Digby F Warner

Summary

Affiliation: University of the Witwatersrand
Country: South Africa

Publications

  1. pmc Tuberculosis chemotherapy: the influence of bacillary stress and damage response pathways on drug efficacy
    Digby F Warner
    Molecular Mycobacteriology Research Unit, Centre of Excellence for Biomedical TB Research, School of Pathology, University of the Witwatersrand and NHLS, P O Box 1038, Johannesburg 2000, South Africa
    Clin Microbiol Rev 19:558-70. 2006
  2. ncbi The survival kit of Mycobacterium tuberculosis
    Digby F Warner
    Nat Med 13:282-4. 2007
  3. pmc Essential roles for imuA'- and imuB-encoded accessory factors in DnaE2-dependent mutagenesis in Mycobacterium tuberculosis
    Digby F Warner
    Faculty of Health Sciences, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg 2000, South Africa
    Proc Natl Acad Sci U S A 107:13093-8. 2010
  4. ncbi A derivative of Mycobacterium smegmatis mc(2)155 that lacks the duplicated chromosomal region
    Digby F Warner
    MRC NHLS WITS Molecular Mycobacteriology Research Unit, DST NRF, School of Pathology of the University of the Witwatersrand, Johannesburg, South Africa
    Tuberculosis (Edinb) 86:438-44. 2006
  5. pmc A riboswitch regulates expression of the coenzyme B12-independent methionine synthase in Mycobacterium tuberculosis: implications for differential methionine synthase function in strains H37Rv and CDC1551
    Digby F Warner
    Molecular Mycobacteriology Research Unit, National Health Laboratory Service, P O Box 1038, Johannesburg 2000, South Africa
    J Bacteriol 189:3655-9. 2007
  6. doi Making ends meet in mycobacteria
    Digby F Warner
    MRC NHLS WITS Molecular Mycobacteriology Research Unit and DST NRF Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Health Sciences, University of the Witwatersrand and the National Health Laboratory Service, PO Box 1038, Johannesburg 2000, South Africa
    Mol Microbiol 79:283-7. 2011
  7. pmc Role of the DinB homologs Rv1537 and Rv3056 in Mycobacterium tuberculosis
    Bavesh D Kana
    MRC NHLS WITS Molecular Mycobacteriology Research Unit, DST NRF Centre of Excellence for Biomedical TB Research, School of Pathology of the University of the Witwatersrand and the National Health Laboratory Service, Johannesburg, South Africa
    J Bacteriol 192:2220-7. 2010
  8. pmc Function and regulation of class I ribonucleotide reductase-encoding genes in mycobacteria
    Mohube B Mowa
    MRC NHLS WITS Molecular Mycobacteriology Research Unit, DST NRF Centre of Excellence for Biomedical TB Research, School of Pathology, University of the Witwatersrand, National Health Laboratory Service, Johannesburg 2000, South Africa
    J Bacteriol 191:985-95. 2009
  9. pmc Functional characterization of a vitamin B12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: implications for propionate metabolism during growth on fatty acids
    Suzana Savvi
    Molecular Mycobacteriology Research Unit, University of the Witwatersrand and National Health Laboratory Service, P O Box 1038, Johannesburg 2000, South Africa
    J Bacteriol 190:3886-95. 2008
  10. doi A pseudokinase debut at the mycobacterial cell wall
    Digby F Warner
    MRC NHLS UCT Molecular Mycobacteriology Research Unit and DST NRF Centre of Excellence for Biomedical Tuberculosis Research, Institute of Infectious Disease and Molecular Medicine, and Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, Private Bag X3, Rondebosch 7701, Cape Town, South Africa
    Sci Signal 5:pe3. 2012

