Pedro L Alonso

Summary

Country: Spain

Publications

  1. pmc A direct comparison of real time PCR on plasma and blood to detect Plasmodium falciparum infection in children
    Abigail A Lamikanra
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, and National Health Service Blood and Transplant, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK
    Malar J 11:201. 2012
  2. pmc Intermittent preventive treatment with sulfadoxine-pyrimethamine does not modify plasma cytokines and chemokines or intracellular cytokine responses to Plasmodium falciparum in Mozambican children
    Diana Quelhas
    Centro de Investigação em Saúde da Manhiça, Manhiça, Mozambique
    BMC Immunol 13:5. 2012
  3. pmc Cluster-randomized study of intermittent preventive treatment for malaria in infants (IPTi) in southern Tanzania: evaluation of impact on survival
    Joanna R M Armstrong Schellenberg
    London School of Hygiene and Tropical Medicine, London, UK
    Malar J 10:387. 2011
  4. pmc Evaluating the effectiveness of IPTi on malaria using routine health information from sentinel health centres in southern Tanzania
    Barbara A Willey
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 10:41. 2011
  5. pmc The acceptability of intermittent preventive treatment of malaria in infants (IPTi) delivered through the expanded programme of immunization in southern Tanzania
    Robert Pool
    London School of Hygiene and Tropical Medicine, London, UK
    Malar J 7:213. 2008
  6. pmc Determinants of household demand for bed nets in a rural area of southern Mozambique
    Claire Chase
    Harvard School of Public Health, Department of Global Health and Population, Boston, MA, USA
    Malar J 8:132. 2009
  7. pmc A country-wide malaria survey in Mozambique. II. Malaria attributable proportion of fever and establishment of malaria case definition in children across different epidemiological settings
    Samuel Mabunda
    National Malaria Control Programme, Maputo, Mozambique
    Malar J 8:74. 2009
  8. pmc A country-wide malaria survey in Mozambique. I. Plasmodium falciparum infection in children in different epidemiological settings
    Samuel Mabunda
    National Malaria Control Programme, Maputo, Mozambique
    Malar J 7:216. 2008
  9. pmc Development of behaviour change communication strategy for a vaccination-linked malaria control tool in southern Tanzania
    Adiel K Mushi
    Ifakara Health Institute, P, O, Box 78373, Dar es Salaam, Tanzania
    Malar J 7:191. 2008
  10. pmc Performance of HRP-2 based rapid diagnostic test for malaria and its variation with age in an area of intense malaria transmission in southern Tanzania
    Anne Laurent
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 9:294. 2010

Detail Information

Publications92

  1. pmc A direct comparison of real time PCR on plasma and blood to detect Plasmodium falciparum infection in children
    Abigail A Lamikanra
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, and National Health Service Blood and Transplant, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK
    Malar J 11:201. 2012
    ..However the efficiencies of each method have not been compared using samples obtained from infants less than one year old...
  2. pmc Intermittent preventive treatment with sulfadoxine-pyrimethamine does not modify plasma cytokines and chemokines or intracellular cytokine responses to Plasmodium falciparum in Mozambican children
    Diana Quelhas
    Centro de Investigação em Saúde da Manhiça, Manhiça, Mozambique
    BMC Immunol 13:5. 2012
    ..Multiple cytokines and chemokines were quantified in plasma by luminex, and antigen-specific cytokine production in whole blood was determined by intracellular cytokine staining and flow cytometry, at ages 5, 9, 12 and 24 months...
  3. pmc Cluster-randomized study of intermittent preventive treatment for malaria in infants (IPTi) in southern Tanzania: evaluation of impact on survival
    Joanna R M Armstrong Schellenberg
    London School of Hygiene and Tropical Medicine, London, UK
    Malar J 10:387. 2011
    ..This study evaluated the effect of IPTi on child survival in the context of a five-district implementation project in southern Tanzania. [Trial registration: clinical trials.gov NCT00152204]...
  4. pmc Evaluating the effectiveness of IPTi on malaria using routine health information from sentinel health centres in southern Tanzania
    Barbara A Willey
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 10:41. 2011
    ....
  5. pmc The acceptability of intermittent preventive treatment of malaria in infants (IPTi) delivered through the expanded programme of immunization in southern Tanzania
    Robert Pool
    London School of Hygiene and Tropical Medicine, London, UK
    Malar J 7:213. 2008
    ..This paper reports on the reception of IPTi during the first implementation study of IPTi in southern Tanzania...
  6. pmc Determinants of household demand for bed nets in a rural area of southern Mozambique
    Claire Chase
    Harvard School of Public Health, Department of Global Health and Population, Boston, MA, USA
    Malar J 8:132. 2009
    ..Few studies have analysed the determinants of demand for bed nets for malaria prevention at the household level, and in particular, how demand for nets compares with demand for other mosquito prevention methods...
