A Arnaiz Villena

Summary

Country: Spain

Publications

  1. ncbi Evolution of MHC-G in primates: a different kind of molecule for each group of species
    A Arnaiz-Villena
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    J Reprod Immunol 43:111-25. 1999
  2. ncbi Phylogeny and rapid northern and southern hemisphere speciation of goldfinches during the Miocene and Pliocene epochs
    A Arnaiz-Villena
    Departamento de Inmunologia y Biologia Molecular, Universidad Complutense de Madrid, Spain
    Cell Mol Life Sci 54:1031-41. 1998
  3. ncbi The origin of Cretan populations as determined by characterization of HLA alleles
    A Arnaiz-Villena
    Department of Immunology and Molecular Biology, H 12 De Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 53:213-26. 1999
  4. ncbi Description of seven new non-human primate MHC-B alleles
    J Martinez-Laso
    Immunology Research Unit, Department of Microbiology, Hospital Clinico San Carlos, Madrid, Spain
    Tissue Antigens 67:85-8. 2006
  5. ncbi High polymorphism of Mhc-E locus in non-human primates: alleles with identical exon 2 and 3 are found in two different species
    M Alvarez
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 49:160-7. 1997
  6. ncbi MHC-F polymorphism and evolution
    J Moscoso
    Department of Immunology, The Madrid Regional Blood Center, Universidad Complutense, Madrid, Spain
    Tissue Antigens 69:136-9. 2007
  7. ncbi Allelic diversity at the primate MHC-DMB locus: presence of a conserved tyrosine inhibitory motif in the cytoplasmic tail
    M Alvarez
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 51:174-82. 1998
  8. ncbi Complete cDNA sequences of the DRB6 gene from humans and chimpanzees: a possible model of a stop codon readingthrough mechanism in primates
    M A Moreno-Pelayo
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Carretera Andalucia, 28041 Madrid, Spain
    Immunogenetics 49:843-50. 1999
  9. ncbi HLA-G polymorphism and evolution
    A Arnaiz-Villena
    Department of Immunology, The Madrid Regional Blood Center, Universidad Complutense, Madrid, Spain
    Tissue Antigens 69:156-9. 2007
  10. ncbi New species-specific alleles at the primate MHC-G locus
    A Corell
    Department of Immunology, 12th of October University Hospital, Complutense University of Madrid, Spain
    Hum Immunol 41:52-5. 1994

Collaborators

  • Antonio Arnaiz-Villena
  • Gilberto Vargas-Alarcon
  • E Moreno
  • E Paz-Artal
  • J Martinez-Laso
  • J Moscoso
  • E Gomez-Casado
  • P Varela
  • P Morales
  • J Zamora
  • M Alvarez
  • M J Castro
  • J I Serrano-Vela
  • N Martinez-Quiles
  • M A Moreno-Pelayo
  • M Perez-Blas
  • S Ferre-Lopez
  • J E Garcia-Ortiz
  • R Alegre
  • R Rojo
  • J M Martin-Villa
  • L M Allende
  • S Distante
  • M Gonzalez-Hevilla
  • P Sanchez-Velasco
  • J Longas
  • E Lowy
  • I Rubio
  • M Garcia-Berciano
  • L Allende
  • C Silvera-Redondo
  • M J Casro
  • R Rojo-Amigo
  • B Perez-Saborido
  • J Ignacio Serrano-Vela
  • M Rosal
  • J R Arguello
  • A Olivo-Díaz
  • H Maldonado-Torres
  • S G E Marsh
  • R Pacheco
  • C A García-Sepúlveda
  • J Granados
  • S Cox
  • H Rangel-Villalobos
  • L E Figuera
  • J A Madrigal
  • L Sandoval-Ramirez
  • A M Little
  • A Corell
  • K J H Robson
  • P Brissot
  • Mark Worwood
  • J Graham-Campbell
  • N Diaz-Campos
  • F Leyva-Cobian
  • A Cemborain
  • Z Layrisse
  • C Silvera
  • F Montoya
  • E Egea
  • A Pacho
  • J Guillen-Perales
  • G Garavito
  • V M Fernandez-Soria
  • C Gorodezky
  • C Garcia-de-la-Torre
  • B Suarez
  • V Fernandez-Soria
  • M Catalfamo
  • D Jaraquemada
  • M J Recio
  • M Alvarez-Tejado
  • C Garcia-Torre
  • E Dominguez
  • Y Guedez
  • C Rodriguez
  • J Martin-Villa

