Anna Lise Williamson

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. Murahwa A, Meiring T, Mbulawa Z, Williamson A. Discovery, characterisation and genomic variation of six novel Gammapapillomavirus types from penile swabs in South Africa. Papillomavirus Res. 2019;7:102-111 pubmed publisher
    ..A retinoblastoma binding domain (pRB) binding domain in E7 protein was additionally identified in HPV214. This study expands the knowledge of the rapidly growing Gammapapillomavirus genus. ..
  2. Mbulawa Z, Johnson L, Marais D, Gustavsson I, Moodley J, Coetzee D, et al. Increased alpha-9 human papillomavirus species viral load in human immunodeficiency virus positive women. BMC Infect Dis. 2014;14:51 pubmed publisher
    ..HIV co-infection significantly increased the combined alpha-9 HPV viral load in women but not viral loads for individual HPV types. High HR-HPV viral load was associated with cervical abnormal cytology. ..
  3. Adler D, Wallace M, Bennie T, Abar B, Sadeghi R, Meiring T, et al. High risk human papillomavirus persistence among HIV-infected young women in South Africa. Int J Infect Dis. 2015;33:219-21 pubmed publisher
    ..Identification of persistent infection with HR-HPV may complement cytological findings in determining the need for colposcopy. ..
  4. request reprint
    Williamson A, Rybiki E, Shephard E, Gray G, Bekker L, Downing K, et al. South African HIV-1 vaccine candidates - the journey from the bench to clinical trials. S Afr Med J. 2012;102:452-5 pubmed
    ..This article describes the history of HIV vaccine research at UCT, and the partnerships that made the project possible. ..
  5. Murahwa A, Meiring T, Mbulawa Z, Williamson A. Complete Genome Sequences of Four Novel Human Gammapapillomavirus Types, HPV-219, HPV-220, HPV-221, and HPV-222, Isolated from Penile Skin Swabs from South African Men. Genome Announc. 2018;6: pubmed publisher
  6. Williamson A. The Interaction between Human Immunodeficiency Virus and Human Papillomaviruses in Heterosexuals in Africa. J Clin Med. 2015;4:579-92 pubmed publisher
    ..Condom use and circumcision reduce the acquisition of HIV-1, and also to some extent of HPV. This review will highlight what is known about the interaction of HIV and HPV, with an emphasis on research in Africa. ..
  7. Offerman K, Carulei O, van der Walt A, Douglass N, Williamson A. The complete genome sequences of poxviruses isolated from a penguin and a pigeon in South Africa and comparison to other sequenced avipoxviruses. BMC Genomics. 2014;15:463 pubmed publisher
    ..Our data supports the independent evolution of these South African avipoxviruses from a common ancestral virus to FWPV and CNPV. ..
  8. Offerman K, Deffur A, Carulei O, Wilkinson R, Douglass N, Williamson A. Six host-range restricted poxviruses from three genera induce distinct gene expression profiles in an in vivo mouse model. BMC Genomics. 2015;16:510 pubmed publisher
    ..These differences may affect the immune response induced to vaccine antigen in vectors based on these viruses. The two novel avipoxviruses were clearly distinguishable from the other viruses. ..
  9. Chattopadhyay K, Williamson A, Hazra A, Dandara C. The combined risks of reduced or increased function variants in cell death pathway genes differentially influence cervical cancer risk and herpes simplex virus type 2 infection among black Africans and the Mixed Ancestry population of South Africa. BMC Cancer. 2015;15:680 pubmed publisher
    ..Our results show that the combined risks of variants in cell death pathway genes are associated with the cervical cancer as well as the HSV-2 infection in the black African and mixed-ancestry population. ..

More Information

Publications16

  1. Mbulawa Z, Coetzee D, Williamson A. Human papillomavirus prevalence in South African women and men according to age and human immunodeficiency virus status. BMC Infect Dis. 2015;15:459 pubmed publisher
    ..The high prevalence of HPV types found in bivalent, quadrivalent and nonavalent vaccines in South African HIV-positive and HIV-negative women and men demonstrate that this population will greatly benefit from current HPV vaccines. ..
  2. Chege G, Burgers W, Müller T, Gray C, Shephard E, Barnett S, et al. DNA-MVA-protein vaccination of rhesus macaques induces HIV-specific immunity in mucosal-associated lymph nodes and functional antibodies. Vaccine. 2017;35:929-937 pubmed publisher
    ..These data demonstrate the feasibility of inducing HIV-specific immunity in the blood and mucosal sites of viral entry by means of DNA and poxvirus-vectored vaccines, in combination with a HIV envelope-based protein vaccine. ..
  3. Carulei O, Douglass N, Williamson A. Comparative analysis of avian poxvirus genomes, including a novel poxvirus from lesser flamingos (Phoenicopterus minor), highlights the lack of conservation of the central region. BMC Genomics. 2017;18:947 pubmed publisher
    ..Sequencing and analysis of further avian poxvirus genomes will help characterise this complex genus of poxviruses. ..
  4. Mbulawa Z, Wilkin T, Goeieman B, Swarts A, Williams S, Levin S, et al. Xpert human papillomavirus test is a promising cervical cancer screening test for HIV-seropositive women. Papillomavirus Res. 2016;2:56-60 pubmed publisher
    ..3% and 91.5%, respectively) and specific (48.4% and 51.0%) for CIN2+ and CIN3 (sensitivity: 95.8% and 97.9%; specificity: 41.4% and 42.8%). Xpert is a promising screening test in HIV-infected women that performs similarly to hc2. ..
  5. Chatterjee K, Dandara C, Hoffman M, Williamson A. CCR2-V64I polymorphism is associated with increased risk of cervical cancer but not with HPV infection or pre-cancerous lesions in African women. BMC Cancer. 2010;10:278 pubmed publisher
    ..This result implies that the role of CCR2 is important in invasive cancer of the cervix but not in HPV infection or in the development of pre-cancers. ..
  6. Lynch A, Tanzer F, Fraser M, Shephard E, Williamson A, Rybicki E. Use of the piggyBac transposon to create HIV-1 gag transgenic insect cell lines for continuous VLP production. BMC Biotechnol. 2010;10:30 pubmed publisher
    ..Improved yield and immunogenicity of transgenic cell-produced VLPs may be achieved with the addition of further genetic elements into the piggyBac integron. ..
  7. Meyers A, Chakauya E, Shephard E, Tanzer F, Maclean J, Lynch A, et al. Expression of HIV-1 antigens in plants as potential subunit vaccines. BMC Biotechnol. 2008;8:53 pubmed publisher
    ..The p17/p24 protein effectively boosted T cell and humoral responses in mice primed by the DNA vaccine pTHGagC, showing that this plant-produced protein has potential for use as a vaccine. ..