoid cell lines from patients with Rubinstein-Taybi syndrome
    J P Lopez-Atalaya
    Instituto de Neurociencias Universidad Miguel Hernandez Consejo Superior de Investigaciones Científicas, San Juan de Alicante, Alicante, Spain
    J Med Genet 49:66-74. 2012
  10. ncbi Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration
    Juan M Alarcon
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Neuron 42:947-59. 2004

Collaborators

Detail Information

Publications25

  1. pmc Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition
    Jose P Lopez-Atalaya
    Instituto de Neurociencias de Alicante Universidad Miguel Hernández Consejo Superior de Investigaciones Científicas, Campus de Sant Joan Apt 18 Sant Joan d Alacant, 03550 Alicante, Spain
    Nucleic Acids Res 41:8072-84. 2013
    ..These results illuminate both the relationship between hippocampal gene expression and histone acetylation and the mechanism of action of these important neuropsychiatric drugs. ..
  2. pmc Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses toward morphine--and morphine withdrawal-related cues
    Carles Sanchis-Segura
    Area de Psicobiologia, Universitat Jaume I de Castello Castello, Spain
    Front Behav Neurosci 3:30. 2009
    ..Our experiments thereby support a role for CREB in striatal neurons regulating approach and avoidance responses toward drug-related cues...
  3. pmc Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders
    Luis M Valor
    Instituto de Neurociencias, Av Santiago Ramon y Cajal s n Sant Joan d Alacant 03550, Alicante, Spain
    Curr Pharm Des 19:5051-64. 2013
    ..Finally, we discuss the potential of ameliorative strategies targeting CBP/p300 for the treatment of these disorders. ..
  4. doi Genetic approaches to investigate the role of CREB in neuronal plasticity and memory
    Angel Barco
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, Campus de Sant Joan, Apt 18, Sant Joan d Alacant, 03550 Alicante, Spain
    Mol Neurobiol 44:330-49. 2011
    ..These findings pave the way for the development of novel therapeutic strategies to treat memory disorders...
  5. doi Synapse-specific stabilization of plasticity processes: the synaptic tagging and capture hypothesis revisited 10 years later
    Angel Barco
    Instituto de Neurociencias de Alicante Universidad Miguel Hernández Consejo Superior de Investigaciones Científicas, Campus de Sant Joan Apt 18, Sant Joan d Alacant, 03550 Alicante, Spain
    Neurosci Biobehav Rev 32:831-51. 2008
    ..We will also discuss the impact of this model in our view of the integrative capability of neurons and associative learning...
  6. ncbi Gene expression profiling of facilitated L-LTP in VP16-CREB mice reveals that BDNF is critical for the maintenance of LTP and its synaptic capture
    Angel Barco
    Center for Neurobiology and Behavior, Columbia University, 1051 Riverside Drive, New York, New York 10032, USA
    Neuron 48:123-37. 2005
    ..We found that the overexpression of brain-derived neurotrophic factor accounts for an important component of this phenotype...
  7. ncbi The Rubinstein-Taybi syndrome: modeling mental impairment in the mouse
    A Barco
    Instituto de Neurociencias de Alicante UMH CSIC, Campus de Sant Joan, Sant Joan d Alacant, Spain
    Genes Brain Behav 6:32-9. 2007
    ....
  8. ncbi Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture
    Angel Barco
    Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Cell 108:689-703. 2002
    ..Our analysis indicates that synaptic capture of CRE-driven gene products may be sufficient for consolidation of LTP and provides insight into the molecular mechanisms of synaptic tagging and synapse-specific potentiation...
  9. doi Histone acetylation deficits in lymphoblastoid cell lines from patients with Rubinstein-Taybi syndrome
    J P Lopez-Atalaya
    Instituto de Neurociencias Universidad Miguel Hernandez Consejo Superior de Investigaciones Científicas, San Juan de Alicante, Alicante, Spain
    J Med Genet 49:66-74. 2012
    ..Previous studies have shown that neuronal histone acetylation is reduced in mouse models of RSTS...
  10. ncbi Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration
    Juan M Alarcon
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Neuron 42:947-59. 2004
    ....
  11. ncbi Enhanced CREB-dependent gene expression increases the excitability of neurons in the basal amygdala and primes the consolidation of contextual and cued fear memory
    Jose Viosca
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, Sant Joan d Alacant, 03550 Alicante, Spain
    Learn Mem 16:193-7. 2009
    ....
  12. doi Ablation of CBP in forebrain principal neurons causes modest memory and transcriptional defects and a dramatic reduction of histone acetylation but does not affect cell viability
    Luis M Valor
    Instituto de Neurociencias de Alicante Universidad Miguel Hernández Consejo Superior de Investigaciones Científicas, Campus de Sant Joan, Sant Joan d Alacant, 03550 Alicante, Spain
    J Neurosci 31:1652-63. 2011
    ..Overall, our study provides novel insights into RSTS etiology and clarifies some of the standing questions concerning the role of CBP and histone acetylation in activity-driven gene expression, memory formation, and neurodegeneration...
