V Arroyo

Summary

Country: Spain

Publications

  1. ncbi Advances in the pathogenesis and treatment of type-1 and type-2 hepatorenal syndrome
    Vicente Arroyo
    Liver Unit, Institute of Digestive and Metabolic Diseases, Hospital Clinic, University of Barcelona, Barcelona, Spain
    J Hepatol 46:935-46. 2007
  2. ncbi Pathogenesis and treatment of hepatorenal syndrome
    Vicente Arroyo
    Liver Unit, Institute of Digestive and Metabolic Diseases, CIBERehd, Hospital Clinic, University of Barcelona, Spain
    Semin Liver Dis 28:81-95. 2008
  3. ncbi The liver and the kidney: mutual clearance or mixed intoxication
    Vicente Arroyo
    Liver Unit, Institute of Digestive and Metabolic Diseases, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Contrib Nephrol 156:17-23. 2007
  4. ncbi Management of hepatorenal syndrome in patients with cirrhosis
    Vicente Arroyo
    Liver Unit, Hospital Clinic Barcelona, University of Barcelona, Villarroel 170, Barcelona, Catalonia 08036, Spain
    Nat Rev Nephrol 7:517-26. 2011
  5. ncbi Pathophysiological basis of albumin use in cirrhosis
    Vicente Arroyo
    Liver Unit, Institut de Malalties Digestives i Metaboliques, Hospital Clinic and Institut d Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Ann Hepatol 10:S6-14. 2011
  6. ncbi Review article: hepatorenal syndrome--how to assess response to treatment and nonpharmacological therapy
    V Arroyo
    Liver Unit, Institute of Digestive and Metabolic Diseases, Hospital Clinic, University of Barcelona, Spain
    Aliment Pharmacol Ther 20:49-54; discussion 55-6. 2004
  7. ncbi Renal and neurohormonal changes following simultaneous administration of systemic vasoconstrictors and dopamine or prostacyclin in cirrhotic patients with hepatorenal syndrome
    J Salo
    Department of Medicine, Hospital Clinic i Provincial, Barcelona, Spain
    J Hepatol 25:916-23. 1996
  8. ncbi Reversibility of hepatorenal syndrome by prolonged administration of ornipressin and plasma volume expansion
    M Guevara
    Liver Unit, Hospital Clinic i Provincial, University of Barcelona, Catalunya, Spain
    Hepatology 27:35-41. 1998
  9. ncbi Nitric oxide production and inducible nitric oxide synthase expression in peritoneal macrophages of cirrhotic patients
    W Jimenez
    Hormonal Laboratory, Hospital Clínic Universitari and Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Hepatology 30:670-6. 1999
  10. ncbi In vitro and in vivo activation of rat hepatic stellate cells results in de novo expression of L-type voltage-operated calcium channels
    R Bataller
    Liver Unit, Hospital Clinic, IDIBAPS, University of Barcelona School of Medicine, Catalunya, Spain
    Hepatology 33:956-62. 2001

Detail Information

Publications101 found, 100 shown here

  1. ncbi Advances in the pathogenesis and treatment of type-1 and type-2 hepatorenal syndrome
    Vicente Arroyo
    Liver Unit, Institute of Digestive and Metabolic Diseases, Hospital Clinic, University of Barcelona, Barcelona, Spain
    J Hepatol 46:935-46. 2007
  2. ncbi Pathogenesis and treatment of hepatorenal syndrome
    Vicente Arroyo
    Liver Unit, Institute of Digestive and Metabolic Diseases, CIBERehd, Hospital Clinic, University of Barcelona, Spain
    Semin Liver Dis 28:81-95. 2008
    ..However, effective treatments of HRS (vasoconstrictors associated with intravenous albumin, transjugular intrahepatic portacaval shunt, albumin dialysis) that can improve survival have recently been introduced...
  3. ncbi The liver and the kidney: mutual clearance or mixed intoxication
    Vicente Arroyo
    Liver Unit, Institute of Digestive and Metabolic Diseases, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Contrib Nephrol 156:17-23. 2007
    ..In this article new concepts on the pathogenesis of hepatorenal syndrome are reported, the current options for prophylaxis are shown, and the most applicable treatments are described...
  4. ncbi Management of hepatorenal syndrome in patients with cirrhosis
    Vicente Arroyo
    Liver Unit, Hospital Clinic Barcelona, University of Barcelona, Villarroel 170, Barcelona, Catalonia 08036, Spain
    Nat Rev Nephrol 7:517-26. 2011
    ..Albumin dialysis is a potentially effective treatment for type 1 HRS still under investigation. Patients with type 2 HRS are treated with repeated large-volume paracentesis or TIPS...
  5. ncbi Pathophysiological basis of albumin use in cirrhosis
    Vicente Arroyo
    Liver Unit, Institut de Malalties Digestives i Metaboliques, Hospital Clinic and Institut d Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Ann Hepatol 10:S6-14. 2011
    ..Impairment of albumin function is one of the most characteristic traits of cirrhosis. Administration of exogenous albumin could be beneficial because of its positive effects on microcirculation...
  6. ncbi Review article: hepatorenal syndrome--how to assess response to treatment and nonpharmacological therapy
    V Arroyo
    Liver Unit, Institute of Digestive and Metabolic Diseases, Hospital Clinic, University of Barcelona, Spain
    Aliment Pharmacol Ther 20:49-54; discussion 55-6. 2004
    ..TIPS is also effective in these patients and the combination of pharmacological treatment followed by TIPS may be the most effective approach...
