A Aranda

Summary

Country: Spain

Publications

  1. pmc Retinoic acid protects human breast cancer cells against etoposide-induced apoptosis by NF-kappaB-dependent but cIAP2-independent mechanisms
    Ana M Jimenez-Lara
    Instituto de Investigaciones Biomédicas de Madrid Alberto Sols, CSIC UAM, Madrid, Spain
    Mol Cancer 9:15. 2010
  2. doi request reprint Thyroid receptor: roles in cancer
    Ana Aranda
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Arturo Duperier 4, 28029 Madrid, Spain
    Trends Endocrinol Metab 20:318-24. 2009
  3. ncbi request reprint Nuclear hormone receptors and gene expression
    A Aranda
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Madrid, Spain
    Physiol Rev 81:1269-304. 2001
  4. ncbi request reprint Ras- and Raf-mediated regulation of transforming growth factor beta 1 gene expression by ligands of tyrosine kinase receptors in PC12 cells
    J M Cosgaya
    , Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Oncogene 12:2651-60. 1996
  5. pmc Synergy between RA and TLR3 promotes type I IFN-dependent apoptosis through upregulation of TRAIL pathway in breast cancer cells
    A R Bernardo
    Department of Endocrine and Nervous System Physiopathology, Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Madrid, Spain
    Cell Death Dis 4:e479. 2013
  6. pmc Association with Ets-1 causes ligand- and AF2-independent activation of nuclear receptors
    R M Tolon
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, 28029 Madrid, Spain
    Mol Cell Biol 20:8793-802. 2000
  7. doi request reprint Thyroid hormone receptor β1 domains responsible for the antagonism with the ras oncogene: role of corepressors
    S Garcia-Silva
    Department of Endocrine and Nervous System Physiopathology, Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Madrid, Spain
    Oncogene 30:854-64. 2011
  8. ncbi request reprint Growth factor ligands of tyrosine kinase receptors activate the Rous sarcoma virus promoter by a Ras- and Raf-dependent mechanism
    J M Cosgaya
    , , Madrid, Spain
    Gene 188:291-3. 1997
  9. ncbi request reprint An element in the region responsible for premature termination of transcription mediates repression of c-myc gene expression by thyroid hormone in neuroblastoma cells
    G Perez-Juste
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas and Universidad Aut noma de Madrid, 28029 Madrid, Spain
    J Biol Chem 275:1307-14. 2000
  10. doi request reprint Activation of the unliganded estrogen receptor by prolactin in breast cancer cells
    L Gonzalez
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Madrid, Spain
    Oncogene 28:1298-308. 2009

Collaborators

  • E Lopez
  • O Martínez-Iglesias
  • S Garcia-Silva
  • J M Cosgaya
  • A R Bernardo
  • A M Jimenez-Lara
  • Ana M Jimenez-Lara
  • L Ruiz-Llorente
  • L Gonzalez
  • A Zambrano
  • A I Castillo
  • R M Tolon
  • Hinrich Gronemeyer
  • G Perez-Juste
  • J Martin-Perez
  • J J A González
  • I Lazaro-Trueba
  • L Garcia
  • R Sánchez-Martínez
  • G Perez Juste

