Joaquin Arino

Summary

Country: Spain

Publications

  1. ncbi request reprint Novel protein phosphatases in yeast
    Joaquin Arino
    Department de Bioquimica i Biologia Molecular, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Bellaterra Spain
    Eur J Biochem 269:1072-7. 2002
  2. pmc Type 2C protein phosphatases in fungi
    Joaquin Arino
    Departament de Bioquimica i Biologia Molecular, Institut de Biotecnologia i Biomedicina, Universitat Autonoma de Barcelona, Cerdanyola del Valles 08193, Barcelona, Spain
    Eukaryot Cell 10:21-33. 2011
  3. doi request reprint Integrative responses to high pH stress in S. cerevisiae
    Joaquin Arino
    Departament de Bioquímica i Biologia Molecular and Institut de Biotecnologia i Biomedicina, Universitat Autonoma de Barcelona, Barcelona, Spain
    OMICS 14:517-23. 2010
  4. pmc Alkali metal cation transport and homeostasis in yeasts
    Joaquin Arino
    Departament de Bioquimica i Biologia Molecular, Ed V, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona, Spain
    Microbiol Mol Biol Rev 74:95-120. 2010
  5. pmc Modulation of yeast alkaline cation tolerance by Ypi1 requires calcineurin
    Maribel Marquina
    Institut de Biotecnologia i Biomedicina and Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona, Spain
    Genetics 190:1355-64. 2012
  6. doi request reprint Molecular analysis of a conditional hal3 vhs3 yeast mutant links potassium homeostasis with flocculation and invasiveness
    Asier González
    Departament de Bioquímica i Biologia Molecular and Institut de Biotecnologia i Biomedicina, Universitat Autonoma de Barcelona, Cerdanyola del Valles, 08193 Barcelona, Spain
    Fungal Genet Biol 53:1-9. 2013
  7. ncbi request reprint Copper and iron are the limiting factors for growth of the yeast Saccharomyces cerevisiae in an alkaline environment
    Raquel Serrano
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra, 08193 Barcelona, Spain
    J Biol Chem 279:19698-704. 2004
  8. ncbi request reprint Functional characterization of the yeast Ppz1 phosphatase inhibitory subunit Hal3: a mutagenesis study
    Ivan Munoz
    Department de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Cerdanyola 08193, Barcelona, Spain
    J Biol Chem 279:42619-27. 2004
  9. doi request reprint Ref2, a regulatory subunit of the yeast protein phosphatase 1, is a novel component of cation homoeostasis
    Jofre Ferrer-Dalmau
    Departament de Bioquímica i Biologia Molecular and Institut de Biotecnologia i Biomedicina, Universitat Autonoma de Barcelona, Barcelona 08193, Spain
    Biochem J 426:355-64. 2010
  10. ncbi request reprint Functional characterization of the Saccharomyces cerevisiae VHS3 gene: a regulatory subunit of the Ppz1 protein phosphatase with novel, phosphatase-unrelated functions
    Amparo Ruiz
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona, Spain
    J Biol Chem 279:34421-30. 2004

Collaborators

  • Jose Ramos
  • Xavier Castells
  • Lynne Yenush
  • Erick Strauss
  • Jesus Giraldo
  • Silvia Atrian
  • Viktor Dombradi
  • Fernando Moreno
  • Joaquin Dopazo
  • Lydie Maresova
  • Enric Vidal
  • Armando Albert
  • Ethel Queralt
  • Amparo Ruiz
  • Asier González
  • Raquel Serrano
  • Antonio Casamayor
  • Carlos Casado
  • Lina Barreto
  • Maria Platara
  • Ivan Munoz
  • Maribel Marquina
  • Ernesto Simon
  • Anna Barceló
  • Cristina Molero
  • Samuel Gelis
  • Silvia Petrezselyova
  • David Canadell
  • Raul Tortosa
  • J Albert Abrie
  • Clara Navarrete
  • Jorge Perez-Valle
  • Jofre Ferrer-Dalmau
  • María Guirola
  • Jordi Moreno-Romero
  • María del Carmen Ruiz
  • M Ayelen Pagani
  • Laia Viladevall
  • Dolores Bernal
  • Elena Hidalgo
  • Mercè Carmona
  • Katalin Petrényi
  • Daniel Valverde-Saubí
  • Mari Carmen Alvarez
  • Iván Olier
  • Marti Pumarola
  • Rito Herrera
  • Juan Maria Torres
  • Maria del Carmen Ruiz de Villa
  • Alex Sanchez
  • Hana Sychrova
  • Carme Costa
  • Miriam Romagosa
  • Jose L Martinez
  • Ayelen Pagani
  • Carmen Melero
  • M Carme Espunya
  • Carolina Larroy
  • M Carmen Martinez
  • Josep A Biosca
  • Aaron Palomino
  • Humberto Martín
  • Raúl García-Salcedo
  • Miguel Angel Sánchez-Garrido
  • Gema Domenech
  • Josep Clotet
  • Nuria Casals
  • James R Chambers

