J Avila

Summary

Country: Spain

Publications

  1. ncbi request reprint GSK-3 inhibitors for Alzheimer's disease
    Jesus Avila
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Fac Ciencias, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Expert Rev Neurother 7:1527-33. 2007
  2. ncbi request reprint Protein kinases involved in the phosphorylation of human tau protein in transfected COS-1 cells
    M Medina
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Universidad Autonoma de Madrid, Spain
    Biochim Biophys Acta 1316:43-50. 1996
  3. doi request reprint Tau kinases and phosphatases
    J Avila
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, C Nicolás Cabrera, 1 Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain
    J Cell Mol Med 12:258-9. 2008
  4. pmc The involvement of cholinergic neurons in the spreading of tau pathology
    Diana Simon
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM Madrid, Spain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas Madrid, Spain
    Front Neurol 4:74. 2013
  5. pmc The tau code
    Jesus Avila
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autónoma de Madrid Madrid, Spain
    Front Aging Neurosci 1:1. 2009
  6. pmc Deconstructing mitochondrial dysfunction in Alzheimer disease
    Vega García-Escudero
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, 28049 Madrid, Spain
    Oxid Med Cell Longev 2013:162152. 2013
  7. pmc Intracellular and extracellular tau
    Jesus Avila
    Centro de Biologia Molecular Severo Ochoa, Campus Cantoblanco, Universidad Autónoma de Madrid Madrid, Spain
    Front Neurosci 4:49. 2010
  8. pmc GSK3β is involved in the relief of mitochondria pausing in a Tau-dependent manner
    María Llorens-Martín
    Departmento de Neurobiología Molecular, Centro de Biologia Molecular Severo Ochoa, Madrid, Spain
    PLoS ONE 6:e27686. 2011
  9. pmc Role of neuroinflammation in adult neurogenesis and Alzheimer disease: therapeutic approaches
    Almudena Fuster-Matanzo
    Department of Molecular Neurobiology, Centro de Biologia Molecular Severo Ochoa CSIC UAM, Madrid, Spain
    Mediators Inflamm 2013:260925. 2013
  10. pmc Tau Phosphorylation by GSK3 in Different Conditions
    Jesus Avila
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Nicolas Cabrera 1, Campus Cantoblanco UAM, 28049 Madrid, Spain
    Int J Alzheimers Dis 2012:578373. 2012

Collaborators

Detail Information

Publications77

  1. ncbi request reprint GSK-3 inhibitors for Alzheimer's disease
    Jesus Avila
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Fac Ciencias, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Expert Rev Neurother 7:1527-33. 2007
    ..In this review, we summarize all these data and discuss the potential of GSK-3 inhibitors for Alzheimer's disease therapy, as well as some of their potential problems...
  2. ncbi request reprint Protein kinases involved in the phosphorylation of human tau protein in transfected COS-1 cells
    M Medina
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Universidad Autonoma de Madrid, Spain
    Biochim Biophys Acta 1316:43-50. 1996
    ....
  3. doi request reprint Tau kinases and phosphatases
    J Avila
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, C Nicolás Cabrera, 1 Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain
    J Cell Mol Med 12:258-9. 2008
  4. pmc The involvement of cholinergic neurons in the spreading of tau pathology
    Diana Simon
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM Madrid, Spain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas Madrid, Spain
    Front Neurol 4:74. 2013
    ..This interaction between tau and muscarinic receptors may be a way, although not the only one, to explain the spreading of tau pathology occurring in AD...
  5. pmc The tau code
    Jesus Avila
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autónoma de Madrid Madrid, Spain
    Front Aging Neurosci 1:1. 2009
    ..Thus, I will discuss whether a tau code exists that might explain the involvement of different tau isoforms in different cellular functions...
  6. pmc Deconstructing mitochondrial dysfunction in Alzheimer disease
    Vega García-Escudero
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, 28049 Madrid, Spain
    Oxid Med Cell Longev 2013:162152. 2013
    ..We have summarized the novel protocols for the generation of neurons by reprogramming or direct transdifferentiation, which offer useful tools to achieve this result. ..
