Dan J Stein

Summary

Affiliation: University of Cape Town
Country: South Africa

Publications

  1. pmc Traditional healers in the treatment of common mental disorders in South Africa
    Katherine Sorsdahl
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    J Nerv Ment Dis 197:434-41. 2009
  2. pmc A survey of participants in two internet support groups for people with hair-pulling
    Belinda R Bruwer
    MRC Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    BMC Psychiatry 5:37. 2005
  3. ncbi request reprint Cosmetic psychopharmacology of anxiety: bioethical considerations
    Dan J Stein
    University of Capetown and Medical Research Council Unit on Anxiety Disorders, Tygerberg 7505, South Africa
    Curr Psychiatry Rep 7:237-8. 2005
  4. ncbi request reprint Which factors predict placebo response in anxiety disorders and major depression? An analysis of placebo-controlled studies of escitalopram
    Dan J Stein
    Department of Psychiatry, University of Cape Town, South Africa
    J Clin Psychiatry 67:1741-6. 2006
  5. ncbi request reprint Evolutionary theory, psychiatry, and psychopharmacology
    Dan J Stein
    University of Cape Town, Cape Town, South Africa
    Prog Neuropsychopharmacol Biol Psychiatry 30:766-73. 2006
  6. ncbi request reprint Advances in understanding the anxiety disorders: the cognitive-affective neuroscience of 'false alarms'
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Ann Clin Psychiatry 18:173-82. 2006
  7. ncbi request reprint Guidelines and algorithms for anxiety disorders: evidence-based excellence or garbage in, garbage out?
    Dan J Stein
    University of Cape Town, Groote Schuur Hospital, Department of Psychiatry, Observatory 7925, South Africa
    Curr Psychiatry Rep 8:253-5. 2006
  8. ncbi request reprint Neurocircuitry of disgust and anxiety in obsessive-compulsive disorder: a positron emission tomography study
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Metab Brain Dis 21:267-77. 2006
  9. ncbi request reprint Obsessive-compulsive spectrum disorders: a multidimensional approach
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Psychiatr Clin North Am 29:343-51. 2006
  10. ncbi request reprint Efficacy of sertraline in posttraumatic stress disorder secondary to interpersonal trauma or childhood abuse
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Ann Clin Psychiatry 18:243-9. 2006

Detail Information

Publications135 found, 100 shown here

  1. pmc Traditional healers in the treatment of common mental disorders in South Africa
    Katherine Sorsdahl
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    J Nerv Ment Dis 197:434-41. 2009
    ..Alternative practitioners, including traditional healers and religious advisors, appear to play a notable role in the delivery of mental health care in South Africa...
  2. pmc A survey of participants in two internet support groups for people with hair-pulling
    Belinda R Bruwer
    MRC Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    BMC Psychiatry 5:37. 2005
    ..This paper reports on the perceived effectiveness of trichotillomania (TTM) internet support groups for people suffering from hair-pulling...
  3. ncbi request reprint Cosmetic psychopharmacology of anxiety: bioethical considerations
    Dan J Stein
    University of Capetown and Medical Research Council Unit on Anxiety Disorders, Tygerberg 7505, South Africa
    Curr Psychiatry Rep 7:237-8. 2005
  4. ncbi request reprint Which factors predict placebo response in anxiety disorders and major depression? An analysis of placebo-controlled studies of escitalopram
    Dan J Stein
    Department of Psychiatry, University of Cape Town, South Africa
    J Clin Psychiatry 67:1741-6. 2006
    ....
  5. ncbi request reprint Evolutionary theory, psychiatry, and psychopharmacology
    Dan J Stein
    University of Cape Town, Cape Town, South Africa
    Prog Neuropsychopharmacol Biol Psychiatry 30:766-73. 2006
    ....
  6. ncbi request reprint Advances in understanding the anxiety disorders: the cognitive-affective neuroscience of 'false alarms'
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Ann Clin Psychiatry 18:173-82. 2006
    ..An integrative framework is required in order to conceptualize this data and to apply it in the clinic...
  7. ncbi request reprint Guidelines and algorithms for anxiety disorders: evidence-based excellence or garbage in, garbage out?
    Dan J Stein
    University of Cape Town, Groote Schuur Hospital, Department of Psychiatry, Observatory 7925, South Africa
    Curr Psychiatry Rep 8:253-5. 2006
  8. ncbi request reprint Neurocircuitry of disgust and anxiety in obsessive-compulsive disorder: a positron emission tomography study
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Metab Brain Dis 21:267-77. 2006
    ..Functional magnetic resonance imaging (fMRI) studies of disgust-inducing visual stimuli in OCD have suggested disorder specific alterations in brain activation during these tasks...