Detail Information

Publications42

  1. ncbi request reprint Novel protein phosphatases in yeast
    Joaquin Arino
    Department de Bioquimica i Biologia Molecular, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Bellaterra Spain
    Eur J Biochem 269:1072-7. 2002
    ..This review will summarize the latest advances in our understanding about how these phosphatases are regulated and fulfil their functions in the yeast cell...
  2. pmc Type 2C protein phosphatases in fungi
    Joaquin Arino
    Departament de Bioquimica i Biologia Molecular, Institut de Biotecnologia i Biomedicina, Universitat Autonoma de Barcelona, Cerdanyola del Valles 08193, Barcelona, Spain
    Eukaryot Cell 10:21-33. 2011
    ..In this work we review the available literature on fungal PP2Cs and explore sequence databases to provide a comprehensive overview of these enzymes in fungi...
  3. doi request reprint Integrative responses to high pH stress in S. cerevisiae
    Joaquin Arino
    Departament de Bioquímica i Biologia Molecular and Institut de Biotecnologia i Biomedicina, Universitat Autonoma de Barcelona, Barcelona, Spain
    OMICS 14:517-23. 2010
    ..In this review we will examine these responses, their possible interactions, and the role that they play in tolerance to high pH stress...
  4. pmc Alkali metal cation transport and homeostasis in yeasts
    Joaquin Arino
    Departament de Bioquimica i Biologia Molecular, Ed V, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona, Spain
    Microbiol Mol Biol Rev 74:95-120. 2010
    ....
  5. pmc Modulation of yeast alkaline cation tolerance by Ypi1 requires calcineurin
    Maribel Marquina
    Institut de Biotecnologia i Biomedicina and Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona, Spain
    Genetics 190:1355-64. 2012
    ..These results point to a complex role of Ypi1 on the regulation of cation homeostasis, largely mediated by the calcineurin phosphatase...
  6. doi request reprint Molecular analysis of a conditional hal3 vhs3 yeast mutant links potassium homeostasis with flocculation and invasiveness
    Asier González
    Departament de Bioquímica i Biologia Molecular and Institut de Biotecnologia i Biomedicina, Universitat Autonoma de Barcelona, Cerdanyola del Valles, 08193 Barcelona, Spain
    Fungal Genet Biol 53:1-9. 2013
    ..This model highlights an unsuspected link between potassium homeostasis and these important morphogenetic events...
  7. ncbi request reprint Copper and iron are the limiting factors for growth of the yeast Saccharomyces cerevisiae in an alkaline environment
    Raquel Serrano
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra, 08193 Barcelona, Spain
    J Biol Chem 279:19698-704. 2004
    ..Supplementation with iron improved somewhat the tolerance of a fet3 strain but was ineffective in a ctr1 mutant, suggesting the existence of additional copper-requiring functions important for tolerance to an alkaline environment...
  8. ncbi request reprint Functional characterization of the yeast Ppz1 phosphatase inhibitory subunit Hal3: a mutagenesis study
    Ivan Munoz
    Department de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Cerdanyola 08193, Barcelona, Spain
    J Biol Chem 279:42619-27. 2004
    ..In contrast, the mutation of His378 did not. This finding suggests that Hal3 may have both Ppz1-dependent and independent functions involving different structural elements...
  9. doi request reprint Ref2, a regulatory subunit of the yeast protein phosphatase 1, is a novel component of cation homoeostasis
    Jofre Ferrer-Dalmau
    Departament de Bioquímica i Biologia Molecular and Institut de Biotecnologia i Biomedicina, Universitat Autonoma de Barcelona, Barcelona 08193, Spain
    Biochem J 426:355-64. 2010
    ..Remarkably, the evidence collected indicates that the role of Ref2 in cation homoeostasis may be unrelated to its previously identified function in the formation of mRNA via the APT (for associated with Pta1) complex...
  10. ncbi request reprint Functional characterization of the Saccharomyces cerevisiae VHS3 gene: a regulatory subunit of the Ppz1 protein phosphatase with novel, phosphatase-unrelated functions
    Amparo Ruiz
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona, Spain
    J Biol Chem 279:34421-30. 2004
    ..These results indicate that, besides its role as Ppz1 inhibitory subunit, Vhs3 (and probably Hal3) might have important Ppz-independent functions...