  7. pmc A country-wide malaria survey in Mozambique. II. Malaria attributable proportion of fever and establishment of malaria case definition in children across different epidemiological settings
    Samuel Mabunda
    National Malaria Control Programme, Maputo, Mozambique
    Malar J 8:74. 2009
    ..In many settings of stable malaria transmission, the presence of asymptomatic malaria parasite carriers is common and the definition of clinical malaria remains uncertain...
  8. pmc A country-wide malaria survey in Mozambique. I. Plasmodium falciparum infection in children in different epidemiological settings
    Samuel Mabunda
    National Malaria Control Programme, Maputo, Mozambique
    Malar J 7:216. 2008
    ..This study aims to characterize the malaria transmission intensities and to estimate the disease burden that may help guide control programme...
  9. pmc Development of behaviour change communication strategy for a vaccination-linked malaria control tool in southern Tanzania
    Adiel K Mushi
    Ifakara Health Institute, P, O, Box 78373, Dar es Salaam, Tanzania
    Malar J 7:191. 2008
    ....
  10. pmc Performance of HRP-2 based rapid diagnostic test for malaria and its variation with age in an area of intense malaria transmission in southern Tanzania
    Anne Laurent
    Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 9:294. 2010
    ..As a result, test specificity may vary between age groups with different prevalence of P. falciparum infection...
  11. pmc Health and survival of young children in southern Tanzania
    Joanna R M Armstrong Schellenberg
    Ifakara Health Research and Development Centre, Ifakara, Tanzania
    BMC Public Health 8:194. 2008
    ..With a view to developing health systems strategies to improve reach to high-risk groups, we present information on health and survival from household and health facility perspectives in five districts of southern Tanzania...
  12. pmc A 10 year study of the cause of death in children under 15 years in Manhiça, Mozambique
    Jahit Sacarlal
    Centro de Investigação em Saúde da Manhiça CISM, Mozambique
    BMC Public Health 9:67. 2009
    ....
  13. pmc Levels and trends of demographic indices in southern rural Mozambique: evidence from demographic surveillance in Manhiça district
    Ariel Q Nhacolo
    Centro de Investigação em Saúde da Manhiça, Ministerio de Saude, Manhiça, Maputo, Mozambique
    BMC Public Health 6:291. 2006
    ....
  14. pmc From strategy development to routine implementation: the cost of Intermittent Preventive Treatment in Infants for malaria control
    Fatuma Manzi
    Ifakara Health Research and Development Centre, Ifakara, Tanzania
    BMC Health Serv Res 8:165. 2008
    ..Although efficacy information is available for many interventions, there is a dearth of data on the resources required for scaling up of health interventions...
  15. pmc Towards an effective malaria vaccine
    Pedro Aide
    National Institute of Health, Ministry of Health, Mozambique
    Arch Dis Child 92:476-9. 2007
  16. pmc A research agenda to underpin malaria eradication
    Pedro L Alonso
    Barcelona Centre for International Health Research Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
    PLoS Med 8:e1000406. 2011
    ....
  17. ncbi request reprint Duration of protection with RTS,S/AS02A malaria vaccine in prevention of Plasmodium falciparum disease in Mozambican children: single-blind extended follow-up of a randomised controlled trial
    Pedro L Alonso
    Centre de Salut Internacional, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Lancet 366:2012-8. 2005
    ..An important remaining issue is the durability of protection against clinical disease in these children...
  18. ncbi request reprint Efficacy of the RTS,S/AS02A vaccine against Plasmodium falciparum infection and disease in young African children: randomised controlled trial
    Pedro L Alonso
    Centre de Salut Internacional, Hospital Clinic IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Lancet 364:1411-20. 2004
    ..RTS,S/AS02A is a pre-erythrocytic vaccine candidate based on Plasmodium falciparum circumsporozoite surface antigen. We aimed to assess vaccine efficacy, immunogenicity, and safety in young African children...
  19. ncbi request reprint Malaria: deploying a candidate vaccine (RTS,S/AS02A) for an old scourge of humankind
    Pedro L Alonso
    Centre for International Health, Hospital Clinic IDIBAPS, University of Barcelona, Spain
    Int Microbiol 9:83-93. 2006
    ..Recent interest by international funding agencies has provided new inputs into initiatives and programs to fight malaria, which, under normal welfare and adequate social development conditions, is a curable disease...
  20. pmc Sub-microscopic infections and long-term recrudescence of Plasmodium falciparum in Mozambican pregnant women
    Alfredo Mayor
    Centre de Recerca en Salut Internacional de Barcelona, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Rosselló 132, E 08036 Barcelona, Spain
    Malar J 8:9. 2009
    ..Control of malaria in pregnancy remains a public health challenge. Improvements in its correct diagnosis and the adequacy of protocols to evaluate anti-malarial drug efficacy in pregnancy, are essential to achieve this goal...
