Dan J Stein

Summary

Affiliation: University of Stellenbosch
Country: South Africa

Publications

  1. ncbi request reprint The Truth and Reconciliation Commission in South Africa: relation to psychiatric status and forgiveness among survivors of human rights abuses
    D Kaminer
    Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    Br J Psychiatry 178:373-7. 2001
  2. pmc Quetiapine augmentation of SRIs in treatment refractory obsessive-compulsive disorder: a double-blind, randomised, placebo-controlled study [ISRCTN83050762]
    Paul D Carey
    MRC Research Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    BMC Psychiatry 5:5. 2005
  3. pmc Pharmacological challenge with a serotonin 1D agonist in alcohol dependence
    Bavanisha Vythilingum
    MRC, Dept of Psychiatry, University of Stellenbosch, South Africa
    BMC Psychiatry 5:31. 2005
  4. pmc Comparison of pain, cortisol levels, and psychological distress in women undergoing surgical termination of pregnancy under local anaesthesia versus intravenous sedation
    Sharain Suliman
    MRC Research Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    BMC Psychiatry 7:24. 2007
  5. ncbi request reprint Fluvoxamine CR in the long-term treatment of social anxiety disorder: the 12- to 24-week extension phase of a multicentre, randomized, placebo-controlled trial
    Dan J Stein
    MRC Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa, and University of Florida, Gainesville, FL, USA
    Int J Neuropsychopharmacol 6:317-23. 2003
  6. doi request reprint Efficacy of pregabalin in depressive symptoms associated with generalized anxiety disorder: a pooled analysis of 6 studies
    Dan J Stein
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    Eur Neuropsychopharmacol 18:422-30. 2008
  7. ncbi request reprint Algorithm for the pharmacotherapy of anxiety disorders
    Dan J Stein
    Medical Research Council Research Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, PO Box 19063, Tygerberg 7505, South Africa
    Curr Psychiatry Rep 5:282-8. 2003
  8. ncbi request reprint The selective serotonin reuptake inhibitor paroxetine is effective in more generalized and in less generalized social anxiety disorder
    D J Stein
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Psychopharmacology (Berl) 158:267-72. 2001
  9. ncbi request reprint Efficacy of paroxetine for relapse prevention in social anxiety disorder: a 24-week study
    Dan J Stein
    University of Stellenbosch, Fransie van Zyl Dr, Tygerberg 7505, Cape Town, South Africa
    Arch Gen Psychiatry 59:1111-8. 2002
  10. ncbi request reprint Functional brain imaging and pharmacotherapy in trichotillomania. Single photon emission computed tomography before and after treatment with the selective serotonin reuptake inhibitor citalopram
    Dan J Stein
    Department of Psychiatry, University of Stellenbosch, P O Box 19063, Tygerberg 7505, Cape Town, South Africa
    Prog Neuropsychopharmacol Biol Psychiatry 26:885-90. 2002

Collaborators

Detail Information

Publications180 found, 100 shown here

  1. ncbi request reprint The Truth and Reconciliation Commission in South Africa: relation to psychiatric status and forgiveness among survivors of human rights abuses
    D Kaminer
    Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    Br J Psychiatry 178:373-7. 2001
    ..Lack of forgiveness may be an important predictor of psychiatric risk in this population...
  2. pmc Quetiapine augmentation of SRIs in treatment refractory obsessive-compulsive disorder: a double-blind, randomised, placebo-controlled study [ISRCTN83050762]
    Paul D Carey
    MRC Research Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    BMC Psychiatry 5:5. 2005
    ..Quetiapine is generally well tolerated and previous open-label data has produced mixed results in OCD and additional controlled data is needed...
  3. pmc Pharmacological challenge with a serotonin 1D agonist in alcohol dependence
    Bavanisha Vythilingum
    MRC, Dept of Psychiatry, University of Stellenbosch, South Africa
    BMC Psychiatry 5:31. 2005
    ..Administration of sumatriptan should therefore produce a craving for alcohol and the desire to drink...