Detail Information

Publications12

  1. pmc Retinoic acid protects human breast cancer cells against etoposide-induced apoptosis by NF-kappaB-dependent but cIAP2-independent mechanisms
    Ana M Jimenez-Lara
    Instituto de Investigaciones Biomédicas de Madrid Alberto Sols, CSIC UAM, Madrid, Spain
    Mol Cancer 9:15. 2010
    ..These ligands can determine the ultimate fate of target cells by stimulating or repressing gene expression directly, or indirectly through crosstalking with other signal transducers...
  2. doi request reprint Thyroid receptor: roles in cancer
    Ana Aranda
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Arturo Duperier 4, 28029 Madrid, Spain
    Trends Endocrinol Metab 20:318-24. 2009
    ..This review highlights recent studies on mechanisms by which loss of expression and/or function of these receptors results in a selective advantage for cellular transformation, tumor development and metastatic growth...
  3. ncbi request reprint Nuclear hormone receptors and gene expression
    A Aranda
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Madrid, Spain
    Physiol Rev 81:1269-304. 2001
    ....
  4. ncbi request reprint Ras- and Raf-mediated regulation of transforming growth factor beta 1 gene expression by ligands of tyrosine kinase receptors in PC12 cells
    J M Cosgaya
    , Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Oncogene 12:2651-60. 1996
    ..These results suggest that during proliferation or growth factor-induced differentiation of sympathetic neurons there is an increase in TGF-beta1 that could be an important mediator of neural cells function...
  5. pmc Synergy between RA and TLR3 promotes type I IFN-dependent apoptosis through upregulation of TRAIL pathway in breast cancer cells
    A R Bernardo
    Department of Endocrine and Nervous System Physiopathology, Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Madrid, Spain
    Cell Death Dis 4:e479. 2013
    ....
  6. pmc Association with Ets-1 causes ligand- and AF2-independent activation of nuclear receptors
    R M Tolon
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, 28029 Madrid, Spain
    Mol Cell Biol 20:8793-802. 2000
    ..These results demonstrate the existence of a novel mechanism, alternative to ligand binding, which can convert an unliganded receptor from an inactive state into a competent transcriptional activator...
  7. doi request reprint Thyroid hormone receptor β1 domains responsible for the antagonism with the ras oncogene: role of corepressors
    S Garcia-Silva
    Department of Endocrine and Nervous System Physiopathology, Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Madrid, Spain
    Oncogene 30:854-64. 2011
    ..This shows an important functional role of endogenous corepressors in suppression of ras-mediated transformation and tumorigenesis by TRβ1...
  8. ncbi request reprint Growth factor ligands of tyrosine kinase receptors activate the Rous sarcoma virus promoter by a Ras- and Raf-dependent mechanism
    J M Cosgaya
    , , Madrid, Spain
    Gene 188:291-3. 1997
    ..Therefore, the RSV promoter should not be used in the determination of transfection efficiency in the studies on regulation of gene expression by ligands of tyrosine kinase receptors, ras and raf...
  9. ncbi request reprint An element in the region responsible for premature termination of transcription mediates repression of c-myc gene expression by thyroid hormone in neuroblastoma cells
    G Perez-Juste
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas and Universidad Aut noma de Madrid, 28029 Madrid, Spain
    J Biol Chem 275:1307-14. 2000
    ..These studies provide insight into mechanisms by which TR mediate transcriptional repression and contribute to the understanding of the important effects of thyroid hormones on growth and differentiation of neuronal cells...
  10. doi request reprint Activation of the unliganded estrogen receptor by prolactin in breast cancer cells
    L Gonzalez
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Madrid, Spain
    Oncogene 28:1298-308. 2009
    ..These results show that ligand-independent ERalpha activation appears to be an important component of the proliferative and transcriptional actions of PRL in breast cancer cells...
  11. ncbi request reprint Histone deacetylase inhibitors: mechanism of action and therapeutic use in cancer
    O Martínez-Iglesias
    Instituto de Investigaciones Biomedicas, Madrid, Spain
    Clin Transl Oncol 10:395-8. 2008
    ..SAHA (vorinostat, Zolinza) was the first HDACi approved by the US Food and Drug Administration to enter the clinical oncology market for treating cutaneous T-cell lymphoma (CTCL) and is being tested for other malignancies...
  12. ncbi request reprint Synergistic activation of the prolactin promoter by vitamin D receptor and GHF-1: role of the coactivators, CREB-binding protein and steroid hormone receptor coactivator-1 (SRC-1)
    A I Castillo
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Mol Endocrinol 13:1141-54. 1999
    ..Furthermore, CBP also increases the activation of the PRL promoter by GHF-1 and the ligand-independent activation by both wild-type and mutant VDR...