Alfonso Araque

Summary

Country: Spain

Publications

  1. pmc Astrocytes mediate in vivo cholinergic-induced synaptic plasticity
    Marta Navarrete
    Instituto Cajal, Consejo Superior de Investigaciones Científicas Madrid, Spain
    PLoS Biol 10:e1001259. 2012
  2. ncbi Astrocyte-neuron interaction at tripartite synapses
    Alberto Pérez-Alvarez
    Instituto Cajal, Doctor Arce 37, Madrid 28002, Spain
    Curr Drug Targets 14:1220-4. 2013
  3. ncbi SNARE protein-dependent glutamate release from astrocytes
    A Araque
    Laboratory of Cellular Signaling, Department of Zoology and Genetics, Iowa State University, Ames, Iowa 50011, USA
    J Neurosci 20:666-73. 2000
  4. pmc Glial cells in neuronal network function
    Alfonso Araque
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    Philos Trans R Soc Lond B Biol Sci 365:2375-81. 2010
  5. doi Astrocytes process synaptic information
    Alfonso Araque
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Neuron Glia Biol 4:3-10. 2008
  6. ncbi Glial modulation of synaptic transmission in culture
    Alfonso Araque
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Glia 47:241-8. 2004
  7. ncbi Synaptically released acetylcholine evokes Ca2+ elevations in astrocytes in hippocampal slices
    Alfonso Araque
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    J Neurosci 22:2443-50. 2002
  8. ncbi Dynamic signaling between astrocytes and neurons
    A Araque
    Instituto Cajal, CSIC, Doctor Arce 37, Madrid 28002, Spain
    Annu Rev Physiol 63:795-813. 2001
  9. ncbi Astrocyte-neuron signaling in the brain--implications for disease
    Alfonso Araque
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Curr Opin Investig Drugs 7:619-24. 2006
  10. doi Endocannabinoids potentiate synaptic transmission through stimulation of astrocytes
    Marta Navarrete
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Neuron 68:113-26. 2010

