Enrique Alvarez

Summary

Country: Spain

Publications

  1. pmc Vaccines to prevent severe acute respiratory syndrome coronavirus-induced disease
    Luis Enjuanes
    Centro Nacional de Biotecnología CNB, CSIC, Campus Universidad Autonoma, Cantoblanco, Darwin 3, 28049 Madrid, Spain
    Virus Res 133:45-62. 2008
  2. ncbi request reprint Identification of essential genes as a strategy to select a SARS candidate vaccine using a SARS-CoV infectious cDNA
    Fernando Almazán
    Centro Nacional de Biotecnologia, CSIC, Madrid, Spain
    Adv Exp Med Biol 581:579-83. 2006
  3. doi request reprint Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein
    José L Nieto-Torres
    Department of Molecular and Cell Biology, Centro Nacional de Biotecnologia CNB CSIC, Darwin 3, Campus Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Virology 415:69-82. 2011
  4. pmc A severe acute respiratory syndrome coronavirus that lacks the E gene is attenuated in vitro and in vivo
    Marta L DeDiego
    Department of Molecular and Cell Biology, Centro Nacional de Biotecnologia, CSIC, Darwin 3, Campus Universidad Autonoma, Cantoblanco, 28049 Madrid, Spain
    J Virol 81:1701-13. 2007
  5. ncbi request reprint Biochemical aspects of coronavirus replication
    Luis Enjuanes
    Centro Nacional de Biotecnologia, CSIC, Madrid, Spain
    Adv Exp Med Biol 581:13-24. 2006
  6. pmc Pathogenicity of severe acute respiratory coronavirus deletion mutants in hACE-2 transgenic mice
    Marta L DeDiego
    Department of Molecular and Cell Biology, Centro Nacional de Biotecnologia CSIC, Campus Universidad Autonoma, Darwin 3, Cantoblanco, 28049 Madrid, Spain
    Virology 376:379-89. 2008
  7. pmc HIV- 1 protease inhibits Cap- and poly(A)-dependent translation upon eIF4GI and PABP cleavage
    Alfredo Castello
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Nicolas Cabrera 1, Universidad Autonoma de Madrid, Cantoblanco, Spain
    PLoS ONE 4:e7997. 2009
  8. doi request reprint The envelope protein of severe acute respiratory syndrome coronavirus interacts with the non-structural protein 3 and is ubiquitinated
    Enrique Alvarez
    Centro Nacional de Biotecnología CNB, CSIC, Darwin 3, Campus Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Virology 402:281-91. 2010
  9. pmc HIV protease cleaves poly(A)-binding protein
    Enrique Alvarez
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Facultad de Ciencias, Universidad Autonoma, Cantoblanco, 28049 Madrid, Spain
    Biochem J 396:219-26. 2006
  10. pmc Construction of a severe acute respiratory syndrome coronavirus infectious cDNA clone and a replicon to study coronavirus RNA synthesis
    Fernando Almazán
    Department of Molecular and Cell Biology, Centro Nacional de Biotecnologia, CSIC, Darwin 3, Campus Universidad Autonoma, Cantoblanco, 28049 Madrid, Spain
    J Virol 80:10900-6. 2006

Collaborators

  • Luis Enjuanes
  • Luis Menéndez-Arias
  • Anjeanette Roberts
  • Stanley Perlman
  • David Escors
  • Kanta Subbarao
  • Ralph Baric
  • ECKARD A WIMMER
  • Julian A Hiscox
  • Michael Jeffers
  • Marta L DeDiego
  • Fernando Almazán
  • Alfredo Castello
  • José L Nieto-Torres
  • Elaine W Lamirande
  • Maria Teresa Rejas
  • Luis Carrasco
  • Wun Ju Shieh
  • Sherif R Zaki
  • Laura González-Santiago
  • Carmen Galan
  • Mohanraj Dhanabal
  • Jaehwan You
  • Jose M Jiménez-Guardeño
  • Jose A Regla-Nava
  • Mercedes Llorente
  • Leonor Kremer
  • Shen Shuo
  • Pablo Moral-López
  • David Franco
  • Juan J Berlanga
  • Lecia Pewe
  • Jadon P Jackson
  • Tim Sheahan
  • Patricia Alfonso
  • Luis F Garcia-Fernandez
  • Alberto Munoz
  • Yajaira Suarez
  • Antonio Nunez
  • J Ignacio Casal
  • Elaine Lamirande
  • Isabel Sola
  • Aitor Nogales
  • Sara Alonso
  • Jose L Moreno
  • Javier Ortego
  • Sonia Zúñiga
  • Carmen Capiscol
  • John MacDougall
  • Nikolai Khramtsov
  • Henri S Lichenstein
  • Brian K Dove
  • Gareth Howell
  • Craig Hackett
  • Frank Wu
  • Maria Zambon
  • William J Larochelle
  • Ferenc L Boldog
  • Paul Heinen
  • Jami Weiner
  • Kelly D McQueeney
  • Suresh Shenoy