  11. ncbi request reprint Transcriptional profiling of the protein phosphatase 2C family in yeast provides insights into the unique functional roles of Ptc1
    Asier González
    Departament de Bioquimica i Biologia Molecular, Edificio V, Universitat Autonoma de Barcelona, 08193 Cerdanyola del Valles, Barcelona, Catalonia, Spain
    J Biol Chem 281:35057-69. 2006
    ....
  12. doi request reprint Lack of DNA helicase Pif1 disrupts zinc and iron homoeostasis in yeast
    María Guirola
    Departament de Genètica and Institut de Biomedicina, Universitat de Barcelona, Barcelona, Spain
    Biochem J 432:595-605. 2010
    ..We postulate that lack of Pif1 forces aconitase to play its DNA protective role as a nucleoid protein and that this triggers a domino effect on iron homoeostasis resulting in increased zinc tolerance...
  13. pmc Ptc6 is required for proper rapamycin-induced down-regulation of the genes coding for ribosomal and rRNA processing proteins in S. cerevisiae
    Asier González
    Institut de Biotecnologia i Biomedicina IBB and Departament de Bioquímica i Biologia Molecular, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Cerdanyola del Valles, Spain
    PLoS ONE 8:e64470. 2013
    ..These effects cannot be attributed to the regulation of the Sch9 kinase, but they could involve modulation of the binding of the Ifh1 co-activator to specific gene promoters...
  14. ncbi request reprint Characterization of the calcium-mediated response to alkaline stress in Saccharomyces cerevisiae
    Laia Viladevall
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Cerdanyola 08193, Spain
    J Biol Chem 279:43614-24. 2004
    ..In conclusion, our results demonstrated that calcium signaling and calcineurin activation represented a significant component of the yeast response to environmental alkalinization...
  15. pmc Function and regulation of the Saccharomyces cerevisiae ENA sodium ATPase system
    Amparo Ruiz
    Departament de Bioquimica i Biologia Molecular, Institut de Biotecnologia i Biomedicina, Barcelona, Spain
    Eukaryot Cell 6:2175-83. 2007
  16. doi request reprint Regulation of Trk-dependent potassium transport by the calcineurin pathway involves the Hal5 kinase
    Carlos Casado
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Barcelona, Spain
    FEBS Lett 584:2415-20. 2010
    ..This suggests that the control exerted by calcineurin on Hal5 expression may be biologically relevant for Trk1 regulation...
  17. pmc Normal function of the yeast TOR pathway requires the type 2C protein phosphatase Ptc1
    Asier González
    Departament de Bioquimica i Biologia Molecular, Ed V, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona, Spain
    Mol Cell Biol 29:2876-88. 2009
    ..All of these results provide the first evidence showing that a type 2C protein phosphatase is required for the normal functioning of the TOR pathway...
  18. ncbi request reprint Role of protein phosphatases 2C on tolerance to lithium toxicity in the yeast Saccharomyces cerevisiae
    Amparo Ruiz
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona, Spain
    Mol Microbiol 62:263-77. 2006
    ..These results indicate that Ptc1p modulates the function of Ena1p by regulating the Hal3/Ppz1,2 pathway. In conclusion, overexpression of PTC3 and lack of PTC1 affect lithium tolerance in yeast, although through different mechanisms...
  19. doi request reprint Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis
    Amparo Ruiz
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Spain
    Nat Chem Biol 5:920-8. 2009
    ..Our results unveil Hal3 and Vhs3 as moonlighting proteins involved in both CoA biosynthesis and protein phosphatase regulation...
  20. doi request reprint The role of the Snf1 kinase in the adaptive response of Saccharomyces cerevisiae to alkaline pH stress
    Antonio Casamayor
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Spain
    Biochem J 444:39-49. 2012
    ....
  21. ncbi request reprint The transcriptional response of the yeast Na(+)-ATPase ENA1 gene to alkaline stress involves three main signaling pathways
    Maria Platara
    Department of Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona
    J Biol Chem 281:36632-42. 2006
    ..Thus, the transcriptional response to alkaline stress of the ENA1 gene integrates three different signaling pathways...
  22. doi request reprint Lack of the Glc7 phosphatase regulatory subunit Ypi1 activates the morphogenetic checkpoint
    Maribel Marquina