  7. pmc Intracellular and extracellular tau
    Jesus Avila
    Centro de Biologia Molecular Severo Ochoa, Campus Cantoblanco, Universidad Autónoma de Madrid Madrid, Spain
    Front Neurosci 4:49. 2010
    ..In this short review is described the toxicity of modified intracellular tau and that of extracellular tau that could be released into the extracellular space after neuron death...
  8. pmc GSK3β is involved in the relief of mitochondria pausing in a Tau-dependent manner
    María Llorens-Martín
    Departmento de Neurobiología Molecular, Centro de Biologia Molecular Severo Ochoa, Madrid, Spain
    PLoS ONE 6:e27686. 2011
    ..We conclude that GSK3B activity regulates mitochondrial axonal trafficking largely in a Tau-dependent manner...
  9. pmc Role of neuroinflammation in adult neurogenesis and Alzheimer disease: therapeutic approaches
    Almudena Fuster-Matanzo
    Department of Molecular Neurobiology, Centro de Biologia Molecular Severo Ochoa CSIC UAM, Madrid, Spain
    Mediators Inflamm 2013:260925. 2013
    ..Considering this, in this paper we revise the relationships between neuroinflammation, Alzheimer disease, and adult neurogenesis, as well as the current therapeutic approaches that have been developed in the field...
  10. pmc Tau Phosphorylation by GSK3 in Different Conditions
    Jesus Avila
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Nicolas Cabrera 1, Campus Cantoblanco UAM, 28049 Madrid, Spain
    Int J Alzheimers Dis 2012:578373. 2012
    ....
  11. pmc Use of okadaic acid to identify relevant phosphoepitopes in pathology: a focus on neurodegeneration
    Miguel Medina
    CIBERNED Center for Networked Biomedical Research in Neurodegenerative Diseases, Valderrebollo 5, Madrid 28041, Spain
    Mar Drugs 11:1656-68. 2013
    ..Finally, its effect on tau hyperhosphorylation and its relevance in neurodegenerative pathologies such as Alzheimer's disease and related dementia will be discussed...
  12. doi request reprint Looking for novel functions of tau
    Jesus Avila
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Madrid, Spain
    Biochem Soc Trans 40:653-5. 2012
    ..The presence of toxic extracellular tau could be the mechanism for the spreading of tau pathology in these neurodegenerative disorders...
  13. ncbi request reprint Role of tau protein in both physiological and pathological conditions
    Jesus Avila
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Campus de Cantoblanco, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Physiol Rev 84:361-84. 2004
    ..The purpose of this review is to define the role of tau protein under normal physiological conditions and to highlight the role of the protein in different tauopathies...
  14. ncbi request reprint The influence of aging in one tauopathy: Alzheimer 's disease
    Jesus Avila
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Campus de Cantoblanco, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Arch Immunol Ther Exp (Warsz) 52:410-3. 2004
    ..In this phosphorylation, some protein kinases related to the insulin-transduction pathway could play a role...
  15. ncbi request reprint Tau function and dysfunction in neurons: its role in neurodegenerative disorders
    Jesus Avila
    Centro de Biologia Molecular CSIC UAM, Universidad Autónoa, Madrid, Spain
    Mol Neurobiol 25:213-31. 2002
    ..It is characterized by the presence of two main brain pathological hallmarks: senile plaques and neurofibrillary tangles (NFTs). NFTs are composed of fibrillar polymers of the abnormally phosphorylated cytoskeletal protein tau...
  16. ncbi request reprint Assembly in vitro of tau protein and its implications in Alzheimer's disease
    Jesus Avila
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Campus de Cantoblanco, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Curr Alzheimer Res 1:97-101. 2004
    ..In this mini-review a descriptive analysis of the different conditions needed for in vitro tau polymerization are summarized...
  17. ncbi request reprint Tau phosphorylation and aggregation in Alzheimer's disease pathology
    Jesus Avila
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Cantoblanco, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    FEBS Lett 580:2922-7. 2006
    ..Also, it is discussed the toxicity of modified tau. In addition, I propose a working model detailing the progression of tau pathologies...
