Michael Soyka

Summary

Publications

  1. ncbi Feasability and safety of transfer from racemic methadone to (R)-methadone in primary care: clinical results from an open study
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    World J Biol Psychiatry 10:217-24. 2009
  2. ncbi [Driving ability with alcohol and drug dependence and schizophrenia]
    M Soyka
    Psychiatrische Klinik, Universitat Munchen, Munchen, Deutschland
    Nervenarzt 85:816-21. 2014
  3. ncbi [Nalmefene: a novel pharmacotherapeutic option for alcoholism]
    M Soyka
    Privatklinik Meiringen, 3860, Meiringen, Schweiz
    Nervenarzt 85:578-82. 2014
  4. ncbi [Psychiatric assessment of alcoholic patients on a waiting list for liver transplantation: which prognostic criteria are empirically proven?]
    M Soyka
    Nervenarzt 84:1075-80. 2013
  5. doi Buprenorphine use in pregnant opioid users: a critical review
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7, 80336, Munich, Germany
    CNS Drugs 27:653-62. 2013
  6. ncbi Buprenorphine and buprenorphine/naloxone intoxication in children - how strong is the risk?
    Michael Soyka
    Department of Psychiatry, University of Munich, Germany
    Curr Drug Abuse Rev 6:63-70. 2013
  7. doi High rehospitalization rate in alcohol-induced psychotic disorder
    Michael Soyka
    Private Hospital Meiringen, Willigen, 3860 Meiringen, Switzerland
    Eur Arch Psychiatry Clin Neurosci 263:309-13. 2013
  8. doi Buprenorphine and buprenorphine/naloxone soluble-film for treatment of opioid dependence
    Michael Soyka
    University of Munich, Psychiatric Hospital, Nussbaumstr 7 Munich Munich, Germany
    Expert Opin Drug Deliv 9:1409-17. 2012
  9. ncbi Opioid antagonists for pharmacological treatment of alcohol dependence - a critical review
    Michael Soyka
    Private Hospital Meiringen, Meiringen, Switzerland
    Curr Drug Abuse Rev 1:280-91. 2008
  10. pmc Outpatient alcoholism treatment--24-month outcome and predictors of outcome
    Michael Soyka
    Private Hospital Meiringen, PO Box 612, CH 3860 Meiringen, Switzerland
    Subst Abuse Treat Prev Policy 4:15. 2009

Detail Information

Publications84

  1. ncbi Feasability and safety of transfer from racemic methadone to (R)-methadone in primary care: clinical results from an open study
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    World J Biol Psychiatry 10:217-24. 2009
    ..2 to 39.8%. Withdrawal symptoms, craving and compliance improved significantly after transfer to (R)-methadone. We conclude that transfer from racemic to (R)-methadone is a safe and practical procedure...
  2. ncbi [Driving ability with alcohol and drug dependence and schizophrenia]
    M Soyka
    Psychiatrische Klinik, Universitat Munchen, Munchen, Deutschland
    Nervenarzt 85:816-21. 2014
    ..In patients with first onset disease this can usually be granted after 1 year of remission from symptoms but in cases of repeated exacerbations longer intervals of 3-5 years are warranted. ..
  3. ncbi [Nalmefene: a novel pharmacotherapeutic option for alcoholism]
    M Soyka
    Privatklinik Meiringen, 3860, Meiringen, Schweiz
    Nervenarzt 85:578-82. 2014
    ..It seems to be interesting that in the therapy studies relevant to approval, nalmefene was not administered for support of abstinence but as an"as needed"medication for reduction of drink volume...
  4. ncbi [Psychiatric assessment of alcoholic patients on a waiting list for liver transplantation: which prognostic criteria are empirically proven?]
    M Soyka
    Nervenarzt 84:1075-80. 2013
    ..The 6-month criterion is not well proven but some studies are indicative. Possible therapeutic interventions for alcoholic patients on a waiting list are discussed. ..
  5. doi Buprenorphine use in pregnant opioid users: a critical review
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7, 80336, Munich, Germany
    CNS Drugs 27:653-62. 2013
    ..These novel findings indicate that buprenorphine is emerging as a first-line treatment for pregnant opioid users...
  6. ncbi Buprenorphine and buprenorphine/naloxone intoxication in children - how strong is the risk?
