Dan Stein

Summary

Location: , South Africa

Publications

  1. pmc A survey of participants in two internet support groups for people with hair-pulling
    Belinda R Bruwer
    MRC Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    BMC Psychiatry 5:37. 2005
  2. pmc Should excessive worry be required for a diagnosis of generalized anxiety disorder? Results from the US National Comorbidity Survey Replication
    Ayelet Meron Ruscio
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Psychol Med 35:1761-72. 2005
  3. ncbi Early life trauma decreases glucocorticoid receptors in rat dentate gyrus upon adult re-stress: reversal by escitalopram
    J D K Uys
    Medical Research Council Research Unit for Anxiety and Stress related Disorders, Department of Medical Physiology, University of Stellenbosch, Tygerberg, 7505 South Africa
    Neuroscience 137:619-25. 2006
  4. pmc Trauma and posttraumatic stress disorder in South Africa: analysis from the South African Stress and Health Study
    Lukoye Atwoli
    Department of Mental Health, School of Medicine, Moi University College of Health Sciences, Eldoret, Kenya
    BMC Psychiatry 13:182. 2013
  5. pmc Comparing the accuracy of brief versus long depression screening instruments which have been validated in low and middle income countries: a systematic review
    Dickens Akena
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    BMC Psychiatry 12:187. 2012
  6. pmc Negative attributions towards people with substance use disorders in South Africa: variation across substances and by gender
    Katherine Sorsdahl
    Department of Psychiatry and Mental Health, University of Cape Town J Block Groote Schuur Hospital Observatory, Cape Town, South Africa
    BMC Psychiatry 12:101. 2012
  7. pmc Mindfulness based cognitive therapy improves frontal control in bipolar disorder: a pilot EEG study
    Fleur M Howells
    Department of Psychiatry, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa
    BMC Psychiatry 12:15. 2012
  8. pmc Towards a genuinely medical model for psychiatric nosology
    Randolph M Nesse
    Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA
    BMC Med 10:5. 2012
  9. pmc Neuropsychological outcomes in adults commencing highly active anti-retroviral treatment in South Africa: a prospective study
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 12:39. 2012
  10. pmc Impact of childhood trauma on functionality and quality of life in HIV-infected women
    Zyrhea C E Troeman
    South African Research Chairs Initiative SARChI, PTSD Program, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Health Qual Life Outcomes 9:84. 2011

Collaborators

Detail Information

Publications124 found, 100 shown here

  1. pmc A survey of participants in two internet support groups for people with hair-pulling
    Belinda R Bruwer
    MRC Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    BMC Psychiatry 5:37. 2005
    ..This paper reports on the perceived effectiveness of trichotillomania (TTM) internet support groups for people suffering from hair-pulling...
  2. pmc Should excessive worry be required for a diagnosis of generalized anxiety disorder? Results from the US National Comorbidity Survey Replication
    Ayelet Meron Ruscio
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Psychol Med 35:1761-72. 2005
    ..No large-scale epidemiological study has ever examined the implications of this requirement for estimates of prevalence, severity, or correlates of GAD...
  3. ncbi Early life trauma decreases glucocorticoid receptors in rat dentate gyrus upon adult re-stress: reversal by escitalopram
    J D K Uys
    Medical Research Council Research Unit for Anxiety and Stress related Disorders, Department of Medical Physiology, University of Stellenbosch, Tygerberg, 7505 South Africa
    Neuroscience 137:619-25. 2006
    ....
  4. pmc Trauma and posttraumatic stress disorder in South Africa: analysis from the South African Stress and Health Study
    Lukoye Atwoli
    Department of Mental Health, School of Medicine, Moi University College of Health Sciences, Eldoret, Kenya
    BMC Psychiatry 13:182. 2013
    ..The aim of this study was to document the epidemiology of trauma and posttraumatic stress disorder (PTSD) in the South African general population...
  5. pmc Comparing the accuracy of brief versus long depression screening instruments which have been validated in low and middle income countries: a systematic review
    Dickens Akena
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    BMC Psychiatry 12:187. 2012
    ..However, it remains unknown whether the brief instruments validated in LMIC are as accurate as the long ones...
  6. pmc Negative attributions towards people with substance use disorders in South Africa: variation across substances and by gender
    Katherine Sorsdahl
    Department of Psychiatry and Mental Health, University of Cape Town J Block Groote Schuur Hospital Observatory, Cape Town, South Africa
    BMC Psychiatry 12:101. 2012
    ....
