Alvar Agusti

Summary

Country: Spain

Publications

  1. doi request reprint [Phenotypic heterogeneity of chronic obstructive pulmonary disease]
    Judith Garcia-Aymerich
    Centro de Investigación en Epidemiología Ambiental CREAL, Barcelona, Espana
    Arch Bronconeumol 45:129-38. 2009
  2. doi request reprint Night-time symptoms: a forgotten dimension of COPD
    A Agusti
    Thorax Institute, Hospital Clinic, IDIBAPS, Villaroel 1170, Barcelona, Spain
    Eur Respir Rev 20:183-94. 2011
  3. ncbi request reprint Biomarkers in COPD
    Alvar Agusti
    Thorax Institute, Hospital Clinic, IDIBAPS, Universitat de Barcelona and CIBER Enfermedades Respiratorias CIBERES, Villarroel 170, 08036 Barcelona, Spain Electronic address
    Clin Chest Med 35:131-41. 2014
  4. doi request reprint The COPD control panel: towards personalised medicine in COPD
    Alvar Agusti
    Hospital Clinic, IDIBAPS, Thorax Institute, University of Barcelona, Barcelona, Spain
    Thorax 68:687-90. 2013
  5. pmc An investigation of the resolution of inflammation (catabasis) in COPD
    Aina Noguera
    Hospital Universitario Son Espases, Palma de Mallorca, Spain
    Respir Res 13:101. 2012
  6. pmc Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype
    Alvar Agusti
    Thorax Institute, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona and Centro de investigación en red de enfermedades respiratorias CIBERES, Barcelona, Spain
    PLoS ONE 7:e37483. 2012
  7. doi request reprint Systemic inflammation and comorbidities in chronic obstructive pulmonary disease
    Alvar Agusti
    Institut del Tòrax, Hospital Clinic, Villarroel 170, Escala 3, Planta 5, 08036 Barcelona, Spain
    Proc Am Thorac Soc 9:43-6. 2012
  8. pmc Systems medicine and integrated care to combat chronic noncommunicable diseases
    Jean Bousquet
    Department of Respiratory Diseases, Arnaud de Villeneuve Hospital, CHU Montpellier, INSERM CESP U1018, Villejuif, France
    Genome Med 3:43. 2011
  9. doi request reprint Current controversies and future perspectives in chronic obstructive pulmonary disease
    Alvar Agusti
    Thorax Institute, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona and Centro deInvestigación Biomèdica en Red de Enfermedades Respiratorias and Centro Internacional de Medicina Respiratoria Avanzada, Mallorca, Illes Balears, Spain
    Am J Respir Crit Care Med 184:507-13. 2011
  10. doi request reprint Addressing the complexity of chronic obstructive pulmonary disease: from phenotypes and biomarkers to scale-free networks, systems biology, and P4 medicine
    Alvar Agusti
    Thorax Institute, Hospital Clinic, IDIBAPS, University of Barcelona, Spain
    Am J Respir Crit Care Med 183:1129-37. 2011