  21. pmc Varying efficacy of intermittent preventive treatment for malaria in infants in two similar trials: public health implications
    Clara Menendez
    Barcelona Center for International Health Research CRESIB, Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Spain
    Malar J 6:132. 2007
    ..Understanding the reasons for the discrepant results will help to elucidate the action mechanism of this intervention, which is essential for rational policy formulation...
  22. doi request reprint The effect of intermittent preventive treatment during pregnancy on malarial antibodies depends on HIV status and is not associated with poor delivery outcomes
    Elisa Serra-Casas
    Barcelona Centre for International Health Research, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    J Infect Dis 201:123-31. 2010
    ..However, studies reporting the effect of IPTp on malaria-specific immunity are scarce and are based on findings in human immunodeficiency virus (HIV)-negative primigravidae...
  23. pmc Impact of malaria at the end of pregnancy on infant mortality and morbidity
    Azucena Bardaji
    Barcelona Centre for International Health Research and Department of Pathology, Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer, Universitat de Barcelona, Spain
    J Infect Dis 203:691-9. 2011
    ..There is some consensus that malaria in pregnancy may negatively affect infant's mortality and malaria morbidity, but there is less evidence concerning the factors involved...
  24. doi request reprint HIV and placental infection modulate the appearance of drug-resistant Plasmodium falciparum in pregnant women who receive intermittent preventive treatment
    Clara Menendez
    Barcelona Centre for International Health Research, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Clin Infect Dis 52:41-8. 2011
    ..We aimed to determine the impact of IPTp and human immunodeficiency virus (HIV) infection on molecular markers of SP resistance and the clinical relevance of resistant infections...
  25. pmc Age-dependent IgG subclass responses to Plasmodium falciparum EBA-175 are differentially associated with incidence of malaria in Mozambican children
    Carlota Dobano
    Barcelona Centre for International Health Research, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Clin Vaccine Immunol 19:157-66. 2012
    ..Deeper understanding of the acquisition of antibodies against vaccine target antigens in early infancy is crucial for the rational development and deployment of malaria control tools in this vulnerable population...
  26. pmc The role of age and exposure to Plasmodium falciparum in the rate of acquisition of naturally acquired immunity: a randomized controlled trial
    Caterina Guinovart
    Centre de Recerca en Salut Internacional de Barcelona CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 7:e32362. 2012
    ..We used chemoprophylaxis to selectively control exposure to P. falciparum during different periods in infancy and explore the effect of age in the build-up of NAI, measured as risk of clinical malaria...
  27. pmc Malaria in rural Mozambique. Part II: children admitted to hospital
    Quique Bassat
    Barcelona Center for International Health Research CRESIB, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Rosselló 132, E 08036 Barcelona, Spain
    Malar J 7:37. 2008
    ..Minimum community based-incidence rates (MCBIRs) complement hospital data, describing the malaria burden in the community...
  28. pmc Impact of the RTS,S malaria vaccine candidate on naturally acquired antibody responses to multiple asexual blood stage antigens
    Joseph J Campo
    Centre de Recerca en Salut Internacional de Barcelona, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 6:e25779. 2011
    ....
  29. pmc Malaria prevention with IPTp during pregnancy reduces neonatal mortality
    Clara Menendez
    Barcelona Centre for International Health Research CRESIB, Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 5:e9438. 2010
    ..Malaria in pregnancy may affect neonatal survival, though no strong evidence exists to support this association...
  30. pmc A randomized placebo-controlled trial of intermittent preventive treatment in pregnant women in the context of insecticide treated nets delivered through the antenatal clinic
    Clara Menendez
    Barcelona Center for International Health Research CRESIB and Department of Pathology Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 3:e1934. 2008
    ..Current recommendations to prevent malaria in African pregnant women rely on insecticide treated nets (ITNs) and intermittent preventive treatment (IPTp). However, there is no information on the safety and efficacy of their combined use...
  31. pmc Parity and placental infection affect antibody responses against Plasmodium falciparum during pregnancy
    Alfredo Mayor
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Infect Immun 79:1654-9. 2011
    ..Results of this study show that parity and placental infection can modulate immune responses during pregnancy against malaria parasites...
  32. pmc Clinico-pathological discrepancies in the diagnosis of causes of maternal death in sub-Saharan Africa: retrospective analysis
    Jaume Ordi
    Department of Pathology Hospital Clinic, Universitat de Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    PLoS Med 6:e1000036. 2009
    ..Clinical diagnostic errors may play a significant role in this problem and might also have major implications for the evaluation of current estimations of causes of maternal death...
  33. doi request reprint Invasive Haemophilus influenzae disease in children less than 5 years of age in Manhiça, a rural area of southern Mozambique
    Anna Roca
    Centre de Recerca en Salut Internacional de Barcelona, Universitat de Barcelona, Barcelona, Spain
    Trop Med Int Health 13:818-26. 2008
    ..To measure the disease burden and epidemiological characteristics of invasive Haemophilus influenzae in rural Mozambican children...