  7. pmc Mindfulness based cognitive therapy improves frontal control in bipolar disorder: a pilot EEG study
    Fleur M Howells
    Department of Psychiatry, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa
    BMC Psychiatry 12:15. 2012
    ..Mindfulness Based Cognitive Therapy combines mindfulness meditation, a form of attentional training, along with aspects of cognitive therapy, and may improve attentional dysfunction in bipolar disorder patients...
  8. pmc Towards a genuinely medical model for psychiatric nosology
    Randolph M Nesse
    Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA
    BMC Med 10:5. 2012
    ..Dissatisfaction with psychiatric nosology may best be alleviated, not by new diagnostic criteria and categories, but by more realistic acknowledgment of the untidy landscape of mental and other medical disorders...
  9. pmc Neuropsychological outcomes in adults commencing highly active anti-retroviral treatment in South Africa: a prospective study
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 12:39. 2012
    ..To date, there have been no cohort studies of the impact of highly active anti-retroviral treatment (HAART) in South Africa where clade C HIV is predominant...
  10. pmc Impact of childhood trauma on functionality and quality of life in HIV-infected women
    Zyrhea C E Troeman
    South African Research Chairs Initiative SARChI, PTSD Program, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Health Qual Life Outcomes 9:84. 2011
    ..While there are many published studies on HIV and functional limitations, there are few in the context of early abuse and its impact on functionality and Quality of Life (QoL) in HIV...
  11. pmc Perceived mental effort correlates with changes in tonic arousal during attentional tasks
    Fleur M Howells
    Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa
    Behav Brain Funct 6:39. 2010
    ....
  12. pmc The effectiveness of problem solving therapy in deprived South African communities: results from a pilot study
    Edith Van't Hof
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    BMC Psychiatry 11:156. 2011
    ..This pilot study evaluates the feasibility, acceptability and effectiveness of this PST program for CMD's in deprived communities around Cape Town...
  13. pmc Subtyping social anxiety disorder in developed and developing countries
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Depress Anxiety 27:390-403. 2010
    ..We aimed to determine whether this holds across a broader set of developed and developing countries, and whether subtyping according to number of performance versus interactional fears would be more useful...
  14. ncbi Hoarding in obsessive-compulsive disorder: clinical and genetic correlates
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    J Clin Psychiatry 66:1155-60. 2005
    ..The clinical and genetic correlates of hoarding in OCD therefore deserve additional investigation...
  15. ncbi Persistence of psychiatric disorders in a cohort of HIV/AIDS patients in South Africa: a 6-month follow-up study
    Benjamin O Olley
    Department of Psychiatry, MRC Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    J Psychosom Res 61:479-84. 2006
    ..However, there are few prospective studies on the rates of psychiatric disorders in HIV/AIDS, particularly in the context of the developing world...
  16. ncbi Measuring anxiety in patients with schizophrenia
    Soraya Seedat
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    J Nerv Ment Dis 195:320-4. 2007
    ..Accurate assessment is challenging yet important. More reliable measures of anxiety disorders in patients with schizophrenia and other psychotic disorders are clearly needed to allow for timely identification and treatment...
  17. pmc Obsessive-compulsive disorder and trichotillomania: a phenomenological comparison
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    BMC Psychiatry 5:2. 2005
    ..Nevertheless, there is evidence of important differences between these two disorders. Some authors have conceptualized the disorders as lying on an OCD spectrum of conditions...
  18. doi Cumulative effect of multiple trauma on symptoms of posttraumatic stress disorder, anxiety, and depression in adolescents
    Sharain Suliman
    Department of Psychiatry, Stellenbosch University, Cape Town, South Africa
    Compr Psychiatry 50:121-7. 2009
    ..Against the backdrop of stressful life events and childhood abuse and neglect, we investigated the cumulative effect of multiple trauma exposure on PTSD, anxiety, and depression in an adolescent sample...
  19. pmc Disability and treatment of psychiatric and physical disorders in South Africa
    Sharain Suliman
    MRC Anxiety and Stress Disorders Unit, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    J Nerv Ment Dis 198:8-15. 2010
    ..Despite high rates of mental disorders and associated disability in South Africa, they are less likely to be treated than physical disorders...
  20. ncbi Escitalopram in obsessive-compulsive disorder: response of symptom dimensions to pharmacotherapy
    Dan J Stein
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    CNS Spectr 13:492-8. 2008
    ..The response of OCD symptom dimensions to 12 weeks of treatment with escitalopram or placebo was investigated...
  21. pmc Intermittent explosive disorder in South Africa: prevalence, correlates and the role of traumatic exposures
    Dylan Fincham
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Stellenbosch, South Africa
    Psychopathology 42:92-8. 2009
    ..In South Africa, given the high rates of violence and trauma, there is particular interest in traumatic exposures as potential risk factors for IED...
