Thomas C Victor

Summary

Affiliation: University of Stellenbosch
Country: South Africa

Publications

  1. pmc Emergence of increased resistance and extensively drug-resistant tuberculosis despite treatment adherence, South Africa
    Alistair D Calver
    West Vaal Hospital, Orkney, South Africa
    Emerg Infect Dis 16:264-71. 2010
  2. ncbi request reprint Prediction of drug resistance in M. tuberculosis: molecular mechanisms, tools, and applications
    Thomas C Victor
    MRC Centre for Molecular and Cellular Biology and Department of Medical Biochemistry, University of Stellenbosch, Tygerberg, South Africa
    IUBMB Life 53:231-7. 2002
  3. pmc Molecular characteristics and global spread of Mycobacterium tuberculosis with a western cape F11 genotype
    Thomas C Victor
    MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch, Tygerberg 7505, South Africa
    J Clin Microbiol 42:769-72. 2004
  4. ncbi request reprint Spread of an emerging Mycobacterium tuberculosis drug-resistant strain in the western Cape of South Africa
    T C Victor
    Department of Science and Technology National Research Foundation DST NRF Centre for Biomedical TB Research Medical Research Council MRC Centre for Molecular and Cellular Biology, Stellenbosch University, Tygerberg, South Africa
    Int J Tuberc Lung Dis 11:195-201. 2007
  5. ncbi request reprint Molecular detection of early appearance of drug resistance during Mycobacterium tuberculosis infection
    Thomas C Victor
    MRC Center for Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch, Tygerberg, South Africa
    Clin Chem Lab Med 40:876-81. 2002
  6. pmc Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology
    Karine Brudey
    Unite de la Tuberculose et des Mycobacteries, Institut Pasteur de Guadeloupe, Guadeloupe
    BMC Microbiol 6:23. 2006
  7. pmc The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa
    Thomas R Ioerger
    Department of Computer Science and Engineering, Texas A and M University, College Station, TX, USA
    BMC Genomics 11:670. 2010
  8. ncbi request reprint Patients with active tuberculosis often have different strains in the same sputum specimen
    Robin M Warren
    Medical Research Council Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, Stellenbosch University, Tygerberg, South Africa
    Am J Respir Crit Care Med 169:610-4. 2004
  9. doi request reprint embB306 mutations as molecular indicators to predict ethambutol susceptibility in Mycobacterium tuberculosis
    Frederick A Sirgel
    DST NRF Centre of Excellence for Biomedical TB Research MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Science, Stellenbosch University, Cape Town, South Africa
    Chemotherapy 58:358-63. 2012
  10. ncbi request reprint Allele frequencies for glutathione S-transferase and N-acetyltransferase 2 differ in African population groups and may be associated with oesophageal cancer or tuberculosis incidence
    Craig H Adams
    Department of Medical Biochemistry, MRC Centre for Molecular and Cellular Biology, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
    Clin Chem Lab Med 41:600-5. 2003

