Sara Alvarez

Summary

Country: Spain

Publications

  1. pmc Gene selection and classification of microarray data using random forest
    Ramon Diaz-Uriarte
    Bioinformatics Unit, Biotechnology Programme, Spanish National Cancer Centre CNIO, Melchor Fernandez Almagro 3, Madrid, 28029, Spain
    BMC Bioinformatics 7:3. 2006
  2. pmc DNA methylation profiles and their relationship with cytogenetic status in adult acute myeloid leukemia
    Sara Alvarez
    Molecular Cytogenetics Group, Centro Nacional Investigaciones Oncologicas, Centro de Investigaciones de Enfermedades Raras, Madrid, Spain
    PLoS ONE 5:e12197. 2010
  3. ncbi request reprint A predictor based on the somatic genomic changes of the BRCA1/BRCA2 breast cancer tumors identifies the non-BRCA1/BRCA2 tumors with BRCA1 promoter hypermethylation
    Sara Alvarez
    Human Genetics Department, Molecular Pathology Programme, Spanish National Cancer Centre, c o Melchor Fernandez Almagro, 28029 Madrid, Spain
    Clin Cancer Res 11:1146-53. 2005
  4. ncbi request reprint Multiple myeloma primary cells show a highly rearranged unbalanced genome with amplifications and homozygous deletions irrespective of the presence of immunoglobulin-related chromosome translocations
    Cristina Largo
    Molecular Cytogenetics Group, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Haematologica 92:795-802. 2007
  5. ncbi request reprint Estrogen receptor status could modulate the genomic pattern in familial and sporadic breast cancer
    Lorenzo Melchor
    Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Center CNIO, Madrid, Spain
    Clin Cancer Res 13:7305-13. 2007
  6. ncbi request reprint Genomic analysis of the 8p11-12 amplicon in familial breast cancer
    Lorenzo Melchor
    Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Center CNIO, Madrid, Spain
    Int J Cancer 120:714-7. 2007
  7. ncbi request reprint The accumulation of specific amplifications characterizes two different genomic pathways of evolution of familial breast tumors
    Lorenzo Melchor
    Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Center, Madrid, Spain
    Clin Cancer Res 11:8577-84. 2005
  8. doi request reprint The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer
    Pedro P Medina
    Lung Cancer Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    Hum Mol Genet 18:1343-52. 2009
  9. ncbi request reprint Identification of overexpressed genes in frequently gained/amplified chromosome regions in multiple myeloma
    Cristina Largo
    Cytogenetics Unit, Spanish National Cancer Centre, CNIO, C Melchor Fernandez Almagro 3, Madrid, 28029, Spain
    Haematologica 91:184-91. 2006
  10. pmc Abrogation of RUNX1 gene expression in de novo myelodysplastic syndrome with t(4;21)(q21;q22)
    Ana Rio-Machín
    Molecular Cytogenetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro, 3, 28029, Madrid, Spain
    Haematologica 97:534-7. 2012