  7. ncbi Renal and neurohormonal changes following simultaneous administration of systemic vasoconstrictors and dopamine or prostacyclin in cirrhotic patients with hepatorenal syndrome
    J Salo
    Department of Medicine, Hospital Clinic i Provincial, Barcelona, Spain
    J Hepatol 25:916-23. 1996
    ..The renal effects of the i.v. infusion of norepinephrine plus prostacyclin in patients with hepatorenal syndrome were also assessed...
  8. ncbi Reversibility of hepatorenal syndrome by prolonged administration of ornipressin and plasma volume expansion
    M Guevara
    Liver Unit, Hospital Clinic i Provincial, University of Barcelona, Catalunya, Spain
    Hepatology 27:35-41. 1998
    ....
  9. ncbi Nitric oxide production and inducible nitric oxide synthase expression in peritoneal macrophages of cirrhotic patients
    W Jimenez
    Hormonal Laboratory, Hospital Clínic Universitari and Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Hepatology 30:670-6. 1999
    ....
  10. ncbi In vitro and in vivo activation of rat hepatic stellate cells results in de novo expression of L-type voltage-operated calcium channels
    R Bataller
    Liver Unit, Hospital Clinic, IDIBAPS, University of Barcelona School of Medicine, Catalunya, Spain
    Hepatology 33:956-62. 2001
    ..We conclude that the activation of HSCs is associated with up-regulation of L-type VOCC that mediate Ca2+ influx and cell contraction. These results may be relevant to the pathogenesis of portal hypertension...
  11. ncbi Complications of cirrhosis. II. Renal and circulatory dysfunction. Lights and shadows in an important clinical problem
    V Arroyo
    Institute of Digestive Diseases and Hormonal Laboratory, Hospital Clinic Universitari, University of Barcelona, Spain
    J Hepatol 32:157-70. 2000
    ..The mechanism of bacterial translocation and of the colonization of bacteria in the ascitic fluid are particularly important to design adequate measures for primary prophylaxis of this severe bacterial infection...
  12. ncbi Transjugular intrahepatic portosystemic shunting versus paracentesis plus albumin for refractory ascites in cirrhosis
    Pere Gines
    Liver Unit, Hospital Clinic, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, University of Barcelona, Instituto Reina Sofia de Investigacion Nefrologica, Barcelona, Catalunya, Spain
    Gastroenterology 123:1839-47. 2002
    ..However, its effect on survival and healthcare costs is still uncertain...
  13. ncbi Randomized trial comparing albumin, dextran 70, and polygeline in cirrhotic patients with ascites treated by paracentesis
    A Gines
    Liver Unit, Hospital Clinic i Provincial, Barcelona, Spain
    Gastroenterology 111:1002-10. 1996
    ..This study investigated the clinical importance of paracentesis-induced-circulatory dysfunction and compared the efficacy of albumin, dextran 70, and polygeline in preventing this complication...
  14. ncbi Human hepatic stellate cells secrete adrenomedullin: potential autocrine factor in the regulation of cell contractility
    M N Görbig
    Institute of Digestive Diseases, Hospital Clinic, Institut d Investigacions Biomèdiques August Pi Sunyer, University of Barcelona School of Medicine, Catalonia, Spain
    J Hepatol 34:222-9. 2001
    ..It is unknown whether human HSCs have receptors for and are able to synthesize the vasodilator peptide adrenomedullin (ADM), a peptide produced by most contractile cells...
  15. ncbi Inactivation of extrahepatic vascular Akt improves systemic hemodynamics and sodium excretion in cirrhotic rats
    G Fernandez-Varo
    Biochemistry and Molecular Genetics Service, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, University of Barcelona, Barcelona, Spain
    J Hepatol 53:1041-8. 2010
    ..Ultimately, we sought to determine whether endothelial transduction of a constitutively inactive mutant of Akt (AA-Akt) improves circulatory function and sodium excretion in cirrhotic rats with ascites...
  16. ncbi Long-term aquaretic efficacy of a selective nonpeptide V(2)-vasopressin receptor antagonist, SR121463, in cirrhotic rats
    W Jimenez
    Hormonal Laboratory, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic Universitari, University of Barcelona and Instituto Reina Sofia de Investigaciones Nefrológicas, Barcelona, Spain
    J Pharmacol Exp Ther 295:83-90. 2000
    ..During the first 6 days of treatment, SR121463 also increased U(Na)V without affecting mean arterial pressure. These data suggest that SR121463 could be of therapeutical value for chronic management of human cirrhosis...
  17. ncbi A prognostic model for predicting survival in cirrhosis with ascites
    G Fernandez-Esparrach
    Liver Unit, Institut de Malalties Digestives, Hospital Clinic, IDIBAPS, Barcelona, Spain
    J Hepatol 34:46-52. 2001
    ..The aim of the current study was to develop a prognostic model to estimate survival of patients with cirrhosis and ascites...
  18. ncbi Increased plasma levels of neuropeptide Y in hepatorenal syndrome
    Juan Uriz
    Liver Unit, Institut de Malalties Digestives, , Barcelona, Spain
    J Hepatol 36:349-55. 2002
    ..CONCLUSIONS: Patients with HRS have increased levels of NPY which are related to circulatory dysfunction and SNS activation and may contribute to renal vasoconstriction...
  19. ncbi Renal failure in patients with cirrhosis and sepsis unrelated to spontaneous bacterial peritonitis: value of MELD score
    Carlos Terra
    Liver Unit, , Universitat de Barcelona, Barcelona, Spain
    Gastroenterology 129:1944-53. 2005
    ..Outcome is poor, even in the setting of reversible renal failure. The MELD score is the best prognostic marker of patients with cirrhosis and sepsis...
