Sanz A, Garcia R, Rodriguez Peña J, Nombela C, Arroyo J. Slt2 MAPK association with chromatin is required for transcriptional activation of Rlm1 dependent genes upon cell wall stress. Biochim Biophys Acta Gene Regul Mech. 2018;1861:1029-1039 pubmed publisher
Fang W, Sanz A, Bartual S, Wang B, Ferenbach A, Farkas V, et al
. Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases. Nat Commun. 2019;10:1669 pubmed publisher
..Together with mutagenesis, the structure suggests a "hydrolysis product assisted" molecular mechanism favouring transglycosylation over hydrolysis. ..
Sanz A, GarcÃa R, RodrÃguez PeÃ±a J, Arroyo J. The CWI Pathway: Regulation of the Transcriptional Adaptive Response to Cell Wall Stress in Yeast. J Fungi (Basel). 2017;4: pubmed publisher
..Since all these regulatory mechanisms are well conserved in pathogenic fungi, improving our knowledge about them will have an impact in the developing of new antifungal therapies. ..
GarcÃa R, Botet J, RodrÃguez PeÃ±a J, Bermejo C, Ribas J, Revuelta J, et al
. Genomic profiling of fungal cell wall-interfering compounds: identification of a common gene signature. BMC Genomics. 2015;16:683 pubmed publisher
..The results may be useful to uncover new potential antifungal targets and develop efficient antifungal strategies by combination of two drugs, one targeting the cell wall and the other interfering with the adaptive mechanisms. ..
GarcÃa R, Sanz A, RodrÃguez PeÃ±a J, Nombela C, Arroyo J. Rlm1 mediates positive autoregulatory transcriptional feedback that is essential for Slt2-dependent gene expression. J Cell Sci. 2016;129:1649-60 pubmed publisher
Sanz A, Garcia R, Rodriguez Peña J, Nombela C, Arroyo J. Cooperation between SAGA and SWI/SNF complexes is required for efficient transcriptional responses regulated by the yeast MAPK Slt2. Nucleic Acids Res. 2016;44:7159-72 pubmed publisher
..Therefore, SAGA complex, through its histone acetylase activity, cooperates with the SWI/SNF complex for the mandatory nucleosome displacement required for full gene expression through the CWI pathway. ..