Peter Zilla

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. ncbi request reprint Optimization of diamine bridges in glutaraldehyde treated bioprosthetic aortic wall tissue
    Paul Huma
    Department of Cardiothoracic Surgery, Cape Heart Centre, University of Cape Town, South Africa
    Biomaterials 23:2099-103. 2002
  2. doi request reprint A computational study of knitted Nitinol meshes for their prospective use as external vein reinforcement
    Helena van der Merwe
    Cardiovascular Research Unit, University of Cape Town, Cape Town, South Africa
    J Biomech 41:1302-9. 2008
  3. doi request reprint Remodeling leads to distinctly more intimal hyperplasia in coronary than in infrainguinal vein grafts
    Peter Zilla
    Christiaan Barnard Department of Cardiothoracic Surgery, University of Cape Town, Cape Town, South Africa
    J Vasc Surg 55:1734-41. 2012
  4. ncbi request reprint Bioprosthetic heart valves: the need for a quantum leap
    Peter Zilla
    Christiaan Barnard Department of Cardiothoracic Surgery, University of Cape Town Medical School and Groote Schuur Hospital, Christian Barnard Building, Anzio Road, 7925 Observatory Cape Town, South Africa
    Biotechnol Appl Biochem 40:57-66. 2004
  5. ncbi request reprint Prosthetic vascular grafts: wrong models, wrong questions and no healing
    Peter Zilla
    Christian Barnard Department of Cardiothoracic Surgery Cardiovascular Research Unit, University of Cape Town Medical School, Cape Town, South Africa
    Biomaterials 28:5009-27. 2007
  6. doi request reprint Constrictive external nitinol meshes inhibit vein graft intimal hyperplasia in nonhuman primates
    Peter Zilla
    Christiaan Barnard Department of Cardiothoracic Surgery, University of Cape Town, Cape Town, South Africa
    J Thorac Cardiovasc Surg 136:717-25. 2008
  7. ncbi request reprint Utilization of shape memory in external vein-graft meshes allows extreme diameter constriction for suppressing intimal hyperplasia: a non-human primate study
    Peter Zilla
    Christiaan Barnard Division of Cardiothoracic Surgery, University of Cape Town, Cape Town, South Africa
    J Vasc Surg 49:1532-42. 2009
  8. ncbi request reprint Diamine-extended glutaraldehyde- and carbodiimide crosslinks act synergistically in mitigating bioprosthetic aortic wall calcification
    Peter Zilla
    Department of Cardiothoracic Surgery, Cape Heart Centre, University of Cape Town, South Africa
    J Heart Valve Dis 14:538-45. 2005
  9. ncbi request reprint Carbodiimide treatment dramatically potentiates the anticalcific effect of alpha-amino oleic acid on glutaraldehyde-fixed aortic wall tissue
    Peter Zilla
    Chris Barnard Division of Cardiothoracic Surgery, Cape Heart Center, University of Cape Town, Cape Town, South Africa
    Ann Thorac Surg 79:905-10. 2005
  10. doi request reprint Knitted nitinol represents a new generation of constrictive external vein graft meshes
    Peter Zilla
    Christiaan Barnard Department of Cardiothoracic Surgery, University of Cape Town, Cape Town, South Africa
    J Vasc Surg 54:1439-50. 2011

Collaborators

  • Neil Davies
  • Deon Bezuidenhout
  • Michael Wolf
  • Michael Beck
  • Andre Brooks
  • Frank Everaerts
  • Thomas Franz
  • Michael Gorlitzer
  • V G Djonov
  • Christian Schmidt
  • Ja Hubbell
  • Andreas H Zisch
  • Timothy Pennel
  • Jacques Scherman
  • Michael Hamman de Vaal
  • Paul Human
  • Louise Bezuidenhout
  • Renee Miller
  • Jeroen Kortsmit
  • Mona Bracher
  • Stephan Dobner
  • Loven Moodley
  • Agneta Geldenhuys
  • Karen Kadner
  • Hugo Krynauw
  • James Neville
  • Micah Litow
  • Helena van der Merwe
  • Johann G Meinhart
  • Manfred Deutsch
  • Ameli E Trantina-Yates
  • Paul Huma
  • Agneta Simionescu
  • George Fercana
  • Dan Simionescu
  • Johann Meinhart
  • Ting Hsien Chuang
  • Matthias P Lutolf
  • Michelle Sun
