Joseph D Spahn

Summary

Publications

  1. doi Establishing the onset of action of intranasal corticosteroids: is there an ideal study design?
    Rohit K Katial
    Weinberg Clinical Research Unit, National Jewish Health and University of Colorado Denver Anschutz Medical Campus, Denver, Colorado, USA
    Allergy Asthma Proc 30:595-604. 2009
  2. doi Bronchoprovocation testing in asthma
    Rohit K Katial
    Department of Medicine, National Jewish Health, Denver, CO 80206, USA
    Immunol Allergy Clin North Am 32:413-31. 2012
  3. ncbi Asthma biomarkers in sputum
    Joseph D Spahn
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology in Pediatrics, National Jewish Health, Denver, CO 80206, USA
    Immunol Allergy Clin North Am 32:387-99. 2012
  4. doi The effect of aspirin desensitization on novel biomarkers in aspirin-exacerbated respiratory diseases
    Rohit K Katial
    Division of Allergy and Immunology, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 126:738-44. 2010
  5. ncbi Safety and application of induced sputum analysis in childhood asthma
    Ronina A Covar
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 114:575-82. 2004
  6. pmc Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma
    Nathan Rabinovitch
    Department of Pediatrics, National Jewish Health and the University of Colorado Denver School of Medicine, Denver, Colo 80206, USA
    J Allergy Clin Immunol 126:545-51.e1-4. 2010
  7. ncbi Characterization of within-subject responses to fluticasone and montelukast in childhood asthma
    Stanley J Szefler
    Department of Pediatrics, National Jewish Medical and Research Medical Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 115:233-42. 2005
  8. ncbi Progression of asthma measured by lung function in the childhood asthma management program
    Ronina A Covar
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 170:234-41. 2004
  9. pmc Predictors of remitting, periodic, and persistent childhood asthma
    Ronina A Covar
    National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 125:359-366.e3. 2010
  10. ncbi Do NHLBI lung function criteria apply to children? A cross-sectional evaluation of childhood asthma at National Jewish Medical and Research Center, 1999-2002
    Keith Paull
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology in Pediatrics, Department of Pediatrics, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Pediatr Pulmonol 39:311-7. 2005