  13. doi Ultrastructural and transcriptional profiling of neuropathological misregulation of CREB function
    L M Valor
    Instituto de Neurociencias de Alicante Universidad Miguel Hernández Consejo Superior de Investigaciones Científicas, Campus de Sant Joan, Apt 18, Sant Joan d Alacant, Alicante 03550, Spain
    Cell Death Differ 17:1636-44. 2010
    ....
  14. ncbi cAMP response element-binding protein-mediated gene expression increases the intrinsic excitability of CA1 pyramidal neurons
    Mikel Lopez de Armentia
    Instituto de Neurociencias de Alicante Universidad Miguel Hernández Consejo Superior de Investigaciones Científicas, Campus de Sant Joan, Sant Joan d Alacant, 03550 Alicante, Spain
    J Neurosci 27:13909-18. 2007
    ..As a result, our study has important implications for both the understanding of the cellular bases of learning and memory and the consideration of therapies targeted to the CREB pathway...
  15. pmc Transient expansion of synaptically connected dendritic spines upon induction of hippocampal long-term potentiation
    Cynthia Lang
    Center for Neurobiology and Behavior, Department of Pharmacology, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 101:16665-70. 2004
    ..Thus, transient spine expansion is a characteristic feature of the initial phases of plasticity at mature synapses and so may contribute to synapse remodeling important for LTP...
  16. ncbi Common molecular mechanisms in explicit and implicit memory
    Angel Barco
    Instituto de Neurociencias de Alicante UMH CSIC, Campus de Sant Joan, Spain
    J Neurochem 97:1520-33. 2006
    ..These two processes share common molecular mechanisms that have been highly conserved through evolution...
  17. ncbi Inhibition of cAMP response element-binding protein reduces neuronal excitability and plasticity, and triggers neurodegeneration
    Dragana Jancic
    Instituto de Neurociencias de Alicante Universidad Miguel Hernández Consejo Superior de Investigaciones Científicas, Campus de Sant Joan, 03550 Alicante, Spain
    Cereb Cortex 19:2535-47. 2009
    ....
  18. ncbi Capture of the late phase of long-term potentiation within and across the apical and basilar dendritic compartments of CA1 pyramidal neurons: synaptic tagging is compartment restricted
    Juan M Alarcon
    Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    J Neurosci 26:256-64. 2006
    ..These results suggest that the tag appears specific to a compartment either apical or basilar and that an additional mechanism may be required to capture across compartments...
  19. doi CREB's control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models
    Eva Benito
    Instituto de Neurociencias de Alicante Universidad Miguel Hernández Consejo Superior de Investigaciones Científicas, Campus de Sant Joan, Apt 18, Sant Joan d Alacant, 03550, Alicante, Spain
    Trends Neurosci 33:230-40. 2010
    ..This discovery reveals new intriguing connections between intrinsic and synaptic plasticity and is likely to have a significant impact on our understanding of the role of CREB in memory formation...
  20. ncbi Activated CREB is sufficient to overcome inhibitors in myelin and promote spinal axon regeneration in vivo
    Ying Gao
    Biology Department, Hunter College, City University of New York, 695 Park Avenue, New York, NY 10021, USA
    Neuron 44:609-21. 2004
    ..These results indicate that CREB plays a central role in overcoming myelin inhibitors and so encourages regeneration in vivo...
  21. pmc CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum
    Amir A Levine
    Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, and Howard Hughes Medical Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 102:19186-91. 2005
    ..Thus, CBP, which forms part of the promoter complex with CREB, mediates sensitivity to cocaine by acetylating histones...
  22. ncbi CREB, memory enhancement and the treatment of memory disorders: promises, pitfalls and prospects
    Angel Barco
    Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, New York, NY 10032, USA
    Expert Opin Ther Targets 7:101-14. 2003
    ....
  23. doi Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contribution of p300 and CBP to Rubinstein-Taybi syndrome etiology
    Jose Viosca
    Instituto de Neurociencias de Alicante Universidad Miguel Hernández Consejo Superior de Investigaciones Científicas, Campus de Sant Joan, Apt 18, Sant Joan d Alacant, 03550 Alicante, Spain
    Neurobiol Dis 37:186-94. 2010
    ....
  24. pmc A semi-persistent adult ocular dominance plasticity in visual cortex is stabilized by activated CREB
    Tony A Pham
    Department of Psychiatry and Behavioral Sciences, University of Washington, School of Medicine, Seattle, Washington 98104, USA
    Learn Mem 11:738-47. 2004
    ..These results suggest that in development and adulthood, the regulation of a trans-synaptic signaling pathway controls the adaptive potential of cortical circuits...
  25. pmc A meeting to remember: meeting on memory and related disorders
    Gregory P Gasic
    Harvard Medical School and Massachussets General Hospital, Boston, Massachusetts 02115, USA
    EMBO Rep 7:768-73. 2006