    Michael Soyka
    Department of Psychiatry, University of Munich, Germany
    Curr Drug Abuse Rev 6:63-70. 2013
    ..Although exposure to buprenorphine and other opioids remains a significant concern in children, the drug seems rather to be safe with respect to severe outcomes, in particular death. ..
  7. doi High rehospitalization rate in alcohol-induced psychotic disorder
    Michael Soyka
    Private Hospital Meiringen, Willigen, 3860 Meiringen, Switzerland
    Eur Arch Psychiatry Clin Neurosci 263:309-13. 2013
    ..More follow-up studies are needed to elucidate this syndrome...
  8. doi Buprenorphine and buprenorphine/naloxone soluble-film for treatment of opioid dependence
    Michael Soyka
    University of Munich, Psychiatric Hospital, Nussbaumstr 7 Munich Munich, Germany
    Expert Opin Drug Deliv 9:1409-17. 2012
    ..A novel buprenorphine/naloxone film has been developed with improved pharmacokinetics and a hopefully lower risk of diversion and accidental intoxications...
  9. ncbi Opioid antagonists for pharmacological treatment of alcohol dependence - a critical review
    Michael Soyka
    Private Hospital Meiringen, Meiringen, Switzerland
    Curr Drug Abuse Rev 1:280-91. 2008
    ..Future studies on the role of different subtypes of alcoholics according to their genetic or psychological profile to explain or even predict the effects of opioid antagonists in the treatment of alcohol dependence are needed...
  10. pmc Outpatient alcoholism treatment--24-month outcome and predictors of outcome
    Michael Soyka
    Private Hospital Meiringen, PO Box 612, CH 3860 Meiringen, Switzerland
    Subst Abuse Treat Prev Policy 4:15. 2009
    ..To study the value of demographic and alcohol-related variables for predicting 24-month treatment outcome in an outpatient setting...
  11. ncbi [Neuro-enhancement from an addiction specialist's viewpoint]
    M Soyka
    Psychiatrische Klinik, Ludwig Maximilians Universitat, Munchen
    Nervenarzt 80:837-9. 2009
    ..To date German psychiatrists have surprisingly not been outspoken on this issue. The author would like to make an emphatic plea against"brain doping" in healthy individuals...
  12. ncbi [Psychiatric assessment of physicians on probation]
    M Soyka
    Psychiatrische Klinik der Universität München, Nussbaumstrasse 7, 80336, Munchen
    Nervenarzt 80:765-6, 768-71. 2009
    ..Based on own experience in this area, some typical cases are described. Physicians with substance use and legal problems are especially common. Some general guidelines for psychiatric assessment are discussed...
  13. doi Cognitive functioning during methadone and buprenorphine treatment: results of a randomized clinical trial
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    J Clin Psychopharmacol 28:699-703. 2008
    ..Selective attention improved in both patient groups during treatment. We propose that the improvement of attention may facilitate rehabilitation of drug-dependent patients...
  14. doi Cognitive function in short- and long-term substitution treatment: are there differences?
    Michael Soyka
    Private Hospital Meiringen, Willigen, Meiringen, Switzerland
    World J Biol Psychiatry 11:400-8. 2010
    ..More longitudinal research and studies controlling for the effects of dosage and duration of opioid addiction are necessary to examine whether cognitive ability may improve under long-term MMT...
  15. ncbi Association for methodology and documentation in psychiatry profiles predict later risk for criminal behavior and violent crimes in former inpatients with affective disorder
    Michael Soyka
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    J Forensic Sci 55:655-9. 2010
    ..As previously demonstrated in another sample of schizophrenic patients, the AMDP syndromes mania (and hostility) is associated with a higher risk of later criminal behavior...
  16. pmc Neurobiology of aggression and violence in schizophrenia
    Michael Soyka
    Psychiatric Hospital, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Schizophr Bull 37:913-20. 2011
    ..Neuroimaging studies may well help further elucidate the interrelationship between neurocognitive functioning, personality traits, and antisocial and violent behavior...
  17. doi A comparison of cognitive function in patients under maintenance treatment with heroin, methadone, or buprenorphine and healthy controls: an open pilot study
    Michael Soyka
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University, Munich, Germany
    Am J Drug Alcohol Abuse 37:497-508. 2011
    ..INTROduction: Cognitive impairment has been reported in drug-dependent patients under opioid maintenance treatment...