  20. ncbi Management of cirrhosis and ascites
    Pere Gines
    Liver Unit, Hospital Clinic and University of Barcelona, Institut d Investigacions Biomèdiques August Pi Sunyer, Barcelona, Spain
    N Engl J Med 350:1646-54. 2004
  21. ncbi New treatments of hepatorenal syndrome
    Vicente Arroyo
    Liver Unit, Institut of Digestive and Metabolic Diseases, Hospital Clinic, University of Barcelona, Spain
    Semin Liver Dis 26:254-64. 2006
    ....
  22. ncbi Norfloxacin vs ceftriaxone in the prophylaxis of infections in patients with advanced cirrhosis and hemorrhage
    Javier Fernandez
    IMDM and IDIBAPS, Liver Unit, Hospital Clinic, University of Barcelona, Villaroel 170, 08036 Barcelona, Spain
    Gastroenterology 131:1049-56; quiz 1285. 2006
    ..This randomized controlled trial was aimed to compare oral norfloxacin vs intravenous ceftriaxone in the prophylaxis of bacterial infection in cirrhotic patients with gastrointestinal bleeding...
  23. ncbi Terlipressin and albumin vs albumin in patients with cirrhosis and hepatorenal syndrome: a randomized study
    Marta Martín-Llahí
    Liver Unit, Hospital Clinic, University of Barcelona School of Medicine, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Barcelona, Spain
    Gastroenterology 134:1352-9. 2008
    ..Hepatorenal syndrome is common in patients with advanced cirrhosis and constitutes a major problem in liver transplantation. There is no effective medical treatment for hepatorenal syndrome...
  24. ncbi MELD score and serum sodium in the prediction of survival of patients with cirrhosis awaiting liver transplantation
    Maria Carlota Londoño
    Liver Unit, Hospital Clinic, Universitat de Barcelona, Institut de Investigacions Biomèdiques August Pi Sunyer, CIBER de Enfermedades Hepáticas y Digestivas and Centro de Investigaciones Biomédicas Esther Koplowitz, Barcelona, Spain
    Gut 56:1283-90. 2007
    ....
  25. ncbi Increased production of vascular endothelial growth factor in peritoneal macrophages of cirrhotic patients with spontaneous bacterial peritonitis
    P Cejudo-Martin
    Hormonal Laboratory, Hospital Clínic Universitari and Institut d Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Hepatology 34:487-93. 2001
    ..These results, therefore, are consistent with the concept that locally released macrophage-derived VEGF may result in increased vascular permeability and plasma leakage in the peritoneal vessels of cirrhotic patients with SBP...
  26. ncbi Review article: albumin for circulatory support in patients with cirrhosis
    P Gines
    Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Barcelona, Spain
    Aliment Pharmacol Ther 16:24-31. 2002
    ..By contrast, the administration of albumin without vasoconstrictors has marginal or no effects on renal function in this setting...
  27. ncbi Use of albumin in the management of patients with decompensated cirrhosis. An independent verdict
    V Arroyo
    Liver Unit, Institut de Malalties Digestives, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
    Dig Liver Dis 35:668-72. 2003
    ..In consequence, although further studies on this indication are clearly required, with the current data it is advisable to use albumin as a plasma expander in patients with massive ascites treated by paracentesis...
  28. ncbi Combined liver-kidney transplantation in patients with cirrhosis and chronic kidney disease
    M E Baccaro
    Liver Unit, Hospital Clinic, University of Barcelona, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Barcelona, Catalunya, Spain
    Nephrol Dial Transplant 25:2356-63. 2010
    ..However, 3-year survival of patients with cirrhosis treated with CLKT is excellent...
  29. ncbi Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis
    Javier Fernandez
    Liver Unit, IMD, and Department of Microbiology and IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Hepatology 35:140-8. 2002
    ..Quinolone-resistant spontaneous bacterial peritonitis constitutes an emergent problem in patients on long-term norfloxacin prophylaxis, with trimethoprim-sulfamethoxazole not being a valid alternative...
  30. ncbi Hyponatremia in patients treated with terlipressin for severe gastrointestinal bleeding due to portal hypertension
    Elsa Solá
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain
    Hepatology 52:1783-90. 2010
    ..It develops rapidly after start of therapy, may be severe in some patients and is associated with neurological complications, and is usually reversible after terlipressin withdrawal...
  31. ncbi Effects of treatment of hepatorenal syndrome before transplantation on posttransplantation outcome. A case-control study
    Tea Restuccia
    Liver Unit, Institute for Digestive Diseases, Hospital Clinic, University of Barcelona, Villarroel 170, Barcelona 08036, Catalunya, Spain
    J Hepatol 40:140-6. 2004
    ..Pretransplant renal function is the major determinant of survival after liver transplantation (LTx). Patients with hepatorenal syndrome (HRS) have a poor outcome after LTx compared with patients transplanted without HRS...
  32. ncbi Pathophysiology, diagnosis and treatment of ascites in cirrhosis
    Vicente Arroyo
    Liver Unit, Institut de Malalties Digestives Hospital Clinic, University of Barcelona, Spain
    Ann Hepatol 1:72-9. 2002
    ..TIPS is more effective in the long term control of ascites but may impair hepatic function and induce chronic hepatic encephalopathy...
  33. ncbi [Circulatory support with albumin in liver cirrhosis]
    V Arroyo
    , , , Universidad de Barcelona, Barcelona, Spain
    Gastroenterol Hepatol 28:74-9. 2005
  34. ncbi [Training of specialists in gastroenterology. Was it time for a review?]
