A Adell

Summary

Country: Spain

Publications

  1. ncbi Lu-AA21004, a multimodal serotonergic agent, for the potential treatment of depression and anxiety
    Albert Adell
    Instituto de Investigaciones Biomédicas de Barcelona, Consejo Superior de Investigaciones Cientificas, and Centro de Investigación Biomédica en Red de Salud Mental, Department of Neurochemistry and Neuropharmacology, Carrer Rosselló 161, Barcelona 08036, Spain
    IDrugs 13:900-10. 2010
  2. ncbi The somatodendritic release of dopamine in the ventral tegmental area and its regulation by afferent transmitter systems
    Albert Adell
    Department of Neurochemistry, Institut d Investigacions Biomediques de Barcelona, CSIC IDIBAPS, Carrer Rosselló 161, 6th Floor, E 08036 Barcelona, Spain
    Neurosci Biobehav Rev 28:415-31. 2004
  3. ncbi Antidepressant properties of substance P antagonists: relationship to monoaminergic mechanisms?
    Albert Adell
    Department of Neurochemistry, Institut d Investigacions Biomediques de Barcelona, CSIC IDIBAPS, Barcelona, Spain
    Curr Drug Targets CNS Neurol Disord 3:113-21. 2004
  4. ncbi The role of 5-HT1B receptors in the regulation of serotonin cell firing and release in the rat brain
    A Adell
    Department of Neurochemistry, Instituto de Investigaciones Biomédicas de Barcelona, CSIC IDIBAPS, Barcelona, Spain
    J Neurochem 79:172-82. 2001
  5. ncbi Origin and functional role of the extracellular serotonin in the midbrain raphe nuclei
    Albert Adell
    Department of Neurochemistry, Institut d Investigacions Biomediques de Barcelona, CSIC IDIBAPS, Carrer Rosselló 161, 6th Floor, E 08036 Barcelona, Spain
    Brain Res Brain Res Rev 39:154-80. 2002
  6. ncbi Comparative study in the rat of the actions of different types of stress on the release of 5-HT in raphe nuclei and forebrain areas
    A Adell
    Department of Neurochemistry, IIBB, CSIC Jordi Girona, Barcelona, Spain
    Neuropharmacology 36:735-41. 1997
  7. ncbi Effects of acute olanzapine after sustained fluoxetine on extracellular monoamine levels in the rat medial prefrontal cortex
    Mercè Amargós-Bosch
    Department of Neurochemistry, Instituto de Investigaciones Biomédicas de Barcelona, CSIC IDIBAPS, Calle Rosellón 161, 6th floor E 08036 Barcelona, Spain
    Eur J Pharmacol 516:235-8. 2005
  8. ncbi How does pindolol improve antidepressant action?
    F Artigas
    Dept of Neurochemistry, Institut d Investigacions Biomèdiques de Barcelona CSIC IDIBAPS Rosselló 161, 08036 Barcelona, Spain
    Trends Pharmacol Sci 22:224-8. 2001
  9. ncbi Certain forms of matrix metalloproteinase-9 accumulate in the extracellular space after microdialysis probe implantation and middle cerebral artery occlusion/reperfusion
    Anna M Planas
    Departament de Farmacologia i Toxicologia, IDIBAPS, Barcelona, Spain
    J Cereb Blood Flow Metab 22:918-25. 2002
  10. ncbi Role of different monoamine receptors controlling MK-801-induced release of serotonin and glutamate in the medial prefrontal cortex: relevance for antipsychotic action
    Xavier López-Gil
    Department of Neurochemistry and Neuropharmacology, Instituto de Investigaciones Biomédicas de Barcelona, CSIC IDIBAPS, Barcelona, Spain
    Int J Neuropsychopharmacol 12:487-99. 2009