  18. doi The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of substance use and related disorders. Part 2: Opioid dependence
    Michael Soyka
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    World J Biol Psychiatry 12:160-87. 2011
    ..To develop evidence-based practice guidelines for the pharmacological treatment of opioid abuse and dependence...
  19. doi Prevalence of delusional jealousy in psychiatric disorders
    Michael Soyka
    Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    J Forensic Sci 56:450-2. 2011
    ..We conclude that delusional jealousy is a comparatively rare phenomenon that is most frequent in schizophrenia and related psychoses. Quite a number of affected patients are aggressive, which may indicate a risk of future violence...
  20. ncbi Less impairment on one portion of a driving-relevant psychomotor battery in buprenorphine-maintained than in methadone-maintained patients: results of a randomized clinical trial
    Michael Soyka
    Psychiatric Hospital, University of Munich, Germany
    J Clin Psychopharmacol 25:490-3. 2005
    ..We assessed whether patients under buprenorphine, a partial mu-opioid agonist, perform better in cognitive tests measuring psychomotor performance as described in previous nonrandomized studies...
  21. doi World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Substance Use and Related Disorders, Part 1: Alcoholism
    Michael Soyka
    Psychiatric Hospital Meiringen, Meiringen, Switzerland
    World J Biol Psychiatry 9:6-23. 2008
    ..This first part of the guidelines covers the treatment of alcohol dependence; Part 2 will be devoted to the treatment of drug dependence...
  22. ncbi Outpatient alcohol detoxification: implementation efficacy and outcome effectiveness of a model project
    Michael Soyka
    Psychiatric Hospital, University Munich, Munich, Germany
    Eur Addict Res 10:180-7. 2004
    ..The aim of the study was to examine the practicability and implementation efficacy of an alcohol outpatient detoxification model and the concomitant 'motivational' psychotherapeutic approach...
  23. doi Retention rate and substance use in methadone and buprenorphine maintenance therapy and predictors of outcome: results from a randomized study
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    Int J Neuropsychopharmacol 11:641-53. 2008
    ..The intensity of withdrawal symptoms showed the strongest correlation with drop-out. Future studies are warranted to further address patient profiles and outcome under different substitution regimens...
  24. ncbi Influence of trait anxiety on inhibitory control in alcohol-dependent patients: simultaneous acquisition of ERPs and BOLD responses
    Susanne Karch
    Department of Psychiatry, Ludwig Maximilians University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    J Psychiatr Res 42:734-45. 2008
    ..This may indicate that comorbid psychiatric symptoms need to be considered when assessing brain responses in alcohol-dependent patients...
  25. ncbi Pharmacotherapy of patients with schizophrenia and substance abuse
    Thomas Wobrock
    Georg August University, Department of Psychiatry and Psychotherapy, Von Siebold Strasse 5, D 37075 Gottingen, Germany
    Expert Opin Pharmacother 10:353-67. 2009
    ..Additional treatment with antidepressants, depending on the patient's psychopathology, as well as with anti-craving agents should be considered...
  26. doi Possible association between OPRM1 genetic variance at the 118 locus and alcohol dependence in a large treatment sample: relationship to alcohol dependence symptoms
    Gabriele Koller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Alcohol Clin Exp Res 36:1230-6. 2012
    ..Conflicting results were reported on the role of the mu-opioid receptor (OPRM1) polymorphism A118G (Asn40Asp, rs1799971) in the development of alcoholism...
  27. doi No association of alcohol dependence with SLC6A5 and SLC6A9 glycine transporter polymorphisms
    Gabriele Koller
    Psychiatrische Klinik, Nussbaumstrasse 7, 80336 Munich, Germany
    Addict Biol 14:506-8. 2009
    ..048, P = 0.049, d.f. = 2), which did not remain significant after correction for multiple testing. There was no association between SLC6A9 glycine transporter polymorphisms and alcohol dependence, and also none in haplotype analysis...
  28. doi Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study
    Ulrich W Preuss
    Department of Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University, Halle Wittenberg, Julius Kühn Str 7, D 06112 Halle, Germany
    Addict Biol 16:323-33. 2011
    ....