  • Jesse R Macadangdang
  • Mazin S Sirry
  • Jithan J Koshy
  • Juliana F Mtwale
  • Paul A Human
  • Johan G Brink
  • Lucie Bruchm├╝ller
  • Lovendran Moodley
  • Padmini Govender
  • B Daya Reddy
  • Glenda Davison
  • Heinrich Schima
  • Jason C Schense
  • Marc Hendriks
  • Walter Michael Halbmayer
  • Mark Torrianni

Detail Information

Publications42

  1. ncbi request reprint Optimization of diamine bridges in glutaraldehyde treated bioprosthetic aortic wall tissue
    Paul Huma
    Department of Cardiothoracic Surgery, Cape Heart Centre, University of Cape Town, South Africa
    Biomaterials 23:2099-103. 2002
    ..The purpose of the present study was to evaluate whether an optimal effect of DA-enhanced fixation can be achieved by titration of dialdehyde and diamine concentrations...
  2. doi request reprint A computational study of knitted Nitinol meshes for their prospective use as external vein reinforcement
    Helena van der Merwe
    Cardiovascular Research Unit, University of Cape Town, Cape Town, South Africa
    J Biomech 41:1302-9. 2008
    ..It was demonstrated that the numerical approach developed was feasible of effectively evaluating design variations of knitted Nitinol meshes towards vein graft behaviour equivalent to arterial mechanics...
  3. doi request reprint Remodeling leads to distinctly more intimal hyperplasia in coronary than in infrainguinal vein grafts
    Peter Zilla
    Christiaan Barnard Department of Cardiothoracic Surgery, University of Cape Town, Cape Town, South Africa
    J Vasc Surg 55:1734-41. 2012
    ..To allow a site-specific, flow-related comparison of remodeling behavior, saphenous vein bypass grafts were simultaneously implanted in femoral and coronary positions...
  4. ncbi request reprint Bioprosthetic heart valves: the need for a quantum leap
    Peter Zilla
    Christiaan Barnard Department of Cardiothoracic Surgery, University of Cape Town Medical School and Groote Schuur Hospital, Christian Barnard Building, Anzio Road, 7925 Observatory Cape Town, South Africa
    Biotechnol Appl Biochem 40:57-66. 2004
    ..In order to dramatically improve the performance of bioprosthetic heart valves, these new developments need to lead to a broad consensus for a paradigm shift in a hitherto rather stagnant field of medical research...
  5. ncbi request reprint Prosthetic vascular grafts: wrong models, wrong questions and no healing
    Peter Zilla
    Christian Barnard Department of Cardiothoracic Surgery Cardiovascular Research Unit, University of Cape Town Medical School, Cape Town, South Africa
    Biomaterials 28:5009-27. 2007
    ..By providing insight into mechanisms and experimental designs which obscured the purpose and scope of several decades of vascular graft studies, future research may better address clinical relevance...
  6. doi request reprint Constrictive external nitinol meshes inhibit vein graft intimal hyperplasia in nonhuman primates
    Peter Zilla
    Christiaan Barnard Department of Cardiothoracic Surgery, University of Cape Town, Cape Town, South Africa
    J Thorac Cardiovasc Surg 136:717-25. 2008
    ..The aim of the present study was to address the issue of optimal mesh size in a nonhuman primate model that mimics the dimensional mismatch typically encountered between clinical vein grafts and their target arteries...
  7. ncbi request reprint Utilization of shape memory in external vein-graft meshes allows extreme diameter constriction for suppressing intimal hyperplasia: a non-human primate study
    Peter Zilla
    Christiaan Barnard Division of Cardiothoracic Surgery, University of Cape Town, Cape Town, South Africa
    J Vasc Surg 49:1532-42. 2009
    ..As this mitigating effect increased with the degree of constriction, we investigated whether extreme constriction was possible without leading to detrimental luminal encroachment...