Detail Information

Publications41

  1. ncbi Evolution of MHC-G in primates: a different kind of molecule for each group of species
    A Arnaiz-Villena
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    J Reprod Immunol 43:111-25. 1999
    ..The data are concordant with the postulated immune inhibitory function for MHC-G in Old World monkeys, anthropoids and humans both at placental and inflammatory level...
  2. ncbi Phylogeny and rapid northern and southern hemisphere speciation of goldfinches during the Miocene and Pliocene epochs
    A Arnaiz-Villena
    Departamento de Inmunologia y Biologia Molecular, Universidad Complutense de Madrid, Spain
    Cell Mol Life Sci 54:1031-41. 1998
    ..Also, reproductive barriers are observed between closely related species and not between other more distant ones. Finally, a tentative classification for genus Carduelis species is suggested...
  3. ncbi The origin of Cretan populations as determined by characterization of HLA alleles
    A Arnaiz-Villena
    Department of Immunology and Molecular Biology, H 12 De Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 53:213-26. 1999
    ..C., when desert desiccation began. They also could be part of the stock that gave rise to Sumerians, Cretans and Iberians; this is supported by both linguistic and HLA genetic data...
  4. ncbi Description of seven new non-human primate MHC-B alleles
    J Martinez-Laso
    Immunology Research Unit, Department of Microbiology, Hospital Clinico San Carlos, Madrid, Spain
    Tissue Antigens 67:85-8. 2006
  5. ncbi High polymorphism of Mhc-E locus in non-human primates: alleles with identical exon 2 and 3 are found in two different species
    M Alvarez
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 49:160-7. 1997
    ..In addition, two Macaca mulatta individuals show an Mhc-E locus duplication. Finally, phylogenetic tree analysis shows that Mhc class I molecules found in Saguinus oedipus (described as Mhc-G homologues) are closer to Mhc-E sequences...
  6. ncbi MHC-F polymorphism and evolution
    J Moscoso
    Department of Immunology, The Madrid Regional Blood Center, Universidad Complutense, Madrid, Spain
    Tissue Antigens 69:136-9. 2007
    ..It is possible that the MHC-F protein could be involved, together with MHC-G and MHC-E, in the natural killer cell activity regulation, although rhesus macaque cannot express complete surface MHC-G orthologue molecules...
  7. ncbi Allelic diversity at the primate MHC-DMB locus: presence of a conserved tyrosine inhibitory motif in the cytoplasmic tail
    M Alvarez
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 51:174-82. 1998
    ..Finally, a clade grouping human and gorilla DMB cDNA sequences is obtained using a dendrogram (as for C4d trees); this is in contrast to others' results that obtain a human/chimpanzee clade using different DNA sequences...
  8. ncbi Complete cDNA sequences of the DRB6 gene from humans and chimpanzees: a possible model of a stop codon readingthrough mechanism in primates
    M A Moreno-Pelayo
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Carretera Andalucia, 28041 Madrid, Spain
    Immunogenetics 49:843-50. 1999
    ....
  9. ncbi HLA-G polymorphism and evolution
    A Arnaiz-Villena
    Department of Immunology, The Madrid Regional Blood Center, Universidad Complutense, Madrid, Spain
    Tissue Antigens 69:156-9. 2007
    ..This seems to suggest that MHC-G genes in New World primates are not orthologous and that their function may be similar to that of classical presenting MHC genes...
  10. ncbi New species-specific alleles at the primate MHC-G locus
    A Corell
    Department of Immunology, 12th of October University Hospital, Complutense University of Madrid, Spain
    Hum Immunol 41:52-5. 1994
    ..Finally, phylogenetic relationships among the six MHC-G alleles, tamarins G-"like" alleles, and other human class I genes (both "classical" and "nonclassic") are discussed...
  11. ncbi HLA-E polymorphism in Amerindians from Mexico (Mazatecans), Colombia (Wayu) and Chile (Mapuches): evolution of MHC-E gene
    A Arnaiz-Villena
    Department of Immunology, The Madrid Regional Blood Center, Universidad Complutense, Madrid, Spain
    Tissue Antigens 69:132-5. 2007
    ....
  12. ncbi Evolutionary relationships between HLA-B alleles as indicated by an analysis of intron sequences
    E Gomez-Casado
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 53:153-60. 1999
    ..Finally, the precise knowledge of these non-coding regions could be important for developing DNA base typing strategies for the HLA-B alleles...
  13. ncbi Lack of MHC-G4 and soluble (G5, G6) isoforms in the higher primates, Pongidae
    M J Castro
    Department of Immunology and Molecular Biology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Hum Immunol 61:1164-8. 2000