    J M Pique
    Asociación Española de Gastroenterología AEG, Spain
    Gastroenterol Hepatol 26:427-36. 2003
  35. ncbi [Adrenal insufficiency in cirrhosis]
    Javier Fernandez
    IMDiM, IDIBAPS, Hospital Clinic, Universidad de Barcelona, CIBERehd, Barcelona, Espana
    Gastroenterol Hepatol 31:606-11. 2008
    ..This chapter summarizes the main aspects of the physiopathology, diagnosis and treatment of this entity in patients with acute or chronic liver disease...
  36. ncbi Effects of contrast media on renal function in patients with cirrhosis: a prospective study
    Monica Guevara
    Liver Unit, Hospital Clinic, Barcelona, Spain
    Hepatology 40:646-51. 2004
    ..Cirrhosis does not appear to be a risk factor for the development of contrast media-induced nephrotoxicity...
  37. ncbi Aquaporin-1 and aquaporin-2 urinary excretion in cirrhosis: Relationship with ascites and hepatorenal syndrome
    Christina Esteva-Font
    Molecular Biology Laboratory, , Barcelona, Spain
    Hepatology 44:1555-63. 2006
    ..Finally, aquaporin-1 does not appear to play a role in the progressive dysregulation of extracellular fluid volume in cirrhosis...
  38. ncbi Effects of celecoxib and naproxen on renal function in nonazotemic patients with cirrhosis and ascites
    Joan Claria
    DNA Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Hepatology 41:579-87. 2005
    ..Further studies are needed to evaluate the long-term safety of this drug in cirrhosis...
  39. ncbi Adrenal insufficiency in patients with cirrhosis and septic shock: Effect of treatment with hydrocortisone on survival
    Javier Fernandez
    Liver Unit, Department of Surgery and Centro de Investigaciones Biomédicas Esther Koplowitz, IMDiM, IDIBAPS, Hospital Clinic, University of Barcelona, Spain
    Hepatology 44:1288-95. 2006
    ..Hydrocortisone administration in these patients is associated with a high frequency of shock resolution and high survival rate...
  40. ncbi A randomized unblinded pilot study comparing albumin versus hydroxyethyl starch in spontaneous bacterial peritonitis
    Javier Fernandez
    Liver Unit, IMDM and IDIBAPS, Hospital Clinic, University of Barcelona, Spain
    Hepatology 42:627-34. 2005
    ..This effect is due not only to volume expansion but also to an action on the peripheral arterial circulation...
  41. ncbi The long-term results of a randomized clinical trial of laparoscopy-assisted versus open surgery for colon cancer
    Antonio M Lacy
    Department of Surgery, Centro de Investigaciones Biomédicas Esther Koplowitz, IMDiM, IDIBAPS, Hospital Clinic, University of Barcelona, Spain
    Ann Surg 248:1-7. 2008
    ..The aim of this study was to compare the long-term outcome of laparoscopy-assisted colectomy (LAC) and open colectomy (OC) for nonmetastatic colon cancer...
  42. ncbi Hyponatremia is a risk factor of hepatic encephalopathy in patients with cirrhosis: a prospective study with time-dependent analysis
    Monica Guevara
    Liver Unit, Hospital Clinic, University of Barcelona, Villarroel 170, Barcelona, Spain
    Am J Gastroenterol 104:1382-9. 2009
    ..The aim of this study was to investigate whether hyponatremia is a risk factor of overt hepatic encephalopathy (HE) in cirrhosis...
  43. ncbi Hyponatremia impairs early posttransplantation outcome in patients with cirrhosis undergoing liver transplantation
    Maria Carlota Londoño
    Liver Unit, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Gastroenterology 130:1135-43. 2006
    ..We aimed to assess the effects of hyponatremia at the time of transplantation on posttransplantation outcome in patients with cirrhosis...
  44. ncbi Effect of intravenous albumin on systemic and hepatic hemodynamics and vasoactive neurohormonal systems in patients with cirrhosis and spontaneous bacterial peritonitis
    Javier Fernandez
    Liver Unit, IMD, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
    J Hepatol 41:384-90. 2004
    ..Albumin administration prevents renal failure and improves survival in spontaneous bacterial peritonitis. This study characterizes the mechanisms of action of albumin in this condition...
  45. ncbi Increased carbon monoxide production in patients with cirrhosis with and without spontaneous bacterial peritonitis
    Dara de Las Heras
    Liver Unit, Department of Pulmonary Medicine, and Hormonal Laboratory, , University of Barcelona, Catalunya, Spain
    Hepatology 38:452-9. 2003
    ..Increased CO production may participate in the disturbance of circulatory function that occurs during severe bacterial infections in cirrhosis...
  46. ncbi Risk factors for hepatic encephalopathy in patients with cirrhosis and refractory ascites: relevance of serum sodium concentration
    Monica Guevara
    Liver Unit Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
    Liver Int 30:1137-42. 2010
    ..In conclusion, in patients with refractory ascites, the occurrence of HE is related to the impairment of liver and renal function and presence of hyponatraemia...
  47. ncbi Primary prophylaxis of spontaneous bacterial peritonitis delays hepatorenal syndrome and improves survival in cirrhosis
    Javier Fernandez
    Liver Unit, Hospital Clinic Barcelona, Barcelona, Spain
    Gastroenterology 133:818-24. 2007
    ..Norfloxacin is highly effective in preventing spontaneous bacterial peritonitis recurrence in cirrhosis, but its role in the primary prevention of this complication is uncertain...