  8. ncbi request reprint Diamine-extended glutaraldehyde- and carbodiimide crosslinks act synergistically in mitigating bioprosthetic aortic wall calcification
    Peter Zilla
    Department of Cardiothoracic Surgery, Cape Heart Centre, University of Cape Town, South Africa
    J Heart Valve Dis 14:538-45. 2005
    ....
  9. ncbi request reprint Carbodiimide treatment dramatically potentiates the anticalcific effect of alpha-amino oleic acid on glutaraldehyde-fixed aortic wall tissue
    Peter Zilla
    Chris Barnard Division of Cardiothoracic Surgery, Cape Heart Center, University of Cape Town, Cape Town, South Africa
    Ann Thorac Surg 79:905-10. 2005
    ....
  10. doi request reprint Knitted nitinol represents a new generation of constrictive external vein graft meshes
    Peter Zilla
    Christiaan Barnard Department of Cardiothoracic Surgery, University of Cape Town, Cape Town, South Africa
    J Vasc Surg 54:1439-50. 2011
    ..We investigated whether pulse compliance, smaller kink-free bending radius, and milder medial atrophy can be achieved by knitting the meshes rather than braiding, without losing the suppressive effect on intimal hyperplasia...
  11. ncbi request reprint Prosthetic heart valves: catering for the few
    Peter Zilla
    Christian Barnard Department of Cardiothoracic Surgery, University of Cape Town Medical School and Groote Schuur Hospital, Anzio Road, 7925 Observatory, Cape Town, South Africa
    Biomaterials 29:385-406. 2008
    ....
  12. pmc Protective constriction of coronary vein grafts with knitted nitinol
    Loven Moodley
    Chris Barnard Department of Cardiothoracic Surgery, University of Cape Town, Cape Town, South Africa
    Eur J Cardiothorac Surg 44:64-71. 2013
    ..As constrictive external mesh support of vein grafts led to the complete suppression of intimal hyperplasia (IH) in infrainguinal grafts, we investigated whether mesh constriction is equally effective in the coronary position...
  13. ncbi request reprint The effect of hydrogel injection on cardiac function and myocardial mechanics in a computational post-infarction model
    Jeroen Kortsmit
    a Cardiovascular Research Unit, Chris Barnard Division of Cardiothoracic Surgery, University of Cape Town, Cape Town, South Africa
    Comput Methods Biomech Biomed Engin 16:1185-95. 2013
    ..In contrast, only functional but no mechanical restitution was shown in the scar model due to hydrogel presence. ..
  14. doi request reprint The beneficial effects of deferred delivery on the efficiency of hydrogel therapy post myocardial infarction
    Karen Kadner
    Cardiovascular Research Unit, Chris Barnard Division of Cardiothoracic Surgery, University of Cape Town, Department of Health Sciences, Cape Town 7925, South Africa
    Biomaterials 33:2060-6. 2012
    ..The results indicate that timing of delivery is important and that very early time points may not be beneficial...
  15. ncbi request reprint Detoxification on top of enhanced, diamine-extended glutaraldehyde fixation significantly reduces bioprosthetic root calcification in the sheep model
    Ameli E Trantina-Yates
    Department of Cardiothoracic Surgery, Cape Heart Centre, University of Cape Town, South Africa
    J Heart Valve Dis 12:93-100; discussion 100-1. 2003
    ..The study aim was to demonstrate the combined effect of all three treatments in a circulatory sheep model...
  16. ncbi request reprint The effects of cross-link density and chemistry on the calcification potential of diamine-extended glutaraldehyde-fixed bioprosthetic heart-valve materials
    Deon Bezuidenhout
    Cardiovascular Research Unit, University of Cape Town, 203 Cape Heart Centre, Anzio Road, Observatory 7925, Cape Town, South Africa
    Biotechnol Appl Biochem 54:133-40. 2009
    ....