    ....
  14. ncbi Allelic diversity at the primate major histocompatibility complex DRB6 locus
    A Corell
    Department of Immunology, Hospital 12 de Octubre, Madrid, Spain
    Immunogenetics 36:33-8. 1992
    ..Also, data are presented supporting that DRB6 may be one of the eldest genes of the DRB family, thus one of the first to diverge from the ancestral DRB gene...
  15. ncbi A novel HLA-G allele (HLA-G*0108) with an alpha-3 domain amino acid change
    J Moscoso
    Department of Immunology, Universidad Complutense, Madrid Regional Blood Center, Madrid, Spain
    Tissue Antigens 70:171-3. 2007
    ..HLA-G molecules give negative signals to Natural Killer and T lymphocytes. In the present paper, a new allele, HLA-G*08, is described, which may be useful for monitoring transplants and for HLA and disease studies...
  16. ncbi HLA-G, -E and -F: allelism, function and evolution
    J Moscoso
    Department of Immunology, Universidad Complutense, The Madrid Regional Blood Center, Madrid, Spain
    Transpl Immunol 17:61-4. 2006
    ..A strong positive directional selection is acting for maintaining the observed low polymorphism on E, F and G loci in human and apes. Invariance must be important for this non-classical class I proteins function...
  17. ncbi Primate Mhc-E and -G alleles
    A Arnaiz-Villena
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Carretera Andalucia, E 28041 Madrid, Spain
    Immunogenetics 46:251-66. 1997
  18. ncbi C4d DNA sequences of two infrequent human allotypes (C4A13 and C4B12) and the presence of signal sequences enhancing recombination
    N Martinez-Quiles
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Carretera de Andalucia, Madrid, Spain
    J Immunol 161:3438-43. 1998
    ....
  19. ncbi Generation of the B*41 group of alleles as indicated by intron sequences
    J Martinez-Laso
    Immunology Research Unit, Department of Microbiology, Hospital Clinico San Carlos, Madrid, Spain
    Tissue Antigens 67:70-4. 2006
    ..B*4105 and B*4106 could be generated from B*4101 allele by point mutations, and B*4103 generation is unclear due to the lack of intron 2. The importance of introns in HLA-B allele polymorphism generation is stressed...
  20. ncbi C4 gene polymorphism in primates: evolution, generation, and Chido and Rodgers antigenicity
    E Paz-Artal
    Immunología Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Immunogenetics 40:381-96. 1994
    ..Finally, further data have been obtained that support trans-species conservation of A-ness and B-ness and the existence of trans-specifically conserved allelic motifs, both in intronic and exonic sequences...
  21. ncbi Description of two new HLA-DRB alleles (DRB1*0310 and DRB3*01012) found in a Spanish infant
    N Martinez-Quiles
    Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 49:658-61. 1997
  22. ncbi The Old World sparrows (genus Passer) phylogeography and their relative abundance of nuclear mtDNA pseudogenes
    L M Allende
    Department of Immunology and Molecular Biology, Hospital 12 de Octubre, Universidad Complutense, Madrid, 28041 Spain
    J Mol Evol 53:144-54. 2001
    ..European and American Emberizinae sparrows are closely related to each other and seem to be the earliest species that radiated among the studied songbirds (all in the Miocene Epoch)...
  23. ncbi HLA alleles in isolated populations from North Spain: origin of the Basques and the ancient Iberians
    P Sanchez-Velasco
    Department of Immunology and Molecular Biology, Hosp 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 61:384-92. 2003
    ..These populations have been compared with neighbouring ones and other Mediterraneans by using neighbour-joining dendrograms and plane genetic distances...
  24. ncbi MHC-F DNA sequences in bonobo, gorilla and orangutan
    R Rojo
    Department of Inmunologia, H 12 Octubre, H Clinico San Carlos, Universidad Complutense, Madrid, Spain
    Tissue Antigens 66:277-83. 2005
    ..The evolutionary pathway of the six-base-pair deletion at exon 2 existing in some primates is put forward...
  25. doi A novel allele, HLA-G*010114, with a non-coding DNA base change in exon 2
    A Arnaiz-Villena
    Department of Immunology, Universidad Complutense, The Madrid Regional Blood Center, Madrid, Spain
    Tissue Antigens 71:258-9. 2008
    ..This relatively high HLA-G DNA polymorphism in comparison with their protein polymorphism suggests that evolutionary forces are acting upon HLA-G for invariance. This may be related to the immunotolerogenic function postulated for HLA-G...
  26. ncbi HLA genes in Macedonians and the sub-Saharan origin of the Greeks
    A Arnaiz-Villena
    Department of Immunology and Molecular Biology, H 12 De Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 57:118-27. 2001