  4. pmc Comparison of pain, cortisol levels, and psychological distress in women undergoing surgical termination of pregnancy under local anaesthesia versus intravenous sedation
    Sharain Suliman
    MRC Research Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    BMC Psychiatry 7:24. 2007
    ..This study compared the effects of local anaesthesia and intravenous sedation, administered for elective surgical termination, on outcomes of pain, cortisol, and psychological distress...
  5. ncbi request reprint Fluvoxamine CR in the long-term treatment of social anxiety disorder: the 12- to 24-week extension phase of a multicentre, randomized, placebo-controlled trial
    Dan J Stein
    MRC Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa, and University of Florida, Gainesville, FL, USA
    Int J Neuropsychopharmacol 6:317-23. 2003
    ....
  6. doi request reprint Efficacy of pregabalin in depressive symptoms associated with generalized anxiety disorder: a pooled analysis of 6 studies
    Dan J Stein
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    Eur Neuropsychopharmacol 18:422-30. 2008
    ..In conclusion, pregabalin, an alternative treatment option for GAD with a novel mechanism of action, also demonstrated efficacy in treating depressive symptoms typically encountered in GAD patients...
  7. ncbi request reprint Algorithm for the pharmacotherapy of anxiety disorders
    Dan J Stein
    Medical Research Council Research Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, PO Box 19063, Tygerberg 7505, South Africa
    Curr Psychiatry Rep 5:282-8. 2003
    ..However, such algorithms run the risk of oversimplifying complex clinical realities, and are only as good as the data on which they rest. In this article, an algorithm for the pharmacotherapy of anxiety disorders is presented...
  8. ncbi request reprint The selective serotonin reuptake inhibitor paroxetine is effective in more generalized and in less generalized social anxiety disorder
    D J Stein
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Psychopharmacology (Berl) 158:267-72. 2001
    ..There are, however, few data to address whether more generalized and less generalized subgroups of social anxiety disorder differ in response to medication...
  9. ncbi request reprint Efficacy of paroxetine for relapse prevention in social anxiety disorder: a 24-week study
    Dan J Stein
    University of Stellenbosch, Fransie van Zyl Dr, Tygerberg 7505, Cape Town, South Africa
    Arch Gen Psychiatry 59:1111-8. 2002
    ..The efficacy of selective serotonin reuptake inhibitors in the acute treatment of social anxiety disorder (social phobia) is well established...
  10. ncbi request reprint Functional brain imaging and pharmacotherapy in trichotillomania. Single photon emission computed tomography before and after treatment with the selective serotonin reuptake inhibitor citalopram
    Dan J Stein
    Department of Psychiatry, University of Stellenbosch, P O Box 19063, Tygerberg 7505, Cape Town, South Africa
    Prog Neuropsychopharmacol Biol Psychiatry 26:885-90. 2002
    ..Pharmacotherapeutic response to SSRIs in trichotillomania may not be as robust as in OCD. Further research is necessary to determine the neurobiological underpinnings of these differences...
  11. ncbi request reprint Obsessive-compulsive disorder
    Dan J Stein
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Lancet 360:397-405. 2002
    ..In the future we can expect more precise delineation of the origins of this disorder, with integration of data from neuroanatomical, neurochemical, neuroethological, neurogenetic, and neuroimmunological research...
  12. ncbi request reprint Moclobemide is effective and well tolerated in the long-term pharmacotherapy of social anxiety disorder with or without comorbid anxiety disorder
    D J Stein
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Int Clin Psychopharmacol 17:161-70. 2002
    ..These data confirm and extend previous findings on the value of moclobemide in the treatment of social anxiety disorder, and strengthen the range of therapeutic options for managing this important disorder...
  13. ncbi request reprint Escitalopram versus paroxetine for social anxiety disorder: an analysis of efficacy for different symptom dimensions
    Dan J Stein
    University of Cape Town, South Africa and University of Florida, Gainesville, USA
    Eur Neuropsychopharmacol 16:33-8. 2006
    ..This paper examines data from a fixed-dose trial of escitalopram versus paroxetine, in order to determine the differential effects of these agents on symptom dimensions in social anxiety disorder (SAD)...