  18. ncbi request reprint Tau protein, the main component of paired helical filaments
    Jesus Avila
    Centro de Biología Molecular Severo Ochoa CSIC UAM Facultad de Ciencias, Campus de Cantoblanco, Universidad Autonoma de Madrid, 28049 Madrid Spain
    J Alzheimers Dis 9:171-5. 2006
    ....
  19. ncbi request reprint Tau in neurodegenerative diseases: tau phosphorylation and assembly
    J Avila
    Centro de Biología Molecular Severo Ochoa CSIC UAM Facultad de Ciencias Campus de Cantoblanco Universidad Autónoma de Madrid, 28049 Madrid, Spain
    Neurotox Res 6:477-82. 2004
    ..Additionally, this link is supported by an in vitro experiment showing the higher capacity of phosphotau to assemble in some specific conditions; and, by a recently reported experiment using a tau transgenic mouse model...
  20. pmc Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau
    Ismael Santa-Maria
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Fac, Ciencias, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Mol Neurodegener 2:17. 2007
    ..We like to emphasize the importance of testing on both types of pathology (amyloid and tau) the potential drugs to be used for AD treatment...
  21. doi request reprint Tau kinase I overexpression induces dentate gyrus degeneration
    Jesus Avila
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Madrid, Spain
    Neurodegener Dis 7:13-5. 2010
    ..We have generated a GSK3 transgenic mouse model to study the consequences of GSK3 activation. In this model, dentate gyrus is degenerated in a process in which phosphorylated tau can be involved...
  22. doi request reprint Role of glycogen synthase kinase-3 in Alzheimer's disease pathogenesis and glycogen synthase kinase-3 inhibitors
    Jesus Avila
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Nicolas Cabrera 1, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    Expert Rev Neurother 10:703-10. 2010
    ..In the present review, we summarize all these data and discuss the potential of GSK-3 inhibitors for Alzheimer's disease therapy, as well as some of their potential problems...
  23. doi request reprint Prospects on the origin of Alzheimer's disease
    Jesus Avila
    Center of Molecular Biology Severo Ochoa, CSIC UAM, Madrid, Spain
    J Alzheimers Dis 20:669-72. 2010
    ....
  24. doi request reprint Centro de Biologia Molecular "Severo Ochoa": a center for basic research into Alzheimer's disease
    Jesus Avila
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Madrid, Spain
    J Alzheimers Dis 21:325-35. 2010
    ..Several groups at the Center are involved in these studies, and, in this spotlight, the work they are carrying out will be described...
  25. doi request reprint Tau phosphorylation in hippocampus results in toxic gain-of-function
    Jesus Avila
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Campus de la Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Biochem Soc Trans 38:977-80. 2010
    ..Once neuronal degeneration takes place, intracellular tau is secreted to the extracellular space. The present review discusses the toxicity of this extracellular tau for surrounding neurons...
  26. ncbi request reprint Tau aggregation into fibrillar polymers: taupathies
    J Avila
    Centro de Biología Molecular Severo Ochoa UAM CSIC, Facultad de Ciencias, Universidad Autonoma de Madrid, 28049, Madrid, Spain
    FEBS Lett 476:89-92. 2000
    ..These two features are commented upon in this review...
  27. ncbi request reprint The inhibition of phosphatidylinositol-3-kinase induces neurite retraction and activates GSK3
    S Sanchez
    , , Madrid, Spain
    J Neurochem 78:468-81. 2001
    ....
  28. ncbi request reprint [The microtubule-associated protein tau in neurodegenerative diseases. Tauopathies]
    M P Sanchez
    Centro de Biologia Molecular, C S I C Universidad de Madrid, Cantoblanco, 28049, Espana
    Rev Neurol 33:169-77. 2001
    ..Those pathologies presenting a tau disfunction are known as tauopathies...
  29. ncbi request reprint FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain
    F Lim
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Mol Cell Neurosci 18:702-14. 2001
    ..Our results show that Tau modifications can provoke lysosomal aberrations and suggest that this may be a cause of neurodegeneration in tauopathies...