Collaborators

Detail Information

Publications23

  1. ncbi Lu-AA21004, a multimodal serotonergic agent, for the potential treatment of depression and anxiety
    Albert Adell
    Instituto de Investigaciones Biomédicas de Barcelona, Consejo Superior de Investigaciones Cientificas, and Centro de Investigación Biomédica en Red de Salud Mental, Department of Neurochemistry and Neuropharmacology, Carrer Rosselló 161, Barcelona 08036, Spain
    IDrugs 13:900-10. 2010
    ..If initial outcomes from these clinical trials prove positive, Lu-AA21004 may pave the way for new multimodal therapies for the treatment of depression and anxiety...
  2. ncbi The somatodendritic release of dopamine in the ventral tegmental area and its regulation by afferent transmitter systems
    Albert Adell
    Department of Neurochemistry, Institut d Investigacions Biomediques de Barcelona, CSIC IDIBAPS, Carrer Rosselló 161, 6th Floor, E 08036 Barcelona, Spain
    Neurosci Biobehav Rev 28:415-31. 2004
    ....
  3. ncbi Antidepressant properties of substance P antagonists: relationship to monoaminergic mechanisms?
    Albert Adell
    Department of Neurochemistry, Institut d Investigacions Biomediques de Barcelona, CSIC IDIBAPS, Barcelona, Spain
    Curr Drug Targets CNS Neurol Disord 3:113-21. 2004
    ..Further research is needed to ascertain whether the mechanism of action of NK(1) receptor antagonists may be relevant to the antidepressant treatment...
  4. ncbi The role of 5-HT1B receptors in the regulation of serotonin cell firing and release in the rat brain
    A Adell
    Department of Neurochemistry, Instituto de Investigaciones Biomédicas de Barcelona, CSIC IDIBAPS, Barcelona, Spain
    J Neurochem 79:172-82. 2001
    ..The effects of higher concentrations of 5-HT1B receptor agonists seem more compatible with the activation of 5-HT1B heteroreceptors on inhibitory neurons...
  5. ncbi Origin and functional role of the extracellular serotonin in the midbrain raphe nuclei
    Albert Adell
    Department of Neurochemistry, Institut d Investigacions Biomediques de Barcelona, CSIC IDIBAPS, Carrer Rosselló 161, 6th Floor, E 08036 Barcelona, Spain
    Brain Res Brain Res Rev 39:154-80. 2002
    ..Overall, it appears that the extracellular concentration of 5-HT in the DR and the MnR is tightly controlled by intrinsic serotonergic mechanisms as well as afferent connections...
  6. ncbi Comparative study in the rat of the actions of different types of stress on the release of 5-HT in raphe nuclei and forebrain areas
    A Adell
    Department of Neurochemistry, IIBB, CSIC Jordi Girona, Barcelona, Spain
    Neuropharmacology 36:735-41. 1997
    ..The release of 5-HT in the forebrain structures is also dependent on the type of stress procedure and the region studied...
  7. ncbi Effects of acute olanzapine after sustained fluoxetine on extracellular monoamine levels in the rat medial prefrontal cortex
    Mercè Amargós-Bosch
    Department of Neurochemistry, Instituto de Investigaciones Biomédicas de Barcelona, CSIC IDIBAPS, Calle Rosellón 161, 6th floor E 08036 Barcelona, Spain
    Eur J Pharmacol 516:235-8. 2005
    ..Therefore, it is possible that the therapeutic benefit of this pharmacological combination may not be associated to changes in the cortical concentration of monoamines, but to postsynaptic blockade of monoaminergic receptors...
  8. ncbi How does pindolol improve antidepressant action?
    F Artigas
    Dept of Neurochemistry, Institut d Investigacions Biomèdiques de Barcelona CSIC IDIBAPS Rosselló 161, 08036 Barcelona, Spain
    Trends Pharmacol Sci 22:224-8. 2001
    ..In this article, recent controversial data on the mechanism of action of pindolol, which are crucial for the development of more rapid and efficient antidepressant therapies, will be discussed...
  9. ncbi Certain forms of matrix metalloproteinase-9 accumulate in the extracellular space after microdialysis probe implantation and middle cerebral artery occlusion/reperfusion
    Anna M Planas
    Departament de Farmacologia i Toxicologia, IDIBAPS, Barcelona, Spain
    J Cereb Blood Flow Metab 22:918-25. 2002
    ....
  10. ncbi Role of different monoamine receptors controlling MK-801-induced release of serotonin and glutamate in the medial prefrontal cortex: relevance for antipsychotic action
    Xavier López-Gil
    Department of Neurochemistry and Neuropharmacology, Instituto de Investigaciones Biomédicas de Barcelona, CSIC IDIBAPS, Barcelona, Spain
    Int J Neuropsychopharmacol 12:487-99. 2009
    ....
  11. ncbi Clozapine and haloperidol differently suppress the MK-801-increased glutamatergic and serotonergic transmission in the medial prefrontal cortex of the rat
    Xavier López-Gil