Collaborators

Detail Information

Publications38

  1. doi request reprint [Phenotypic heterogeneity of chronic obstructive pulmonary disease]
    Judith Garcia-Aymerich
    Centro de Investigación en Epidemiología Ambiental CREAL, Barcelona, Espana
    Arch Bronconeumol 45:129-38. 2009
    ..The information provided has the potential to increase our understanding of the heterogeneity of COPD phenotypes and help us plan future studies on aspects that are as yet unexplored...
  2. doi request reprint Night-time symptoms: a forgotten dimension of COPD
    A Agusti
    Thorax Institute, Hospital Clinic, IDIBAPS, Villaroel 1170, Barcelona, Spain
    Eur Respir Rev 20:183-94. 2011
    ..In summary, night-time symptoms in COPD warrant further clinical investigation with validated tools...
  3. ncbi request reprint Biomarkers in COPD
    Alvar Agusti
    Thorax Institute, Hospital Clinic, IDIBAPS, Universitat de Barcelona and CIBER Enfermedades Respiratorias CIBERES, Villarroel 170, 08036 Barcelona, Spain Electronic address
    Clin Chest Med 35:131-41. 2014
    ..Here, the authors review some general concepts in the field, discuss currently validated biomarkers in COPD, and speculate on potential future developments. ..
  4. doi request reprint The COPD control panel: towards personalised medicine in COPD
    Alvar Agusti
    Hospital Clinic, IDIBAPS, Thorax Institute, University of Barcelona, Barcelona, Spain
    Thorax 68:687-90. 2013
    ..In fact, the recently released Global Initiative for Chronic Obstructive Lung Disease (GOLD), 2011 revision has proposed a new combined assessment method using three variables (symptoms, airflow limitation and exacerbations)...
  5. pmc An investigation of the resolution of inflammation (catabasis) in COPD
    Aina Noguera
    Hospital Universitario Son Espases, Palma de Mallorca, Spain
    Respir Res 13:101. 2012
    ..Because inflammation does not resolve in COPD, we hypothesized that catabasis may be abnormal in these patients...
  6. pmc Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype
    Alvar Agusti
    Thorax Institute, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona and Centro de investigación en red de enfermedades respiratorias CIBERES, Barcelona, Spain
    PLoS ONE 7:e37483. 2012
    ..To explore if the persistence of systemic inflammation is associated with poor clinical outcomes in COPD we assessed patients recruited to the well-characterized ECLIPSE cohort (NCT00292552)...
  7. doi request reprint Systemic inflammation and comorbidities in chronic obstructive pulmonary disease
    Alvar Agusti
    Institut del Tòrax, Hospital Clinic, Villarroel 170, Escala 3, Planta 5, 08036 Barcelona, Spain
    Proc Am Thorac Soc 9:43-6. 2012
    ....
  8. pmc Systems medicine and integrated care to combat chronic noncommunicable diseases
    Jean Bousquet
    Department of Respiratory Diseases, Arnaud de Villeneuve Hospital, CHU Montpellier, INSERM CESP U1018, Villejuif, France
    Genome Med 3:43. 2011
    ..This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems...
  9. doi request reprint Current controversies and future perspectives in chronic obstructive pulmonary disease
    Alvar Agusti
    Thorax Institute, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona and Centro deInvestigación Biomèdica en Red de Enfermedades Respiratorias and Centro Internacional de Medicina Respiratoria Avanzada, Mallorca, Illes Balears, Spain
    Am J Respir Crit Care Med 184:507-13. 2011
    ..Yet, there are many uncertainties and controversies that require further work. This review discusses these controversies and anticipates some of the changes that may occur in the near future in the field of COPD...
  10. doi request reprint Addressing the complexity of chronic obstructive pulmonary disease: from phenotypes and biomarkers to scale-free networks, systems biology, and P4 medicine
    Alvar Agusti
    Thorax Institute, Hospital Clinic, IDIBAPS, University of Barcelona, Spain
    Am J Respir Crit Care Med 183:1129-37. 2011
    ....
  11. pmc Characterisation of COPD heterogeneity in the ECLIPSE cohort
    Alvar Agusti
    Thorax Institute, Hospital Clinic, IDIBAPS, Universitat de Barcelona, Spain
    Respir Res 11:122. 2010
    ..Chronic obstructive pulmonary disease (COPD) is a complex condition with pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of COPD in a large and well characterised and controlled COPD cohort (ECLIPSE)...
  12. doi request reprint [COPD and systemic inflammation. A link for comorbidity]
    Alvar Agusti
    Institut del Tòrax, Hospital Clinic, Universitat de Barcelona, CIBER Enfermedades Respiratorias, Fundación Caubet CIMERA, Illes Balears, Espana
    Arch Bronconeumol 45:14-7. 2009
    ..Therefore, the association between systemic inflammation and comorbidity in COPD is a tempting, but unproven, one...
  13. doi request reprint Characteristics, stability and outcomes of the 2011 GOLD COPD groups in the ECLIPSE cohort
    Alvar Agusti
    Hospital Clinic, IDIBAPS, Universitat de Barcelona and CIBER Enfermedades Respiratorias, FISIB, Mallorca, Spain