  30. ncbi request reprint Phosphorylation of microtubule-associated protein 2 (MAP2) and its relevance for the regulation of the neuronal cytoskeleton function
    C Sanchez
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autónoma de Madrid CSIC UAM, Cantoblanco, 28049, Madrid, Spain
    Prog Neurobiol 61:133-68. 2000
    ..Here we will review the current knowledge about the regulation of MAP2 function through phosphorylation/dephosphorylation and its relevance in the broader context of neuronal functions...
  31. doi request reprint Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3beta
    T Engel
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Fac Ciencias, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Neuroscience 157:772-80. 2008
    ..These studies also allow us to propose a model of spreading of pathology through the hippocampus as a consequence of GSK-3 and tau dysregulation...
  32. pmc Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice
    J J Lucas
    Centro de Biologia Molecular Severo Ochoa, CSIC Universidad Autonoma de Madrid, Departamento de Morfologia, Facultad de Medicina, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    EMBO J 20:27-39. 2001
    ....
  33. doi request reprint Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells
    A Gómez-Ramos
    Centro de Biologia Molecular Severo Ochoa, c Nicolas Cabrera no 1, Campus de Cantoblanco, 28049, Madrid, Spain
    Mol Cell Neurosci 37:673-81. 2008
    ..Therefore blocking M1 and for M3 receptors, by using specific receptor antagonists, can prevent that tau toxic effect that could take place in tauopathies...
  34. ncbi request reprint Characterization of a double (amyloid precursor protein-tau) transgenic: tau phosphorylation and aggregation
    M Perez
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Neuroscience 130:339-47. 2005
    ..Also, they suggest that different types of tau filamentous polymers can occur in different mouse models for tauopathies, like those used for Alzheimer's disease or FTDP-17...
  35. ncbi request reprint Participation of structural microtubule-associated proteins (MAPs) in the development of neuronal polarity
    C Gonzalez-Billault
    Centro de Biologia Molecular Severo Ochoa, CSIC, Universidad Autonoma de Madrid, Campus Cantoblanco, Madrid, Spain
    J Neurosci Res 67:713-9. 2002
    ..Together these results show a synergistic role for MAP1B/MAP2 and MAP1B/TAU...
  36. ncbi request reprint Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease
    E Martín-Aparicio
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, 28049 Madrid, Spain
    J Neurosci 21:8772-81. 2001
    ..This correlated with the lack of cell death in symptomatic HD94 mice, thus demonstrating that neuronal dysfunction, and not cell loss, triggered by mutant huntingtin underlies symptomatology...
  37. ncbi request reprint Phosphorylation and dephosphorylation in the proline-rich C-terminal domain of microtubule-associated protein 2
    C Sanchez
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
    Eur J Biochem 241:765-71. 1996
    ..This motif can be rapidly dephosphorylated in vitro by protein-phosphatase 1 (PP1) and 2A (PP2A) catalytic subunits but not by PP2B...
  38. ncbi request reprint Overcoming cell death and tau phosphorylation mediated by PI3K-inhibition: a cell assay to measure neuroprotection
    D Simon
    Centro de Biología Molecular Severo Ochoa CIBERNED CSIC UAM, c Nicolas Cabrera no 1, Cantoblanco, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    CNS Neurol Disord Drug Targets 10:208-14. 2011
    ..Finally, we designed a neuronal cell model of apoptosis using the phosphatidylinositol kinase-3 inhibitor LY294002. Finally, we summarize several new compounds with "neuroprotective" properties...
  39. ncbi request reprint Acetylsalicylic acid decreases tau phosphorylation at serine 422
    E Tortosa
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Facultad de Ciencias, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Neurosci Lett 396:77-80. 2006
    ..In this work, we have found that in the presence of acetylsalicylic acid, at a concentration like that used for anti-inflammatory treatments, tau phosphorylation at serine 422 decreases...
  40. ncbi request reprint Regulation of neuronal cytoskeleton by lysophosphatidic acid: role of GSK-3
    C L Sayas
    Centro de Biologia Molecular Severo Ochoa, CSIC Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    Biochim Biophys Acta 1582:144-53. 2002
    ..The upregulation of GSK-3 activity by LPA seems to be a general process as it occurs in diverse neuronal cells of different species in correlation with the neurite retraction process...