  48. ncbi Prostaglandins and other cyclooxygenase-dependent arachidonic acid metabolites and the kidney in liver disease
    Joan Claria
    DNA Unit, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Universitat de Barcelona, Barcelona 08036, Spain
    Prostaglandins Other Lipid Mediat 72:19-33. 2003
  49. ncbi Renal failure after upper gastrointestinal bleeding in cirrhosis: incidence, clinical course, predictive factors, and short-term prognosis
    A Cardenas
    Liver Unit, Institut de Malalties Digestives, Hospital Clinic, University of Barcelona, Spain
    Hepatology 34:671-6. 2001
    ..Renal failure is a strong predictor of mortality in patients with cirrhosis and gastrointestinal bleeding...
  50. ncbi Matrix metalloproteinase 2 in reduced-size liver transplantation: beyond the matrix
    S Padrissa-Altés
    Experimental Hepatic Ischemia Reperfusion Unit, Institut d Investigacions Biomèdiques de Barcelona Consejo Superior de Investigaciones Científicas, Barcelona, Spain
    Am J Transplant 10:1167-77. 2010
    ..Our results open up new possibilities for therapeutic treatments to reduce I/R injury and increase liver regeneration after ROLT, which are the main limitations in living-donor transplantation...
  51. ncbi Management of ascites and hepatic hydrothorax
    Andres Cardenas
    Institut de Malalties Digestives i Metaboliques, University of Barcelona, Hospital Clinic, Villaroel 170, Barcelona 08036, Spain
    Best Pract Res Clin Gastroenterol 21:55-75. 2007
    ..This article reviews the most current concepts of pathogenesis, clinical findings, diagnosis, and treatment of these complications of cirrhosis...
  52. ncbi Terlipressin therapy with and without albumin for patients with hepatorenal syndrome: results of a prospective, nonrandomized study
    Rolando Ortega
    Liver Unit, Institut de Malalties Digestives, , University of Barcelona, , Catalunya, Spain
    Hepatology 36:941-8. 2002
    ..In conclusion, terlipressin therapy reverses HRS in a high proportion of patients. Recurrence rate after treatment withdrawal is uncommon. Albumin appears to improve markedly the beneficial effects of terlipressin...
  53. ncbi Effect of the V1a/V2-AVP receptor antagonist, Conivaptan, on renal water metabolism and systemic hemodynamics in rats with cirrhosis and ascites
    Guillermo Fernandez-Varo
    Hormonal Laboratory, Hospital Clinic Universitari, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona and Instituto Reina Sofia de Investigaciones Nefrológicas IRSIN, Villarroel 170, 08036, Barcelona, Spain
    J Hepatol 38:755-61. 2003
    ..This is important, particularly considering that blockade of V(1a)-AVP receptors could aggravate cardiocirculatory function in decompensated cirrhosis...
  54. ncbi Predictors of response to therapy with terlipressin and albumin in patients with cirrhosis and type 1 hepatorenal syndrome
    André Nazar
    Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalunya, Spain
    Hepatology 51:219-26. 2010
    ..Alternative treatment strategies to terlipressin and albumin should be investigated for patients with type 1 HRS and low likelihood of response to vasoconstrictor therapy...
  55. ncbi Sustained aquaretic effect of the V2-AVP receptor antagonist, RWJ-351647, in cirrhotic rats with ascites and water retention
    Josefa Ros
    Unitat de Cèl lules Troncals, Hospital Clínic Univesitari, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Instituto Reina Sofía de Investigaciones Nefrológicas, Barcelona, Spain
    Br J Pharmacol 146:654-61. 2005
    ..5 These data suggest that RWJ-351647 could be therapeutically useful in the treatment of water retention in human cirrhosis...
  56. ncbi Hepatorenal syndrome-pathogenesis and treatment
    Andres Cardenas
    Liver Unit, Institut de Malalties Digestives Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
    Curr Gastroenterol Rep 4:1-4. 2002
  57. ncbi Gene transduction of an active mutant of akt exerts cytoprotection and reduces graft injury after liver transplantation
    M Morales Ruiz
    Department of Biochemistry and Molelular Genetics, Hospital Clinic, IDIBAPS, University of Barcelona and IRSIN, Spain
    Am J Transplant 7:769-78. 2007
    ..In conclusion, myr-Akt gene therapy effectively exerts cytoprotection against hepatic I/R injury regardless of the Akt-dependent eNOS activation...
  58. ncbi Origins of cardiac dysfunction in cirrhosis
    W Jimenez
    Hormonal Laboratory, Hospital Clinic, University of Barcelona, Spain
    Gut 52:1392-4. 2003
  59. ncbi Atorvastatin attenuates angiotensin II-induced inflammatory actions in the liver
    Montserrat Moreno
    Institut de Malalties Digestives i Metaboliques, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigación Biomédica Esther Koplowitz, Barcelona, Catalonia, Spain
    Am J Physiol Gastrointest Liver Physiol 296:G147-56. 2009
    ..These results indicate that atorvastatin attenuates the pathogenic events induced by ANG II in the liver both in vivo and in vitro. Therefore, statins could have beneficial effects in conditions characterized by hepatic inflammation...