  9. ncbi request reprint Obsessive-compulsive spectrum disorders: a multidimensional approach
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Psychiatr Clin North Am 29:343-51. 2006
    ..As further progress is made in understanding the cognitive-affective neuroscience of OCD and related conditions, constructs about obsessive-compulsive spectrum disorders will become increasingly sharp...
  10. ncbi request reprint Efficacy of sertraline in posttraumatic stress disorder secondary to interpersonal trauma or childhood abuse
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Ann Clin Psychiatry 18:243-9. 2006
    ..This analysis was conducted to specifically assess the efficacy of sertraline in the treatment of PTSD secondary to interpersonal trauma or childhood abuse...
  11. ncbi request reprint Hoarding in obsessive-compulsive disorder: clinical and genetic correlates
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    J Clin Psychiatry 66:1155-60. 2005
    ..The clinical and genetic correlates of hoarding in OCD therefore deserve additional investigation...
  12. pmc Subtyping social anxiety disorder in developed and developing countries
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Depress Anxiety 27:390-403. 2010
    ..We aimed to determine whether this holds across a broader set of developed and developing countries, and whether subtyping according to number of performance versus interactional fears would be more useful...
  13. ncbi request reprint Cluster analysis of obsessive-compulsive spectrum disorders in patients with obsessive-compulsive disorder: clinical and genetic correlates
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg, 7505, Cape Town, South Africa
    Compr Psychiatry 46:14-9. 2005
    ..Comorbidity of the putative OCSDs in OCD has, however, not often been systematically investigated...
  14. doi request reprint Characterization of HIV-Associated Neurocognitive Disorders among individuals starting antiretroviral therapy in South Africa
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    AIDS Behav 15:1197-203. 2011
    ..In a regression model, a lower level of education and male gender were predictive of HIV-D. These findings suggest that HAND are highly prevalent in primary care settings in South Africa where clade C HIV is predominant...
  15. ncbi request reprint Corrigendum to "gender in obsessive-compulsive disorder: clinical and genetic findings" [Eur. Neuropsychopharmacol. 14 (2004) 105-113]
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Eur Neuropsychopharmacol 14:437-45. 2004
    ..There is increasing recognition that obsessive-compulsive disorder (OCD) is not a homogeneous entity. It has been suggested that gender may contribute to the clinical and biological heterogeneity of OCD...
  16. doi request reprint Comorbid obsessive-compulsive personality disorder in obsessive-compulsive disorder (OCD): a marker of severity
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    Prog Neuropsychopharmacol Biol Psychiatry 35:1087-92. 2011
    ..It remains unclear, however, whether OCPD in OCD represents a distinct subtype of OCD or whether it is simply a marker of severity in OCD...
  17. pmc Disability and treatment of psychiatric and physical disorders in South Africa
    Sharain Suliman
    MRC Anxiety and Stress Disorders Unit, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    J Nerv Ment Dis 198:8-15. 2010
    ..Despite high rates of mental disorders and associated disability in South Africa, they are less likely to be treated than physical disorders...
  18. ncbi request reprint Early- versus late-onset obsessive-compulsive disorder: investigating genetic and clinical correlates
    Sian M J Hemmings
    MRC Unit on Anxiety and Stress Disorders, University of Stellenbosch, Medical School, PO Box 19063, Tygerberg 7505, South Africa
    Psychiatry Res 128:175-82. 2004
    ..These data support a role for the dopaminergic system, which may be relevant to the development of early-onset OCD...
  19. doi request reprint Is trichotillomania a stereotypic movement disorder? An analysis of body-focused repetitive behaviors in people with hair-pulling
    Dan J Stein
    University of Cape Town, Rondebosch, South Africa
    Ann Clin Psychiatry 20:194-8. 2008
    ..Comorbidity of symptoms might support the idea that they are indicative of an underlying stereotypic disorder, and we therefore explored their frequency in people with hair-pulling...
  20. pmc The impact of the Truth and Reconciliation Commission on psychological distress and forgiveness in South Africa
    Dan J Stein
    University of Cape Town, Cape Town, South Africa
    Soc Psychiatry Psychiatr Epidemiol 43:462-8. 2008
    ..However, there was also a concern that individuals with TRC relevant experience would simply be re-traumatized by participation in the process. To date, there has been little empirical data for either hypothesis...
  21. doi request reprint Catechol-o-methyltransferase genotype and childhood trauma may interact to impact schizotypal personality traits
    Jonathan Savitz
    MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Behav Genet 40:415-23. 2010
    ..We raise the possibility that genetically-driven variation in COMT may interact with childhood trauma to contribute to the risk of developing schizotypal personality traits...
  22. doi request reprint Altered prefrontal cortical function during processing of fear-relevant stimuli in pregnancy
    Annerine Roos
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, P O Box 19063, Tygerberg 7505, South Africa
    Behav Brain Res 222:200-5. 2011
    ....