  22. ncbi Trichotillomania and skin-picking: a phenomenological comparison
    Christine Lochner
    Department of Psychiatry, MRC Unit on Stress and Anxiety Disorder, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Depress Anxiety 15:83-6. 2002
    ..Future work to assess the implications of overlap for clinical evaluation and intervention in the two conditions may be useful...
  23. ncbi Trauma and posttraumatic stress disorder in an urban Xhosa primary care population: prevalence, comorbidity, and service use patterns
    Paul D Carey
    MRC Unit for Stress and Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg 7505, Cape Town, South Africa
    J Nerv Ment Dis 191:230-6. 2003
    ..In this population, trauma and PTSD were highly prevalent and associated with significant unidentified morbidity and comorbidity. Patients remain untreated for years in the current system of primary care consultations...
  24. ncbi An A-B-C model of habit disorders: hair-pulling, skin-picking, and other stereotypic conditions
    Dan J Stein
    Department of Mental Health and Psychiatry, University of Cape Town, South Africa
    CNS Spectr 11:824-7. 2006
    ..An affect regulation, behavioral addiction, and cognitive control (A-B-C) approach is outlined to conceptualizing and managing these conditions...
  25. ncbi What is the self? A psychobiological perspective
    Dan J Stein
    Department of Mental Health and Psychiatry, University of Cape Town, South Africa
    CNS Spectr 12:333-6. 2007
    ..A cognitive-affective neuroscience approach provides a conceptual basis from which clinical research can further explore how best to assess and treat a wide range of disruptions to the self...
  26. ncbi Panic disorder: the psychobiology of external treat and introceptive distress
    Dan J Stein
    Department of Psychiatry and Mental Health, University of Cape Town, South Africa
    CNS Spectr 13:26-30. 2008
    ..Genetic and environmental contributors to panic disorder are beginning to be delineated. Effective pharmacotherapy and psychotherapy are able to normalize the relevant psychobiology...
  27. ncbi Posttraumatic stress disorder and occupational disability in South African Security Force members
    Robin A Emsley
    Department of Psychiatry and Medical Research Council Unit for Anxiety and Stress Disorders, University of Stellenbosch, PO Box 19063, Tygerberg 7505, Cape Town, South Africa
    J Nerv Ment Dis 191:237-41. 2003
    ..These findings suggest that posttrauma factors may be as important as pretrauma and peritrauma variables in the development of PTSD...
  28. ncbi Escitalopram in the treatment of social anxiety disorder: analysis of efficacy for different clinical subgroups and symptom dimensions
    Dan J Stein
    MRC Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    Depress Anxiety 20:175-81. 2004
    ..A six-factor model of social anxiety symptoms is supported by the distinctive association between these symptom dimensions and different areas of disability, but did not predict differential response to escitalopram...
  29. doi Posttraumatic stress disorder symptoms in adolescents: risk factors versus resilience moderation
    Dylan S Fincham
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg, Cape Town 7505, South Africa
    Compr Psychiatry 50:193-9. 2009
    ..Although evidence suggests that resilience may moderate the relationship between some of these risk factors and PTSD symptoms, no studies to date have examined these risk factors collectively...
  30. doi Chronic hair-pulling: phenomenology-based subtypes
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    J Anxiety Disord 24:196-202. 2010
    ..Future work, incorporating further investigation of the role of gender and psychobiological and treatment outcomes, is needed before definitive conclusions about hair-pulling subtypes can be drawn...
  31. ncbi The psychiatric sequelae of human rights violations: a challenge for primary health care
    Nompumelelo Zungu-Dirwayi
    Medical Research Council Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    J Nerv Ment Dis 192:255-9. 2004
    ..Misdiagnosis and ineffective treatment of survivors of human rights abuses are likely to pose a significant drain on primary care resources. Accurate diagnosis and appropriate treatment are important challenges in primary care settings...
  32. ncbi Gender in obsessive-compulsive disorder: clinical and genetic findings
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, P O Box 19063, Tygerberg 7505, Cape Town, South Africa
    Eur Neuropsychopharmacol 14:105-13. 2004
    ..There is increasing recognition that obsessive-compulsive disorder (OCD) is not a homogeneous entity. It has been suggested that gender may contribute to the clinical and biological heterogeneity of OCD...
  33. doi Neuropsychological task performance in bipolar spectrum illness: genetics, alcohol abuse, medication and childhood trauma
    Jonathan B Savitz
    Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Bipolar Disord 10:479-94. 2008
    ....