    Department of Neurochemistry and Neuropharmacology, Instituto de Investigaciones Biomédicas de Barcelona, CSIC IDIBAPS, Barcelona, Spain
    Neuropsychopharmacology 32:2087-97. 2007
    ..The ability of clozapine to block excessive cortical 5-HT efflux elicited by MK-801 might be related to the superior efficacy of this drug in treating negative/cognitive symptoms of schizophrenia...
  12. ncbi Pindolol augmentation of antidepressant response
    Francesc Artigas
    Department of Neurochemistry, Institut d Investigacions Biomèdiques de Barcelona IIBB, CSIC IDIBAPS, Barcelona, Spain
    Curr Drug Targets 7:139-47. 2006
    ....
  13. ncbi Co-expression and in vivo interaction of serotonin1A and serotonin2A receptors in pyramidal neurons of prefrontal cortex
    Mercè Amargós-Bosch
    Department of Neurochemistry, Institut d Investigacions Biomèdiques de Barcelona CSIC, IDIBAPS, Barcelona, Spain
    Cereb Cortex 14:281-99. 2004
    ....
  14. ncbi Regulation of the release of 5-hydroxytryptamine in the median raphe nucleus of the rat by catecholaminergic afferents
    A Adell
    Department of Neurochemistry, Instituto de Investigaciones Biomédicas de Barcelona, CSIC IDIBAPS, Jordi Girona 18 26, 08034 Barcelona, Spain
    Eur J Neurosci 11:2305-11. 1999
    ....
  15. ncbi In vivo efflux of serotonin in the dorsal raphe nucleus of 5-HT1A receptor knockout mice
    Analía Bortolozzi
    Department of Neurochemistry, Instituto de Investigaciones Biomédicas de Barcelona, CSIC IDIBAPS, Barcelona, Spain
    J Neurochem 88:1373-9. 2004
    ..The increased responsiveness of the extracellular 5-HT in the DR of 5-HT1A receptor knockout mice reflects a lack of the autoinhibitory control exerted by 5-HT1A autoreceptors...
  16. ncbi In vivo modulation of 5-hydroxytryptamine release in mouse prefrontal cortex by local 5-HT(2A) receptors: effect of antipsychotic drugs
    Analía Bortolozzi
    Department of Neurochemistry, Institut d Investigacions Biomèdiques de Barcelona CSIC, IDIBAPS, 08036 Barcelona, Spain
    Eur J Neurosci 18:1235-46. 2003
    ..In particular, the reversal by classical antipsychotics may involve blockade of alpha1-adrenoceptors, whereas that of atypical antipsychotics may involve 5-hydroxytryptamine2A receptors and alpha1-adrenoceptors...
  17. ncbi Antipsychotic drugs reverse the AMPA receptor-stimulated release of 5-HT in the medial prefrontal cortex
    Mercè Amargós Bosch
    Department of Neurochemistry and Neuropharmacology, Institut d Investigacions Biomèdiques de Barcelona CSIC, IDIBAPS, Barcelona, Spain
    J Neurochem 102:550-61. 2007
    ..These results suggest that, besides their action in limbic striatum, antipsychotic drugs may attenuate glutamatergic transmission in PFC, possibly by interacting with 5-HT(2A) and/or alpha(1)-adrenoceptors...
  18. ncbi Unraveling monoamine receptors involved in the action of typical and atypical antipsychotics on glutamatergic and serotonergic transmission in prefrontal cortex
    Xavier López-Gil
    Department of Neurochemistry and Neuropharmacology, Instituto de Investigaciones Biomédicas de Barcelona, CSIC IDIBAPS, Barcelona, Spain
    Curr Pharm Des 16:502-15. 2010
    ....
  19. ncbi The therapeutic role of 5-HT1A and 5-HT2A receptors in depression
    Pau Celada
    Department of Neurochemistry, , , Barcelona, Spain
    J Psychiatry Neurosci 29:252-65. 2004
    ....
  20. ncbi Clozapine and olanzapine, but not haloperidol, suppress serotonin efflux in the medial prefrontal cortex elicited by phencyclidine and ketamine
    Mercè Amargós-Bosch
    Department of Neurochemistry, Institut d Investigacions Biomediques de Barcelona, CSIC IDIBAPS, 08036 Barcelona, Spain
    Int J Neuropsychopharmacol 9:565-73. 2006
    ..These findings indicate that an increased serotonergic transmission in the mPFC is a functional consequence of NMDA receptor hypofunction and this effect is blocked by atypical antipsychotic drugs...
  21. ncbi Stimulation of alpha1-adrenoceptors in the rat medial prefrontal cortex increases the local in vivo 5-hydroxytryptamine release: reversal by antipsychotic drugs
    Mercè Amargós-Bosch
    Department of Neurochemistry, Institut d Investigacions Biomèdiques de Barcelona CSIC, IDIBAPS, Barcelona, Spain
    J Neurochem 87:831-42. 2003
    ....
  22. ncbi Strategies for producing faster acting antidepressants
    Albert Adell
    Department of Neurochemistry, , IDIBAPS, Barcelona, Spain
    Drug Discov Today 10:578-85. 2005
    ....
  23. ncbi Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease
    Jose R Pineda
    Departament de Biologia Cel lular i Anatomia Patològica, Facultat de Medicina, Universitat de Barcelona, Spain
    J Neurochem 93:1057-68. 2005
    ....