Research Grants

Collaborators

Detail Information

Publications28

  1. pmc Emergence of increased resistance and extensively drug-resistant tuberculosis despite treatment adherence, South Africa
    Alistair D Calver
    West Vaal Hospital, Orkney, South Africa
    Emerg Infect Dis 16:264-71. 2010
    ..These data call for improved infection control measures, implementation of rapid diagnostics, enhanced active screening strategies, and pharmacokinetic studies to determine optimal dosages and treatment regimens...
  2. ncbi request reprint Prediction of drug resistance in M. tuberculosis: molecular mechanisms, tools, and applications
    Thomas C Victor
    MRC Centre for Molecular and Cellular Biology and Department of Medical Biochemistry, University of Stellenbosch, Tygerberg, South Africa
    IUBMB Life 53:231-7. 2002
    ..This review focuses on molecular mechanisms, methods and applications as a possible new diagnostic tool for the early molecular detection of drug resistance in M. tuberculosis...
  3. pmc Molecular characteristics and global spread of Mycobacterium tuberculosis with a western cape F11 genotype
    Thomas C Victor
    MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch, Tygerberg 7505, South Africa
    J Clin Microbiol 42:769-72. 2004
    ..Careful study of dominant compared to rare strains should provide clues to their success and possibly provide new ideas for combating TB...
  4. ncbi request reprint Spread of an emerging Mycobacterium tuberculosis drug-resistant strain in the western Cape of South Africa
    T C Victor
    Department of Science and Technology National Research Foundation DST NRF Centre for Biomedical TB Research Medical Research Council MRC Centre for Molecular and Cellular Biology, Stellenbosch University, Tygerberg, South Africa
    Int J Tuberc Lung Dis 11:195-201. 2007
    ..South Africa has a high burden of drug-resistant tuberculosis (TB)...
  5. ncbi request reprint Molecular detection of early appearance of drug resistance during Mycobacterium tuberculosis infection
    Thomas C Victor
    MRC Center for Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch, Tygerberg, South Africa
    Clin Chem Lab Med 40:876-81. 2002
    ....
  6. pmc Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology
    Karine Brudey
    Unite de la Tuberculose et des Mycobacteries, Institut Pasteur de Guadeloupe, Guadeloupe
    BMC Microbiol 6:23. 2006
    ....
  7. pmc The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa
    Thomas R Ioerger
    Department of Computer Science and Engineering, Texas A and M University, College Station, TX, USA
    BMC Genomics 11:670. 2010
    ..Although the outbreak is considered to be due to clonal transmission, the relationship among drug resistant isolates has not yet been established...
  8. ncbi request reprint Patients with active tuberculosis often have different strains in the same sputum specimen
    Robin M Warren
    Medical Research Council Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, Stellenbosch University, Tygerberg, South Africa
    Am J Respir Crit Care Med 169:610-4. 2004
    ..This finding could influence our understanding of the epidemiology of disease in high-incidence regions and our understanding for vaccine development...
  9. doi request reprint embB306 mutations as molecular indicators to predict ethambutol susceptibility in Mycobacterium tuberculosis
    Frederick A Sirgel
    DST NRF Centre of Excellence for Biomedical TB Research MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Science, Stellenbosch University, Cape Town, South Africa
    Chemotherapy 58:358-63. 2012
    ..Discordant results in conventional susceptibility testing of ethambutol against Mycobacterium tuberculosis may lead to underreporting of drug resistance...
  10. ncbi request reprint Allele frequencies for glutathione S-transferase and N-acetyltransferase 2 differ in African population groups and may be associated with oesophageal cancer or tuberculosis incidence
    Craig H Adams
    Department of Medical Biochemistry, MRC Centre for Molecular and Cellular Biology, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
    Clin Chem Lab Med 41:600-5. 2003
    ..In addition, the high proportion of NAT2 "fast" alleles may partially explain the high tuberculosis prevalence in South Africans, due to reduced isoniazid efficacy in the presence of rapid acetylation...
  11. doi request reprint gyrA mutations and phenotypic susceptibility levels to ofloxacin and moxifloxacin in clinical isolates of Mycobacterium tuberculosis