  23. doi request reprint Relationship between apolipoprotein E4 genotype and white matter integrity in HIV-positive young adults in South Africa
    Jacqueline Hoare
    Department of Psychiatry and Mental Health, University of Cape Town, Anzio Road Observatory, Cape Town 7925, South Africa
    Eur Arch Psychiatry Clin Neurosci 263:189-95. 2013
    ..007). These data indicate that the ε4 allelic variant of ApoE is associated with memory impairment and white matter damage of the corpus callosum in HIV-positive subjects...
  24. ncbi request reprint Dissociative experiences in obsessive-compulsive disorder and trichotillomania: clinical and genetic findings
    Christine Lochner
    Medical Research Council Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenboch, Cape Town, South Africa
    Compr Psychiatry 45:384-91. 2004
    ..g., lower age) and comorbidity profile (e.g., increased incidence of impulse dyscontrol disorders). Additional work is necessary before conclusions about the role of monoaminergic systems in mediating such dissociation can be drawn...
  25. doi request reprint Cumulative effect of multiple trauma on symptoms of posttraumatic stress disorder, anxiety, and depression in adolescents
    Sharain Suliman
    Department of Psychiatry, Stellenbosch University, Cape Town, South Africa
    Compr Psychiatry 50:121-7. 2009
    ..Against the backdrop of stressful life events and childhood abuse and neglect, we investigated the cumulative effect of multiple trauma exposure on PTSD, anxiety, and depression in an adolescent sample...
  26. pmc Intermittent explosive disorder in South Africa: prevalence, correlates and the role of traumatic exposures
    Dylan Fincham
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Stellenbosch, South Africa
    Psychopathology 42:92-8. 2009
    ..In South Africa, given the high rates of violence and trauma, there is particular interest in traumatic exposures as potential risk factors for IED...
  27. ncbi request reprint Cluster analysis of obsessive-compulsive symptomatology: identifying obsessive-compulsive disorder subtypes
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    Isr J Psychiatry Relat Sci 45:164-76. 2008
    ..There is increasing evidence that obsessive-compulsive disorder (OCD) is a heterogeneous disorder. Different clinical subtypes may be characterized by differing pathophysiological mechanisms and treatment outcomes...
  28. pmc Early childhood adversity and later hypertension: data from the World Mental Health Survey
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Groote Schur Hospital, Anzio Road, Cape Town, South Africa
    Ann Clin Psychiatry 22:19-28. 2010
    ....
  29. ncbi request reprint The relationship between childhood abuse and dissociation. Is it influenced by catechol-O-methyltransferase (COMT) activity?
    Jonathan B Savitz
    MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    Int J Neuropsychopharmacol 11:149-61. 2008
    ..The current findings support the involvement of the COMT Val158Met polymorphism in mediating the relationship between trauma and psychopathology...
  30. pmc Single photon emission computed tomography (SPECT) of anxiety disorders before and after treatment with citalopram
    Paul D Carey
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, 7505, Cape Town, South Africa
    BMC Psychiatry 4:30. 2004
    ..This paper further examines the notion of overlap in the neurocircuitry of treatment and indeed treatment response across anxiety disorders with SSRI treatment...
  31. pmc Dissociation in posttraumatic stress disorder: evidence from the world mental health surveys
    Dan J Stein
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    Biol Psychiatry 73:302-12. 2013
    ..Cross-national population epidemiologic surveys were analyzed to evaluate generalizability of the subtype in more diverse samples...
  32. doi request reprint Reduced fear-recognition sensitivity following acute buprenorphine administration in healthy volunteers
    Jonathan C Ipser
    Department of Psychiatry, University of Cape Town, South Africa
    Psychoneuroendocrinology 38:166-70. 2013
    ..Moreover, the absence of an effect of buprenorphine on mood provides evidence of a direct influence of opioids upon the core fear system in the human brain...
  33. pmc Evidence for fractional anisotropy and mean diffusivity white matter abnormalities in the internal capsule and cingulum in patients with obsessive-compulsive disorder
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    J Psychiatry Neurosci 37:193-9. 2012
    ..In this study, we used diffusion tensor imaging (DTI) to examine white matter integrity in specific regions of interest (ROIs) in patients with OCD...
  34. doi request reprint White matter correlates of apathy in HIV-positive subjects: a diffusion tensor imaging study
    Jacqueline Hoare
    Department of Psychiatry and Mental Health, University of Cape Town, Anzio Road Observatory, 7925, Cape Town, South Africa
    J Neuropsychiatry Clin Neurosci 22:313-20. 2010
    ..Results of the study confirmed the hypothesis which anticipated changes associated with apathy in white matter tracts that relay through the medial prefrontal cortex...