  29. ncbi Clinical correlates of later violence and criminal offences in schizophrenia
    Michael Soyka
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstr 7, 80336 Munich, Germany
    Schizophr Res 94:89-98. 2007
    ..Violence and criminality in patients with schizophrenia has been described in several studies but prediction of later criminal behavior is difficult...
  30. ncbi Outpatient alcoholism treatment: predictors of outcome after 3 years
    Miriam Bottlender
    Department of Psychiatry, Ludwig Maximilians University, Munich, Nussbaumstr 7, 80336 Munich, Germany
    Drug Alcohol Depend 80:83-9. 2005
    ..This prospective study investigated predictors for relapse 3 years after completion of an intensive outpatient treatment programme for alcoholism...
  31. doi Criminal behaviour and violent crimes in former inpatients with affective disorder
    Christian Graz
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    J Affect Disord 117:98-103. 2009
    ..Several studies have reported criminal and violent behaviour in people with schizophrenia but few have investigated the association between affective disorders and violent behaviour...
  32. ncbi Effects of haloperidol and risperidone on psychomotor performance relevant to driving ability in schizophrenic patients compared to healthy controls
    Michael Soyka
    Psychiatric Hospital, Ludwig Maximilians University of Munich, Naussbaumstrasse 7, D 80336 Munich, Germany
    J Psychiatr Res 39:101-8. 2005
    ..Among patients with risperidone, seven patients (35%) passed all test parameters without major failures. Clinical implications of these findings are discussed...
  33. doi Analysis of single nucleotide polymorphisms and haplotypes in the neuropeptide Y gene: no evidence for association with alcoholism in a German population sample
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Alcohol Clin Exp Res 32:430-4. 2008
    ..The aim of the present study was to analyze these variants in a large sample of the Munich Gene Bank of Alcoholism...
  34. ncbi Delinquency and criminal offenses in former schizophrenic inpatients 7-12 years following discharge
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 254:289-94. 2004
    ..Previously, we reported a high prevalence of aggression in a large sample of schizophrenic patients treated between 1990-1995 in the psychiatric hospital of the University of Munich...
  35. ncbi OCDS craving scores predict 24-month outcome in alcoholic outpatients
    Michael Soyka
    Private Hospital Meiringen, Meiringen, Switzerland
    Am J Addict 19:264-9. 2010
    ..OCDS scores were higher in patients with a less favorable outcome. In line with previous findings, our results showed that the intensity of craving as measured by the OCDS may predict outcome in outpatient alcoholics...
  36. ncbi Efficacy of an intensive outpatient rehabilitation program in alcoholism: predictors of outcome 6 months after treatment
    Miriam Bottlender
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Eur Addict Res 11:132-7. 2005
    ..In summary, results of this study indicate a favorable outcome of socially stable alcohol-dependent patients and patients with a lower degree of depression, anxiety and craving in an intensive outpatient rehabilitation program...
  37. ncbi One-year mortality rates of patients receiving methadone and buprenorphine maintenance therapy: a nationally representative cohort study in 2694 patients
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    J Clin Psychopharmacol 26:657-60. 2006
    ..Taking into account the high comorbidity of opioid dependent patients and the severity of dependence, the mortality rate of approximately 1% confirms that maintenance treatment could be regarded as a fairly safe treatment...
  38. ncbi Suicidal behavior in alcohol-dependent subjects: the role of personality disorders
    Ulrich W Preuss
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Germany
    Alcohol Clin Exp Res 30:866-77. 2006
    ....
  39. doi Acamprosate supports abstinence, naltrexone prevents excessive drinking: evidence from a meta-analysis with unreported outcomes
    Susanne Rösner
    IFT, Institut für Therapieforschung, Munich, Germany
    J Psychopharmacol 22:11-23. 2008
    ..Benefits in the treatment of alcohol dependence might be optimized by matching the efficacy profiles of specific antidipsotropics with the motivational status of alcohol-dependent patients...
  40. doi Pharmacological challenge with naloxone and cue exposure in alcohol dependence: results of a randomized, double-blind placebo-controlled trial
    Martin Lieb
    Department of Psychiatry, Bezirksklinikum Regensburg, Regensburg, Germany
    World J Biol Psychiatry 14:539-46. 2013
    ..Altered cortisol response to opioid receptor blockade not only in alcohol dependent persons, but also in persons with a family history of alcohol dependency was reported...