    Eur Respir J 42:636-46. 2013
    ..However the assumption that symptoms do not equate to risk appears to be naïve, as groups B and C carry equally poor clinical outcomes, though for different reasons. ..
  14. doi request reprint Molecular mechanisms of inflammation during exacerbations of chronic obstructive pulmonary disease
    Ana L Kersul
    Servicio de Neumologia, Hospital Universitario Son Dureta, Palma de Mallorca, Spain
    Arch Bronconeumol 47:176-83. 2011
    ..The mechanisms of this inflammatory process are not well known...
  15. doi request reprint Abnormal levels of circulating endothelial progenitor cells during exacerbations of COPD
    Ernest Sala
    Servei de Pneumologia, Hospital Universitari Son Dureta, 07014, Palma de Mallorca, Spain
    Lung 188:331-8. 2010
    ..003). In a subset of 12 patients who could be studied during both ECOPD and clinical stability, the EPCs levels increased during ECOPD. We conclude that EPC levels are increased during ECOPD, likely in relation to VEGF upregulation...
  16. doi request reprint Anti-tissue antibodies are related to lung function in chronic obstructive pulmonary disease
    Belén Núñez
    Hospital Son Dureta, C Andrea Doria 55, Palma de Mallorca, Spain
    Am J Respir Crit Care Med 183:1025-31. 2011
    ..Chronic obstructive pulmonary disease (COPD) is a multicomponent disease. Autoimmunity can contribute to the pathogenesis of COPD...
  17. ncbi request reprint FAQs about the GOLD 2011 assessment proposal of COPD: a comparative analysis of four different cohorts
    Alvar Agusti
    Hospital Clinic, IDIBAPS, Universitat de Barcelona, Barcelona
    Eur Respir J 42:1391-401. 2013
    ..These results identify several strengths and shortcomings of the new GOLD assessment proposal, particularly that group B is associated with more morbidity and high mortality. ..
  18. doi request reprint Investigating the natural history of lung function: facts, pitfalls, and opportunities
    Robab Kohansal
    Program of Epidemiology and Clinical Research, Fundación Caubet CIMERA Illes Balears, Recinte Hospital Joan March, Illes Balears, Spain
    Chest 135:1330-41. 2009
    ..Finally, some characteristics of an "ideal" study on the natural history of lung function decline are recommended, both in health and disease...
  19. ncbi request reprint Lungs, bone marrow, and adipose tissue. A network approach to the pathobiology of chronic obstructive pulmonary disease
    Alvar Agusti
    1 Thorax Institute, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    Am J Respir Crit Care Med 188:1396-406. 2013
    ..The caveats and limitations of the hypothesis, as well as the experimental and clinical research needed to test and explore the proposed model, are also briefly discussed. ..
  20. doi request reprint Abnormal lung aging in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
    Rosa Faner
    Fundación Investigación Sanitaria Illes Balears, Centro de Investigación Biomédica en Red Enfermedades Respiratorias CIBERES, Palma de Mallorca, and Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Am J Respir Crit Care Med 186:306-13. 2012
    ..A better understanding of these abnormalities may help in the design of novel and better therapeutic interventions for these patients...
  21. doi request reprint The GOLD initiative 2011: a change of paradigm?
    Roberto Rodriguez-Roisin
    Servei de Pneumologia, Institut del Tòrax, Hospital Clinic, Universitat de Barcelona, IDIBAPS and CIBERES, Barcelona, Spain
    Arch Bronconeumol 48:286-9. 2012
    ..This revision debates not only the most significant aspects, which remain relatively intact, but also, and in particular, those that have been substantially modified compared with the GOLD revision from 2006...
  22. doi request reprint [Clinical phenotypes of COPD]
    Patricia Sobradillo
    Ciber en Enfermedades Respiratorias, Mallorca, Espana
    Arch Bronconeumol 46:8-11. 2010
    ..The present article reviews current knowledge of this topic...
  23. ncbi request reprint Monitoring breathing rate at home allows early identification of COPD exacerbations
    Aina M Yanez
    Fundación de Investigación Sanitaria Illes Balears, Edificio S Hospital Universitario Son Espases, Palma de Mallorca, Spain
    Chest 142:1524-9. 2012
    ..Respiratory frequency increases during exacerbations of COPD (ECOPD). We hypothesized that this increase can be detected at home before ECOPD hospitalization...
  24. doi request reprint Telomere shortening in sleep apnea syndrome
    Antonia Barcelo
    Servei de Analisis Cliniques, Hospital Universitari Son Dureta, C Andrea Doria 55, 07014, Palma de Mallorca, Spain
    Respir Med 104:1225-9. 2010
    ..Because these conditions also occur in patients with Obstructive Sleep Apnea Syndrome (OSAS), we hypothesized that TL would be reduced in patients with OSAS...
  25. doi request reprint Low erythropoietin plasma levels during exacerbations of COPD
    Ernest Sala
    Servei de Pneumologia, Hospital Universitari Son Dureta, C Andrea Doria 55, Palma de Mallorca, Spain
    Respiration 80:190-7. 2010
    ....