Collaborators

Detail Information

Publications28

  1. doi Establishing the onset of action of intranasal corticosteroids: is there an ideal study design?
    Rohit K Katial
    Weinberg Clinical Research Unit, National Jewish Health and University of Colorado Denver Anschutz Medical Campus, Denver, Colorado, USA
    Allergy Asthma Proc 30:595-604. 2009
    ..Studies conducted in an environmental exposure chamber to determine onset of action for INSs may be of superior design because outcomes are significantly less variable and more reproducible than those of other types...
  2. doi Bronchoprovocation testing in asthma
    Rohit K Katial
    Department of Medicine, National Jewish Health, Denver, CO 80206, USA
    Immunol Allergy Clin North Am 32:413-31. 2012
    ..The information obtained from studies with BPC has provided insights into the pathogenesis and pathophysiology of asthma, and the relationships between airway inflammation and bronchial hyper-responsiveness...
  3. ncbi Asthma biomarkers in sputum
    Joseph D Spahn
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology in Pediatrics, National Jewish Health, Denver, CO 80206, USA
    Immunol Allergy Clin North Am 32:387-99. 2012
    ..By effectively treating sputum eosinophilia, the number of asthma exacerbations can be significantly reduced compared with managing asthma based on symptoms and lung function...
  4. doi The effect of aspirin desensitization on novel biomarkers in aspirin-exacerbated respiratory diseases
    Rohit K Katial
    Division of Allergy and Immunology, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 126:738-44. 2010
    ..Patients with aspirin-exacerbated respiratory disease have been shown to benefit clinically from aspirin desensitization followed by chronic high-dose aspirin therapy. However, the mechanism of this phenomenon is still unclear...
  5. ncbi Safety and application of induced sputum analysis in childhood asthma
    Ronina A Covar
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 114:575-82. 2004
    ..The Childhood Asthma Management Program (CAMP) study was designed to evaluate the long-term effects of budesonide and nedocromil compared with placebo in children with mild to moderate asthma across 8 centers...
  6. pmc Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma
    Nathan Rabinovitch
    Department of Pediatrics, National Jewish Health and the University of Colorado Denver School of Medicine, Denver, Colo 80206, USA
    J Allergy Clin Immunol 126:545-51.e1-4. 2010
    ..A subset of children with asthma respond better to leukotriene receptor antagonists than to inhaled corticosteroids. Information is needed to identify children with these preferential responses...
  7. ncbi Characterization of within-subject responses to fluticasone and montelukast in childhood asthma
    Stanley J Szefler
    Department of Pediatrics, National Jewish Medical and Research Medical Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 115:233-42. 2005
    ..Responses to inhaled corticosteroids (ICSs) and leukotriene receptor antagonists (LTRAs) vary among asthmatic patients...
  8. ncbi Progression of asthma measured by lung function in the childhood asthma management program
    Ronina A Covar
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 170:234-41. 2004
    ..The course and mechanisms of lung function reduction or slow lung growth velocity in children with asthma must be defined...
  9. pmc Predictors of remitting, periodic, and persistent childhood asthma
    Ronina A Covar
    National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 125:359-366.e3. 2010
    ..The course of mild to moderate persistent asthma in children is not clearly established...
  10. ncbi Do NHLBI lung function criteria apply to children? A cross-sectional evaluation of childhood asthma at National Jewish Medical and Research Center, 1999-2002
    Keith Paull
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology in Pediatrics, Department of Pediatrics, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Pediatr Pulmonol 39:311-7. 2005
    ..The NHLBI FEV(1) cutoff values do not appear to accurately stratify pediatric asthma, and no useful FEV(1) cutoff could be generated...
  11. ncbi Quantitative computed tomography detects peripheral airway disease in asthmatic children
    Neal Jain
    Division of Allergy Clinical Immunology, Department of Pediatrics, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Pediatr Pulmonol 40:211-8. 2005
    ..This data suggest that quantitative HRCT may be a useful tool in the evaluation of peripheral airflow obstruction in children with asthma...
  12. ncbi Asthma biomarkers in sputum
    Joseph D Spahn
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology in Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Immunol Allergy Clin North Am 27:607-22; vi. 2007
    ..Sputum eosinophilia also predicts asthma relapse in subjects who have their inhaled glucocorticoid reduced or withdrawn. Lastly, inhaled glucocorticoid therapy can be titrated to keep the sputum eosinophil count at or below 2%...
  13. ncbi A comparison of the clinical characteristics of children and adults with severe asthma
    Henry A Jenkins
    Division of Clinical Pharmacology, the Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology in Pediatrics, National Jewish Medical and Research Center and, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Chest 124:1318-24. 2003
    ..This study sought to better define the clinical characteristics of severe asthma in both children and adults, and to evaluate the effect of asthma duration on multiple parameters of disease severity...