  17. doi request reprint Patient-specific prediction of intrinsic mechanical loadings on sub-muscular pectoral pacemaker implants based on an inter-species transfer function
    Michael Hamman de Vaal
    Cardiovascular Research Unit, Chris Barnard Department of Cardiothoracic Surgery, University of Cape Town, Cape Town, South Africa
    J Biomech 44:2525-31. 2011
    ..The transfer function provides a basis for the prediction of patient-specific maximum mechanical loadings on a sub-muscular pectoral cardiac pacemaker implant through non- or minimal invasive measurements on the patient...
  18. doi request reprint Covalent surface heparinization potentiates porous polyurethane scaffold vascularization
    Deon Bezuidenhout
    Cardiovascular Research Unit, Chris Barnard Division of Cardiothoracic Surgery, Faculty of Health Sciences University of Cape Town, Cape Town, South Africa
    J Biomater Appl 24:401-18. 2010
    ..This could be a valuable tool for in vivo tissue engineering applications where enhanced vascularization is required...
  19. doi request reprint Association of Ang-2 with integrin beta 2 controls Ang-2/PDGF-BB-dependent upregulation of human peripheral blood monocyte fibrinolysis
    Louise Bezuidenhout
    Cardiovascular Research Unit, Chris Barnard Division of Cardiothoracic Surgery, Department of Health Sciences, University of Cape Town, 203 Cape Heart Centre, Anzio Road, Observatory, 7925 Cape Town, South Africa
    Inflammation 32:393-401. 2009
    ..In addition, Ang-2 was shown to upregulate PDGFR-beta expression in monocytes. Therefore several components of the mechanism via which the novel interaction of Ang-2 and PDGF-BB with monocytes occurs have been identified...
  20. ncbi request reprint Outcomes of myocardial infarction hydrogel injection therapy in the human left ventricle dependent on injectate distribution
    Renee Miller
    Cardiovascular Research Unit, Chris Barnard Division of Cardiothoracic Surgery, University of Cape Town, Observatory, South Africa
    Int j numer method biomed eng 29:870-84. 2013
    ..1% and 13.7% in FI. The layered injectate had a greater impact on infarct stress and strain at acute stage, whereas the bulk injectate exhibited greater benefits at FI stage. These findings were confirmed by our previous in vivo results...
  21. doi request reprint Degradation-induced changes of mechanical properties of an electro-spun polyester-urethane scaffold for soft tissue regeneration
    Hugo Krynauw
    Cardiovascular Research Unit, Chris Barnard Department of Cardiothoracic Surgery, Faculty of Health Sciences, University of Cape Town, Observatory 7935, South Africa
    J Biomed Mater Res B Appl Biomater 99:359-68. 2011
    ..Future studies will include degradation in biological fluids and assessment of molecular weight for an advanced understanding of the material changes during degradation...
  22. pmc Sustaining neovascularization of a scaffold through staged release of vascular endothelial growth factor-A and platelet-derived growth factor-BB
    Neil H Davies
    Cardiovascular Research Unit, University of Cape Town, Cape Town, South Africa
    Tissue Eng Part A 18:26-34. 2012
    ..05 vs. heparinized scaffold). Thus, the covalent modification of a porous scaffold with heparin allows for the differential release of VEGF and PDGF-BB that results in both a rapid and sustained increase in scaffold vascularization...
  23. ncbi request reprint Induced chronic hypoxia negates the pro-angiogenic effect of surface immobilized heparin in a polyurethane porous scaffold
    Christian Schmidt
    Cardiovascular Research Unit, University of Cape Town, South Africa
    J Biomed Mater Res A 98:621-8. 2011
    ..05). This suggests that endogenous growth factor production was limiting under chronic hypoxia but that an angiogenic response could still occur with exogenous delivery of factors...
  24. doi request reprint Differentiating transmural from transanastomotic prosthetic graft endothelialization through an isolation loop-graft model
    Timothy Pennel
    Christian Barnard Department of Cardiothoracic Surgery, Cardiovascular Research Unit, University of Cape Town, Cape Town, South Africa
    J Vasc Surg 58:1053-61. 2013
    ..We describe an isolation loop-graft model that clearly separates these distinctly different events...