  41. ncbi request reprint Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients
    L Ulloa
    , Fac de Ciencias, , Spain
    Brain Res Mol Brain Res 26:113-22. 1994
    ..Thus, a possible common phosphorylation of axonal MAPs such as tau or MAP1B may correlate with their association with those aberrant cytoskeletal structures present in AD...
  42. ncbi request reprint Semaphorin 3C preserves survival and induces neuritogenesis of cerebellar granule neurons in culture
    M T Moreno-Flores
    Centro de Biologia Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Madrid, Spain
    J Neurochem 87:879-90. 2003
    ..These data support the idea that secreted sema3C favors survival and neuritogenesis of cultured CGNs...
  43. pmc Role of glycosaminoglycans in determining the helicity of paired helical filaments
    M Arrasate
    Centro de Biologia Molecular CSIC UAM, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
    Am J Pathol 151:1115-22. 1997
    ..Heparinase or chondroitinase treatment of PHFs results in the formation of straight structures. All of these results suggest a role for sulfated glycosaminoglycans in determining the helicity of PHFs...
  44. ncbi request reprint Microtubule-associated protein 2 phosphorylation is decreased in the human epileptic temporal lobe cortex
    C Sanchez
    Centro de Biologia Molecular Severo Ochoa, Departamento de Biologia Molecular, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
    Neuroscience 107:25-33. 2001
    ..Also, MAP2 dephosphorylation may lead to alterations of the neuronal cytoskeleton and eventually to neuronal damage and loss, which is typical of epileptic patients...
  45. ncbi request reprint Two modes of microtubule-associated protein 1B phosphorylation are differentially regulated during peripheral nerve regeneration
    A Ramon-Cueto
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
    Brain Res 815:213-26. 1999
    ....
  46. ncbi request reprint GSK3beta-mediated phosphorylation of the microtubule-associated protein 2C (MAP2C) prevents microtubule bundling
    C Sanchez
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Eur J Cell Biol 79:252-60. 2000
    ..Interestingly, these MAP2C species were enriched in cytoskeleton-unbound protein preparations. These data suggests that GSK3-mediated phosphorylation of MAP2 may modify its binding to microtubules and regulate microtubule stability...
  47. ncbi request reprint Distribution and characteristics of betaII tubulin-enriched microtubules in interphase cells
    R Armas-Portela
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Centro Nacional de Biotecnologia, CSIC, Madrid, E 28049, Spain
    Exp Cell Res 248:372-80. 1999
    ....
  48. ncbi request reprint Tauopathies
    F Hernandez
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Fac Ciencias, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Cell Mol Life Sci 64:2219-33. 2007
    ..The purpose of this work is to review the possible mechanisms for tau alterations that could lead to the onset of tau pathology. First we will focus on tau turnover, then on tau phosphorylation and, finally, on tau aggregation...
  49. ncbi request reprint In vitro assembly of tau protein: mapping the regions involved in filament formation
    M Perez
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Biochemistry 40:5983-91. 2001
    ..This tau segment forms filaments regardless of whether is incubated with heparin. Moreover, such filaments differ in diameter and morphology, suggesting a different mechanism of self-assembly...
  50. ncbi request reprint The zeta isozyme of protein kinase C binds to tubulin through the pseudosubstrate domain
    M Garcia-Rocha
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Spain
    Exp Cell Res 230:1-8. 1997
    ....
  51. doi request reprint Expression of frontotemporal dementia with parkinsonism associated to chromosome 17 tau induces specific degeneration of the ventral dentate gyrus and depressive-like behavior in mice
    M Llorens-Martin
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, c Nicolas Cabrera 1, Universidad Autonoma de Madrid, Campus Cantoblanco, 28049 Madrid, Spain
    Neuroscience 196:215-27. 2011
    ..Finally, we suggest that this transgenic mouse, which overexpresses human FTPD tau, may serve as a useful model to study specific functions of the ventral dentate gyrus...
  52. doi request reprint A culture model for neurite regeneration of human spinal cord neurons
    T Koechling
    Departamento de Biologia Molecular, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    J Neurosci Methods 201:346-54. 2011
    ....