  34. doi request reprint Etiology and epidemiology of viral pneumonia among hospitalized children in rural Mozambique: a malaria endemic area with high prevalence of human immunodeficiency virus
    Cristina O'Callaghan-Gordo
    Barcelona Center for International Health Research CRESIB, Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Pediatr Infect Dis J 30:39-44. 2011
    ..The role of viruses in pediatric pneumonia remains poorly studied in sub-Saharan Africa, where pneumonia-associated mortality is high...
  35. pmc Immunoglobulins against the surface of Plasmodium falciparum-infected erythrocytes increase one month after delivery
    Alfredo Mayor
    Barcelona Centre for International Health Research, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Malar J 11:130. 2012
    ..Immunological and physiological alterations associated with pregnancy that persist after delivery may contribute to the susceptibility to P. falciparum during early postpartum period...
  36. pmc Malaria in rural Mozambique. Part I: children attending the outpatient clinic
    Caterina Guinovart
    Barcelona Center for International Health Research CRESIB, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Rosselló 132, E 08036 Barcelona, Spain
    Malar J 7:36. 2008
    ..Malaria represents a huge burden for the health care services across Africa. Describing malaria attending health services contributes to quantify the burden and describe the epidemiology and clinical presentation...
  37. pmc Erythropoietin levels are not independently associated with malaria-attributable severe disease in Mozambican children
    Núria Díez-Padrisa
    Centre de Recerca en Salut Internacional de Barcelona, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 6:e24090. 2011
    ..Severe malaria is difficult to differentiate from other forms of malaria or other infections with similar symptoms. Any parameter associated to malaria-attributable severe disease could help to improve severe malaria diagnosis...
  38. pmc Age interactions in the development of naturally acquired immunity to Plasmodium falciparum and its clinical presentation
    John J Aponte
    Barcelona Centre for International Health Research, Hospital Clinic IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    PLoS Med 4:e242. 2007
    ..We investigated the role of age in disease incidence and the effects of chemoprophylaxis on clinical immunity development to Plasmodium falciparum during a randomised controlled trial...
  39. doi request reprint Severe malaria and concomitant bacteraemia in children admitted to a rural Mozambican hospital
    Quique Bassat
    Barcelona Center for International Health Research, University of Barcelona, Barcelona, Spain
    Trop Med Int Health 14:1011-9. 2009
    ..To describe the prevalence, aetiology and prognostic implications of coexisting invasive bacterial disease in children admitted with severe malaria in a rural Mozambican Hospital...
  40. ncbi request reprint Relationship between haemoglobin and haematocrit in the definition of anaemia
    Llorenç Quintó
    Centre de Salut Internacional, CSI, Hospital Clinic IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Trop Med Int Health 11:1295-302. 2006
    ..Haematocrit (Hct) (%) is usually defined as three times the value of haemoglobin (Hgb) (g/dl), while the clinical definition of anaemia is related to either an abnormal Hct or Hgb value...
  41. pmc The epidemiology of malaria in adults in a rural area of southern Mozambique
    Alfredo Mayor
    Center for International Health, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    Malar J 6:3. 2007
    ..The present study was undertaken to investigate the clinical, parasitological and haematological status of adults exposed to malaria, and to characterize parasites in these individuals who progressively acquire protective immunity...
  42. pmc Low antibodies against Plasmodium falciparum and imbalanced pro-inflammatory cytokines are associated with severe malaria in Mozambican children: a case-control study
    Eduard Rovira-Vallbona
    Barcelona Centre for International Health Research, CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Malar J 11:181. 2012
    ..Altered antibody and cellular immunity against P. falciparum might contribute to increase the risk of developing SM...
  43. pmc Epidemiology, molecular characterization and antibiotic resistance of Neisseria meningitidis from patients ≤15 years in Manhiça, rural Mozambique
    Ana Belén Ibarz-Pavón
    Centre de Recerca en Salut Internacional de Barcelona, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 6:e19717. 2011
    ..With the event of upcoming vaccines microbiological and epidemiological information is urgently needed...
  44. pmc Transcription of var genes other than var2csa in Plasmodium falciparum parasites infecting Mozambican pregnant women
    Eduard Rovira-Vallbona
    Barcelona Centre for International Health Research, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    J Infect Dis 204:27-35. 2011
    ..This phenomenon is mediated by a var gene coding for VAR2CSA, which adheres to chondroitin sulphate A. However, the contribution of parasites transcribing other var genes to maternal infections has not been well characterized...
  45. pmc Insights into long-lasting protection induced by RTS,S/AS02A malaria vaccine: further results from a phase IIb trial in Mozambican children
    Caterina Guinovart
    Barcelona Centre for International Health Research, Hospital Clinic IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 4:e5165. 2009
    ..We performed a new, exploratory analysis to explore differences in the duration of protection among participants to better understand the protection afforded by RTS,S...