  14. ncbi request reprint Escitalopram in the treatment of social anxiety disorder: analysis of efficacy for different clinical subgroups and symptom dimensions
    Dan J Stein
    MRC Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    Depress Anxiety 20:175-81. 2004
    ..A six-factor model of social anxiety symptoms is supported by the distinctive association between these symptom dimensions and different areas of disability, but did not predict differential response to escitalopram...
  15. ncbi request reprint WCA Recommendations for the long-term treatment of posttraumatic stress disorder
    Dan J Stein
    Medical Research Council Research Unit on Anxiety Disorder, University of Stellenbosch, Cape Town, Tygerberg, South Africa
    CNS Spectr 8:31-9. 2003
    ..Only SSRIs have been proven effective and safe in long-term randomized controlled trials. Current guidelines from the Expert Consensus Panel for PTSD recommend treatment of chronic PTSD for a minimum of 12-24 months...
  16. ncbi request reprint The social anxiety disorder spectrum
    Dan J Stein
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    J Clin Psychiatry 65:27-33; quiz 34-6. 2004
    ..Nevertheless, phenomenological and psychobiological data have led to the hypothesis that social anxiety symptoms and disorders lie on various dimensions...
  17. ncbi request reprint Depression and anxiety in the developing world: is it time to medicalise the suffering?
    Dan J Stein
    Department of Pyschiatry, University of Stellenbosch, Cape Town 7505, South Africa
    Lancet 364:233-4. 2004
  18. ncbi request reprint Social anxiety disorder and generalized anxiety disorder: serotonergic and dopaminergic neurocircuitry
    Dan J Stein
    Medical Research Council Unit on Anxiety Disorders, The University of Stellenbosch, Tygerberg, Cape Town, South Africa
    J Clin Psychiatry 63:12-9. 2002
    ..Future work will undoubtedly clarify how genetic and environmental factors interact to fashion the neurocircuitry that mediates anxiety symptoms...
  19. ncbi request reprint Hoarding in obsessive-compulsive disorder: clinical and genetic correlates
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    J Clin Psychiatry 66:1155-60. 2005
    ..The clinical and genetic correlates of hoarding in OCD therefore deserve additional investigation...
  20. ncbi request reprint Cluster analysis of obsessive-compulsive spectrum disorders in patients with obsessive-compulsive disorder: clinical and genetic correlates
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg, 7505, Cape Town, South Africa
    Compr Psychiatry 46:14-9. 2005
    ..Comorbidity of the putative OCSDs in OCD has, however, not often been systematically investigated...
  21. pmc Subtyping social anxiety disorder in developed and developing countries
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Depress Anxiety 27:390-403. 2010
    ..We aimed to determine whether this holds across a broader set of developed and developing countries, and whether subtyping according to number of performance versus interactional fears would be more useful...
  22. ncbi request reprint Genetic correlates in trichotillomania--A case-control association study in the South African Caucasian population
    Sian M J Hemmings
    MRC US Centre for Molecular and Cellular Biology, University of Stellenbosch, Tygerberg, South Africa
    Isr J Psychiatry Relat Sci 43:93-101. 2006
    ..Some have argued, however, that TTM is an obsessive-compulsive spectrum disorder (OCSD). There is some evidence that both disorders (OCD and TTM) are mediated by serotonergic (5-HT) and dopaminergic pathways...
  23. ncbi request reprint Early- versus late-onset obsessive-compulsive disorder: investigating genetic and clinical correlates
    Sian M J Hemmings
    MRC Unit on Anxiety and Stress Disorders, University of Stellenbosch, Medical School, PO Box 19063, Tygerberg 7505, South Africa
    Psychiatry Res 128:175-82. 2004
    ..These data support a role for the dopaminergic system, which may be relevant to the development of early-onset OCD...
  24. ncbi request reprint Corrigendum to "gender in obsessive-compulsive disorder: clinical and genetic findings" [Eur. Neuropsychopharmacol. 14 (2004) 105-113]
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Eur Neuropsychopharmacol 14:437-45. 2004
    ..There is increasing recognition that obsessive-compulsive disorder (OCD) is not a homogeneous entity. It has been suggested that gender may contribute to the clinical and biological heterogeneity of OCD...