  34. ncbi Efficacy of paroxetine for relapse prevention in social anxiety disorder: a 24-week study
    Dan J Stein
    University of Stellenbosch, Fransie van Zyl Dr, Tygerberg 7505, Cape Town, South Africa
    Arch Gen Psychiatry 59:1111-8. 2002
    ..The efficacy of selective serotonin reuptake inhibitors in the acute treatment of social anxiety disorder (social phobia) is well established...
  35. ncbi Cluster analysis of obsessive-compulsive spectrum disorders in patients with obsessive-compulsive disorder: clinical and genetic correlates
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg, 7505, Cape Town, South Africa
    Compr Psychiatry 46:14-9. 2005
    ..Comorbidity of the putative OCSDs in OCD has, however, not often been systematically investigated...
  36. ncbi 5-HT2A: its role in frontally mediated executive function and related psychopathology
    Dan J Stein
    Department of Mental Health and Psychiatry, University of Cape Town, South Africa
    CNS Spectr 12:512-6. 2007
    ..Conversely, many antidepressants result in decreased levels of 5-HT2A receptor levels, and blockade of 5-HT2A receptors has proven useful in the treatment of a number of psychiatric disorders...
  37. ncbi Prevalence and characteristics of trauma and post-traumatic stress symptoms in operational members of the South African National Defence Force
    Soraya Seedat
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, P O Box 19063, Tygerberg, 7505, Cape Town, South Africa
    Mil Med 168:71-5. 2003
    ..These findings highlight the high rates of exposure to multiple, noncombat-related trauma in military personnel, the potentially high rates of PTSD, and the role of inflicted trauma as an additional risk factor for PTSD...
  38. ncbi Psychobiology of mindfulness
    Dan J Stein
    Department of Psychiatry and Mental Health at the University of Cape Town, Cape Town, South Africa
    CNS Spectr 13:752-6. 2008
    ..A number of rigorous studies of mindfulness-based cognitive therapy for depression have been positive. However, much remains to be discovered about the underlying mechanisms of and clinical indications for mindfulness-based approaches...
  39. ncbi Efficacy of sertraline in posttraumatic stress disorder secondary to interpersonal trauma or childhood abuse
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Ann Clin Psychiatry 18:243-9. 2006
    ..This analysis was conducted to specifically assess the efficacy of sertraline in the treatment of PTSD secondary to interpersonal trauma or childhood abuse...
  40. pmc Social determinants of psychological distress in a nationally-representative sample of South African adults
    Landon Myer
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    Soc Sci Med 66:1828-40. 2008
    ....
  41. ncbi Childhood trauma in obsessive-compulsive disorder, trichotillomania, and controls
    Christine Lochner
    MRC Unit on Stress and Anxiety Disorders, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Depress Anxiety 15:66-8. 2002
    ....
  42. ncbi A systematic review of the quality of information on the treatment of anxiety disorders on the internet
    Jonathan C Ipser
    Department of Psychiatry and Mental Health, University of Cape Town, Groote Schuur Hospital, Observatory, South Africa
    Curr Psychiatry Rep 9:303-9. 2007
    ..The paper closes by considering limitations of the review and possible future research avenues...
  43. ncbi Advances in understanding the anxiety disorders: the cognitive-affective neuroscience of 'false alarms'
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Ann Clin Psychiatry 18:173-82. 2006
    ..An integrative framework is required in order to conceptualize this data and to apply it in the clinic...
  44. pmc Cross-national analysis of the associations between traumatic events and suicidal behavior: findings from the WHO World Mental Health Surveys
    Dan J Stein
    Department of Psychiatry, Groote Schuur Hospital, Cape Town, South Africa
    PLoS ONE 5:e10574. 2010
    ..Moreover, few data are available on such associations in developing countries. The current study addresses each of these issues...
  45. ncbi Specific phobia: a disorder of fear conditioning and extinction
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    CNS Spectr 11:248-51. 2006
    ..Advances in the cognitive-affective neuroscience of fear processing may ultimately lead to new approaches to the clinical management of phobias...
  46. ncbi A systematic review of the quality and impact of anxiety disorder meta-analyses
    Jonathan C Ipser
    Department of Psychiatry and Mental Health, University of Cape Town, Groote Schuur Hospital, Anzio Road, Observatory, Cape Town, South Africa
    Curr Psychiatry Rep 11:302-9. 2009
    ..A list of the meta-analyses included in this review is available on an evidence-based website of anxiety and trauma-related disorders...
  47. doi Traditional healer attitudes and beliefs regarding referral of the mentally ill to Western doctors in South Africa
    Katherine Sorsdahl
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    Transcult Psychiatry 47:591-609. 2010
    ..Recommendations include the need for traditional healers to be trained to identify potential cases of mental illness in their communities and for dialogue between traditional and allopathic physicians in regard to mental health care...