  53. pmc Evidence for the role of MAP1B in axon formation
    C Gonzalez-Billault
    Centro de Biologia Molecular, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Mol Biol Cell 12:2087-98. 2001
    ..Taken together, this study provides direct evidence showing that by promoting microtubule dynamics and regulating cytoskeletal organization MAP1B has a crucial role in axon formation...
  54. ncbi request reprint Intra- and extracellular protein interactions with tau
    F Hernandez
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Spain
    Curr Alzheimer Res 7:670-6. 2010
    ..Different regions of tau are involved in these interactions and some of them are more conserved throughout evolution than others...
  55. ncbi request reprint Role of phosphorylated MAPlB in neuritogenesis
    J Avila
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Spain
    Cell Biol Int 18:309-14. 1994
    ..Additionally, CK II-phosphorylated MAPlB is present in cell bodies and dendrites where no PDPK-phosphorylated MAPlB is observed. These results suggest distinct roles for both types of modifications of MAPlB in developing neurons...
  56. ncbi request reprint Microtubule-associated protein-2 located in growth regions of rat hippocampal neurons is highly phosphorylated at its proline-rich region
    C Sánchez Martín
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco 28049, Madrid, Spain
    Neuroscience 101:885-93. 2000
    ..From these results we suggest that the phosphorylation of MAP2 at its proline-rich region is an important event during neuritogenesis...
  57. doi request reprint Motor alterations are reduced in mice lacking the PARK2 gene in the presence of a human FTDP-17 mutant form of four-repeat tau
    P Navarro
    Fundacion Jimenez Diaz Capio Clinica Ntra Sra Concepcion, Universidad Autonoma de Madrid, 28040 Madrid, Spain
    J Neurol Sci 275:139-44. 2008
    ..This mouse model will hopefully help to study the causes of the motor deficits associated with certain neuropathologies related to the tau and parkin proteins, and to find appropriate treatments...
  58. ncbi request reprint Olfactory ensheathing glia: properties and function
    A Ramon-Cueto
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
    Brain Res Bull 46:175-87. 1998
    ..In addition, we provide some evidence of the potentiality that ensheathing glia might have as a promoter of axonal regeneration within the injured nervous system...
  59. doi request reprint Lithium, a potential protective drug in Alzheimer's disease
    T Engel
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Facultad de Ciencias, Universidad Autonoma de Madrid, Madrid, Spain
    Neurodegener Dis 5:247-9. 2008
    ..In this short article, we have done a review on tau phosphorylation in Alzheimer's disease and other tauopathies, and on the inhibition of kinases like GSK-3, involved in tau modification...
  60. ncbi request reprint A cAMP-activated pathway, including PKA and PI3K, regulates neuronal differentiation
    S Sanchez
    Centro de Biologia Molecular Severo Ochoa, CSIC Universidad Autonoma de Madrid, Cantoblanco Madrid, Spain
    Neurochem Int 44:231-42. 2004
    ..Moreover, our results showed that when elongation is initiated, PI3K is still essential for maintenance of the neuronal morphology, whereas PKA or MAPK (ERKs or p38) activation does not appear to be necessary during this process...
  61. ncbi request reprint Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level
    C Quintana
    IMM CNM, CSIC, Madrid, Spain
    J Struct Biol 153:42-54. 2006
    ..2004. Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer's disease. Neurobiol. Aging 25, 5-18)...
  62. ncbi request reprint OP18/stathmin binds near the C-terminus of tubulin and facilitates GTP binding
    F J Moreno
    Centro de Biologia Molecular, Severo Ochoa, CSIC UAM lt Madrid, Spain
    Eur J Biochem 262:557-62. 1999
    ..We also observed that the binding of stathmin to tubulin can modulate the binding of GTP to tubulin, as a consequence of a conformational change in the beta-tubulin subunit that occurs upon interaction of stathmin with tubulin...