  41. ncbi Flupenthixol in relapse prevention in schizophrenics with comorbid alcoholism: results from an open clinical study
    Michael Soyka
    Psychiatric Hospital University of Munich, Munich, Germany
    Eur Addict Res 9:65-72. 2003
    ..Although the efficacy of flupenthixol as an anti-craving drug in dual diagnosis patients has to be explored in further studies, the drug may be considered a promising medication for these patients...
  42. doi Association of VMAT2 gene polymorphisms with alcohol dependence
    Christoph Fehr
    Department of Psychiatry and Psychotherapy, University of Mainz, Untere Zahlbacher Str 8, 55131, Mainz, Germany
    J Neural Transm 120:1161-9. 2013
    ..53), whereas G-allele containing haplotypes confer protection against alcohol dependence. Taken together, there is supporting evidence for a contribution of VMAT2 gene variants to phenotypes of alcohol dependence. ..
  43. doi Criminal behavior in opioid-dependent patients before and during maintenance therapy: 6-year follow-up of a nationally representative cohort sample
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    J Forensic Sci 57:1524-30. 2012
    ..Maintenance therapy is effective in the reduction in both narcotics-related and acquisition crime...
  44. doi Lack of association between SNPs in the NEUROD2 gene and alcohol dependence in a German patient sample
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Psychiatry Res 187:220-3. 2011
    ..Our results do not provide evidence for an involvement of NEUROD2 polymorphisms in the pathophysiology of alcohol dependence. Further association studies are needed to confirm our findings...
  45. ncbi Influence of anxiety on electrophysiological correlates of response inhibition capacities in alcoholism
    Susanne Karch
    Dept of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Clin EEG Neurosci 38:89-95. 2007
    ..The results emphasize the importance of monitoring trait anxiety in studies regarding cognitive functions in subjects with alcohol use disorder...
  46. ncbi Association of personality disorders with Type A and Type B alcoholics
    Miriam Bottlender
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Muenchen, Germany
    Eur Arch Psychiatry Clin Neurosci 256:55-61. 2006
    ..The impact of other personality disorders does not play a substantial role in subtyping alcoholics...
  47. ncbi New pharmacological approaches for the treatment of alcoholism
    Michael Soyka
    Private Hospital Meiringen, P O Box 612, CH 3860 Meiringen, Switzerland
    Expert Opin Pharmacother 7:2341-53. 2006
    ..Tricyclics have been found to be more effective than serotonin reuptake inhibitors in improving depressive symptoms in these patients...
  48. ncbi Treatment of alcohol withdrawal syndrome with a combination of tiapride/carbamazepine: results of a pooled analysis in 540 patients
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7, 80336, , Germany
    Eur Arch Psychiatry Clin Neurosci 256:395-401. 2006
    ..In line with previous research, the results from this study give further evidence that a combination of the anticonvulsant carbamazepine and tiapride is an effective and safe treatment for alcohol withdrawal treatment...
  49. ncbi [The relationship between self-efficacy and abstinence from alcohol after outpatient and inpatient treatment--a two year follow-up]
    Christina Zingg
    Privatklinik Meiringen, Meiringen, Schweiz
    Psychother Psychosom Med Psychol 59:307-13. 2009
    ..The strongest relationship between AASE and treatment outcome could be found for subjects in short-term inpatient treatment. The impact of the results for clinical practice is discussed...
  50. ncbi Use of acamprosate and different kinds of psychosocial support in relapse prevention of alcoholism. Results from a non-blind, multicentre study
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    Drugs R D 3:1-12. 2002
    ..To determine abstinence rates and to obtain safety data during the use of integrated therapy with acamprosate and the main established psychotherapeutic intervention programmes in the treatment of alcohol dependence...
  51. ncbi The efficacy of the dopamine D2/D3 antagonist tiapride in maintaining abstinence: a randomized, double-blind, placebo-controlled trial in 299 alcohol-dependent patients
    Stefan Bender
    Department of Psychiatry and Psychotherapy, Rhine State Hospital, University Hospital Essen, Germany
    Int J Neuropsychopharmacol 10:653-60. 2007
    ..Regarding the high success rate in the placebo group the influence of psychosocial treatment in studies investigating drug effects on the course of alcohol dependence has to be considered...