Detail Information

Publications17

  1. pmc Vaccines to prevent severe acute respiratory syndrome coronavirus-induced disease
    Luis Enjuanes
    Centro Nacional de Biotecnología CNB, CSIC, Campus Universidad Autonoma, Cantoblanco, Darwin 3, 28049 Madrid, Spain
    Virus Res 133:45-62. 2008
    ..After preclinical trials in animal models, efficacy and safety evaluation of the most promising vaccine candidates described has to be performed in humans...
  2. ncbi request reprint Identification of essential genes as a strategy to select a SARS candidate vaccine using a SARS-CoV infectious cDNA
    Fernando Almazán
    Centro Nacional de Biotecnologia, CSIC, Madrid, Spain
    Adv Exp Med Biol 581:579-83. 2006
  3. doi request reprint Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein
    José L Nieto-Torres
    Department of Molecular and Cell Biology, Centro Nacional de Biotecnologia CNB CSIC, Darwin 3, Campus Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Virology 415:69-82. 2011
    ..A topological conformation in which SARS-CoV E protein amino terminus is oriented towards the lumen of intracellular membranes and carboxy terminus faces cell cytoplasm is proposed...
  4. pmc A severe acute respiratory syndrome coronavirus that lacks the E gene is attenuated in vitro and in vivo
    Marta L DeDiego
    Department of Molecular and Cell Biology, Centro Nacional de Biotecnologia, CSIC, Darwin 3, Campus Universidad Autonoma, Cantoblanco, 28049 Madrid, Spain
    J Virol 81:1701-13. 2007
    ..Therefore, the SARS-CoV that lacks the E gene is attenuated in hamsters, might be a safer research tool, and may be a good candidate for the development of a live attenuated SARS-CoV vaccine...
  5. ncbi request reprint Biochemical aspects of coronavirus replication
    Luis Enjuanes
    Centro Nacional de Biotecnologia, CSIC, Madrid, Spain
    Adv Exp Med Biol 581:13-24. 2006
  6. pmc Pathogenicity of severe acute respiratory coronavirus deletion mutants in hACE-2 transgenic mice
    Marta L DeDiego
    Department of Molecular and Cell Biology, Centro Nacional de Biotecnologia CSIC, Campus Universidad Autonoma, Darwin 3, Cantoblanco, 28049 Madrid, Spain
    Virology 376:379-89. 2008
    ..These data indicate that E gene might be a virulence factor influencing replication level, tissue tropism and pathogenicity of SARS-CoV, suggesting that DeltaE attenuated viruses are promising vaccine candidates...
  7. pmc HIV- 1 protease inhibits Cap- and poly(A)-dependent translation upon eIF4GI and PABP cleavage
    Alfredo Castello
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Nicolas Cabrera 1, Universidad Autonoma de Madrid, Cantoblanco, Spain
    PLoS ONE 4:e7997. 2009
    ..However, HIV-1 genomic mRNA can be translated under these conditions, giving rise to the production of Gag polyprotein...
  8. doi request reprint The envelope protein of severe acute respiratory syndrome coronavirus interacts with the non-structural protein 3 and is ubiquitinated
    Enrique Alvarez
    Centro Nacional de Biotecnología CNB, CSIC, Darwin 3, Campus Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Virology 402:281-91. 2010
    ..It was shown that E protein was ubiquitinated in vitro and in cell culture, suggesting that the interaction between nsp3 and E protein may play a role in the E protein ubiquitination status and therefore on its turnover...
  9. pmc HIV protease cleaves poly(A)-binding protein
    Enrique Alvarez
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Facultad de Ciencias, Universidad Autonoma, Cantoblanco, 28049 Madrid, Spain
    Biochem J 396:219-26. 2006