  25. doi request reprint Cell specific ingrowth hydrogels
    Mona Bracher
    Cardiovascular Research Unit, Chris Barnard Division of Cardiothoracic Surgery, University of Cape Town, Department of Health Sciences, Cape Town, South Africa
    Biomaterials 34:6797-803. 2013
    ....
  26. doi request reprint Dimensional analysis of human saphenous vein grafts: Implications for external mesh support
    Paul Human
    Christiaan Barnard Department of Cardiothoracic Surgery, University of Cape Town, Observatory, South Africa
    J Thorac Cardiovasc Surg 137:1101-8. 2009
    ..To determine the degree of constriction required for the elimination of dimensional irregularities in clinically used vein grafts, a detailed anatomic study of human saphenous veins was conducted...
  27. ncbi request reprint The in vivo assessment of mechanical loadings on pectoral pacemaker implants
    Michael Hamman de Vaal
    Cardiovascular Research Unit, Chris Barnard Department of Cardiothoracic Surgery, University of Cape Town, Cape Town, South Africa
    J Biomech 43:1717-22. 2010
    ..The study demonstrated the feasibility of the developed system for the assessment of in vivo mechanical loading conditions of implantable pacemakers with potential for use for other implantable therapeutic devices...
  28. ncbi request reprint Rapid three-dimensional quantification of VEGF-induced scaffold neovascularisation by microcomputed tomography
    Christian Schmidt
    Cardiovascular Research Unit, University of Cape Town, South Africa
    Biomaterials 30:5959-68. 2009
    ..Thus whilst micro-CT gives an accurate three-dimensional quantification of the VEGF-induced increase in perfused vessels, resolution needs to be maximized for accurate sizing of a microvascular network's components...
  29. doi request reprint Covalent incorporation and controlled release of active dexamethasone from injectable polyethylene glycol hydrogels
    Deon Bezuidenhout
    Christiaan Barnard Department of Cardiothoracic Surgery, University of Cape Town, Cape Town, South Africa
    J Biomed Mater Res A 101:1311-8. 2013
    ..Dexamethasone can thus be incorporated using nucleophilic addition chemistry to produce gels that are capable of sustained release of the active drug. The methodology is applicable to a variety of drugs that contain hydroxyl groups...
  30. doi request reprint The dosage dependence of VEGF stimulation on scaffold neovascularisation
    Neil Davies
    Cardiovascular Research Unit, Chris Barnard Division of Cardiothoracic Surgery, University of Cape Town, Department of Health Sciences, 203 Cape Heart Centre, Anzio Road, Observatory, 7925 Cape Town, South Africa
    Biomaterials 29:3531-8. 2008
    ..These results suggest concentration of VEGF plays a critical role in the nature and persistence of vasculature formed in a tissue regenerative scaffold...
  31. ncbi request reprint A synthetic non-degradable polyethylene glycol hydrogel retards adverse post-infarct left ventricular remodeling
    Stephan Dobner
    Cardiovascular Research Unit, Chris Barnard Division of Cardiothoracic Surgery, University of Cape Town Department of Health Sciences, Cape Town, South Africa
    J Card Fail 15:629-36. 2009
    ..We have tested a non-degradable polyethylene glycol (PEG) gel in a rat infarction model...
  32. ncbi request reprint Effect of well defined dodecahedral porosity on inflammation and angiogenesis
    Deon Bezuidenhout
    Cardiovascular Research Unit, Cape Heart Centre, University of Cape Town Medical School, South Africa
    ASAIO J 48:465-71. 2002
    ..Thus, a significant decrease in inflammatory response could be achieved without adversely affecting the degree of neovascularization by increasing the size of the pores...
  33. ncbi request reprint A slow-release fibrin matrix increases adeno-associated virus transduction of wound repair cells in vivo
    Christian Schmidt
    1Cardiovascular Research Unit, University of Cape Town, South Africa
    J Biomater Appl 28:1408-18. 2014
    ..These findings inform efforts to optimise biodegradable scaffolds for the localised delivery of AAV in tissue engineering...