  48. doi Association between antenatal distress and uterine artery pulsatility index
    Bavanisha Vythilingum
    Department of Psychiatry J Block, Groote Schuur Hospital, University of Cape Town, Anzio Road, Observatory, Cape Town, 7925, South Africa
    Arch Womens Ment Health 13:359-64. 2010
    ....
  49. doi Association between apolipoprotein E4 genotype and human immunodeficiency virus-associated dementia in younger adults starting antiretroviral therapy in South Africa
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, South Africa
    J Neurovirol 16:377-83. 2010
    ..These findings suggest that the ε4 allelic variant in HIV-positive individuals is not associated with the development of HAD in Southern Africa...
  50. doi Pharmacotherapy for social anxiety disorder: a systematic review
    Jonathan C Ipser
    UCT Department of Psychiatry and Mental Health, Groote Schuur Hospital, J 2 Anzio Road, Observatory, 7925, South Africa
    Expert Rev Neurother 8:235-57. 2008
    ..Cochrane Reviews are regularly updated as new evidence emerges and in response to feedback, and The Cochrane Library should be consulted for the most recent version of the review...
  51. doi Does highly active antiretroviral therapy improve neurocognitive function? A systematic review
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    J Neurovirol 16:101-14. 2010
    ..Studies examining the long-term effects of HAART on HIV-associated neurocognitive disorders (HANDs) using uniform methods of data collection are needed, together with clear reporting of HAART regimens...
  52. doi Associations between mental disorders and subsequent onset of hypertension
    Dan J Stein
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa Electronic address
    Gen Hosp Psychiatry 36:142-9. 2014
    ..Further, there are few data available on how such associations vary by gender or over life course...
  53. doi Classification systems in psychiatry: diagnosis and global mental health in the era of DSM-5 and ICD-11
    Dan J Stein
    Department of Psychiatry, University of Cape Town, South Africa
    Curr Opin Psychiatry 26:493-7. 2013
    ..This article reviews recent work in this area, and suggests potential ways forward for psychiatric nosology, focusing in particular on the need for improved classification approaches for public and global mental health...
  54. pmc Patient advocacy and DSM-5
    Dan J Stein
    Department of Psychiatry, University of Cape Town and Groote Schuur Hospital J2, Anzio Rd, Observatory 7925, Cape Town, South Africa
    BMC Med 11:133. 2013
    ....
  55. doi Efficacy of the novel antidepressant agomelatine for anxiety symptoms in major depression
    Dan J Stein
    Department of Psychiatry, University of Cape Town, South Africa
    Hum Psychopharmacol 28:151-9. 2013
    ..Here, we investigated the efficacy of agomelatine in anxious depression...
  56. doi Revenge and forgiveness in the New South Africa
    Dan Joseph Stein
    Department of Psychiatry, University of Cape Town, Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa
    Behav Brain Sci 36:37-8. 2013
    ..At the same time, the rich range of revenge and forgiveness phenomena in real-life settings is likely to require explanatory concepts other than specialized modules and their computational outputs...
  57. doi Psychiatry and mental health research in South Africa: national priorities in a low and middle income context
    D Stein
    Department of Psychiatry and Mental Health, University of Cape Town, South Africa
    Afr J Psychiatry (Johannesbg) 15:427-31. 2012
    ..Finally, some general conclusions that the majority of summit delegates participating in the discussion on research agreed to, are presented...
  58. doi Psychiatric contributions from South Africa: ex Africa semper aliquid novi
    D J Stein
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    Afr J Psychiatry (Johannesbg) 15:323-8. 2012
    ..It briefly covers seminal contributions in evolutionary theory, psychotherapy, and neuroscience, as well as conceptual and practical contributions to reconciliation...
  59. doi Agomelatine prevents relapse in generalized anxiety disorder: a 6-month randomized, double-blind, placebo-controlled discontinuation study
    Dan J Stein
    Department of Psychiatry, Groote Schuur Hospital, Cape Town, South Africa
    J Clin Psychiatry 73:1002-8. 2012
    ..This study evaluated the efficacy and tolerability of agomelatine in the prevention of relapse in patients with generalized anxiety disorder (GAD)...
  60. pmc Psychopharmacological enhancement: a conceptual framework
    Dan J Stein
    Department of Psychiatry, University of Cape Town and Stellenbosch University, Groote Schuur Hospital, Anzio St, Cape Town 7925, South Africa
    Philos Ethics Humanit Med 7:5. 2012
    ..The use of psychotropics for sub-threshold phenomena requires a judicious weighing of the relevant facts (which are often sparse) and values...