    Institut de Biotecnologia i Biomedicina and Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Cerdanyola 08193, Spain
    Int J Biochem Cell Biol 44:1862-71. 2012
    ..Deletion of SWE1 restored normal Cdc11 levels in the absence of Ypi1. These results demonstrate that Ypi1 plays an important role in the morphogenesis checkpoint, possibly by regulating Swe1...
  23. doi request reprint Development of a predictor for human brain tumors based on gene expression values obtained from two types of microarray technologies
    Xavier Castells
    Grup d Aplicacions Biomèdiques de la RMN GABRMN, Facultat de Biociencies, Universitat Autonoma de Barcelona, Cerdanyola del Valles, Barcelona, Spain
    OMICS 14:157-64. 2010
    ..At any rate, this study paves the way for further application of gene signatures to more stringent biopsy discrimination challenges...
  24. pmc Regulation of ENA1 Na(+)-ATPase gene expression by the Ppz1 protein phosphatase is mediated by the calcineurin pathway
    Amparo Ruiz
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona, Spain
    Eukaryot Cell 2:937-48. 2003
    ..In conclusion, we have identified a novel role for calcineurin, but not alkalinization, in the control of ENA1 expression in ppz1 mutants...
  25. pmc A genomewide screen for tolerance to cationic drugs reveals genes important for potassium homeostasis in Saccharomyces cerevisiae
    Lina Barreto
    Institut de Biotecnologia i Biomedicina, Universitat Autonoma de Barcelona, Cerdanyola del Valles 08193, Barcelona, Spain
    Eukaryot Cell 10:1241-50. 2011
    ..A subset of 27 representative mutants were selected and subjected to diverse biochemical tests that, in some cases, allowed us to postulate the basis for the observed phenotypes...
  26. ncbi request reprint Use of yeast genetic tools to define biological roles of novel protein phosphatases
    Joaquin Arino
    Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, Spain
    Methods Mol Biol 365:299-307. 2007
    ..This is particularly useful given the large variety of important biological processes performed by these of enzymes, often necessaries for cell survival, which makes in some cases infeasible the generation of null mutants...
  27. ncbi request reprint Disruption of iron homeostasis in Saccharomyces cerevisiae by high zinc levels: a genome-wide study
    M Ayelen Pagani
    Departament de Genetica, Universitat de Barcelona, Barcelona, Spain
    Mol Microbiol 65:521-37. 2007
    ..These findings suggest that high zinc levels may alter the assembly and/or function of iron-sulphur-containing proteins, as well as the biosynthesis of haem groups, thus establishing a link between zinc, iron and sulphur metabolism...
  28. ncbi request reprint Signaling alkaline pH stress in the yeast Saccharomyces cerevisiae through the Wsc1 cell surface sensor and the Slt2 MAPK pathway
    Raquel Serrano
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    J Biol Chem 281:39785-95. 2006
    ..Moreover, these results provide a new example of the complexity of the response of budding yeast to the alkalinization of the environment...
  29. ncbi request reprint The Ppz protein phosphatases regulate Trk-independent potassium influx in yeast
    Amparo Ruiz
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona, Spain
    FEBS Lett 578:58-62. 2004
    ....
  30. doi request reprint The short-term response of yeast to potassium starvation
    Lina Barreto
    Institut de Biotecnologia i Biomedicina and Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona, Spain
    Environ Microbiol 14:3026-42. 2012
    ....
  31. doi request reprint Direct regulation of genes involved in glucose utilization by the calcium/calcineurin pathway
    Amparo Ruiz
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Edificio V, Campus de Bellaterra, Cerdanyola, Barcelona 08193, Spain
    J Biol Chem 283:13923-33. 2008
    ..We propose that alkalinization of the medium results in impaired glucose utilization and that activation of certain glucose-metabolizing genes by calcineurin contributes to yeast survival under this stress situation...
  32. doi request reprint The Schizosaccharomyces pombe fusion gene hal3 encodes three distinct activities
    Cristina Molero
    Institut de Biotecnologia i Biomedicina and Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Cerdanyola del Valles, Spain
    Mol Microbiol 90:367-82. 2013