    Frederick A Sirgel
    DST NRF Centre of Excellence for Biomedical TB Research MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Science, Stellenbosch University, Stellenbosch, South Africa
    J Antimicrob Chemother 67:1088-93. 2012
    ..To compare mutations in the quinolone resistance-determining region of the gyrA gene and flanking sequences with the MICs of ofloxacin and moxifloxacin for Mycobacterium tuberculosis...
  12. doi request reprint Mutations in the rrs A1401G gene and phenotypic resistance to amikacin and capreomycin in Mycobacterium tuberculosis
    Frederick A Sirgel
    DST NRF Centre of Excellence for Biomedical TB Research MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Science, Stellenbosch University, Cape Town, South Africa
    Microb Drug Resist 18:193-7. 2012
    ..Agar-based CC testing was found to be unreliable for resistance recognition of CAP in particular...
  13. ncbi request reprint Drug resistance in Mycobacterium tuberculosis
    Rabia Johnson
    Division of Molecular Biology and Human Genetics, Department of Biomedical Science, Faculty of Health Science, Tygerberg, Stellenbosch University, South Africa
    Curr Issues Mol Biol 8:97-111. 2006
    ....
  14. ncbi request reprint Antimicrobial resistance in tuberculosis: an international perspective
    Paul D van Helden
    Molecular Biology and Human Genetics, MRC Centre for Molecular and Cellular Biology, DST NRF Centre of Excellence for Biomedical TB Research, Faculty of Health Sciences, Stellenbosch University, PO Box 19063, Tygerberg 7505, South Africa
    Expert Rev Anti Infect Ther 4:759-66. 2006
    ..We highlight some of the controversies and new findings in this area, as well as future perspectives requiring more active interventions, in addition to new technology and developments...
  15. ncbi request reprint The role of IS6110 in the evolution of Mycobacterium tuberculosis
    Christopher R E McEvoy
    DST NRF Centre of Excellence in Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
    Tuberculosis (Edinb) 87:393-404. 2007
    ..tuberculosis and conclude that the presence of a moderate IS6110 copy number within the genome may provide the pathogen with a selective advantage that has aided its virulence...
  16. pmc Potential of rapid diagnosis for controlling drug-susceptible and drug-resistant tuberculosis in communities where Mycobacterium tuberculosis infections are highly prevalent
    Pieter W Uys
    Faculty of Health Sciences, MRC Center for Molecular and Cellular Biology, DST NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Tygerberg, South Africa
    J Clin Microbiol 47:1484-90. 2009
    ..The simulations showed that the rapid diagnosis of drug resistance can be expected to reduce the incidence of drug-resistant cases provided the additional measure of screening within the community is implemented...
  17. pmc The rationale for using rifabutin in the treatment of MDR and XDR tuberculosis outbreaks
    Frederick A Sirgel
    DST NRF Centre of Excellence for Biomedical TB Research, Division of Molecular Biology and Human Genetics, Faculty of Health Science, Stellenbosch University, Stellenbosch, South Africa
    PLoS ONE 8:e59414. 2013
    ..The use of RFB in the ECP may improve therapeutic success and consequently minimise the risk of ongoing transmission of drug resistant M. tuberculosis strains...
  18. doi request reprint Discordant drug susceptibility for mycobacterium tuberculosis within families
    James A Seddon
    Desmond Tutu TB Centre, Faculty of Health Sciences, Stellenbosch University, and Tygerberg Children s Hospital, Tygerberg, South Africa
    Pediatr Infect Dis J 31:783-5. 2012
    ..However, it is important to obtain a microbiologic diagnosis as it is possible for the child to have a different susceptibility profile to the source case. We present 2 such cases...
  19. doi request reprint Emergence and treatment of multidrug resistant (MDR) and extensively drug-resistant (XDR) tuberculosis in South Africa
    Elizabeth M Streicher
    DST NRF Centre of Excellence for Biomedical TB Research MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, South Africa
    Infect Genet Evol 12:686-94. 2012
    ..An important step towards for curbing this epidemic will be collaboration between clinicians, laboratories and researchers to establish scientific knowledge and medical expertise to more efficiently guide public health policy...
  20. pmc Rifampicin reduces susceptibility to ofloxacin in rifampicin-resistant Mycobacterium tuberculosis through efflux