  35. ncbi request reprint Escitalopram in obsessive-compulsive disorder: response of symptom dimensions to pharmacotherapy
    Dan J Stein
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    CNS Spectr 13:492-8. 2008
    ..The response of OCD symptom dimensions to 12 weeks of treatment with escitalopram or placebo was investigated...
  36. doi request reprint Neuropsychological task performance in bipolar spectrum illness: genetics, alcohol abuse, medication and childhood trauma
    Jonathan B Savitz
    Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Bipolar Disord 10:479-94. 2008
    ....
  37. doi request reprint Knowledge of and stigma associated with mental disorders in a South african community sample
    Katherine R Sorsdahl
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    J Nerv Ment Dis 198:742-7. 2010
    ..Further effort is required to educate the public about the psychobiological underpinnings of psychiatric disorders and about the value of effective treatments...
  38. doi request reprint Changes in regional brain volumes in social anxiety disorder following 12 weeks of treatment with escitalopram
    Naseema Cassimjee
    Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg 7505, South Africa
    Metab Brain Dis 25:369-74. 2010
    ..These preliminary findings require replication to determine their reliability, and extension to determine whether or not they are disorder specific...
  39. pmc Obsessive-compulsive disorder and trichotillomania: a phenomenological comparison
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    BMC Psychiatry 5:2. 2005
    ..Nevertheless, there is evidence of important differences between these two disorders. Some authors have conceptualized the disorders as lying on an OCD spectrum of conditions...
  40. doi request reprint Reliability of the lay adherence counsellor administered substance abuse and mental illness symptoms screener (SAMISS) and the International HIV Dementia Scale (IHDS) in a primary care HIV clinic in Cape Town, South Africa
    Erica Breuer
    Centre for Public Mental Health, Department of Psychiatry and Mental Health, University of Cape Town, Rondebosch, Cape Town, South Africa
    AIDS Behav 16:1464-71. 2012
    ....
  41. doi request reprint Recall of early non-fatal suicidality in a nationally representative sample of South Africans
    Ermien van Pletzen
    Centre for Higher Education Development, University of Cape Town, Cape Town, South Africa
    Ethn Health 17:149-59. 2012
    ..We investigated the prevalence of self-reported early suicidality (suicidal ideation, planning and attempts) in a nationally representative sample of South Africans...
  42. pmc Neuropsychological outcomes in adults commencing highly active anti-retroviral treatment in South Africa: a prospective study
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 12:39. 2012
    ..To date, there have been no cohort studies of the impact of highly active anti-retroviral treatment (HAART) in South Africa where clade C HIV is predominant...
  43. doi request reprint White-Matter damage in Clade C HIV-positive subjects: a diffusion tensor imaging study
    Jacqueline Hoare
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    J Neuropsychiatry Clin Neurosci 23:308-15. 2011
    ..This study provides evidence that white-matter integrity is compromised in individuals infected with clade C HIV...
  44. ncbi request reprint Social anxiety disorder: psychobiological and evolutionary underpinnings
    Dan J Stein
    Department of Mental Health and Psychiatry, University of Cape Town, South Africa
    CNS Spectr 12:806-9. 2007
    ....
  45. doi request reprint Common mental disorders among HIV-infected individuals in South Africa: prevalence, predictors, and validation of brief psychiatric rating scales
    Landon Myer
    Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    AIDS Patient Care STDS 22:147-58. 2008
    ..More generally, HIV care and treatment services represent an important venue to identify and manage individuals with common mental disorders in resource-limited settings...
  46. ncbi request reprint Investigating the possible effects of trauma experiences and 5-HTT on the dissociative experiences of patients with OCD using path analysis and multiple regression
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    Neuropsychobiology 56:6-13. 2007
    ..Here, two different but related statistical techniques (multiple regression and partial least squares), confirmed that physical neglect and the 5-HTT genotype jointly play a role in predicting dissociation in OCD...
  47. ncbi request reprint Psychobiology of mindfulness
    Dan J Stein
    Department of Psychiatry and Mental Health at the University of Cape Town, Cape Town, South Africa
    CNS Spectr 13:752-6. 2008
    ..A number of rigorous studies of mindfulness-based cognitive therapy for depression have been positive. However, much remains to be discovered about the underlying mechanisms of and clinical indications for mindfulness-based approaches...
  48. pmc Quetiapine augmentation of SRIs in treatment refractory obsessive-compulsive disorder: a double-blind, randomised, placebo-controlled study [ISRCTN83050762]
    Paul D Carey
    MRC Research Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    BMC Psychiatry 5:5. 2005
    ..Quetiapine is generally well tolerated and previous open-label data has produced mixed results in OCD and additional controlled data is needed...