  52. ncbi Effects of irritability on craving before and after cue exposure in abstinent alcoholic inpatients: experimental data on subjective response and heart rate
    Sonnig S W Chiang
    Psychiatric Hospital of Munich University, Munich, Germany
    Neuropsychobiology 46:150-60. 2002
    ..Irritability is often linked with problem drinking. The aim of this study is to examine the possible influence of irritability on craving induced by a cue-exposure paradigm...
  53. pmc Predictive value of obsessive-compulsive drinking scale (OCDS) for outcome in alcohol-dependent inpatients: results of a 24-month follow-up study
    Peggy Schmidt
    Psychiatric Hospital, Ludwig Maximilians University, Nussbaumstr, 7, 80336 Munich, Germany
    Subst Abuse Treat Prev Policy 6:14. 2011
    ..The present study examined whether craving as measured by the obsessive-compulsive drinking scale (OCDS) predict long-term outcome in alcohol-dependent inpatients...
  54. ncbi A combination of carbamazepine/tiapride in outpatient alcohol detoxification. Results from an open clinical study
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7, 80336 Munchen, Germany
    Eur Arch Psychiatry Clin Neurosci 252:197-200. 2002
    ..Results from this study suggest that a combination of the anticonvulsant carbamazepine and tiapride is an effective and safe treatment for outpatient alcohol detoxification in patients with moderate severity of withdrawal syndrome...
  55. doi Emerging drugs to treat alcoholism
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstr 7 80336 Munich, Germany
    Expert Opin Emerg Drugs 15:695-711. 2010
    ..Alcoholism is a widespread disorder with substantial mortality and negative treatment outcomes. To date, few medications have been found to reduce relapse rates or drinking in alcohol-dependent patients...
  56. ncbi Hyponatremia-induced seizure during carbamazepine treatment
    Bettina Holtschmidt-Taschner
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 8:51-3. 2007
    ..CCT and ECG were normal. To our knowledge, this is the first description of a seizure related to hyponatremia in an adult carbamazepine-treated patient...
  57. ncbi Effects of haloperidol and atypical neuroleptics on psychomotor performance and driving ability in schizophrenic patients. Results from an experimental study
    Sabine Kagerer
    Psychiatric Hospital, Dtstion C4, University of Munich, Nussbaumstrasse 7, DE 80336 Munich, Germany
    Neuropsychobiology 47:212-8. 2003
    ..Only 1 (5%) subject passed all subtests without major failures and could be regarded as competent to drive. Among patients with atypical neuroleptics, 7 patients (24%) passed all test parameters without major failures...
  58. ncbi Co-consumption of benzodiazepines in heroin users, methadone-substituted and codeine-substituted patients
    Markus Backmund
    Kolner Platz 1, Munchen, 80804, Germany
    J Addict Dis 24:17-29. 2005
    ..05) were associated with concomitant daily consumption of BZDs in opioid dependent subjects. These finding underline the need to further explore the causes, interactions and consequences of concomitant BZD and opiate use...
  59. ncbi Adherence and mental side effects during hepatitis C treatment with interferon alfa and ribavirin in psychiatric risk groups
    Martin Schaefer
    Department of Psychiatry, Charite, Humboldt University, Berlin, Germany
    Hepatology 37:443-51. 2003
    ..Preexisting psychiatric disorders or present methadone substitution should no longer be regarded as contraindications to treatment of chronic hepatitis C with IFN-alpha and ribavirin in an interdisciplinary setting...
  60. ncbi Use of acamprosate and opioid antagonists in the treatment of alcohol dependence: a European perspective
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    Am J Addict 12:S69-80. 2003
    ..Some centers suggest naltrexone not only for patients aiming for abstinence but also for patients for whom continued drinking is a therapeutic possibility or a clinical inevitability...
  61. ncbi Impact of craving on alcohol relapse during, and 12 months following, outpatient treatment
    Miriam Bottlender
    Department of Psychiatry, Ludwig Maximilians University, Munich, Nussbaumstrasse 7, 80336 Muenchen, Germany
    Alcohol Alcohol 39:357-61. 2004
    ..1995) and relapse during and after completion of an intensive outpatient treatment programme...