    Gail E Louw
    Department of Biomedical Sciences, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
    Am J Respir Crit Care Med 184:269-76. 2011
    ..Central dogma suggests that rifampicin resistance in Mycobacterium tuberculosis develops solely through rpoB gene mutations...
  21. ncbi request reprint Drug susceptibility testing using molecular techniques can enhance tuberculosis diagnosis
    Rabia Johnson
    DST NRF Centre of Excellence in Biomedical Tuberculosis Research MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Science, Tygerberg, Stellenbosch University, South Africa
    J Infect Dev Ctries 2:40-5. 2008
    ..The aim of this study was to evaluate the performance and time to diagnosis of a genotypic drug susceptibility testing method...
  22. ncbi request reprint Mutational and expression analysis of tbnat and its response to isoniazid
    Carolyn Sholto-Douglas-Vernon
    MRC Centre for Molecular and Cellular Biology and Department of Medical Biochemistry, University of Stellenbosch, Faculty of Health Sciences, PO Box 19063, Tygerberg, 7505, South Africa
    J Med Microbiol 54:1189-97. 2005
    ..The increased expression in the susceptible isolates suggests that INH affects tbnat expression. tbnat may contribute to INH susceptibility, but in combination with other factors...
  23. ncbi request reprint Polymorphisms and mutations found in the regions flanking exons 5 to 8 of the TP53 gene in a population at high risk for esophageal cancer in South Africa
    Marelette Vos
    University of Stellenbosch, MRC Center for Molecular and Cellular Biology, Department of Medical Biochemistry, P O Box 19063, 7505, Tygerberg, South Africa
    Cancer Genet Cytogenet 140:23-30. 2003
    ..The point mutations include the polymorphism in codon 72 (Arg-->Pro), which has recently been associated with an increased risk of developing human papilloma virus-associated cancers...
  24. doi request reprint Impact of drug resistance on clinical outcome in children with tuberculous meningitis
    James A Seddon
    Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
    Pediatr Infect Dis J 31:711-6. 2012
    ..Tuberculous meningitis (TBM) is associated with delayed diagnosis and poor outcome in children. This study investigated the impact of drug resistance on clinical outcome in children with TBM...
  25. doi request reprint Tuberculosis assays: past, present and future
    Novel N Chegou
    DST NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, University of Stellenbosch, PO Box 19063, Francie van Zijl Drive, Tygerberg 7505, South Africa
    Expert Rev Anti Infect Ther 9:457-69. 2011
    ..Host markers associated with active disease may hold promise, especially in situations where sputum diagnostics are problematic, including in children, HIV-infected individuals and in the case of extrapulmonary TB...
  26. doi request reprint Detecting drug-resistant tuberculosis: the importance of rapid testing
    Kim G P Hoek
    Division of Medical Microbiology, Department of Pathology, University of Stellenbosch, Tygerberg, South Africa
    Mol Diagn Ther 15:189-94. 2011
    ....
  27. ncbi request reprint The spectrum of mutations in TP53 in laryngeal cancer patients from a high-incidence population shows similarities to many of the known mutational hotspots
    Desire Barnard
    Department of Medical Biochemistry, MRC Centre for Molecular and Cellular Biology, University of Stellenbosch, PO Box 19063, Tygerberg 7505, South Africa
    Cancer Genet Cytogenet 145:126-32. 2003
    ..The data confirm that the region between codons 175 and 273 of TP53 is a mutational hotspot region for cancers in general; six novel mutations were found within this same region...
  28. ncbi request reprint Energy metabolism and drug efflux in Mycobacterium tuberculosis
    Philippa A Black
    DST NRF Centre of Excellence for Biomedical Tuberculosis Research MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa
    Antimicrob Agents Chemother 58:2491-503. 2014
    ..tuberculosis and their association, if any, with drug transport and concomitant effects on drug resistance. The implications of inhibiting drug extrusion, through the use of efflux pump inhibitors, are also discussed. ..

Research Grants1

  1. INH resistance in Beijing/W isolates of M. tuberculosis
    Thomas Victor; Fiscal Year: 2004
    ..It will also allow comparative analysis to other local outbreak drug resistant strains and will help unravel the mechanisms that lead to the development and spread of drug resistance in local communities. ..