  60. ncbi Hepatorenal syndrome in cirrhosis: pathogenesis and treatment
    Vicente Arroyo
    Liver Unit, Institute of Digestive Disease, Hospital Clinic, University of Barcelona, Villaroel 170, 08036 Barcelona, Spain
    Gastroenterology 122:1658-76. 2002
  61. ncbi Hypoxia is an inducer of vasodilator agents in peritoneal macrophages of cirrhotic patients
    Pilar Cejudo-Martin
    Hormonal Laboratory, Liver Unit, Institut de Malalties Digestives, Hospital Clínic Universitari and Institut d Investigacions Biomèdiques August Pi i Sunyer and Instituto Reina Sofia de Investigaciones Nefrológicas, University of Barcelona, Spain
    Hepatology 36:1172-9. 2002
    ..These data suggest that a local reduction in O(2) tension could enhance the synthesis of macrophage-derived vasodilators, thus aggravating the circulatory disturbance of these patients...
  62. ncbi MELD score and clinical type predict prognosis in hepatorenal syndrome: relevance to liver transplantation
    Carlo Alessandria
    Liver Unit, , Universitat de Barcelona, Barcelona, Spain
    Hepatology 41:1282-9. 2005
    ..These data can be useful in the management of patients with HRS, particularly for patients who are candidates for liver transplantation...
  63. ncbi Ascites and hepatorenal syndrome in cirrhosis: pathophysiological basis of therapy and current management
    Vicente Arroyo
    Liver Unit, Institute of Digestive Diseases, , Villarroel, 170, University of Barcelona, 08036 Barcelona, Spain
    J Hepatol 38:S69-89. 2003
  64. ncbi Effect of angiotensin II and bradykinin inhibition in rat reduced-size liver transplantation
    Susagna Padrissa-Altés
    Experimental Hepatic Ischemia Reperfusion Unit, Institut d Investigacions Biomediques de Barcelona, Consejo Superior de Investigaciones Cientícas, Barcelona, Spain
    Liver Transpl 15:313-20. 2009
    ..Consequently, it may be of clinical interest to apply both treatments simultaneously...
  65. ncbi Renal effects of selective cyclooxygenase inhibition in experimental liver disease
    Marta López-Parra
    Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Spain
    Adv Exp Med Biol 525:133-6. 2003
  66. ncbi High-density lipoproteins reduce the effect of endotoxin on cytokine production and systemic hemodynamics in cirrhotic rats with ascites
    Maria Jose Ramirez
    Liver Unit, Hospital Clinic Universitari, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Villarroel 170, Barcelona 08036, Spain
    J Hepatol 40:424-30. 2004
    ..High-density lipoproteins (HDL) have a high capacity to inactivate endotoxin. The aim was to determine if HDL reduces the effect of endotoxin on cytokine production and systemic hemodynamics in experimental cirrhosis...
  67. ncbi Cyclooxygenase-1 derived prostaglandins are involved in the maintenance of renal function in rats with cirrhosis and ascites
    Marta López-Parra
    DNA Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona 08036, Spain
    Br J Pharmacol 135:891-900. 2002
    ..4. These results indicate that despite abundant renal COX-2 protein expression, the maintenance of renal function in cirrhotic rats is mainly dependent on COX-1-derived prostaglandins...
  68. ncbi Hepatorenal syndrome
    Pere Gines
    Liver Unit, Hospital Cli nic, Institut d Investigacions Biomèdiques August Pi Sunyer, University of Barcelona School of Medicine, Barcelona, Catalunya, Spain
    Lancet 362:1819-27. 2003
    ..Although these findings need to be confirmed, these two strategies represent innovative approaches to lower the frequency of HRS in clinical practice...
  69. ncbi Human myofibroblastic hepatic stellate cells express Ca(2+)-activated K(+) channels that modulate the effects of endothelin-1 and nitric oxide
    X Gasull
    Laboratory of Neurophysiology, University of Barcelona School of Medicine, IDIBAPS, Catalonia, Barcelona, Spain
    J Hepatol 35:739-48. 2001
    ..CONCLUSIONS: Activated human HSCs contain BK(Ca) channels that modulate the contractile effect of endothelin-1 and mediate the inhibitory action of NO...
  70. ncbi Review article: albumin in the treatment of liver diseases--new features of a classical treatment
    V Arroyo
    Liver Unit, Institute of Digestive Diseases, Hospital Clinic, University of Barcelona, Spain
    Aliment Pharmacol Ther 16:1-5. 2002
    ..Based on this capacity an albumin dialysis system (MARS) has recently been developed. The usefulness of this system in the management of patients with acute and chronic liver failure is, at present, under evaluation...
  71. ncbi ERCP in orthotopic liver transplanted patients
    Alfredo Mata
    Section of GI Endoscopy, Motility and Functional GI Tests, Institut de Malalties Digestives, Hospital Clinic, Barcelona, Spain
    Hepatogastroenterology 51:1801-4. 2004
    ..CONCLUSIONS: Because of its availability, diagnostic accuracy, treatment efficacy and safety, ERCP should be used as the first-line procedure for treatment of biliary tract complications after OLT...
  72. ncbi Increased anandamide induced relaxation in mesenteric arteries of cirrhotic rats: role of cannabinoid and vanilloid receptors
    M Domenicali
    Laboratorio Hormonal, Hospital Clinic Universitari, Villarroel 170, Barcelona 08036, Spain
    Gut 54:522-7. 2005
    ....
  73. ncbi Protection from hepatic lipid accumulation and inflammation by genetic ablation of 5-lipoxygenase
    Esther Titos
    Department of Biochemistry and Molecular Genetics, Hospital Clinic, IDIBAPS, CIBEK, University of Barcelona, Barcelona 08036, Spain
    Prostaglandins Other Lipid Mediat 92:54-61. 2010
    ..These findings confirm at a genetic level that Alox5 plays a pathogenic role in the response of the liver to injury...