  62. doi Cannabinoid receptor 1 blocker rimonabant (SR 141716) for treatment of alcohol dependence: results from a placebo-controlled, double-blind trial
    Michael Soyka
    Department of Psychiatry, Ludwig Maximilian University of Munich, Munich, Germany
    J Clin Psychopharmacol 28:317-24. 2008
    ..Taking the substantial numbers of animal studies suggesting a possible role of CB1 antagonists for the treatment of alcohol dependence into account, it seems worthwhile to further test cannabinoid blockers in the treatment of alcoholism...
  63. doi Nalmefene for treatment of alcohol dependence
    Michael Soyka
    University of Munich, Psychiatric Hospital, Nussbaumstr 7, D 80336 Munich, Germany
    Expert Opin Investig Drugs 19:1451-9. 2010
    ..Despite numerous established psychosocial approaches, relapse to heavy drinking is common in alcohol-dependent patients after detoxification and relapse prevention remains a significant medical challenge...
  64. ncbi SNP- and haplotype analysis of the tryptophan hydroxylase 2 gene in alcohol-dependent patients and alcohol-related suicide
    Peter Zill
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Neuropsychopharmacology 32:1687-94. 2007
    ..Further analysis are needed to confirm these results...
  65. doi Characterization of patients discharged from inpatient treatment for burnout: use of psychological characteristics to identify aftercare needs
    Annina K Haberthür
    University of Bern, Department of Psychology, Clinical Psychology and Psychotherapy, Bern, Switzerland
    J Clin Psychol 65:1039-55. 2009
    ..This grouping, with subsequent characterization according to symptom levels, provides important information indicating possible needs for aftercare and suggests areas for improvement of previous care...
  66. doi Neuropsychological assessment of driving ability and self-evaluation: a comparison between driving offenders and a control group
    Christina Zingg
    Eur Arch Psychiatry Clin Neurosci 259:491-8. 2009
    ..Conversely, younger drivers rather underassessed their performance...
  67. pmc PDYN rs2281285 variant association with drinking to avoid emotional or somatic discomfort
    Ulrich W Preuss
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany Department of Psychiatry, Martin Luther University, Halle Wittenberg, Germany
    PLoS ONE 8:e78688. 2013
    ..The aim of this study was to replicate a previously reported association of the PDYN rs2281285 variant with negative craving using a different phenotyping approach...
  68. ncbi Impact of different personality dimensions (NEO Five-Factor Inventory) on the outcome of alcohol-dependent patients 6 and 12 months after treatment
    Miriam Bottlender
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstr 7, 80336 Munich, Germany
    Psychiatry Res 136:61-7. 2005
    ..These results are in line with prior research on this topic...
  69. ncbi Opioid antagonists for alcohol dependence
    Susanne Rösner
    Psychiatric Hospital, University of Munich, Nußbaumstr 7, Munich, Germany, 80336
    Cochrane Database Syst Rev 12:CD001867. 2010
    ..Therapeutic success of psychosocial programs for relapse prevention is moderate and could be increased by an adjuvant treatment with the opioid antagonists naltrexone and nalmefene...
  70. ncbi Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts
    Gunter Schumann
    Department of Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 54:1422-6. 2003
    ....
  71. doi Why should addiction medicine be an attractive field for young physicians?
    Michael Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    Addiction 104:169-72. 2009
    ..Yet, we believe that the medical specialties of addiction medicine/psychiatry are not attracting the interest and enthusiasm of young physicians. What can be done?..
  72. ncbi Thalamic hypofunction in alcohol hallucinosis: FDG PET findings
    Michael Soyka
    Psychiatric Hospital, University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Psychiatry Res 139:259-62. 2005
    ..When the second patient was retested after clinical recovery, FDG PET findings were normalized, suggesting the probable thalamic dysfunction to be a functional rather than a structural abnormality...
  73. ncbi Effects of scopolamine on matching to sample paradigm and related tests in human subjects
    G Koller
    Department of Psychiatry, University of Munich, Munich, Germany
    Neuropsychobiology 48:87-94. 2003
    ..Thus, the scopolamine-induced effects in the present study seem to be more relevant to Alzheimer's disease in an advanced phase than to normal aging...
  74. ncbi [Where are the 1.9 million patients dependent on legal drugs hiding?]