  25. ncbi request reprint Gender in obsessive-compulsive disorder: clinical and genetic findings
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, P O Box 19063, Tygerberg 7505, Cape Town, South Africa
    Eur Neuropsychopharmacol 14:105-13. 2004
    ..There is increasing recognition that obsessive-compulsive disorder (OCD) is not a homogeneous entity. It has been suggested that gender may contribute to the clinical and biological heterogeneity of OCD...
  26. doi request reprint Exercise increases BDNF levels in the striatum and decreases depressive-like behavior in chronically stressed rats
    Lelanie Marais
    Division of Medical Physiology, Stellenbosch University, Tygerberg, PO Box 19063, 7505, South Africa
    Metab Brain Dis 24:587-97. 2009
    ..The mechanism by which depressive-like behavior was improved may have been mediated through increased striatal BDNF levels, resulting in increased neuroplasticity and the prevention of neuronal death...
  27. doi request reprint Catechol-o-methyltransferase genotype and childhood trauma may interact to impact schizotypal personality traits
    Jonathan Savitz
    MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Behav Genet 40:415-23. 2010
    ..We raise the possibility that genetically-driven variation in COMT may interact with childhood trauma to contribute to the risk of developing schizotypal personality traits...
  28. doi request reprint Characterization of HIV-Associated Neurocognitive Disorders among individuals starting antiretroviral therapy in South Africa
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    AIDS Behav 15:1197-203. 2011
    ..In a regression model, a lower level of education and male gender were predictive of HIV-D. These findings suggest that HAND are highly prevalent in primary care settings in South Africa where clade C HIV is predominant...
  29. doi request reprint Comorbid obsessive-compulsive personality disorder in obsessive-compulsive disorder (OCD): a marker of severity
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    Prog Neuropsychopharmacol Biol Psychiatry 35:1087-92. 2011
    ..It remains unclear, however, whether OCPD in OCD represents a distinct subtype of OCD or whether it is simply a marker of severity in OCD...
  30. doi request reprint Is trichotillomania a stereotypic movement disorder? An analysis of body-focused repetitive behaviors in people with hair-pulling
    Dan J Stein
    University of Cape Town, Rondebosch, South Africa
    Ann Clin Psychiatry 20:194-8. 2008
    ..Comorbidity of symptoms might support the idea that they are indicative of an underlying stereotypic disorder, and we therefore explored their frequency in people with hair-pulling...
  31. pmc Disability and treatment of psychiatric and physical disorders in South Africa
    Sharain Suliman
    MRC Anxiety and Stress Disorders Unit, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    J Nerv Ment Dis 198:8-15. 2010
    ..Despite high rates of mental disorders and associated disability in South Africa, they are less likely to be treated than physical disorders...
  32. pmc Perpetration of gross human rights violations in South Africa: association with psychiatric disorders
    Dan J Stein
    Department of Psychiatry and Mental Health, University of Cape Town
    S Afr Med J 99:390-5. 2009
    ..Prior work has suggested an association between perpetration and post-traumatic stress disorder (PTSD), but this remains controversial...
  33. pmc The impact of the Truth and Reconciliation Commission on psychological distress and forgiveness in South Africa
    Dan J Stein
    University of Cape Town, Cape Town, South Africa
    Soc Psychiatry Psychiatr Epidemiol 43:462-8. 2008
    ..However, there was also a concern that individuals with TRC relevant experience would simply be re-traumatized by participation in the process. To date, there has been little empirical data for either hypothesis...
  34. doi request reprint Altered prefrontal cortical function during processing of fear-relevant stimuli in pregnancy
    Annerine Roos
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, P O Box 19063, Tygerberg 7505, South Africa
    Behav Brain Res 222:200-5. 2011
    ....
  35. doi request reprint A proteomic analysis of the ventral hippocampus of rats subjected to maternal separation and escitalopram treatment
    Lelanie Marais
    Division of Medical Physiology, University of Stellenbosch, PO Box 19063, Tygerberg, 7505, South Africa
    Metab Brain Dis 24:569-86. 2009
    ..The results indicate which cytosolic proteins are changed by early life stress and may therefore be involved in the development of depression...