  74. ncbi Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury
    Pau Sancho Bru
    Liver Unit, Institut Clinic de Malalties Digestives i Metaboliques, Barcelona, Catalonia, Spain
    Gastroenterology 133:2019-28. 2007
    ..Recent studies have suggested that the kallikrein-kinin system regulates tissue fibrogenesis. We hypothesize that bradykinin (BK), the main effector peptide of this system, regulates hepatic fibrogenesis...
  75. ncbi Are angiotensin II receptor antagonists useful strategies in steatotic and nonsteatotic livers in conditions of partial hepatectomy under ischemia-reperfusion?
    Fernando S Ramalho
    Experimental Hepatic Ischemia Reperfusion Unit, Institut d Investigacions Biomèdiques de Barcelona Consejo Superior de Investigaciones Científicas, Barcelona, Spain
    J Pharmacol Exp Ther 329:130-40. 2009
    ....
  76. ncbi Hecker R, Sherlock S. Electrolyte and circulatory changes in terminal liver failure [Lancet 1956;2:1221-1225]
    Vicente Arroyo
    Liver Unit, Institut de Malalties Digestives, Hospital Clinic, University of Barcelona, Barcelona, Spain
    J Hepatol 36:315-20. 2002
  77. ncbi The hepatic apelin system: a new therapeutic target for liver disease
    Alessandro Principe
    Biochemistry and Molecular Genetics Service, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Hepatology 48:1193-201. 2008
    ....
  78. ncbi Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C
    Jordi Colmenero
    Liver Unit, Institut Clinic de Malalties Digestives i Metaboliques, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Catalonia, Spain
    Am J Physiol Gastrointest Liver Physiol 297:G726-34. 2009
    ..Controlled studies are warranted to assess the effect of AT1 receptor blockers in chronic liver injury...
  79. ncbi Chronology of hemodynamic changes in asymptomatic in vitro fertilization patients and relationship with ovarian steroids and cytokines
    Dolors Manau
    , , Faculty of Medicine, University of Barcelona, Spain
    Fertil Steril 77:1178-83. 2002
    ..These hemodynamic changes occur in the absence of variations in the circulating levels of cytokines potentially involved in ovarian hyperstimulation syndrome...
  80. ncbi The selective cyclooxygenase-2 inhibitor celecoxib modulates the formation of vasoconstrictor eicosanoids and activates PPARgamma. Influence of albumin
    Marta López-Parra
    DNA Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Villarroel 170, Barcelona 08036, Spain
    J Hepatol 42:75-81. 2005
    ..In the current study, we investigated the molecular mechanisms underlying the effects of the selective COX-2 inhibitor, celecoxib, and assessed the influence of albumin on its actions...
  81. ncbi Effects of dilutional hyponatremia on brain organic osmolytes and water content in patients with cirrhosis
    Tea Restuccia
    Liver Unit, , Barcelona, Spain
    Hepatology 39:1613-22. 2004
    ..These findings may be relevant to the pathogenesis of encephalopathy in hyponatremic patients...
  82. ncbi Sodium retention in cirrhotic rats is associated with increased renal abundance of sodium transporter proteins
    Patrícia Fernández-Llama
    Fundacio Puigvert, Renal Unit and Hypertension, Barcelona, Spain
    Kidney Int 67:622-30. 2005
    ..Liver cirrhosis with ascites is associated with a decrease in renal sodium excretion and therefore sodium retention...
  83. ncbi Ascites from cirrhotic patients induces angiogenesis through the phosphoinositide 3-kinase/Akt signaling pathway
    Manuel Morales-Ruiz
    Hormonal Laboratory, Hospital Clinic and Institut d Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Villarroel 170 Barcelona 08036, Spain
    J Hepatol 43:85-91. 2005
    ..Ascites in patients with cirrhosis is associated with worsening of systemic hemodynamics. Thus, the aim of this study was to investigate the biological activity of ascites on endothelial cells...
  84. ncbi Refractory ascites
    Andres Cardenas
    Liver Unit, Institute of Digestive Diseases, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Dig Dis 23:30-8. 2005
    ..This article will discuss the pathophysiology, clinical features and therapy of refractory ascites in cirrhosis...
  85. ncbi Microarray analysis of endothelial differentially expressed genes in liver of cirrhotic rats
    Sònia Tugues
    Hormonal Laboratory, Hospital Clinic and Institut d Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona
    Gastroenterology 129:1686-95. 2005
    ..Therefore, the aim of this study was to evaluate differences in gene expression patterns between liver endothelial cells (LECs) from control and cirrhotic rats by using microarrays...
  86. ncbi Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells
    Pau Sancho-Bru
    Liver Unit, , , Villarroel 170, Barcelona, Spain
    Am J Physiol Gastrointest Liver Physiol 291:G877-84. 2006
    ..We conclude that NE stimulates NF-kappaB and induces cell contraction and proinflammatory effects in human HSC. Catecholamines may participate in the pathogenesis of portal hypertension and liver fibrosis by targeting HSC...
  87. ncbi Inhibition of 5-lipoxygenase-activating protein abrogates experimental liver injury: role of Kupffer cells
    Esther Titos
    , , University of Barcelona School of Medicine, Barcelona 08036, Spain
    J Leukoc Biol 78:871-8. 2005
    ..These findings support the concept that modulation of the 5-LO pathway by FLAP inhibition may be useful in the prevention of hepatotoxin-induced necro-inflammatory injury...
  88. ncbi Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S-hydroxy-DHA
    Ana González-Périz
    Department of Biochemistry and Molecular Genetics, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona School of Medicine, Barcelona 08036, Spain
    FASEB J 20:2537-9. 2006
    ..Taken together, these findings identify a potential role for DHA-derived products, specifically 17S-HDHA and protectin D1, in mediating the protective effects of dietary DHA in necroinflammatory liver injury...