  26. doi request reprint Differential effects of smoking and COPD upon circulating myeloid derived suppressor cells
    Sergio Scrimini
    Fundación Investigación Sanitaria Illes Balears FISIB, Hospital Universitari Son Espases, Palma de Mallorca, Spain Centro de Investigación Biomédica En Red de Enfermedades Respiratorias CIBERES, Mallorca, Spain
    Respir Med 107:1895-903. 2013
    ..The effects of smoking on MDSCs and their potential participation in COPD immunopathogenesis have not been explored so far...
  27. doi request reprint HLA distribution in COPD patients
    Rosa Faner
    Fundació Investigació Sanitaria Illes Balears FISIB, Palma de Mallorca, Barcelona, Spain
    COPD 10:138-46. 2013
    ..Auto-immune diseases are characterized by an abnormal distribution of HLA class II alleles (DR and DQ). The distribution of DRB1 and DQB1 alleles has not been investigated in COPD...
  28. pmc Systemic inflammatory response to smoking in chronic obstructive pulmonary disease: evidence of a gender effect
    Rosa Faner
    Fundació Privada Clínic per a la Recerca Biomèdica, Barcelona, Spain Institut D investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona, Spain CIBER Enfermedades Respiratorias CIBERES, Barcelona, Spain
    PLoS ONE 9:e97491. 2014
    ..An abnormal pulmonary and systemic inflammatory response to smoking is thought to play a major pathogenic role in COPD, but this has never been tested directly...
  29. doi request reprint The natural history of chronic airflow obstruction revisited: an analysis of the Framingham offspring cohort
    Robab Kohansal
    Epidemiology and Clinical Research, Fundación Caubet CIMERA Illes Balears, Recinte Hospital Joan March, 07110 Bunyola, Illes Balears, Spain
    Am J Respir Crit Care Med 180:3-10. 2009
    ..Understanding normal lung development and aging in health and disease, both in men and in women, is essential to interpreting any therapeutic intervention...
  30. doi request reprint Pathophysiology of muscle dysfunction in COPD
    Joaquim Gea
    Servei de Pneumologia, Hospital del Mar IMIM, Universitat Pompeu Fabra, Barcelona, Spain
    J Appl Physiol (1985) 114:1222-34. 2013
    ..In the present review we examine the current state of the art of the pathophysiology of muscle dysfunction in COPD...
  31. doi request reprint P4 medicine: the future around the corner
    Patricia Sobradillo
    Ciber en Enfermedades Respiratorias, Barcelona, Spain
    Arch Bronconeumol 47:35-40. 2011
    ..This review establishes the conceptual bases and discusses the principal aspects of this new medicine, known as "P4 Medicine" standing for personalized, predictive, preventive and participatory...
  32. ncbi request reprint Lung function abnormalities are highly frequent in patients with heart failure and preserved ejection fraction
    Rut Andrea
    Thorax Institute, Hospital Clinic, IDIBAPS, University of Barcelona, Spain Electronic address
    Heart Lung Circ 23:273-9. 2014
    ..In this study we explore the frequency, type and severity of lung function abnormalities in HFPEF...
  33. doi request reprint Immune response in chronic obstructive pulmonary disease
    Rosa Faner
    FISIB, CIBER Enfermedades Respiratorias CIBERES, Mallorca, Spain
    Expert Rev Clin Immunol 9:821-33. 2013
    ....
  34. doi request reprint [Phenotypic characterization and course of chronic obstructive pulmonary disease in the PAC-COPD Study: design and methods]
    J Garcia-Aymerich
    Centre for Research in Environmental Epidemiology CREAL, Institut Municipal d Investigació Mèdica Hospital del Mar, Universitat Pompeu Fabra, CIBER de Epidemiología y Salud Pública CIBERESP, Barcelona, Espana
    Arch Bronconeumol 45:4-11. 2009
    ....
  35. ncbi request reprint Inflammatory proteins in patients with obstructive sleep apnea with and without daytime sleepiness
    Mónica de la Peña Bravo
    Hospital Universitario Son Dureta, Servicio de Neumologia, Palma de Mallorca, Baleares 07014, Spain
    Sleep Breath 11:177-85. 2007
    ..e., TNFalpha, IL-6, ICAM-1, 8-iso-PGF2alpha, and P-selectin in the context of sleep-disordered breathing...
  36. doi request reprint COPD as a systemic disease
    Alvar Agusti
    Fundación Caubet CIMERA Illes Balears, Mallorca, Spain
    COPD 5:133-8. 2008
    ....
  37. ncbi request reprint [Reduced expression of the sarcoplasmic calcium pump SERCA2 in skeletal muscle from patients with chronic obstructive pulmonary disease and low body weight]
    Montse Morla
    Institut Universitari d Investigacio en Ciencies de la Salut IUNICS, Palma de Mallorca, Baleares, Espana
    Arch Bronconeumol 43:4-8. 2007
    ....
  38. doi request reprint Is the CAT questionnaire sensitive to changes in health status in patients with severe COPD exacerbations?
    Alvar Agusti
    Hospital Clinic IDIBAPS, Barcelona and CIBER Enfermedades Respiratorias, Barcelona, Spain
    COPD 9:492-8. 2012
    ..63; p < 0.01). Change in CAT correlated well with Δ SGRQ (r = 0.63; p < 0.01). The CAT showed to be sensitive to the change in health status associated with ECOPD. We also provide evidence of the validity of the Spanish version...