  49. ncbi request reprint Brain-derived neurotrophic factor: the neurotrophin hypothesis of psychopathology
    Dan J Stein
    Department of Psychiatry and Mental Health at the University of Cape Town, Cape Town, South Africa
    CNS Spectr 13:945-9. 2008
    ..Nevertheless, the neurotrophin hypothesis has already given impetus to a range of valuable research...
  50. doi request reprint Validity of the International HIV Dementia Scale in South Africa
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, South Africa
    AIDS Patient Care STDS 25:95-101. 2011
    ..Variable performance in neuropsychological testing may account for false negative screens. The inclusion of brief tests of executive function in a screening battery should be considered...
  51. doi request reprint Grey matter abnormalities in social anxiety disorder: a pilot study
    Supriya Syal
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    Metab Brain Dis 27:299-309. 2012
    ..Additional work is needed to investigate the causal mechanisms involved in such structural abnormalities in SAD...
  52. doi request reprint Sensitivity and specificity of a visual depression screening instrument among HIV-positive individuals in Uganda, an area with low literacy
    Dickens Akena
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    AIDS Behav 16:2399-406. 2012
    ..The AVIDI demonstrated a good psychometric property and can therefore be used to screen for depression in settings with higher rates of illiteracy...
  53. pmc Characterization of South African adolescents with alcohol use disorders but without psychiatric or polysubstance comorbidity
    Helen L Ferrett
    Department of Psychiatry, Stellenbosch University, Tygerberg, South Africa
    Alcohol Clin Exp Res 35:1705-15. 2011
    ..Here, we characterize a unique sample of treatment-naïve adolescents without such comorbidity to help identify vulnerable youth who may benefit from early intervention...
  54. doi request reprint Differential effects of escitalopram challenge on disgust processing in obsessive-compulsive disorder
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    Behav Brain Res 226:274-80. 2012
    ....
  55. doi request reprint Chronic hair-pulling: phenomenology-based subtypes
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    J Anxiety Disord 24:196-202. 2010
    ..Future work, incorporating further investigation of the role of gender and psychobiological and treatment outcomes, is needed before definitive conclusions about hair-pulling subtypes can be drawn...
  56. ncbi request reprint Anxiety symptom severity and functional recovery or relapse
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Groote Schuur Hospital J 2, Anzio Rd, Observatory 7925, Cape Town, South Africa
    Ann Clin Psychiatry 21:81-8. 2009
    ..Recovery could potentially be defined as a lack of disability, with an associated reduction in symptom severity. Conversely, relapse could potentially be defined in terms of either increased disability or increased symptoms...
  57. doi request reprint The prevalence and predictors of stigma amongst people living with HIV/AIDS in the Western Province
    Katherine R Sorsdahl
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    AIDS Care 23:680-5. 2011
    ..There are a number of possible reasons for low reports of HIV-related stigma, including having access to treatment and not disclosing HIV status...
  58. doi request reprint Should OCD be classified as an anxiety disorder in DSM-V?
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Depress Anxiety 27:495-506. 2010
    ..If this change is made, the name of this category should be changed to reflect this proposed change...
  59. ncbi request reprint Single photon emission computed tomography in posttraumatic stress disorder before and after treatment with a selective serotonin reuptake inhibitor
    Soraya Seedat
    Department of Psychiatry, University of Stellenbosch, Tygerberg, 7505, Cape Town, South Africa
    J Affect Disord 80:45-53. 2004
    ..However, the neural substrates of PTSD remain poorly understood and the effect of selective serotonin reuptake inhibition on regional cerebral activity is deserving of further investigation...
  60. ncbi request reprint An A-B-C model of habit disorders: hair-pulling, skin-picking, and other stereotypic conditions
    Dan J Stein
    Department of Mental Health and Psychiatry, University of Cape Town, South Africa
    CNS Spectr 11:824-7. 2006
    ..An affect regulation, behavioral addiction, and cognitive control (A-B-C) approach is outlined to conceptualizing and managing these conditions...
  61. ncbi request reprint Beauty and the beast: Psychobiologic and evolutionary perspectives on body dysmorphic disorder
    Dan J Stein
    Department of Psychiatry, University of Cape Town, South Africa
    CNS Spectr 11:419-22. 2006
    ..Speculatively, disruptions in cognitive-affective processes relevant to judgements about physical beauty lead to BDD...
  62. doi request reprint Selective attention to fearful faces during pregnancy
    Annerine Roos
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, Stellenbosch University, P O Box 19063, Tygerberg 7505, South Africa
    Prog Neuropsychopharmacol Biol Psychiatry 37:76-80. 2012
    ....