Collaborators

Detail Information

Publications13

  1. pmc Gene selection and classification of microarray data using random forest
    Ramon Diaz-Uriarte
    Bioinformatics Unit, Biotechnology Programme, Spanish National Cancer Centre CNIO, Melchor Fernandez Almagro 3, Madrid, 28029, Spain
    BMC Bioinformatics 7:3. 2006
    ..Thus, it is important to understand the performance of random forest with microarray data and its possible use for gene selection...
  2. pmc DNA methylation profiles and their relationship with cytogenetic status in adult acute myeloid leukemia
    Sara Alvarez
    Molecular Cytogenetics Group, Centro Nacional Investigaciones Oncologicas, Centro de Investigaciones de Enfermedades Raras, Madrid, Spain
    PLoS ONE 5:e12197. 2010
    ..However, further studies to discuss the prognostic value and the relationship of the epigenetic signatures with defined genomic rearrangements in acute myeloid leukemia are required...
  3. ncbi request reprint A predictor based on the somatic genomic changes of the BRCA1/BRCA2 breast cancer tumors identifies the non-BRCA1/BRCA2 tumors with BRCA1 promoter hypermethylation
    Sara Alvarez
    Human Genetics Department, Molecular Pathology Programme, Spanish National Cancer Centre, c o Melchor Fernandez Almagro, 28029 Madrid, Spain
    Clin Cancer Res 11:1146-53. 2005
    ..This fact suggests that somatic BRCA1 inactivation could modify the profile of tumor progression in most of the BRCAX cases...
  4. ncbi request reprint Multiple myeloma primary cells show a highly rearranged unbalanced genome with amplifications and homozygous deletions irrespective of the presence of immunoglobulin-related chromosome translocations
    Cristina Largo
    Molecular Cytogenetics Group, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Haematologica 92:795-802. 2007
    ..Our objective was the genomic characterization of CD 138 positive primary MM samples by means of a high resolution array CGH platform...
  5. ncbi request reprint Estrogen receptor status could modulate the genomic pattern in familial and sporadic breast cancer
    Lorenzo Melchor
    Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Center CNIO, Madrid, Spain
    Clin Cancer Res 13:7305-13. 2007
    ....
  6. ncbi request reprint Genomic analysis of the 8p11-12 amplicon in familial breast cancer
    Lorenzo Melchor
    Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Center CNIO, Madrid, Spain
    Int J Cancer 120:714-7. 2007
    ..Finally, we found correlation between the 8p11-12 amplification and proliferation (Ki-67) and cyclin E expression, which further proves in familial tumors the poor prognosis association previously reported in sporadic breast cancer...
  7. ncbi request reprint The accumulation of specific amplifications characterizes two different genomic pathways of evolution of familial breast tumors
    Lorenzo Melchor
    Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Center, Madrid, Spain
    Clin Cancer Res 11:8577-84. 2005
    ....
  8. doi request reprint The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer
    Pedro P Medina
    Lung Cancer Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    Hum Mol Genet 18:1343-52. 2009
    ..In conclusion, our results show that, in lung cancer, SOX4 is overexpressed due to gene amplification and provide evidence of oncogenic properties of SOX4...
  9. ncbi request reprint Identification of overexpressed genes in frequently gained/amplified chromosome regions in multiple myeloma
    Cristina Largo
    Cytogenetics Unit, Spanish National Cancer Centre, CNIO, C Melchor Fernandez Almagro 3, Madrid, 28029, Spain
    Haematologica 91:184-91. 2006
    ..We aimed to characterize genes that are amplified and overexpressed in human myeloma cell lines (HMCL) to provide putative molecular targets for MM therapy...
  10. pmc Abrogation of RUNX1 gene expression in de novo myelodysplastic syndrome with t(4;21)(q21;q22)
    Ana Rio-Machín
    Molecular Cytogenetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro, 3, 28029, Madrid, Spain
    Haematologica 97:534-7. 2012
    ....
  11. ncbi request reprint De novo erythroleukemia chromosome features include multiple rearrangements, with special involvement of chromosomes 11 and 19
    Juan C Cigudosa
    Cytogenetics Unit, Department of Human Genetics, Spanish National Cancer Center, Melchior Fernandez Almagro, 3 28029 Madrid, Spain
    Genes Chromosomes Cancer 36:406-12. 2003
    ..1, 20q11.2, and 21q11.2. This is the first molecular cytogenetic description of the karyotype abnormalities present in patients with ERL. It should assist in the identification of genes involved in erythroleukemogenesis...
  12. ncbi request reprint Gains, losses and complex karyotypes in myeloid disorders: a light at the end of the tunnel
    Sara Alvarez
    Cytogenetics Unit, Centro Nacional de de Investigaciones Oncológicas CNIO, Madrid, Spain
    Hematol Oncol 23:18-25. 2005
    ..These specific alterations could be used in the near future as therapeutic targets or markers for the risk stratification of patients, detection of minimal residual disease and the development of new therapeutic interventions...
  13. ncbi request reprint Cytogenetic profile of myelodysplastic syndromes with complex karyotypes: an analysis using spectral karyotyping
    Angel Martinez-Ramirez
    Department of Human Genetics, Spanish National Cancer Centre, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Cancer Genet Cytogenet 153:39-47. 2004
    ..Fluorescence in situ hybridization analysis showed amplification of genes previously identified in myeloid and/or hematological processes, such as HER2neu, MLL, and AML1, which could represent frequent events in MDS with CK...