  14. ncbi Steroid therapy for asthma in children
    Joseph D Spahn
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology in Pediatrics, Division of Pediatric Clinical Pharmacology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Curr Opin Pediatr 19:300-5. 2007
    ..To highlight studies that have contributed significantly to our current knowledge of inhaled glucocorticoids in childhood asthma...
  15. ncbi Relations between exhaled nitric oxide and measures of disease activity among children with mild-to-moderate asthma
    Ronina A Covar
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology and the Division of Allergy Clinical Immunology, Department of Pediatrics, Denver, Colorado, USA
    J Pediatr 142:469-75. 2003
    ..Exhaled nitric oxide (FE(NO)) was evaluated in children with asthma after 4 to 6 years of treatment with budesonide, nedocromil, or albuterol as needed...
  16. ncbi The need for pediatric studies of allergy and asthma medications
    Stanley J Szefler
    National Jewish Medical and Research Center, 1400 Jackson Street, Room J304, Denver, CO 80206, USA
    Curr Allergy Asthma Rep 3:478-83. 2003
    ..In this review, we discuss the background for this effort and the continuing impact it will have on the future management of allergy and asthma in children...
  17. ncbi Histopathology of severe childhood asthma: a case series
    Henry A Jenkins
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology in Pediatrics, Division of Clinical Pharmacology, National Jewish Medical and Research Center, Denver, CO, USA
    Chest 124:32-41. 2003
    ..The currently accepted model of asthma holds that persistent airway inflammation leads to various symptoms of asthma, airway hyperresponsiveness, and airway remodeling that ultimately results in permanent loss of lung function...
  18. ncbi Is forced expiratory volume in one second the best measure of severity in childhood asthma?
    Joseph D Spahn
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology in Pediatrics, National Jewish Medical and Research Center, Univerisity of Colorado Health Sciences Center, CO 80206, USA
    Am J Respir Crit Care Med 169:784-6. 2004
  19. doi Long-term treatment with fluticasone propionate/salmeterol via Diskus improves asthma control versus fluticasone propionate alone
    Rohit K Katial
    National Jewish Health, Denver, Colorado, USA
    Allergy Asthma Proc 32:127-36. 2011
    ..In addition, FSC 250/50 micrograms-treated subjects experienced fewer severe asthma exacerbations than subjects treated with FP 250 micrograms...
  20. doi Clinical assessment of asthma progression in children and adults
    Joseph D Spahn
    Division of Clinical Pharmacology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 121:548-57; quiz 558-9. 2008
    ..Studies evaluating progressive loss of lung function, the best-studied measure of asthma progression, are also reviewed, followed by a brief discussion of whether asthma progression can be modified by inhaled glucocorticoid therapy...
  21. ncbi Office-based objective measures in childhood asthma
    Joseph D Spahn
    National Jewish Medical and Research Center, Denver, Colorado, USA
    J Pediatr 148:11-5. 2006
  22. ncbi Racial differences in T-lymphocyte response to glucocorticoids
    Monica J Federico
    National Jewish Medical and Research Center, 1400 Jackson St J316, Denver, CO 80206, USA
    Chest 127:571-8. 2005
    ..Asthma morbidity and mortality is increased in blacks...
  23. doi Antihistamine therapy in allergicĀ rhinitis
    Flavia C L Hoyte
    Division of Allergy, Asthma, and Immunology, National Jewish Health, 1400 Jackson Street, Room K624, Denver, CO 80206, USA
    Immunol Allergy Clin North Am 31:509-43. 2011
    ..Certain patient populations, such as children and pregnant or lactating women, require special consideration regarding antihistamine choice and dosing as part of rhinitis therapy...
  24. ncbi The changing face of severe childhood asthma: A comparison of two cohorts of children evaluated at National Jewish Health over the past 20 years
    Monica B Reddy
    Division of Clinical Pharmacology, Department of Pediatrics, National Jewish Health, Denver, Colorado, USA
    Allergy Asthma Proc 35:119-25. 2014
    ..This is most likely because of the use of more effective medications for childhood asthma. ..
  25. ncbi Childhood asthma: new insights into management
    Joseph D Spahn
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver 80206, USA
    J Allergy Clin Immunol 109:3-13. 2002
    ....
  26. doi Adding montelukast to fluticasone propionate/salmeterol for control of asthma and seasonal allergic rhinitis
    Rohit K Katial
    National Jewish Health, Denver, Colorado, USA
    Allergy Asthma Proc 31:68-75. 2010
    ..Optimal disease control in patients with asthma and allergic rhinitis should be achieved by the most effective therapy directed toward each disease component...
  27. pmc IgG antibodies produced during subcutaneous allergen immunotherapy mediate inhibition of basophil activation via a mechanism involving both FcgammaRIIA and FcgammaRIIB
    Carol T Cady
    Division of Allergy and Immunology, National Jewish Health, Denver, USA
    Immunol Lett 130:57-65. 2010
    ....
  28. doi Intranasal antihistamines for allergic rhinitis: examining the clinical impact
    Heather R Cassell
    Division of Pediatric Allergy and Immunology, National Jewish Health, Denver, Colorado, USA
    Allergy Asthma Proc 30:349-57. 2009
    ..It is equally important to identify the individuals who have had less success with their current therapies to determine if intranasal antihistamines would be an important adjunct in therapy...