  46. ncbi request reprint Safety of the RTS,S/AS02D candidate malaria vaccine in infants living in a highly endemic area of Mozambique: a double blind randomised controlled phase I/IIb trial
    John J Aponte
    Barcelona Centre for International Health Research CRESIB, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    Lancet 370:1543-51. 2007
    ..We aimed to assess the safety, immunogenicity, and initial efficacy of the malaria vaccine RTS,S/AS02D in infants in Africa...
  47. doi request reprint Viral acute respiratory infections among infants visited in a rural hospital of southern Mozambique
    Cristina O'Callaghan-Gordo
    Barcelona Centre for International Health Research, Hospital Clínic Institut d Investigacions Biomèdicas August Pí i Sunyer, Universitat de Barcelona, Barcelona, Spain
    Trop Med Int Health 16:1054-60. 2011
    ..To determine the epidemiology and clinical presentation of virus-associated acute respiratory infections (ARI) in Mozambican infants...
  48. pmc Costs associated with low birth weight in a rural area of Southern Mozambique
    Elisa Sicuri
    Barcelona Centre for International Health Research CRESIB, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 6:e28744. 2011
    ..This study aims to estimate the costs to the health system and to the household and the Disability Adjusted Life Years (DALYs) arising from infant deaths associated with LBW in Southern Mozambique...
  49. ncbi request reprint Impact of maternal human immunodeficiency virus infection on birth outcomes and infant survival in rural Mozambique
    Denise Naniche
    Barcelona Center for International Health Research, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    Am J Trop Med Hyg 80:870-6. 2009
    ..6-22.4). Assessment of the impact of HIV infection on birth outcomes in rural Africa is essential for tailoring public health measures to reduce mother-to-child transmission of HIV and excess infant mortality...
  50. pmc An autopsy study of maternal mortality in Mozambique: the contribution of infectious diseases
    Clara Menendez
    Barcelona Center for International Health Research CRESIB and Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Spain
    PLoS Med 5:e44. 2008
    ..The aim of this study was to accurately describe the causes of maternal death in order to contribute to its reduction, in one of the regions of the world with the highest maternal mortality ratios...
  51. ncbi request reprint Haematological and biochemical indices in young African children: in search of reference intervals
    Llorenç Quintó
    Centre de Salut Internacional, Hospital Clinic IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Trop Med Int Health 11:1741-8. 2006
    ..Few studies have been performed in Africa questioning the validity of these values when applied to local African populations...
  52. ncbi request reprint Antibody response after RSV infection in children younger than 1 year of age living in a rural area of Mozambique
    Anna Roca
    Unitat d Epidemiologia i Bioestadística UASP, Hospital Clinic, Universitat de Barcelona, Spain
    J Med Virol 69:579-87. 2003
    ..Restricted cross-reactivity and neutralizing capacity of antibodies generated by young children might be expected to induce only moderate protection in subsequent epidemics against genetically distant strains...
  53. doi request reprint A variant in the gene FUT9 is associated with susceptibility to placental malaria infection
    Martin Sikora
    Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Hum Mol Genet 18:3136-44. 2009
    ..These results therefore suggest an involvement of this antigen in the pathogenesis of placental malaria infection...
  54. pmc Clinical malaria in African pregnant women
    Azucena Bardaji
    Barcelona Centre for International Health Research, Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Malar J 7:27. 2008
    ..This study aim to characterize the clinical presentation of malaria in African pregnant women and to evaluate the adequacy of case management based on clinical complaints...
  55. pmc Persistence of Plasmodium falciparum parasites in infected pregnant Mozambican women after delivery
    Elisa Serra-Casas
    Barcelona Centre for International Health Research, Hospital Clinic, Universitat de Barcelona, Rosselló 132, 08036 Barcelona, Spain
    Infect Immun 79:298-304. 2011
    ..Interventions that reduce malaria during pregnancy may translate into a lower risk of postpartum infection...
  56. pmc Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor
    Alfredo Mayor
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 6:e19422. 2011
    ..Identification of P. falciparum cytoadherence phenotypes that are associated with severe malaria may lead to the development of novel strategies against life-threatening malaria...
  57. ncbi request reprint Epidemiology and clinical presentation of shigellosis in children less than five years of age in rural Mozambique
    Inacio Mandomando
    Centro de Investigação em Saúde da Manhiça, IDIBAPS Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Pediatr Infect Dis J 26:1059-61. 2007
    ..7% versus 0.4%, P = 0.004), and from dysentery than nondysenteric diarrhea (24.1% versus 3.5%, P < 0.001). Shigella flexneri 2a, S. sonnei, and S. flexneri 6, were the most prevalent serotypes...