Collaborators

Detail Information

Publications25

  1. pmc Astrocytes mediate in vivo cholinergic-induced synaptic plasticity
    Marta Navarrete
    Instituto Cajal, Consejo Superior de Investigaciones Científicas Madrid, Spain
    PLoS Biol 10:e1001259. 2012
    ..Therefore, the astrocyte Ca²⁺ signal is necessary for cholinergic-induced synaptic plasticity, indicating that astrocytes are directly involved in brain storage information...
  2. ncbi Astrocyte-neuron interaction at tripartite synapses
    Alberto Pérez-Alvarez
    Instituto Cajal, Doctor Arce 37, Madrid 28002, Spain
    Curr Drug Targets 14:1220-4. 2013
    ..We also discuss how this novel view of astrocytic functions on brain physiology is prompting us to reconsider the possible astrocytic roles in brain diseases, and specifically in depression. ..
  3. ncbi SNARE protein-dependent glutamate release from astrocytes
    A Araque
    Laboratory of Cellular Signaling, Department of Zoology and Genetics, Iowa State University, Ames, Iowa 50011, USA
    J Neurosci 20:666-73. 2000
    ....
  4. pmc Glial cells in neuronal network function
    Alfonso Araque
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    Philos Trans R Soc Lond B Biol Sci 365:2375-81. 2010
    ....
  5. doi Astrocytes process synaptic information
    Alfonso Araque
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Neuron Glia Biol 4:3-10. 2008
    ..Consequently, astrocytes can be considered as cellular elements involved in information processing by the nervous system...
  6. ncbi Glial modulation of synaptic transmission in culture
    Alfonso Araque
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Glia 47:241-8. 2004
    ....
  7. ncbi Synaptically released acetylcholine evokes Ca2+ elevations in astrocytes in hippocampal slices
    Alfonso Araque
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    J Neurosci 22:2443-50. 2002
    ..Therefore, our results show the existence of cholinergic neuron-astrocyte signaling and suggest that astrocytes are a target of axonal inputs from different brain areas...
  8. ncbi Dynamic signaling between astrocytes and neurons
    A Araque
    Instituto Cajal, CSIC, Doctor Arce 37, Madrid 28002, Spain
    Annu Rev Physiol 63:795-813. 2001
    ....
  9. ncbi Astrocyte-neuron signaling in the brain--implications for disease
    Alfonso Araque
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Curr Opin Investig Drugs 7:619-24. 2006
    ..Therefore, astrocytes may be considered as appropriate cellular targets to direct therapeutic approaches for the treatment of several brain diseases...
  10. doi Endocannabinoids potentiate synaptic transmission through stimulation of astrocytes
    Marta Navarrete
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Neuron 68:113-26. 2010
    ..Therefore, astrocytes respond to endocannabinoids that then potentiate synaptic transmission, indicating that astrocytes are actively involved in brain physiology...
  11. ncbi Properties of synaptically evoked astrocyte calcium signal reveal synaptic information processing by astrocytes
    Gertrudis Perea
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    J Neurosci 25:2192-203. 2005
    ..Therefore, because astrocytes discriminate and integrate synaptic information, we propose that they can be considered as cellular elements involved in the information processing by the nervous system...
  12. ncbi Astrocytes potentiate transmitter release at single hippocampal synapses
    Gertrudis Perea
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Science 317:1083-6. 2007
    ..This persistent plasticity was mGluR-mediated but N-methyl-d-aspartate receptor-independent. These results indicate that astrocytes are actively involved in the transfer and storage of synaptic information...
  13. doi Endocannabinoids mediate neuron-astrocyte communication
    Marta Navarrete
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    Neuron 57:883-93. 2008
    ..They also reveal the existence of an endocannabinoid-glutamate signaling pathway where astrocytes serve as a bridge for nonsynaptic interneuronal communication...
  14. doi Tripartite synapses: astrocytes process and control synaptic information
    Gertrudis Perea
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    Trends Neurosci 32:421-31. 2009
    ....
  15. doi Astrocyte calcium signal and gliotransmission in human brain tissue
    Marta Navarrete
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    Cereb Cortex 23:1240-6. 2013
    ..These results reveal the existence of reciprocal signaling between neurons and astrocytes in human brain tissue, indicating that astrocytes are relevant in human neurophysiology and are involved in human brain function...
  16. doi GLIA modulates synaptic transmission
    Gertrudis Perea
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    Brain Res Rev 63:93-102. 2010
    ..Reciprocal communication between astrocytes and neurons is therefore part of the intercellular signaling processes involved in brain function...
  17. doi Gliotransmitters travel in time and space
    Alfonso Araque
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    Neuron 81:728-39. 2014
    ..We propose that astrocytes mainly signal through high-affinity slowly desensitizing receptors to modulate neurons and perform integration in spatiotemporal domains complementary to those of neurons. ..
  18. ncbi Synaptic information processing by astrocytes
    Gertrudis Perea
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Doctor Arce 37, Madrid 28002, Spain
    J Physiol Paris 99:92-7. 2006
    ..Consequently, we propose that astrocytes can be considered as cellular elements involved in information processing by the nervous system...
  19. ncbi Glial calcium signaling and neuron-glia communication
    Gertrudis Perea
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Doctor Arce 37, Madrid 28002, Spain
    Cell Calcium 38:375-82. 2005
    ..Therefore, we propose that astrocytes can be considered as cellular elements involved in the information processing by the nervous system...
  20. ncbi Communication between astrocytes and neurons: a complex language
    Gertrudis Perea
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    J Physiol Paris 96:199-207. 2002
    ..We are beginning to realize that the communication between astrocytes and neurons uses a quite complex language...
  21. pmc Confocal microscopy for astrocyte in vivo imaging: Recycle and reuse in microscopy
    Alberto Pérez-Alvarez
    Instituto Cajal, Consejo Superior de Investigaciones Científicas Madrid, Spain
    Front Cell Neurosci 7:51. 2013
    ..Therefore, in spite of certain limitations that need to be carefully considered, LSCM constitutes a useful, convenient, and affordable tool for brain studies in vivo...
  22. ncbi Basal synaptic transmission: astrocytes rule!
    Marta Navarrete
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    Cell 146:675-7. 2011
    ..These results demonstrate the relevance of astrocyte calcium in neurophysiology and confirm that astrocytes are actively involved in synaptic function...
  23. ncbi Estradiol regulates the slow Ca2+-activated K+ current in hippocampal pyramidal neurons
    Hugo F Carrer
    Instituto de Investigación Médica M y M Ferreyra Consejo Nacional de Investigaciones Científicas y Técnicas, 5000 Cordoba, Argentina
    J Neurosci 23:6338-44. 2003
    ....
  24. ncbi Adenosine released by astrocytes contributes to hypoxia-induced modulation of synaptic transmission
    Eduardo D Martin
    Unidad Asociada Neurodeath, UCLM CSIC, Departamento de Ciencias Médicas, Universidad de Castilla La Mancha, Albacete, Spain
    Glia 55:36-45. 2007
    ..Therefore, adenosine release from astrocytes serves as a protective mechanism by down regulating the synaptic activity level during demanding conditions such as transient hypoxia...
  25. doi DREAM mediates cAMP-dependent, Ca2+-induced stimulation of GFAP gene expression and regulates cortical astrogliogenesis
    Beatriz Cebolla
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, 28029 Madrid, Spain
    J Neurosci 28:6703-13. 2008
    ..These results identify the PACAP-cAMP-Ca(2+)-DREAM cascade as a new pathway to activate GFAP gene expression during astrocyte differentiation...