    ..The time period when these relationships might have occurred was ancient but uncertain and might be related to the displacement of Egyptian-Ethiopian people living in pharaonic Egypt...
  27. ncbi Generation of the HLA-B35, -B5, -B16, and B15 groups of alleles studied by intron 1 and 2 sequence analysis
    E Gomez-Casado
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Immunogenetics 46:469-76. 1997
    ..Intronic sequences are also potentially useful to design DNA typing strategies...
  28. ncbi Description of HLA-A*6803 and A*68N in Mazatecan Indians from Mexico
    G Vargas-Alarcon
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Carretera de Andalucia, 28041 Madrid, Spain
    Immunogenetics 46:446-7. 1997
  29. ncbi A new HLA-B35 (B*3516) allele found in a Mexican of Nahua (Aztec) descent
    G Vargas-Alarcon
    Department of Immunology and Rheumatology, Hospital 12 de Octubre, Universidad Complutense, Carretera Andalucia, 28041 Madrid, Spain
    Immunogenetics 43:244-5. 1996
  30. ncbi A new HLA-B15 allele (B*1522) found in Bari-Motilones Amerindians in Venezuela: comparison of its intron 2 sequence with those of B*1501 and B*3504
    J Martinez-Laso
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Immunogenetics 43:108-9. 1996
  31. ncbi A new HLA-B15 allele (B*1541) found in a Mexican of Nahua (Aztec) descent
    A Olivo-Díaz
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Carretera de Andalucia, E 28041 Madrid, Spain
    Immunogenetics 48:148-51. 1998
  32. ncbi Lack of HLA-G soluble isoforms in Graves-Basedow thyrocytes and complete cDNA sequence of the HLA-G*01012 allele
    M J Castro
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Eur J Immunogenet 25:311-5. 1998
    ....
  33. ncbi Complete cDNA sequence of the HLA-DRB1*09012 allele
    N Martinez-Quiles
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Eur J Immunogenet 25:307-9. 1998
    ..In the DR9 antigen, two synonymous allelic variants (DRB1*09011 and 09012) were officially recognized, though it was later found that the first one contained an error and both sequences were, thus, identical...
  34. ncbi Homozygous HLA-G*0105N healthy individuals indicate that membrane-anchored HLA-G1 molecule is not necessary for survival
    M J Casro
    Department of Immunology and Molecular Biology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Tissue Antigens 56:232-9. 2000
    ..Also, individuals homozygous for HLA-G*0105N are healthy and with no indications of immunodeficiency or autoimmunity...
  35. ncbi A new HLA-Cw allele (Cw*0808) found in a Colombian Mestizo individual possibly generated by an intralocus/interloci gene conversion
    C Silvera-Redondo
    Departamento de Inmunologia y Biologia Molecular, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Immunogenetics 51:1053-7. 2000
  36. ncbi Three new HLA-G alleles and their linkage disequilibria with HLA-A
    P Morales
    Hospital Universitario 12 de Octubre, Universidad Complutense, Madrid, Spain
    Immunogenetics 38:323-31. 1993
    ..It may be inferred from preliminary data that in primates HLA-A/G haplotypes bearing G*II may have appeared later than those bearing G*I...
  37. ncbi Description of a new HLA-E (E*01031) allele and its frequency in the Spanish population
    E Gomez-Casado
    Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
    Hum Immunol 54:69-73. 1997
    ..However, the intron 2 sequence of the E*0102 allele bears a two-base deletion not found in apes...
  38. ncbi High-resolution molecular characterization of the HLA class I and class II in the Tarahumara Amerindian population
    J E Garcia-Ortiz
    Departamento de Inmunobiología Molecular, Centro de Investigacion Biomedica, Facultad de Medicina, Universidad Autonoma de Coahuila, 27000 Torreón, Mexico
    Tissue Antigens 68:135-46. 2006
    ....
  39. ncbi Polymorphism and distribution of HLA-DR2 alleles in Mexican populations
    G Vargas-Alarcon
    Cellular Biology Section, Physiology Department, Instituto Nacional de la Nutricion Salvador Zubiran, D F, Mexico, Mexico
    Hum Immunol 62:286-91. 2001
    ....
  40. ncbi Lack of association between the polymorphism at the heat-shock protein (HSP70-2) gene and systemic lupus erythematosus (SLE) in the Mexican mestizo population
    G Vargas-Alarcon
    Cellular Biology Section, Department of Physiology, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano 1, Tlalpan 14080, Mexico City
    Genes Immun 1:367-70. 2000
    ....
  41. ncbi The origin and spread of the HFE-C282Y haemochromatosis mutation
    S Distante
    Hepatology Unit, Aker University Hospital, Oslo, Norway
    Hum Genet 115:269-79. 2004
    ..We conclude that the HFE C282Y mutation occurred in mainland Europe before 4,000 BC...