  34. ncbi request reprint A mathematical method for constraint-based cluster analysis towards optimized constrictive diameter smoothing of saphenous vein grafts
    Thomas Franz
    Chris Barnard Division of Cardiothoracic Surgery, University of Cape Town, Cape Town, South Africa
    Med Biol Eng Comput 48:519-29. 2010
    ..The method can easily be implemented in computer-based intelligent systems for the analysis of larger data sets using the diameter classes identified as initial cluster structure...
  35. pmc The performance of cross-linked acellular arterial scaffolds as vascular grafts; pre-clinical testing in direct and isolation loop circulatory models
    Timothy Pennel
    Christian Barnard Department of Cardiothoracic Surgery, Cardiovascular Research Unit, University of Cape Town, Faculty of Health Sciences, Cape Heart Center, Chris Barnard Building, Anzio Road, ZA 7925 Observatory, Cape Town, South Africa
    Biomaterials 35:6311-22. 2014
    ..Overall these results point to the outstanding potential of crosslinked arterial scaffolds as small diameter vascular grafts. ..
  36. ncbi request reprint Rheumatic mitral repair versus replacement in a threshold country: the impact of commissural fusion
    Agneta Geldenhuys
    Christiaan Barnard Division of Cardiothoracic Surgery, Groote Schuur Hospital, University of Cape Town, South Africa
    J Heart Valve Dis 21:424-32. 2012
    ..Against this background, the predictors of failure were assessed and the overall performance of repairs compared with replacements in a 10-year cohort of rheumatic single mitral valve procedures...
  37. ncbi request reprint Pulmonary artery banding: still a valuable option in developing countries?
    Andre Brooks
    Christiaan Barnard Division of Cardiothoracic Surgery, Red Cross Children s Hospital, University of Cape Town, Cape Town, South Africa
    Eur J Cardiothorac Surg 41:272-6. 2012
    ..We examined whether the socio-economic circumstances of a developing country justify pulmonary artery banding (PAB) for the deferral of perceived high-risk patients requiring biventricular repair...
  38. ncbi request reprint Ang-2 and PDGF-BB cooperatively stimulate human peripheral blood monocyte fibrinolysis
    Louise Bezuidenhout
    Cardiovascular Research Unit, University of Cape Town Medical School, Anzio Road, Observatory, 7925, Cape Town, South Africa
    J Leukoc Biol 81:1496-503. 2007
    ..These data give further credence to the concept of Ang-2 as a key regulator of several essential phases of wound healing...
  39. ncbi request reprint Reduction of calcification of carbodiimide-processed heart valve tissue by prior blocking of amine groups with monoaldehydes
    Frank Everaerts
    Medtronic Inc, Minneapolis, USA
    J Heart Valve Dis 15:269-77. 2006
    ..Failure of implanted bioprostheses due to calcification is a commonly occurring phenomenon. In order to prevent calcification, many alternative cross-linking methods to glutaraldehyde (GA) have been developed and evaluated...
  40. ncbi request reprint Cell-demanded release of VEGF from synthetic, biointeractive cell ingrowth matrices for vascularized tissue growth
    Andreas H Zisch
    Department of Materials Science and Institute for Biomedical Engineering, Swiss Federal Institute of Technology Zurich and University of Zurich, Switzerland
    FASEB J 17:2260-2. 2003
    ....
  41. ncbi request reprint Hyperlipidemia coincides with reversible growth impairment of cultured human autologous endothelial cells
    Johann Meinhart
    First Department of Surgery and Ludwig Boltzmann Institut for Applied Cardiovascular Biology, City Hospital Vienna Lainz, Vienna, Austria
    Endothelium 9:239-46. 2002
    ..The authors conclude that hyperlipidemia may lead to growth impairment of cultured human endothelial cells. This growth inhibition is reversible if the supplemented autologous serum is replaced by pooled serum with low lipid content...
  42. ncbi request reprint Enhanced endothelial cell retention on shear-stressed synthetic vascular grafts precoated with RGD-cross-linked fibrin
    Johann G Meinhart
    First Department of Surgery, Hospital Lainz, Vienna, Austria
    Tissue Eng 11:887-95. 2005
    ..The failure of higher RGD concentrations to enhance endothelial cell attachment may be explained by competitive binding of endothelial cells to non-cross-linked RGD...