  36. doi request reprint Relationship between apolipoprotein E4 genotype and white matter integrity in HIV-positive young adults in South Africa
    Jacqueline Hoare
    Department of Psychiatry and Mental Health, University of Cape Town, Anzio Road Observatory, Cape Town 7925, South Africa
    Eur Arch Psychiatry Clin Neurosci 263:189-95. 2013
    ..007). These data indicate that the ε4 allelic variant of ApoE is associated with memory impairment and white matter damage of the corpus callosum in HIV-positive subjects...
  37. pmc Single photon emission computed tomography (SPECT) of anxiety disorders before and after treatment with citalopram
    Paul D Carey
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, 7505, Cape Town, South Africa
    BMC Psychiatry 4:30. 2004
    ..This paper further examines the notion of overlap in the neurocircuitry of treatment and indeed treatment response across anxiety disorders with SSRI treatment...
  38. ncbi request reprint The relationship between childhood abuse and dissociation. Is it influenced by catechol-O-methyltransferase (COMT) activity?
    Jonathan B Savitz
    MRC UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
    Int J Neuropsychopharmacol 11:149-61. 2008
    ..The current findings support the involvement of the COMT Val158Met polymorphism in mediating the relationship between trauma and psychopathology...
  39. pmc Intermittent explosive disorder in South Africa: prevalence, correlates and the role of traumatic exposures
    Dylan Fincham
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Stellenbosch, South Africa
    Psychopathology 42:92-8. 2009
    ..In South Africa, given the high rates of violence and trauma, there is particular interest in traumatic exposures as potential risk factors for IED...
  40. doi request reprint Knowledge of and stigma associated with mental disorders in a South african community sample
    Katherine R Sorsdahl
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    J Nerv Ment Dis 198:742-7. 2010
    ..Further effort is required to educate the public about the psychobiological underpinnings of psychiatric disorders and about the value of effective treatments...
  41. doi request reprint Changes in regional brain volumes in social anxiety disorder following 12 weeks of treatment with escitalopram
    Naseema Cassimjee
    Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg 7505, South Africa
    Metab Brain Dis 25:369-74. 2010
    ..These preliminary findings require replication to determine their reliability, and extension to determine whether or not they are disorder specific...
  42. pmc Life stress and mental disorders in the South African stress and health study
    Soraya Seedat
    MRC Stress and Anxiety Disorders Unit, Department of Psychiatry, Stellenbosch University, Tygerberg, W Cape
    S Afr Med J 99:375-82. 2009
    ..We examined the association of recent life events and past adversities to mood, anxiety, substance use and impulse control disorders in South Africa...
  43. doi request reprint Cumulative effect of multiple trauma on symptoms of posttraumatic stress disorder, anxiety, and depression in adolescents
    Sharain Suliman
    Department of Psychiatry, Stellenbosch University, Cape Town, South Africa
    Compr Psychiatry 50:121-7. 2009
    ..Against the backdrop of stressful life events and childhood abuse and neglect, we investigated the cumulative effect of multiple trauma exposure on PTSD, anxiety, and depression in an adolescent sample...
  44. ncbi request reprint Early maternal separation alters the response to traumatization: resulting in increased levels of hippocampal neurotrophic factors
    Jacqueline Faure
    Department of Medical Physiology, University of Stellenbosch, Tygerberg, Western Cape, South Africa
    Metab Brain Dis 22:183-95. 2007
    ....
  45. ncbi request reprint Dissociative experiences in obsessive-compulsive disorder and trichotillomania: clinical and genetic findings
    Christine Lochner
    Medical Research Council Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenboch, Cape Town, South Africa
    Compr Psychiatry 45:384-91. 2004
    ..g., lower age) and comorbidity profile (e.g., increased incidence of impulse dyscontrol disorders). Additional work is necessary before conclusions about the role of monoaminergic systems in mediating such dissociation can be drawn...