  61. ncbi No health without mental health: establishing psychiatry as a major discipline in an African Faculty of Health Sciences
    Lynn Gillis
    Department of Psychiatry and Mental Health, University of Cape Town
    S Afr Med J 102:449-51. 2012
    ..Nevertheless, considerable strides have been made towards moving psychiatry from the periphery of society and medicine to a central discipline within the Faculty of Health Sciences at UCT...
  62. doi A 2012 evidence-based algorithm for the pharmacotherapy for obsessive-compulsive disorder
    Dan J Stein
    University of Cape Town Department of Psychiatry, Groote Schuur Hospital, Cape Town, South Africa
    Curr Psychiatry Rep 14:211-9. 2012
    ..In creating this algorithm, we have drawn on the body of published evidence, as well as on expert opinion...
  63. pmc Early childhood adversity and later hypertension: data from the World Mental Health Survey
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Groote Schur Hospital, Anzio Road, Cape Town, South Africa
    Ann Clin Psychiatry 22:19-28. 2010
    ....
  64. doi Obsessive-compulsive disorder: diagnostic and treatment issues
    Dan J Stein
    Deparment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    Psychiatr Clin North Am 32:665-85. 2009
    ..There is a growing evidence base on OCD symptom dimensions and subtyping, and it is timely to consider incorporating some of these emerging data into diagnostic classification systems...
  65. pmc Perpetration of gross human rights violations in South Africa: association with psychiatric disorders
    Dan J Stein
    Department of Psychiatry and Mental Health, University of Cape Town
    S Afr Med J 99:390-5. 2009
    ..Prior work has suggested an association between perpetration and post-traumatic stress disorder (PTSD), but this remains controversial...
  66. doi The DSM-IV-based Generalized Anxiety Disorder Severity Scale: preliminary validation using data from a trial of agomelatine versus placebo
    Dan J Stein
    Department of Psychiatry, University of Cape Town, South Africa
    J Nerv Ment Dis 197:391-4. 2009
    ..The most robust DGSS items were derived, and an exploratory factor analysis yielded a 2-factor structure of the DGSS. The DGSS is potentially a useful scale for the assessment of GAD in clinical trials of this disorder...
  67. ncbi Social anxiety disorder in the West and in the East
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Groote Schuur Hospital J 2, Anzio Rd, Observatory 7925, Cape Town, South Africa
    Ann Clin Psychiatry 21:109-17. 2009
    ..In recent years, however, similar assessments and treatments have been utilized across the world...
  68. ncbi Anxiety symptom severity and functional recovery or relapse
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Groote Schuur Hospital J 2, Anzio Rd, Observatory 7925, Cape Town, South Africa
    Ann Clin Psychiatry 21:81-8. 2009
    ..Recovery could potentially be defined as a lack of disability, with an associated reduction in symptom severity. Conversely, relapse could potentially be defined in terms of either increased disability or increased symptoms...
  69. doi Should OCD be classified as an anxiety disorder in DSM-V?
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Depress Anxiety 27:495-506. 2010
    ..If this change is made, the name of this category should be changed to reflect this proposed change...
  70. doi Trichotillomania (hair pulling disorder), skin picking disorder, and stereotypic movement disorder: toward DSM-V
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Rondebosch, Cape Town, South Africa
    Depress Anxiety 27:611-26. 2010
    ....
  71. doi A 2010 evidence-based algorithm for the pharmacotherapy of social anxiety disorder
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Groote Schuur Hospital J 2, Observatory 7925, Cape Town, South Africa
    Curr Psychiatry Rep 12:471-7. 2010
    ..The algorithm comprises eight sequential steps, beginning with those focused on diagnosis and initiating treatment and ending with the management of the treatment-refractory patient...
  72. doi Threat detection, precautionary responses, and anxiety disorders
    Dan J Stein
    University of Cape Town, Cape Town, South Africa
    Neurosci Biobehav Rev 35:1075-9. 2011
    ....
  73. doi Meta-structure issues for the DSM-5: how do anxiety disorders, obsessive-compulsive and related disorders, post-traumatic disorders, and dissociative disorders fit together?
    Dan J Stein
    University of Cape Town Department of Psychiatry, Groote Schuur Hospital J 2, Anzio Road, Observatory 7925, Cape Town, South Africa
    Curr Psychiatry Rep 13:248-50. 2011
    ..Despite the imperfections of any meta-structure, we are hopeful that each revision of the nosology will bring with it greater diagnostic validity and clinical utility...
  74. doi Effects of escitalopram on sleep problems in patients with major depression or generalized anxiety disorder
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Groote Schuur Hospital J 2, Observatory 7925, Cape Town, South Africa
    Adv Ther 28:1021-37. 2011
    ..First-line antidepressants, including the selective serotonin reuptake inhibitors (SSRIs) and serotonin noradrenaline reuptake inhibitors (SNRIs), may have different effects on sleep...