  63. pmc Predictors of transitions across stages of alcohol use and alcohol-use disorders in South Africa
    Sharain Suliman
    Medical Research Council Anxiety and Stress Disorders Unit, Department of Psychiatry, University of Stellenbosch, P O Box 19063, Tygerberg 7505, Cape Town, South Africa
    J Stud Alcohol Drugs 71:695-703. 2010
    ....
  64. pmc Risk for post-traumatic stress disorder associated with different forms of interpersonal violence in South Africa
    Debra Kaminer
    Department of Psychology, University of Cape Town, South Africa
    Soc Sci Med 67:1589-95. 2008
    ..Recommendations for mental health service provision in South Africa and for future research on the relative risk for PTSD are offered...
  65. pmc Perceived mental effort correlates with changes in tonic arousal during attentional tasks
    Fleur M Howells
    Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa
    Behav Brain Funct 6:39. 2010
    ....
  66. pmc Cross-national analysis of the associations between traumatic events and suicidal behavior: findings from the WHO World Mental Health Surveys
    Dan J Stein
    Department of Psychiatry, Groote Schuur Hospital, Cape Town, South Africa
    PLoS ONE 5:e10574. 2010
    ..Moreover, few data are available on such associations in developing countries. The current study addresses each of these issues...
  67. ncbi request reprint Persistence of psychiatric disorders in a cohort of HIV/AIDS patients in South Africa: a 6-month follow-up study
    Benjamin O Olley
    Department of Psychiatry, MRC Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    J Psychosom Res 61:479-84. 2006
    ..However, there are few prospective studies on the rates of psychiatric disorders in HIV/AIDS, particularly in the context of the developing world...
  68. ncbi request reprint Genetics and personality traits in patients with social anxiety disorder: a case-control study in South Africa
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    Eur Neuropsychopharmacol 17:321-7. 2007
    ..to compare differences in temperament dimensions between carriers of different (dominant vs. recessive) alleles for selected polymorphisms in SAD patients...
  69. doi request reprint Neuropsychological status of bipolar I disorder: impact of psychosis
    Jonathan Savitz
    Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    Br J Psychiatry 194:243-51. 2009
    ....
  70. doi request reprint Clinical correlates of HIV-associated neurocognitive disorders in South Africa
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, South Africa, Anzio Road, Observatory, Cape Town 7925, South Africa
    AIDS Behav 14:371-8. 2010
    ..This underlines the impact of HIV on the nervous system and the importance of screening for co morbid mental health conditions...
  71. doi request reprint Evaluating the behavioural consequences of early maternal separation in adult C57BL/6 mice; the importance of time
    Johan H van Heerden
    Department of Molecular and Cell Biology, University of Cape Town, Private Bag 7701, Rondebosch, South Africa
    Behav Brain Res 207:332-42. 2010
    ..The extension of conventional analysis strategies, to include time as a significant dimension of behaviour on the EPM, identified behavioural nuances, which could reflect adaptive aspects of stress-driven behaviours in MS mice...
  72. ncbi request reprint Response of symptom dimensions in obsessive-compulsive disorder to treatment with citalopram or placebo
    Dan J Stein
    University of Cape Town, Cape Town, South Africa
    Rev Bras Psiquiatr 29:303-7. 2007
    ..There is increasing evidence that the symptoms of obsessive-compulsive disorder lie on discrete dimensions. Relatively little work has, however, explored the relationship between such factors and response to pharmacotherapy...
  73. ncbi request reprint Escitalopram in the treatment of multisomatoform disorder: a double-blind, placebo-controlled trial
    Jacqueline E Muller
    Department of Psychiatry, Stellenbosch University, South Africa
    Int Clin Psychopharmacol 23:43-8. 2008
    ..Compared with placebo, escitalopram was associated with lower symptom scores, increased response and remission rates, and improved functioning...
  74. ncbi request reprint Trauma and posttraumatic stress disorder in an urban Xhosa primary care population: prevalence, comorbidity, and service use patterns
    Paul D Carey
    MRC Unit for Stress and Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg 7505, Cape Town, South Africa
    J Nerv Ment Dis 191:230-6. 2003
    ..In this population, trauma and PTSD were highly prevalent and associated with significant unidentified morbidity and comorbidity. Patients remain untreated for years in the current system of primary care consultations...
  75. doi request reprint The validity of DSM-IV-TR criteria B and C of hair-pulling disorder (trichotillomania): evidence from a clinical study
    Christine Lochner
    Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    Psychiatry Res 189:276-80. 2011
    ..Our study does not provide convincing support for the inclusion of the current diagnostic criteria B and C for TTM in DSM-5...
  76. ncbi request reprint Measuring anxiety in patients with schizophrenia
    Soraya Seedat
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    J Nerv Ment Dis 195:320-4. 2007
    ..Accurate assessment is challenging yet important. More reliable measures of anxiety disorders in patients with schizophrenia and other psychotic disorders are clearly needed to allow for timely identification and treatment...