  63. doi request reprint Ultrastructural localization of fructose-1,6-bisphosphatase in mouse brain
    Z D Velásquez
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Fac Ciencias, Universidad Autonoma de Madrid, Madrid, Spain Instituto de Bioquímica, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile
    Microsc Res Tech 74:329-36. 2011
    ..The possible role of fructose-1,6-bisphosphatase in neurons and astrocytes is discussed...
  64. doi request reprint GSK-3β overexpression causes reversible alterations on postsynaptic densities and dendritic morphology of hippocampal granule neurons in vivo
    M Llorens-Martin
    Department of Molecular Neurobiology, Centro de Biologia Molecular Severo Ochoa CSIC UAM, Madrid, Spain
    Mol Psychiatry 18:451-60. 2013
    ..Taken together, these data indicate that GSK-3β is crucial for hippocampal function, thereby supporting this kinase as a relevant target for the treatment of AD...
  65. pmc Characterization by atomic force microscopy of Alzheimer paired helical filaments under physiological conditions
    F Moreno-Herrero
    Departamento de Fisica de la Materia Condensada, Facultad de Ciencias, Universidad Autonoma de Madrid, 28049, Madrid, Spain
    Biophys J 86:517-25. 2004
    ..Direct comparison of the experimental data with structural models has been performed. From this we conclude that the PHF structure is compatible with two coupled ribbons with an overall height of 20 nm and a width of 10 nm...
  66. ncbi request reprint The marine sphingolipid-derived compound ES 285 triggers an atypical cell death pathway
    M Salcedo
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, 28049, Madrid, Spain
    Apoptosis 12:395-409. 2007
    ..Thus, these data suggest that ES 285-triggers an atypical cell death program when compared to other sphingosine-dependent apoptosis pathways...
  67. ncbi request reprint Apolipoprotein E4 stimulates sulfation of glycosaminoglycans in neural cells
    P Bonay
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, 28049, Madrid, Spain
    Biochim Biophys Acta 1535:217-20. 2001
    ....
  68. ncbi request reprint Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia
    A Ramon-Cueto
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Facultad de Ciencias, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Neuron 25:425-35. 2000
    ..Therefore, OEG transplantation provides a useful repair strategy in adult mammals with traumatic spinal cord injuries. Our results with these cells could lead to new therapies for the treatment of spinal cord lesions in humans...
  69. ncbi request reprint Isolation of a phosphorylated soluble tau fraction from Alzheimer's disease brain
    M D Ledesma
    , , Spain
    Neurobiol Aging 16:515-22. 1995
    ..These modifications may be a prerequisite for PHF formation...
  70. pmc Characterisation of antimitotic products from marine organisms that disorganise the microtubule network: ecteinascidin 743, isohomohalichondrin-B and LL-15
    M Garcia-Rocha
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Spain
    Br J Cancer 73:875-83. 1996
    ..The first two compounds prevent microtubule assembly and GTP binding to tubulin. Ecteinascidin 743 disorganises the microtubule network but it does not seem to interact directly with tubulin...
  71. ncbi request reprint Calmodulin binds to a tubulin binding site of the microtubule-associated protein tau
    R Padilla
    Centro de Biologia Molecular, Universidad Autonoma, Madrid, Spain
    Mol Cell Biochem 97:35-41. 1990
    ....
  72. doi request reprint Isolation of microtubules and microtubule proteins
    J Avila
    Centro de Biologia Molecular, Facultad de Ciencias, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    Curr Protoc Cell Biol . 2008
    ..5). The last protocol describes the application of a new technique that allows visualizing the quality of polymerized microtubules based on atomic force microscopy (AFM)...
  73. ncbi request reprint Perinatal lethality of microtubule-associated protein 1B-deficient mice expressing alternative isoforms of the protein at low levels
    C Gonzalez-Billault
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Spain
    Mol Cell Neurosci 16:408-21. 2000
    ..Analyses of these mice indicate the presence of several neural defects and suggest the participation of MAP1B in neuronal migration...
  74. ncbi request reprint Tau as a molecular marker of development, aging and neurodegenerative disorders
    Felix Hernandez
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Fac Ciencias, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Curr Aging Sci 1:56-61. 2008
    ..Thus, tau isoforms can be used as markers to follow neuronal development, aging or neurodegeneration...