  75. doi Efficacy and tolerability of extended release quetiapine fumarate (quetiapine XR) monotherapy in patients with generalised anxiety disorder: an analysis of pooled data from three 8-week placebo-controlled studies
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Hum Psychopharmacol 26:614-28. 2011
    ..Prospectively planned pooled analysis evaluating efficacy and tolerability of acute quetiapine XR monotherapy in generalised anxiety disorder...
  76. ncbi Pharmacotherapy of posttraumatic stress disorder: a review of meta-analyses and treatment guidelines
    Dan J Stein
    Department of Psychiatry and Mental Health, University of Cape Town
    CNS Spectr 14:25-31. 2009
    ..Assessment of these meta-analyses and guidelines provides an opportunity to review the strengths and weaknesses of the evidence-base...
  77. ncbi Cape Town consensus on posttraumatic stress disorder
    Dan J Stein
    CNS Spectr 14:52-8. 2009
    ..We consider, in turn, the diagnosis and evaluation, psychobiology, pharmacotherapy, psychotherapy, and prevention of PTSD...
  78. doi Classifying hypersexual disorders: compulsive, impulsive, and addictive models
    Dan J Stein
    University of Cape Town, Private Bag X3, Rondebosch 7701, Cape Town, South Africa
    Psychiatr Clin North Am 31:587-91. 2008
    ....
  79. doi Onset of activity and time to response on individual CAPS-SX17 items in patients treated for post-traumatic stress disorder with venlafaxine ER: a pooled analysis
    Dan J Stein
    University of Cape Town, Cape Town, South Africa
    Int J Neuropsychopharmacol 12:23-31. 2009
    ..The early and persistent effect of venlafaxine ER over placebo on anger/irritability is noteworthy in view of the clinical significance of these symptoms in PTSD...
  80. pmc Lifetime prevalence of psychiatric disorders in South Africa
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Br J Psychiatry 192:112-7. 2008
    ....
  81. ncbi Post-traumatic stress disorder: medicine and politics
    Dan J Stein
    UCT Department of Psychiatry, Groote Schuur Hospital, J 2, Anzio Road, Observatory 7925, Cape Town, South Africa
    Lancet 369:139-44. 2007
    ..In this Review we discuss the advantages and disadvantages of medicalising trauma response, using examples from South Africa, the Armed Services, and post-disaster, to draw attention to our argument...
  82. ncbi Escitalopram in obsessive-compulsive disorder: a randomized, placebo-controlled, paroxetine-referenced, fixed-dose, 24-week study
    Dan J Stein
    University of Cape Town, Republic of South Africa
    Curr Med Res Opin 23:701-11. 2007
    ..A randomized, placebo controlled fixed-dose trial was undertaken to determine the efficacy and tolerability of escitalopram in obsessive-compulsive disorder (OCD), using paroxetine as the active reference...
  83. pmc The impact of the Truth and Reconciliation Commission on psychological distress and forgiveness in South Africa
    Dan J Stein
    University of Cape Town, Cape Town, South Africa
    Soc Psychiatry Psychiatr Epidemiol 43:462-8. 2008
    ..However, there was also a concern that individuals with TRC relevant experience would simply be re-traumatized by participation in the process. To date, there has been little empirical data for either hypothesis...
  84. ncbi Response of symptom dimensions in obsessive-compulsive disorder to treatment with citalopram or placebo
    Dan J Stein
    University of Cape Town, Cape Town, South Africa
    Rev Bras Psiquiatr 29:303-7. 2007
    ..There is increasing evidence that the symptoms of obsessive-compulsive disorder lie on discrete dimensions. Relatively little work has, however, explored the relationship between such factors and response to pharmacotherapy...
  85. doi Efficacy of agomelatine in generalized anxiety disorder: a randomized, double-blind, placebo-controlled study
    Dan J Stein
    Department of Psychiatry, University of Cape Town, South Africa
    J Clin Psychopharmacol 28:561-6. 2008
    ..A randomized, double-blind, placebo-controlled trial was designed to assess the efficacy of agomelatine in generalized anxiety disorder (GAD)...
  86. ncbi From research methods to clinical practice in psychiatry: challenges and opportunities in the developing world
    Dan J Stein
    Department of Psychiatry, University of Cape Town, South Africa
    Int Rev Psychiatry 19:573-81. 2007
    ..We conclude with a wish list for the way forwards...
