Gert Uves van Zyl

Summary

Affiliation: University of Stellenbosch
Country: South Africa

Publications

  1. pmc Low lopinavir plasma or hair concentrations explain second-line protease inhibitor failures in a resource-limited setting
    Gert Uves van Zyl
    Division of Medical Virology, Department of Pathology, NHLS Tygerberg and Stellenbosch University, Tygerberg, South Africa
    J Acquir Immune Defic Syndr 56:333-9. 2011
  2. pmc It is time to consider third-line options in antiretroviral-experienced paediatric patients?
    Gert U van Zyl
    Division of Medical Virology, Stellenbosch University, and National Health Laboratory Service Tygerberg, Parow, Cape Town, South Africa
    J Int AIDS Soc 14:55. 2011
  3. doi request reprint Antiretroviral resistance patterns and factors associated with resistance in adult patients failing NNRTI-based regimens in the Western Cape, South Africa
    Gert U van Zyl
    Division of Medical Virology, Stellenbosch University, Tygerberg, Cape Town, South Africa
    J Med Virol 83:1764-9. 2011
  4. pmc Pooling strategies to reduce the cost of HIV-1 RNA load monitoring in a resource-limited setting
    G U van Zyl
    Division of Medical Virology, Stellenbosch University, and National Health Laboratory Service, Tygerberg, South Africa
    Clin Infect Dis 52:264-70. 2011
  5. doi request reprint NucliSens EasyQ HIV-1 V1.2 system: Detection of human plasma-derived background signal
    G U van Zyl
    Division of Medical Virology, National Health Laboratory Service and Stellenbosch University, Tygerberg 7505, South Africa
    J Virol Methods 165:318-9. 2010
  6. doi request reprint Surveillance of transmitted resistance to antiretroviral drug classes among young children in the Western Cape Province of South Africa
    Gert U van Zyl
    Division of Medical Virology, Stellenbosch University, Tygerberg, South Africa
    Pediatr Infect Dis J 29:370-1. 2010
  7. doi request reprint Protease inhibitor resistance in South African children with virologic failure
    Gert U van Zyl
    Centre for Infectious Diseases, Division of Medical Virology, Tygerberg and Stellenbosch University, Cape Town, South Africa
    Pediatr Infect Dis J 28:1125-7. 2009
  8. doi request reprint Zidovudine with nevirapine for the prevention of HIV mother-to-child transmission reduces nevirapine resistance in mothers from the Western Cape, South Africa
    G U van Zyl
    Faculty of Health Sciences and National Health Laboratory Service NHLS Tygerberg, Division of Medical Virology, Department Pathology, Stellenbosch University, Cape Town, South Africa
    J Med Virol 80:942-6. 2008
  9. doi request reprint Extraction buffer contaminated bacterially as a cause of invalid HIV-1 viral load results on the NucliSens EasyQ system
    M Claassen
    Division of Medical Virology, National Health Laboratory Service Tygerberg Department of Pathology, Faculty of Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa
    J Virol Methods 150:80-1. 2008
  10. ncbi request reprint Pitfalls with rapid HIV antibody testing in HIV-infected children in the Western Cape, South Africa
    M Claassen
    Discipline of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Stellenbosch and NHLS, Tygerberg 7505, South Africa
    J Clin Virol 37:68-71. 2006