  46. pmc Early childhood adversity and later hypertension: data from the World Mental Health Survey
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Groote Schur Hospital, Anzio Road, Cape Town, South Africa
    Ann Clin Psychiatry 22:19-28. 2010
    ....
  47. ncbi request reprint Depression and anxiety in multisomatoform disorder: prevalence and clinical predictors in primary care
    Jacqueline E Muller
    Medical Research Council Unit on Anxiety Disorders, Department of Psychiatry, Stellenbosch University, Tygerberg, W Cape
    S Afr Med J 98:473-6. 2008
    ..The aim of this study was to evaluate the prevalence of depressive and anxiety disorders in a South African sample MSD, and to compare demographic and clinical outcomes in those patients with and without co-morbidity...
  48. ncbi request reprint Cluster analysis of obsessive-compulsive symptomatology: identifying obsessive-compulsive disorder subtypes
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    Isr J Psychiatry Relat Sci 45:164-76. 2008
    ..There is increasing evidence that obsessive-compulsive disorder (OCD) is a heterogeneous disorder. Different clinical subtypes may be characterized by differing pathophysiological mechanisms and treatment outcomes...
  49. doi request reprint Neuropsychological task performance in bipolar spectrum illness: genetics, alcohol abuse, medication and childhood trauma
    Jonathan B Savitz
    Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Bipolar Disord 10:479-94. 2008
    ....
  50. ncbi request reprint Persistence of psychiatric disorders in a cohort of HIV/AIDS patients in South Africa: a 6-month follow-up study
    Benjamin O Olley
    Department of Psychiatry, MRC Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    J Psychosom Res 61:479-84. 2006
    ..However, there are few prospective studies on the rates of psychiatric disorders in HIV/AIDS, particularly in the context of the developing world...
  51. pmc Dissociation in posttraumatic stress disorder: evidence from the world mental health surveys
    Dan J Stein
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    Biol Psychiatry 73:302-12. 2013
    ..Cross-national population epidemiologic surveys were analyzed to evaluate generalizability of the subtype in more diverse samples...
  52. doi request reprint Reduced fear-recognition sensitivity following acute buprenorphine administration in healthy volunteers
    Jonathan C Ipser
    Department of Psychiatry, University of Cape Town, South Africa
    Psychoneuroendocrinology 38:166-70. 2013
    ..Moreover, the absence of an effect of buprenorphine on mood provides evidence of a direct influence of opioids upon the core fear system in the human brain...
  53. pmc Evidence for fractional anisotropy and mean diffusivity white matter abnormalities in the internal capsule and cingulum in patients with obsessive-compulsive disorder
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    J Psychiatry Neurosci 37:193-9. 2012
    ..In this study, we used diffusion tensor imaging (DTI) to examine white matter integrity in specific regions of interest (ROIs) in patients with OCD...
  54. doi request reprint Recall of early non-fatal suicidality in a nationally representative sample of South Africans
    Ermien van Pletzen
    Centre for Higher Education Development, University of Cape Town, Cape Town, South Africa
    Ethn Health 17:149-59. 2012
    ..We investigated the prevalence of self-reported early suicidality (suicidal ideation, planning and attempts) in a nationally representative sample of South Africans...
  55. pmc Obsessive-compulsive disorder and trichotillomania: a phenomenological comparison
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    BMC Psychiatry 5:2. 2005
    ..Nevertheless, there is evidence of important differences between these two disorders. Some authors have conceptualized the disorders as lying on an OCD spectrum of conditions...
  56. doi request reprint Investigating SAPAP3 variants in the etiology of obsessive-compulsive disorder and trichotillomania in the South African white population
    Leigh Boardman
    Division of Molecular Biology and Human Genetics, Department Biomedical Sciences, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa
    Compr Psychiatry 52:181-7. 2011
    ..Results from a recent knockout animal model suggest that SAP90/PSD95-associated protein 3 (SAPAP3) may be involved in the pathophysiology of both disorders...
  57. ncbi request reprint WCA recommendations for the long-term treatment of generalized anxiety disorder
    Christer Allgulander
    Department of Psychiatry, Harvard University School of Medicine, Boston, Massachusetts, USA
    CNS Spectr 8:53-61. 2003
    ..Treatment gains after a 12-week course of CBT may be maintained for up to 1 year. Currently, no guidelines exist for the long-term treatment of GAD...