  77. ncbi request reprint Trichotillomania and skin-picking: a phenomenological comparison
    Christine Lochner
    Department of Psychiatry, MRC Unit on Stress and Anxiety Disorder, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Depress Anxiety 15:83-6. 2002
    ..Future work to assess the implications of overlap for clinical evaluation and intervention in the two conditions may be useful...
  78. ncbi request reprint Community attitudes toward and knowledge of mental illness in South Africa
    Charmaine J Hugo
    MRC Unit on Anxiety Disorders, Dept of Psychiatry, University of Stellenbosch, Tygerberg 7505, South Africa
    Soc Psychiatry Psychiatr Epidemiol 38:715-9. 2003
    ..Nevertheless, there is little research on the attitudes of lay persons toward mental illness within the South African community...
  79. doi request reprint Posttraumatic stress disorder symptoms in adolescents: risk factors versus resilience moderation
    Dylan S Fincham
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg, Cape Town 7505, South Africa
    Compr Psychiatry 50:193-9. 2009
    ..Although evidence suggests that resilience may moderate the relationship between some of these risk factors and PTSD symptoms, no studies to date have examined these risk factors collectively...
  80. ncbi request reprint What is the self? A psychobiological perspective
    Dan J Stein
    Department of Mental Health and Psychiatry, University of Cape Town, South Africa
    CNS Spectr 12:333-6. 2007
    ..A cognitive-affective neuroscience approach provides a conceptual basis from which clinical research can further explore how best to assess and treat a wide range of disruptions to the self...
  81. ncbi request reprint Escitalopram in the treatment of social anxiety disorder: analysis of efficacy for different clinical subgroups and symptom dimensions
    Dan J Stein
    MRC Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    Depress Anxiety 20:175-81. 2004
    ..A six-factor model of social anxiety symptoms is supported by the distinctive association between these symptom dimensions and different areas of disability, but did not predict differential response to escitalopram...
  82. ncbi request reprint Panic disorder: the psychobiology of external treat and introceptive distress
    Dan J Stein
    Department of Psychiatry and Mental Health, University of Cape Town, South Africa
    CNS Spectr 13:26-30. 2008
    ..Genetic and environmental contributors to panic disorder are beginning to be delineated. Effective pharmacotherapy and psychotherapy are able to normalize the relevant psychobiology...
  83. ncbi request reprint Posttraumatic stress disorder and occupational disability in South African Security Force members
    Robin A Emsley
    Department of Psychiatry and Medical Research Council Unit for Anxiety and Stress Disorders, University of Stellenbosch, PO Box 19063, Tygerberg 7505, Cape Town, South Africa
    J Nerv Ment Dis 191:237-41. 2003
    ..These findings suggest that posttrauma factors may be as important as pretrauma and peritrauma variables in the development of PTSD...
  84. ncbi request reprint The psychiatric sequelae of human rights violations: a challenge for primary health care
    Nompumelelo Zungu-Dirwayi
    Medical Research Council Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    J Nerv Ment Dis 192:255-9. 2004
    ..Misdiagnosis and ineffective treatment of survivors of human rights abuses are likely to pose a significant drain on primary care resources. Accurate diagnosis and appropriate treatment are important challenges in primary care settings...
  85. ncbi request reprint Gender in obsessive-compulsive disorder: clinical and genetic findings
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, P O Box 19063, Tygerberg 7505, Cape Town, South Africa
    Eur Neuropsychopharmacol 14:105-13. 2004
    ..There is increasing recognition that obsessive-compulsive disorder (OCD) is not a homogeneous entity. It has been suggested that gender may contribute to the clinical and biological heterogeneity of OCD...
  86. ncbi request reprint Efficacy of paroxetine for relapse prevention in social anxiety disorder: a 24-week study
    Dan J Stein
    University of Stellenbosch, Fransie van Zyl Dr, Tygerberg 7505, Cape Town, South Africa
    Arch Gen Psychiatry 59:1111-8. 2002
    ..The efficacy of selective serotonin reuptake inhibitors in the acute treatment of social anxiety disorder (social phobia) is well established...
  87. ncbi request reprint Prevalence and characteristics of trauma and post-traumatic stress symptoms in operational members of the South African National Defence Force
    Soraya Seedat
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, P O Box 19063, Tygerberg, 7505, Cape Town, South Africa
    Mil Med 168:71-5. 2003
    ..These findings highlight the high rates of exposure to multiple, noncombat-related trauma in military personnel, the potentially high rates of PTSD, and the role of inflicted trauma as an additional risk factor for PTSD...