  89. ncbi Impaired extracellular matrix degradation in aortic vessels of cirrhotic rats
    Guillermo Fernandez Varo
    Department of Biochemistry and Molecular Genetics, Hospital Clinic Universitari, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    J Hepatol 46:440-6. 2007
    ..Increased nitric oxide synthase (NOS) activity has been involved in the pathogenesis of this phenomenon. Therefore, we assessed the NO-regulated cell signaling pathways participating in vascular remodeling in cirrhosis...
  90. ncbi Diagnosis, prevention and treatment of hepatorenal syndrome in cirrhosis
    Francesco Salerno
    Department of Internal Medicine, Policlinico IRCCS San Donato, University of Milan, Via Morandi, 30, 20097 San Donato (MI, Italy
    Gut 56:1310-8. 2007
  91. ncbi Systemic, renal, and hepatic hemodynamic derangement in cirrhotic patients with spontaneous bacterial peritonitis
    Luis Ruiz-del-Arbol
    Liver Hemodynamic Unit, Department of Gastroenterology, Hospital Ramon y Cajal, University of Alcala de Henares, Madrid, Spain
    Hepatology 38:1210-8. 2003
    ..This occurs despite rapid resolution of infection and is associated with an extremely poor prognosis...
  92. ncbi Transduction of the liver with activated Akt normalizes portal pressure in cirrhotic rats
    Manuel Morales-Ruiz
    Hormonal Laboratory, Hospital Clnic Universitari, Villarroel 170, Barcelona 08036, Spain
    Gastroenterology 125:522-31. 2003
    ..For this reason the aims of the present study were to determine whether there is an impaired Akt activation in cirrhotic livers and how this phenomenon relates to the decrease in NO production associated with portal hypertension...
  93. ncbi Restricted use of albumin for spontaneous bacterial peritonitis
    Samuel H Sigal
    Gut 56:597-9. 2007
  94. ncbi The role of nitric oxide in the pathogenesis of systemic and splanchnic vasodilation in cirrhotic rats before and after the onset of ascites
    Paolo Angeli
    Department of Clinical and Experimental Medicine, University of Padua, Via Giustiniani 2, Padova 35100, Italy
    Liver Int 25:429-37. 2005
    ..The role of nitric oxide (NO) in the pathogenesis of splanchnic arterial vasodilation in cirrhosis has been recently debated by some experimental studies...
  95. ncbi Hepatorenal syndrome
    Andres Cardenas
    Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Ann Hepatol 2:23-9. 2003
    ..Prevention of hepatorenal syndrome with albumin infusion is recommended in patients with spontaneous bacterial peritonitis and with pentoxifylline in patients with acute alcoholic hepatitis...
  96. ncbi Circulatory function and hepatorenal syndrome in cirrhosis
    Luis Ruiz-del-Arbol
    Hepatic Hemodynamic Unit, Gastroenterology Department, Hospital Ramon y Cajal, University of Alcala, Ctra de Colmenar Viejo Km 9 1, 28034 Madrid, Spain
    Hepatology 42:439-47. 2005
    ..No changes were observed in peripheral vascular resistance. In conclusion, these data indicate that hepatorenal syndrome is the result of a decrease in cardiac output in the setting of a severe arterial vasodilation...
  97. ncbi Mechanisms of water and sodium retention in cirrhosis and the pathogenesis of ascites
    Andres Cardenas
    Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Dana 501, Boston, MA 02215, USA
    Best Pract Res Clin Endocrinol Metab 17:607-22. 2003
    ..The net effect is avid retention of sodium and water as well as renal vasoconstriction. The mechanisms of sodium and water retention and ascites formation in patients with cirrhosis are discussed in this review...
  98. ncbi Human hepatic stellate cells show features of antigen-presenting cells and stimulate lymphocyte proliferation
    Odette Viñas
    Laboratory of Immunology, Hospital Clinic, University of Barcelona School of Medicine, Institut d Investigacios Biomèdiques August Pi Sunyer IDIBAPS, Villaroel 170, 08036 Barcelona, Catalonia, Spain
    Hepatology 38:919-29. 2003
    ..In conclusion, human activated HSCs express molecules for antigen presentation, internalize macromolecules, and modulate T-lymphocyte proliferation. These results suggest that HSCs may play a role in the immune function of the liver...
  99. ncbi Regression of fibrosis after chronic stimulation of cannabinoid CB2 receptor in cirrhotic rats
    Javier Muñoz-Luque
    Servicio de Bioquímica y Genética Molecular, Hospital Clinic Universitari, Villarroel 170, Barcelona 08036, Spain
    J Pharmacol Exp Ther 324:475-83. 2008
    ....
  100. ncbi The management of ascites in cirrhosis: report on the consensus conference of the International Ascites Club
    Kevin P Moore
    Centre for Hepatology, Royal Free and University College Medical School, UCL, London, United Kingdom
    Hepatology 38:258-66. 2003
    ..Liver transplantation should be considered for all ascitic patients, and this should preferably be performed prior to the development of renal dysfunction to prevent further compromise of their prognosis...
  101. ncbi Gene expression profiling of renal dysfunction in rats with experimental cirrhosis
    Marta López-Parra
    Laboratory of Biochemistry and Molecular Genetics, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona School of Medicine, Barcelona, Spain
    J Hepatol 45:221-9. 2006
    ..In this investigation, we used microarrays to monitor global gene expression changes in the kidney of cirrhotic rats...