  87. doi Is trichotillomania a stereotypic movement disorder? An analysis of body-focused repetitive behaviors in people with hair-pulling
    Dan J Stein
    University of Cape Town, Rondebosch, South Africa
    Ann Clin Psychiatry 20:194-8. 2008
    ..Comorbidity of symptoms might support the idea that they are indicative of an underlying stereotypic disorder, and we therefore explored their frequency in people with hair-pulling...
  88. ncbi Trichotillomania, stereotypic movement disorder, and related disorders
    Dan J Stein
    UCT Department of Psychiatry, Groote Schuur Hospital J 2, Observatory 7925, Cape Town, South Africa
    Curr Psychiatry Rep 9:301-2. 2007
    ..Such disorders deserve greater recognition in the official nosology, and there would seem to be clinical utility in classifying them in the same diagnostic category...
  89. ncbi Psychobiology of anxiety disorders and obsessive-compulsive spectrum disorders
    Dan J Stein
    Department of Psychiatry and Mental Health at the University of Cape Town, Cape Town, South Africa
    CNS Spectr 13:23-8. 2008
    ....
  90. ncbi Which factors predict placebo response in anxiety disorders and major depression? An analysis of placebo-controlled studies of escitalopram
    Dan J Stein
    Department of Psychiatry, University of Cape Town, South Africa
    J Clin Psychiatry 67:1741-6. 2006
    ....
  91. pmc Broadening the definition of generalized anxiety disorder: effects on prevalence and associations with other disorders in the National Comorbidity Survey Replication
    Ayelet Meron Ruscio
    Department of Health Care Policy, Harvard Medical School, USA
    J Anxiety Disord 21:662-76. 2007
    ..Further research is needed to determine whether broadening the current diagnostic criteria results in a more valid characterization of GAD...
  92. doi The neuropsychiatry and neuropsychology of lipoid proteinosis
    Helena B Thornton
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    J Neuropsychiatry Clin Neurosci 20:86-92. 2008
    ..These findings are consistent with involvement of the medial temporal areas in cognitive and emotive processing...
  93. doi Social anxiety disorder
    Murray B Stein
    Department of Psychiatry, University of California San Diego 92093 0855, USA
    Lancet 371:1115-25. 2008
    ....
  94. ncbi Prevalence of obsessive compulsive disorder in first- and multi-episode male patients with schizophrenia-spectrum disorders
    Liezl Koen
    S Afr Med J 93:517-8. 2003
  95. ncbi Endocrine, cognitive and hippocampal/cortical 5HT 1A/2A receptor changes evoked by a time-dependent sensitisation (TDS) stress model in rats
    Brian H Harvey
    Division of Pharmacology, School of Pharmacy, Potchefstroom University for Christian Higher Education, 2520, Potchefstroom, South Africa
    Brain Res 983:97-107. 2003
    ..Moreover, TDS stress induces diverse adaptive 5HT receptor changes in critical brain areas involved in emotion and memory that may underlie the effect of stress on cognitive function...
  96. ncbi Social anxiety disorder
    Debra Kaminer
    MRC Unit on Anxiety Disorders, South Africa
    World J Biol Psychiatry 4:103-10. 2003
    ....
  97. ncbi Algorithm for the pharmacotherapy of anxiety disorders
    Dan J Stein
    Medical Research Council Research Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, PO Box 19063, Tygerberg 7505, South Africa
    Curr Psychiatry Rep 5:282-8. 2003
    ..However, such algorithms run the risk of oversimplifying complex clinical realities, and are only as good as the data on which they rest. In this article, an algorithm for the pharmacotherapy of anxiety disorders is presented...
  98. ncbi What do South African psychiatrists and GPs think, feel and know about evidence-based mental health care?
    Nandi Siegfried
    S Afr Med J 93:114-7. 2003
  99. ncbi Escitalopram prevents relapse of obsessive-compulsive disorder
    Naomi A Fineberg
    Postgraduate Medical School, University of Hertfordshire, Hatfield, United Kingdom
    Eur Neuropsychopharmacol 17:430-9. 2007
    ..These results demonstrate that escitalopram is effective for long-term treatment and relapse prevention in OCD...
  100. ncbi Problematic internet use: proposed classification and diagnostic criteria
    Nathan A Shapira
    Department of Psychiatry, E f and W L McKnight Brain Institute, University of Florida, Gainesville, Florida 32610 0383, USA
    Depress Anxiety 17:207-16. 2003
    ..For these reasons, we propose specific diagnostic criteria that will allow for consistent identification and assist in further study of this behavior...
  101. ncbi Social anxiety disorder: psychobiological and evolutionary underpinnings
    Dan J Stein
    Department of Mental Health and Psychiatry, University of Cape Town, South Africa
    CNS Spectr 12:806-9. 2007
    ....