  58. ncbi request reprint The effects of short-term iron supplementation on iron status in infants in malaria-endemic areas
    Clara Menendez
    Center for International Health y Departamento de Bioquimica Clínica Institut d Investigacions Biome diques August Pi i Sunyer Hospital Clinic, Villarroeal 170, E 08036, Barcelona, Spain
    Am J Trop Med Hyg 71:434-40. 2004
    ..7% versus 37.3% at 12 months of age). We concluded that iron supplementation between the ages of 2-6 months improves iron status at least up to 12 months of age. Malaria infection does not contribute to iron deficiency...
  59. doi request reprint Comparison of placental blood microscopy and the ICT HRP2 rapid diagnostic test to detect placental malaria
    Ruth Aguilar
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Trans R Soc Trop Med Hyg 106:573-5. 2012
    ..Discordances were found at low parasitemias (<500 parasites/μL) or negative microscopy. The results suggest that the HRP2-RDTs from ICT diagnostics is a good alternative to microscopy for diagnosing placental malaria at delivery...
  60. pmc Naturally-acquired humoral immune responses against the N- and C-termini of the Plasmodium vivax MSP1 protein in endemic regions of Brazil and Papua New Guinea using a multiplex assay
    Carmen Fernandez-Becerra
    Barcelona Centre for International Health Research CRESIB, Hospital Clinic IDIBAPS, Universitat de Barcelona, Rosello 132, 08036 Barcelona, Spain
    Malar J 9:29. 2010
    ....
  61. ncbi request reprint Seasonal variations in maternal mortality in Maputo, Mozambique: the role of malaria
    Cleofe Romagosa
    Department of Pathology, Hospital Clinic, University of Barcelona Institut d Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
    Trop Med Int Health 12:62-7. 2007
    ..To evaluate the impact of malaria on maternal death through the analysis of the seasonal variations of crude and malaria-specific maternal mortality rates...
  62. pmc Distinguishing malaria from severe pneumonia among hospitalized children who fulfilled integrated management of childhood illness criteria for both diseases: a hospital-based study in Mozambique
    Quique Bassat
    Barcelona Centre for International Health Research, Hospital Clinic, University of Barcelona, Spain
    Am J Trop Med Hyg 85:626-34. 2011
    ....
  63. pmc High antibody responses against Plasmodium falciparum in immigrants after extended periods of interrupted exposure to malaria
    Gemma Moncunill
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona Barcelona, Catalonia, Spain
    PLoS ONE 8:e73624. 2013
    ..Malaria immunity is commonly believed to wane in the absence of Plasmodium falciparum exposure, based on limited epidemiological data and short-lived antibody responses in some longitudinal studies in endemic areas...
  64. pmc Lower respiratory tract infections associated with rhinovirus during infancy and increased risk of wheezing during childhood. A cohort study
    Cristina O'Callaghan-Gordo
    Barcelona Centre for International Health Research, CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 8:e69370. 2013
    ..The aim of the study was to evaluate whether LRTI hospitalization associated with rhinovirus during infancy was associated with an increased risk of wheezing - a proxy measure of asthma - during childhood...
  65. pmc Functional and immunological characterization of a Duffy binding-like alpha domain from Plasmodium falciparum erythrocyte membrane protein 1 that mediates rosetting
    Alfredo Mayor
    Barcelona Centre for International Health Research, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    Infect Immun 77:3857-63. 2009
    ..Further studies are required to elucidate the role of these antibodies in protection from malaria...
  66. doi request reprint Intermittent preventive treatment of malaria in pregnant women and infants: making best use of the available evidence
    Azucena Bardaji
    University of Barcelona, Hospital Clinic, Barcelona Centre for International Health Research, Roselló, 132, 08036, Barcelona, Spain
    Expert Opin Pharmacother 13:1719-36. 2012
    ..Yet, the effectiveness of the IPT strategy may be impaired by the increasing resistance to sulfadoxine-pyrimethamine (SP), and the scarcity of alternative antimalarial drugs...
  67. pmc Cost-effectiveness of intermittent preventive treatment of malaria in pregnancy in southern Mozambique
    Elisa Sicuri
    Barcelona Centre for International Health Research RESIB, Hospital Clinic IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 5:e13407. 2010
    ..Malaria in pregnancy is a public health problem for endemic countries. Economic evaluations of malaria preventive strategies in pregnancy are needed to guide health policies...
  68. pmc Feasibility of flow cytometry for measurements of Plasmodium falciparum parasite burden in studies in areas of malaria endemicity by use of bidimensional assessment of YOYO-1 and autofluorescence
    Joseph J Campo
    Centro de Reserca en Salud Internacional de Barcelona, Hospital Clinic Barcelona Universitat de Barcelona, Barcelona, Spain
    J Clin Microbiol 49:968-74. 2011
    ..YOYO-1(530/585) is a high-throughput tool with great potential if the limitations of negative controls and heterogeneous levels of background signal can be overcome...