Detail Information

Publications11

  1. pmc Low lopinavir plasma or hair concentrations explain second-line protease inhibitor failures in a resource-limited setting
    Gert Uves van Zyl
    Division of Medical Virology, Department of Pathology, NHLS Tygerberg and Stellenbosch University, Tygerberg, South Africa
    J Acquir Immune Defic Syndr 56:333-9. 2011
    ..In resource-limited settings, many patients, with no prior protease inhibitor (PI) treatment on a second-line, high genetic barrier, ritonavir-boosted PI-containing regimen have virologic failure...
  2. pmc It is time to consider third-line options in antiretroviral-experienced paediatric patients?
    Gert U van Zyl
    Division of Medical Virology, Stellenbosch University, and National Health Laboratory Service Tygerberg, Parow, Cape Town, South Africa
    J Int AIDS Soc 14:55. 2011
    ..The historic use of full-dose ritonavir as part of an unboosted protease inhibitor (PI)-based antiretroviral therapy regimen in some South African children contributes to the frequent accumulation of major PI resistance mutations...
  3. doi request reprint Antiretroviral resistance patterns and factors associated with resistance in adult patients failing NNRTI-based regimens in the Western Cape, South Africa
    Gert U van Zyl
    Division of Medical Virology, Stellenbosch University, Tygerberg, Cape Town, South Africa
    J Med Virol 83:1764-9. 2011
    ..Major protease inhibitor mutations were not detected. A delayed response to ART failure may risk accumulation of TAMs in patients on an NNRTI-based regimen. The use of NVP rather than EFV was associated with ETV resistance...
  4. pmc Pooling strategies to reduce the cost of HIV-1 RNA load monitoring in a resource-limited setting
    G U van Zyl
    Division of Medical Virology, Stellenbosch University, and National Health Laboratory Service, Tygerberg, South Africa
    Clin Infect Dis 52:264-70. 2011
    ..Recently, the use of pooling strategies with a clinically appropriate viral load threshold was shown to be accurate and efficient for monitoring when the prevalence of virologic failure is low...
  5. doi request reprint NucliSens EasyQ HIV-1 V1.2 system: Detection of human plasma-derived background signal
    G U van Zyl
    Division of Medical Virology, National Health Laboratory Service and Stellenbosch University, Tygerberg 7505, South Africa
    J Virol Methods 165:318-9. 2010
    ..In this case HIV-negative human plasma should be included routinely in addition to NTCs, which would allow rapid detection of a background signal...
  6. doi request reprint Surveillance of transmitted resistance to antiretroviral drug classes among young children in the Western Cape Province of South Africa
    Gert U van Zyl
    Division of Medical Virology, Stellenbosch University, Tygerberg, South Africa
    Pediatr Infect Dis J 29:370-1. 2010
    ..The estimated NRTI and protease inhibitor transmitted antiretroviral resistance prevalence is low (<5%), predicting good therapeutic response in Western Cape infants...
  7. doi request reprint Protease inhibitor resistance in South African children with virologic failure
    Gert U van Zyl
    Centre for Infectious Diseases, Division of Medical Virology, Tygerberg and Stellenbosch University, Cape Town, South Africa
    Pediatr Infect Dis J 28:1125-7. 2009
    ..We explored antiretroviral resistance mutations in pediatric patients failing PI-based antiretroviral therapy and the predictors of major PI resistance mutations (MPIRM) in these patients...
  8. doi request reprint Zidovudine with nevirapine for the prevention of HIV mother-to-child transmission reduces nevirapine resistance in mothers from the Western Cape, South Africa
    G U van Zyl
    Faculty of Health Sciences and National Health Laboratory Service NHLS Tygerberg, Division of Medical Virology, Department Pathology, Stellenbosch University, Cape Town, South Africa
    J Med Virol 80:942-6. 2008
    ..1%, 95% confidence interval: 8.7-25.6%), which appears to be lower than in studies with sd NVP alone (37.5%, 95% confidence interval: 23.0-50.6%)...
  9. doi request reprint Extraction buffer contaminated bacterially as a cause of invalid HIV-1 viral load results on the NucliSens EasyQ system
    M Claassen
    Division of Medical Virology, National Health Laboratory Service Tygerberg Department of Pathology, Faculty of Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa
    J Virol Methods 150:80-1. 2008
    ..This experience underlines the necessity of state-of-the-art assay design incorporating adequate internal controls and calibrators...
  10. ncbi request reprint Pitfalls with rapid HIV antibody testing in HIV-infected children in the Western Cape, South Africa
    M Claassen
    Discipline of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Stellenbosch and NHLS, Tygerberg 7505, South Africa
    J Clin Virol 37:68-71. 2006
    ..Rapid HIV antibody tests are commonly used for HIV diagnosis in the developing world. These tests are generally reported as sensitive, despite paucity of evaluations in paediatric populations...