    ..Therefore, Sp hal3 represents a fusion event that joined three different functional activities in the same gene. The possible advantage derived from this surprising combination of essential proteins is discussed. ..
  33. ncbi request reprint Use of tetracycline-regulatable promoters for functional analysis of protein phosphatases in yeast
    Joaquin Arino
    Departament de Bioquimica i Biologia Molecular, Universitat Autònoma de Barcelona Bellaterra, Barcelona, 08193, Spain
    Methods Enzymol 366:347-58. 2003
  34. pmc The role of the protein kinase A pathway in the response to alkaline pH stress in yeast
    Carlos Casado
    Institut de Biotecnologia i Biomedicina and Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Cerdanyola del Valles, Bellaterra 08193, Barcelona, Spain
    Biochem J 438:523-33. 2011
    ..However, the relevance of attenuation of PKA in high pH tolerance is probably not restricted to regulation of Msn2 function...
  35. ncbi request reprint Mutagenesis analysis of the yeast Nha1 Na+/H+ antiporter carboxy-terminal tail reveals residues required for function in cell cycle
    Ernesto Simon
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona, Spain
    FEBS Lett 545:239-45. 2003
    ..The later is rather conserved in other related antiporters, while the former is not...
  36. ncbi request reprint Use of the TRP1 auxotrophic marker for gene disruption and phenotypic analysis in yeast: a note of warning
    Asier González
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Barcelona, Spain
    FEMS Yeast Res 8:2-5. 2008
    ..Therefore, its use in the past should be revisited and utilization of this marker should be avoided in future analyses...
  37. doi request reprint A role for protein kinase CK2 in plant development: evidence obtained using a dominant-negative mutant
    Jordi Moreno-Romero
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Plant J 55:118-30. 2008
    ..Our results are consistent with a model in which CK2 plays a key role in cell division and cell expansion, with compelling effects on Arabidopsis development...
  38. doi request reprint Automated brain tumor biopsy prediction using single-labeling cDNA microarrays-based gene expression profiling
    Xavier Castells
    Grup d aplicacions Biomèdiques de la RMN, Departament de Bioquimica i Biologia Molecular, Facultat de Biociencies, Universitat Autonoma de Barcelona, Spain
    Diagn Mol Pathol 18:206-18. 2009
    ..Herewith, we demonstrate that primary brain tumor types can be discriminated using microarray data in an automated and objective way...
  39. pmc Assessing differential expression measurements by highly parallel pyrosequencing and DNA microarrays: a comparative study
    Joaquin Arino
    Departament de Bioquímica y Biología Molecular and Institut de Biotecnologia i Biomedicina, Universitat Autonoma de Barcelona, Cerdanyola del Valles, Spain
    OMICS 17:53-9. 2013
    ..Thus, even in a scenario of low coverage the concordance in the measurements is quite acceptable. On the other hand, the comparatively longer read size obtained by pyrosequencing allows detecting unconventional splicing forms...
  40. ncbi request reprint Identification of multicopy suppressors of cell cycle arrest at the G1-S transition in Saccharomyces cerevisiae
    Ivan Munoz
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Bellaterra 08193, Barcelona
    Yeast 20:157-69. 2003
    ..The possible relationship between the known functions of these suppressor genes and the progress through the G(1)-S transition is discussed...
  41. pmc Central nervous system gene expression changes in a transgenic mouse model for bovine spongiform encephalopathy
    Raul Tortosa
    Departament de Medicina i Cirurgia Animals, Universitat Autonoma de Barcelona, 08193, Cerdanyola del Valles, Barcelona, Spain
    Vet Res 42:109. 2011
    ..Genes non-previously related to prion diseases should be taken into consideration for further investigations...
  42. ncbi request reprint The transcriptional response to alkaline pH in Saccharomyces cerevisiae: evidence for calcium-mediated signalling
    Raquel Serrano
    Departament de Bioquimica i Biologia Molecular, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Bellaterra, E 08193, Barcelona, Spain
    Mol Microbiol 46:1319-33. 2002
    ..These results demonstrate that the transcriptional response to alkaline pH involves different signalling mechanisms, and that calcium signalling is a relevant component of this response...