  69. ncbi request reprint Detection of Salmonella enterica serotype typhimurium DT104 in Mozambique
    Joaquim Ruiz
    Centre de Recerca en Salut Internacional de Barcelona, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Am J Trop Med Hyg 79:918-20. 2008
    ..0005). Results showed the need for continuous surveillance of Salmonella spp. serotypes circulating in this area...
  70. doi request reprint Blood oxidative stress markers and Plasmodium falciparum malaria in non-immune African children
    Ruth Aguilar
    Barcelona Centre for International Health Research CRESIB, Hospital Clinic University of Barcelona, Barcelona, Spain Manhiça Health Research Centre CISM, Maputo, Mozambique CIBER Epidemiology and Public Health CIBERESP, Barcelona, Spain
    Br J Haematol 164:438-50. 2014
    ..Further studies will show whether or not higher membrane-haemoglobin values at the first malaria episode may provide protection against malaria. ..
  71. pmc Comparison of commercial kits to measure cytokine responses to Plasmodium falciparum by multiplex microsphere suspension array technology
    Tamara K Berthoud
    Barcelona Centre for International Health Research, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Malar J 10:115. 2011
    ..A series of comparison experiments were carried out to determine the most appropriate method for our subsequent studies...
  72. ncbi request reprint The safety and efficacy of sulfadoxine-pyrimethamine, amodiaquine, and their combination in the treatment of uncomplicated Plasmodium falciparum malaria
    David Schellenberg
    Unidad de Epidemiologia, Hospital Clinic, Barcelona, Spain
    Am J Trop Med Hyg 67:17-23. 2002
    ..6% vs. SP 29.9%; P = 0.001). The level of R1 resistance to SP may herald a rapid decline in its efficacy as SP drug pressure increases. Coadministration of AQ+SP may delay this...
  73. pmc Challenges in the diagnosis of iron deficiency in children exposed to high prevalence of infections
    Ruth Aguilar
    Barcelona Centre for International Heath Research, Hospital Clinic, University of Barcelona, Barcelona, Spain
    PLoS ONE 7:e50584. 2012
    ..With the objective of improving iron deficiency diagnosis and thus, its management, we evaluated the performance of iron markers in children exposed to high infection pressure...
  74. pmc Increased expression levels of the pvcrt-o and pvmdr1 genes in a patient with severe Plasmodium vivax malaria
    Carmen Fernandez-Becerra
    Barcelona Centre for International Health Research CRESIB, Hospital Clinic IDIBAPS, Universitat de Barcelona, Rosello 132, 4a planta, 08036, Barcelona, Spain
    Malar J 8:55. 2009
    ..There are increasing reports of severe clinical cases exclusively associated with Plasmodium vivax infections. Notably, this severity has been recently suggested to be associated with chloroquine resistance...
  75. pmc Procalcitonin and C-reactive protein for invasive bacterial pneumonia diagnosis among children in Mozambique, a malaria-endemic area
    Núria Díez-Padrisa
    Centre de Recerca en Salut Internacional de Barcelona, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 5:e13226. 2010
    ..Procalcitonin (PCT) and C-reactive protein (CRP) are used in developed countries to differentiate between viral and bacterial causes of pneumonia. Validity of these markers needs to be further explored in Africa...
  76. ncbi request reprint Polarisation microscopy increases the sensitivity of hemozoin and Plasmodium detection in the histological assessment of placental malaria
    Cleofe Romagosa
    Department of Anatomical Pathology, Facultat de Medicina, Institut d Investigacions Biomèdiques August Pi i Sunyer Hospital Clínic, Universitat de Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Acta Trop 90:277-84. 2004
    ..This method can be useful to investigators working in the malaria field...
  77. doi request reprint Public health challenges and prospects for malaria control and elimination
    Pedro L Alonso
    Barcelona Centre for International Health Research, Hospital Clinic, Universitat de Barcelona, Spain
    Nat Med 19:150-5. 2013
    ..Addressing these challenges in a comprehensive and timely way will allow us to sustain the gains made so far and make further progress in control and progressive elimination...
  78. doi request reprint Pyrethroid use-malaria control and individual applications by households for other pests and home garden use
    Maria Luisa Feo
    Institute of Environmental Assessment and Water Research IDÆA CSIC, Jordi Girona, Barcelona, Catalonia, Spain
    Environ Int 38:67-72. 2012
    ....
  79. ncbi request reprint Methods for determining vaccine efficacy and effectiveness and the main barriers to developing a fully deployable malaria vaccine
    Caterina Guinovart
    Barcelona Center for International Health Research, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Rosselló 132, Barcelona, Spain
    Am J Trop Med Hyg 77:276-81. 2007
    ..Deployment of a safe and effective malaria vaccine administered in early childhood could become a major public health tool, particularly in sub-Saharan Africa...