Detail Information

Publications11

  1. pmc Tuberculosis chemotherapy: the influence of bacillary stress and damage response pathways on drug efficacy
    Digby F Warner
    Molecular Mycobacteriology Research Unit, Centre of Excellence for Biomedical TB Research, School of Pathology, University of the Witwatersrand and NHLS, P O Box 1038, Johannesburg 2000, South Africa
    Clin Microbiol Rev 19:558-70. 2006
    ..tuberculosis genome...
  2. ncbi The survival kit of Mycobacterium tuberculosis
    Digby F Warner
    Nat Med 13:282-4. 2007
  3. pmc Essential roles for imuA'- and imuB-encoded accessory factors in DnaE2-dependent mutagenesis in Mycobacterium tuberculosis
    Digby F Warner
    Faculty of Health Sciences, University of the Witwatersrand and the National Health Laboratory Service, Johannesburg 2000, South Africa
    Proc Natl Acad Sci U S A 107:13093-8. 2010
    ....
  4. ncbi A derivative of Mycobacterium smegmatis mc(2)155 that lacks the duplicated chromosomal region
    Digby F Warner
    MRC NHLS WITS Molecular Mycobacteriology Research Unit, DST NRF, School of Pathology of the University of the Witwatersrand, Johannesburg, South Africa
    Tuberculosis (Edinb) 86:438-44. 2006
    ..This mutation did not affect the growth rate, surface properties or transformation efficiency of the organism, confirming the potential utility of DeltaDRKIN for the study of genes contained within the duplicated region...
  5. pmc A riboswitch regulates expression of the coenzyme B12-independent methionine synthase in Mycobacterium tuberculosis: implications for differential methionine synthase function in strains H37Rv and CDC1551
    Digby F Warner
    Molecular Mycobacteriology Research Unit, National Health Laboratory Service, P O Box 1038, Johannesburg 2000, South Africa
    J Bacteriol 189:3655-9. 2007
    ..Expression analysis confirmed that the B(12) riboswitch is a transcriptional regulator of metE in M. tuberculosis...
  6. doi Making ends meet in mycobacteria
    Digby F Warner
    MRC NHLS WITS Molecular Mycobacteriology Research Unit and DST NRF Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Health Sciences, University of the Witwatersrand and the National Health Laboratory Service, PO Box 1038, Johannesburg 2000, South Africa
    Mol Microbiol 79:283-7. 2011
    ..Here, we consider the implications of their observations, which include the asymmetric cross-regulation of pathway function, for the role of DSB repair in mycobacterial pathogenesis...
  7. pmc Role of the DinB homologs Rv1537 and Rv3056 in Mycobacterium tuberculosis
    Bavesh D Kana
    MRC NHLS WITS Molecular Mycobacteriology Research Unit, DST NRF Centre of Excellence for Biomedical TB Research, School of Pathology of the University of the Witwatersrand and the National Health Laboratory Service, Johannesburg, South Africa
    J Bacteriol 192:2220-7. 2010
    ..tuberculosis do not behave like their counterparts from other organisms...
  8. pmc Function and regulation of class I ribonucleotide reductase-encoding genes in mycobacteria
    Mohube B Mowa
    MRC NHLS WITS Molecular Mycobacteriology Research Unit, DST NRF Centre of Excellence for Biomedical TB Research, School of Pathology, University of the Witwatersrand, National Health Laboratory Service, Johannesburg 2000, South Africa
    J Bacteriol 191:985-95. 2009
    ..Together, our observations identify a potential vulnerability in dNTP provision in mycobacteria and thereby offer a compelling rationale for pursuing the class Ib RNR as a target for drug discovery...
  9. pmc Functional characterization of a vitamin B12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: implications for propionate metabolism during growth on fatty acids
    Suzana Savvi
    Molecular Mycobacteriology Research Unit, University of the Witwatersrand and National Health Laboratory Service, P O Box 1038, Johannesburg 2000, South Africa
    J Bacteriol 190:3886-95. 2008
    ..tuberculosis in mice...
  10. doi A pseudokinase debut at the mycobacterial cell wall
    Digby F Warner
    MRC NHLS UCT Molecular Mycobacteriology Research Unit and DST NRF Centre of Excellence for Biomedical Tuberculosis Research, Institute of Infectious Disease and Molecular Medicine, and Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, Private Bag X3, Rondebosch 7701, Cape Town, South Africa
    Sci Signal 5:pe3. 2012
    ....
  11. pmc Ribonucleotide reduction in Mycobacterium tuberculosis: function and expression of genes encoding class Ib and class II ribonucleotide reductases
    Stephanie S Dawes
    School of Pathology of the National Health Laboratory Service and Department of Molecular Medicine and Hematology, University of the Witwatersrand Medical School, Johannesburg 2000, South Africa
    Infect Immun 71:6124-31. 2003
    ..tuberculosis in this mouse model...