    ..An additional cleavage site located at position 410 was detected for HIV-2 protease. These findings indicate that some retroviruses may share with picornaviruses and caliciviruses the capacity to proteolyse PABP...
  10. pmc Construction of a severe acute respiratory syndrome coronavirus infectious cDNA clone and a replicon to study coronavirus RNA synthesis
    Fernando Almazán
    Department of Molecular and Cell Biology, Centro Nacional de Biotecnologia, CSIC, Darwin 3, Campus Universidad Autonoma, Cantoblanco, 28049 Madrid, Spain
    J Virol 80:10900-6. 2006
    ..The SARS reverse genetic system developed as a BAC constitutes a useful tool for the study of fundamental viral processes and also for developing genetically defined vaccines...
  11. pmc The eukaryotic translation initiation factor 4GI is cleaved by different retroviral proteases
    Enrique Alvarez
    Centro de Biologia Molecular CSIC UAM, Facultad de Ciencias, Universidad Autonoma, Cantoblanco, 28049 Madrid, Spain
    J Virol 77:12392-400. 2003
    ....
  12. ncbi request reprint Differential cleavage of eIF4GI and eIF4GII in mammalian cells. Effects on translation
    Alfredo Castello
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias and Centro Nacional de Biotecnología Universidad Autónoma, Cantoblanco, 28049 Madrid, Spain
    J Biol Chem 281:33206-16. 2006
    ..Finally, translation of an mRNA containing encephalomyocarditis virus internal ribosome entry site when the two isoforms of eIF4G are differentially hydrolyzed has been examined...
  13. ncbi request reprint Subcellular localization of the severe acute respiratory syndrome coronavirus nucleocapsid protein
    Jaehwan You
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, Garstang Building, University of Leeds, Leeds LS2 9JT, UK
    J Gen Virol 86:3303-10. 2005
    ..However, cytoplasmic localization was directed by region III and was the dominant localization signal in the protein...
  14. pmc A live attenuated severe acute respiratory syndrome coronavirus is immunogenic and efficacious in golden Syrian hamsters
    Elaine W Lamirande
    Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, USA
    J Virol 82:7721-4. 2008
    ..Despite being attenuated in replication in the respiratory tract, rSARS-CoV-DeltaE is an immunogenic and efficacious vaccine in hamsters...
  15. ncbi request reprint Proteomic analysis of the resistance to aplidin in human cancer cells
    Laura González-Santiago
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Arturo Duperier, 4, E 28029 Madrid, Spain
    J Proteome Res 6:1286-94. 2007
    ..These deregulated proteins are candidates to mediate, at least partially, Aplidin action and might provide a route to the cells to escape the induction of apoptosis by this drug...
  16. ncbi request reprint Recombinant semaphorin 6A-1 ectodomain inhibits in vivo growth factor and tumor cell line-induced angiogenesis
    Mohanraj Dhanabal
    CuraGen Corporation, Branford, Connecticut, USA
    Cancer Biol Ther 4:659-68. 2005
    ..These findings reveal a novel therapeutic utility for Sema 6A-1 (Sema-ECD) as an inhibitor of growth factor as well as tumor-induced angiogenesis...
  17. ncbi request reprint Preclinical characterization of CG53135 (FGF-20) in radiation and concomitant chemotherapy/radiation-induced oral mucositis
    Enrique Alvarez
    CuraGen Corp, Branford, Connecticut 06405, USA
    Clin Cancer Res 9:3454-61. 2003
    ..The purpose of this study was to evaluate the activity of CG53135 (FGF-20), a protein with in vitro mitogenic activity on epithelial and mesenchymal cells, in two in vivo models of oral mucositis (OM)...