  80. ncbi request reprint Prevalence of respiratory syncytial virus IgG antibodies in infants living in a rural area of Mozambique
    Anna Roca
    Unitat d Epidemiologia i Bioestadística UASP, Hospital Clinic, Universitat de Barcelona, Spain
    J Med Virol 67:616-23. 2002
    ..The results reinforce the concept of maternal vaccination for the control of RSV in very young children in whom the risk and severity of infection are the highest...
  81. pmc Plasmodium vivax malaria in Mali: a study from three different regions
    Maria Bernabeu
    Barcelona Centre for International Health Research, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Malar J 11:405. 2012
    ..Recent reports, however, suggest the circulation of P. vivax in sub-Saharan Africa...
  82. ncbi request reprint Field trials
    Pedro L Alonso
    Epidemiology and Biostatistics Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Methods Mol Med 72:607-16. 2002
  83. pmc Approaching the target: the path towards an effective malaria vaccine
    Alberto L García-Basteiro
    Preventative Medicine and Epidemiology Unit, Hospital Clinic, Barcelona, Spain
    Mediterr J Hematol Infect Dis 4:e2012015. 2012
    ..This first vaccine against a human parasite is a groundbreaking achievement, but improved malaria vaccines conferring higher protection will be needed if the aspiration of malaria eradication is to be achieved...
  84. ncbi request reprint Malaria infection does not appear to modify the risk of bronchiolitis early in life
    Clara Menendez
    Unidad de Epidemiologia y Bioestadistica, Institut d Investigaciones Mediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Pediatr Infect Dis J 21:249-54. 2002
    ..Information on the role of parasites in this context is limited. Bronchiolitis in infancy has been linked with asthmatic symptoms later in childhood, although the underlying cause of this association is unknown...
  85. ncbi request reprint The severe gout of Holy Roman Emperor Charles V
    Jaume Ordi
    Department of Pathology, Hospital Clínic d Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona
    N Engl J Med 355:516-20. 2006
  86. ncbi request reprint Dissemination of Salmonella enterica serotype agona and multidrug-resistant Salmonella enterica serotype typhimurium in Cuba
    Roberto Cabrera
    Servicio de Microbiologia, IDIBAPS, Hospital Clinic, Barcelona, Spain
    Am J Trop Med Hyg 74:1049-53. 2006
    ..This is the first report of the widespread dissemination of a multiresistant clone of S. enterica serotype Typhimurium definitive phage type 104 in Cuba...
  87. ncbi request reprint Safety of the RTS,S/AS02A malaria vaccine in Mozambican children during a Phase IIb trial
    Jahit Sacarlal
    Centro de Investigação em Saúde de Manhiça, Manhiça, Mozambique
    Vaccine 26:174-84. 2008
    ..Overall, these results indicate that the RTS,S/AS02A vaccine has a good safety profile and well tolerated when given in three doses to semi-immune children living in malaria-endemic areas...
  88. ncbi request reprint Plasmodium falciparum multiple infections in Mozambique, its relation to other malariological indices and to prospective risk of malaria morbidity
    Alfredo Mayor
    Centro de Investigaçao em Saúde da Manhiça CISM Ministerio de Saúde, Maputo, Mozambique
    Trop Med Int Health 8:3-11. 2003
    ..This change in the association between multiplicity and risk of clinical malaria may indicate a shift in the host response to P. falciparum...
  89. pmc Malaria: progress, perils, and prospects for eradication
    Brian M Greenwood
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Clin Invest 118:1266-76. 2008
    ..Insights into parasite biology, human immunity, and vector behavior will guide efforts to translate parasite and mosquito genome sequences into novel interventions...
  90. pmc Impact of intermittent preventive treatment with sulfadoxine-pyrimethamine on antibody responses to erythrocytic-stage Plasmodium falciparum antigens in infants in Mozambique
    Diana Quelhas
    Centro de Investigação em Saúde da Manhiça CISM, Manhiça, Mozambique
    Clin Vaccine Immunol 15:1282-91. 2008
    ..IPTi with SP given through the EPI reduces the frequency of malarial illness while allowing the development of naturally acquired antibody responses to P. falciparum antigens...
  91. ncbi request reprint Epidemiology and clinical presentation of respiratory syncytial virus infection in a rural area of southern Mozambique
    Maria P Loscertales
    Centro de Investigação em Saúde da Manhiça, Ministerio de Saude, Maputo, Mozambique
    Pediatr Infect Dis J 21:148-55. 2002
    ....
  92. ncbi request reprint Etiology of diarrhea in children younger than 5 years of age admitted in a rural hospital of southern Mozambique
    Inácio M Mandomando
    Centro de Investigação em Saúde da Manhiça, Moçambique
    Am J Trop Med Hyg 76:522-7. 2007
    ..Resistance to trimethoprim-sulphametoxazole and ampicillin was high. Etiologic data on diarrheal diseases and susceptibility patterns of diarrheal pathogens are important tools for clinical management and control strategic planning...