    M Soyka
    Psychiatrische Klinik und Poliklinik, Ludwig Maximilians Universitat, Munchen
    Nervenarzt 76:72-7. 2005
    ..Although the number of patients dependent on legal drugs is estimated to be as high as 1.9 million, very few are in clinical treatment. Research deficits in this area are evident...
  75. ncbi [Is the European Addiction Severity Index a useful tool in the diagnostic routines of alcohol dependence?]
    P Schmidt
    Psychiatrische Klinik der Ludwig Maximilians Universität München, Nussbaumstrasse 7, 80336 Munich, Germany
    Fortschr Neurol Psychiatr 75:541-8. 2007
    ..To study the validity of the EuropASI in the patient allocation context and to measure the alcohol severity changes with treatment...
  76. doi Factors influencing long-term changes in mental health after interferon-alpha treatment of chronic hepatitis C
    F Schmidt
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Aliment Pharmacol Ther 30:1049-59. 2009
    ..Little is known about long-term effects on mental health after treatment independent from viral response and the influence of pre-existing psychiatric risk-factors...
  77. ncbi Fatal poisoning in methadone and buprenorphine treated patients -- are there differences?
    M Soyka
    Psychiatric Hospital, University of Munich, Munich, Germany
    Pharmacopsychiatry 39:85-7. 2006
    ..Some recent studies have suggested a lower risk of fatal intoxications in drug-dependent patients under buprenorphine compared to methadone treatment...
  78. ncbi Flupenthixol as a potential pharmacotreatment of alcohol and cocaine abuse/dependence
    M Soyka
    Psychiatric Hospital University of Munich, Nussbaumstr 7, D 80336 MUnchen, Germany
    Eur Neuropsychopharmacol 10:325-32. 2000
    ..Future studies should focus on dosing issues, the differentiation between short- and long-term effects and the identification of subgroups of patients with particular psychopathology...
  79. ncbi Prevalence of alcohol and drug abuse in schizophrenic inpatients
    M Soyka
    Psychiatric Hospital, University of Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 242:362-72. 1993
    ..Dual diagnosis" schizophrenics had a significantly higher rate of suicide attempts and were less likely to be married. Possible clinical implications of these findings are discussed...
  80. ncbi Psychopathology in dual diagnosis and non-addicted schizophrenics--are there differences?
    M Soyka
    Psychiatric Hospital, University of Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 251:232-8. 2001
    ..Implications for the self-medication hypothesis for substance use in schizophrenia and future research in this area are discussed...
  81. doi [Evidence-based treatments in the inpatient rehabilitation of alcoholics]
    P Schmidt
    Klinik für Psychiatrie und Psychotherapie der Ludwig Maximilians Universität München, Nussbaumstrasse 7, Munich
    Fortschr Neurol Psychiatr 76:86-90. 2008
    ..We examined the analogy of both treatment elements used in inpatient rehabilitation of alcohol dependents and the published knowledge concerning the effectiveness of therapy elements...
  82. ncbi [Aggressiveness in schizophrenia: prevalence, psychopathological and sociodemographic correlates]
    M Soyka
    Psychiatrische Klinik der Universität München, Germany
    Fortschr Neurol Psychiatr 70:171-7. 2002
    ..Psychopathological symptoms significantly associated with aggression were e.p. delusional ideas and disorganized thinking. Possible risk factors for aggression in schizophrenia and clinical implications are discussed...
  83. ncbi [Combined outpatient alcoholism therapy and occupational rehabilitation on welfare recipients--results of a pilot study]
    M Horak
    Klinik und Poliklinik für Psychiatrie und Psychotherapi, Munchen, Germany
    Fortschr Neurol Psychiatr 70:429-37. 2002
    ..We consider this pilot project a successful starting point for further development of treatment approaches targeted more specifically at this group of patients...
  84. ncbi Effects of heroin-assisted treatment on alcohol consumption: findings of the German randomized controlled trial
    C Haasen
    Department of Psychiatry, Centre for Interdisciplinary Addiction Research, University Medical Centre Eppendorf, Hamburg, Germany
    Alcohol 43:259-64. 2009
    ..The greater benefit of HAT in reducing alcohol use may be due to the greater daily frequency of dispensing heroin coupled with a requirement of sobriety at each dosing occasion...