  88. ncbi request reprint 5-HT2A: its role in frontally mediated executive function and related psychopathology
    Dan J Stein
    Department of Mental Health and Psychiatry, University of Cape Town, South Africa
    CNS Spectr 12:512-6. 2007
    ..Conversely, many antidepressants result in decreased levels of 5-HT2A receptor levels, and blockade of 5-HT2A receptors has proven useful in the treatment of a number of psychiatric disorders...
  89. doi request reprint Does highly active antiretroviral therapy improve neurocognitive function? A systematic review
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    J Neurovirol 16:101-14. 2010
    ..Studies examining the long-term effects of HAART on HIV-associated neurocognitive disorders (HANDs) using uniform methods of data collection are needed, together with clear reporting of HAART regimens...
  90. pmc Household food insufficiency and mental health in South Africa
    Katherine Sorsdahl
    J Block Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa
    J Epidemiol Community Health 65:426-31. 2011
    ..The relationship between food insufficiency and mental disorders within a nationally representative sample of South African adults was examined...
  91. doi request reprint Traditional healer attitudes and beliefs regarding referral of the mentally ill to Western doctors in South Africa
    Katherine Sorsdahl
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    Transcult Psychiatry 47:591-609. 2010
    ..Recommendations include the need for traditional healers to be trained to identify potential cases of mental illness in their communities and for dialogue between traditional and allopathic physicians in regard to mental health care...
  92. doi request reprint Association between antenatal distress and uterine artery pulsatility index
    Bavanisha Vythilingum
    Department of Psychiatry J Block, Groote Schuur Hospital, University of Cape Town, Anzio Road, Observatory, Cape Town, 7925, South Africa
    Arch Womens Ment Health 13:359-64. 2010
    ....
  93. doi request reprint Association between apolipoprotein E4 genotype and human immunodeficiency virus-associated dementia in younger adults starting antiretroviral therapy in South Africa
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, South Africa
    J Neurovirol 16:377-83. 2010
    ..These findings suggest that the ε4 allelic variant in HIV-positive individuals is not associated with the development of HAD in Southern Africa...
  94. ncbi request reprint Childhood trauma in obsessive-compulsive disorder, trichotillomania, and controls
    Christine Lochner
    MRC Unit on Stress and Anxiety Disorders, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Depress Anxiety 15:66-8. 2002
    ....
  95. ncbi request reprint Psychobiology of anxiety disorders and obsessive-compulsive spectrum disorders
    Dan J Stein
    Department of Psychiatry and Mental Health at the University of Cape Town, Cape Town, South Africa
    CNS Spectr 13:23-8. 2008
    ....
  96. doi request reprint Perspectives towards mental illness in people living with HIV/AIDS in South Africa
    Katherine R Sorsdahl
    Department of Psychiatry and Mental Health, University of Cape Town, Groote Schuur Hospital, South Africa
    AIDS Care 22:1418-27. 2010
    ..Interventions designed to increase mental health literacy and reduce the stigma associated with psychiatric disorders may increase the likelihood of PLWHA seeking treatment should they suffer from these conditions...
  97. ncbi request reprint A systematic review of the quality and impact of anxiety disorder meta-analyses
    Jonathan C Ipser
    Department of Psychiatry and Mental Health, University of Cape Town, Groote Schuur Hospital, Anzio Road, Observatory, Cape Town, South Africa
    Curr Psychiatry Rep 11:302-9. 2009
    ..A list of the meta-analyses included in this review is available on an evidence-based website of anxiety and trauma-related disorders...
  98. doi request reprint Efficacy of agomelatine in generalized anxiety disorder: a randomized, double-blind, placebo-controlled study
    Dan J Stein
    Department of Psychiatry, University of Cape Town, South Africa
    J Clin Psychopharmacol 28:561-6. 2008
    ..A randomized, double-blind, placebo-controlled trial was designed to assess the efficacy of agomelatine in generalized anxiety disorder (GAD)...
  99. doi request reprint Pharmacotherapy for social anxiety disorder: a systematic review
    Jonathan C Ipser
    UCT Department of Psychiatry and Mental Health, Groote Schuur Hospital, J 2 Anzio Road, Observatory, 7925, South Africa
    Expert Rev Neurother 8:235-57. 2008
    ..Cochrane Reviews are regularly updated as new evidence emerges and in response to feedback, and The Cochrane Library should be consulted for the most recent version of the review...
  100. doi request reprint Classifying hypersexual disorders: compulsive, impulsive, and addictive models
    Dan J Stein
    University of Cape Town, Private Bag X3, Rondebosch 7701, Cape Town, South Africa
    Psychiatr Clin North Am 31:587-91. 2008
    ....
  101. pmc Social determinants of psychological distress in a nationally-representative sample of South African adults
    Landon Myer
    School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    Soc Sci Med 66:1828-40. 2008
    ....