  58. pmc Mental health service use among South Africans for mood, anxiety and substance use disorders
    Soraya Seedat
    MRC Stress and Anxiety Disorders Unit, Department of Psychiatry, Stellenbosch University, Tygerberg, W Cape
    S Afr Med J 99:346-52. 2009
    ..Europe and North America have low rates of mental health service use despite high rates of mental disorder. Little is known about mental health service use among South Africans...
  59. ncbi request reprint Psychopharmacology of maternal separation anxiety in vervet monkeys
    Lelanie Marais
    Department of Medical Physiology, University of Stellenbosch and MRC Unit on Anxiety Disorders, Tygerberg, South Africa
    Metab Brain Dis 21:201-10. 2006
    ..Although limited by a small sample size, this study demonstrates the possibility of investigating the psychopharmacology of early adversity in a non-human primate model...
  60. ncbi request reprint Escitalopram in obsessive-compulsive disorder: response of symptom dimensions to pharmacotherapy
    Dan J Stein
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    CNS Spectr 13:492-8. 2008
    ..The response of OCD symptom dimensions to 12 weeks of treatment with escitalopram or placebo was investigated...
  61. doi request reprint White matter correlates of apathy in HIV-positive subjects: a diffusion tensor imaging study
    Jacqueline Hoare
    Department of Psychiatry and Mental Health, University of Cape Town, Anzio Road Observatory, 7925, Cape Town, South Africa
    J Neuropsychiatry Clin Neurosci 22:313-20. 2010
    ..Results of the study confirmed the hypothesis which anticipated changes associated with apathy in white matter tracts that relay through the medial prefrontal cortex...
  62. doi request reprint Reliability of the lay adherence counsellor administered substance abuse and mental illness symptoms screener (SAMISS) and the International HIV Dementia Scale (IHDS) in a primary care HIV clinic in Cape Town, South Africa
    Erica Breuer
    Centre for Public Mental Health, Department of Psychiatry and Mental Health, University of Cape Town, Rondebosch, Cape Town, South Africa
    AIDS Behav 16:1464-71. 2012
    ....
  63. pmc Neuropsychological outcomes in adults commencing highly active anti-retroviral treatment in South Africa: a prospective study
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 12:39. 2012
    ..To date, there have been no cohort studies of the impact of highly active anti-retroviral treatment (HAART) in South Africa where clade C HIV is predominant...
  64. ncbi request reprint Investigating the possible effects of trauma experiences and 5-HTT on the dissociative experiences of patients with OCD using path analysis and multiple regression
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    Neuropsychobiology 56:6-13. 2007
    ..Here, two different but related statistical techniques (multiple regression and partial least squares), confirmed that physical neglect and the 5-HTT genotype jointly play a role in predicting dissociation in OCD...
  65. doi request reprint Common mental disorders among HIV-infected individuals in South Africa: prevalence, predictors, and validation of brief psychiatric rating scales
    Landon Myer
    Infectious Diseases Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
    AIDS Patient Care STDS 22:147-58. 2008
    ..More generally, HIV care and treatment services represent an important venue to identify and manage individuals with common mental disorders in resource-limited settings...
  66. ncbi request reprint Genetics and personality traits in patients with social anxiety disorder: a case-control study in South Africa
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    Eur Neuropsychopharmacol 17:321-7. 2007
    ..to compare differences in temperament dimensions between carriers of different (dominant vs. recessive) alleles for selected polymorphisms in SAD patients...
  67. ncbi request reprint Social anxiety disorder: psychobiological and evolutionary underpinnings
    Dan J Stein
    Department of Mental Health and Psychiatry, University of Cape Town, South Africa
    CNS Spectr 12:806-9. 2007
    ....
  68. ncbi request reprint Investigating the role of the brain-derived neurotrophic factor (BDNF) val66met variant in obsessive-compulsive disorder (OCD)
    Sian M J Hemmings
    MRC US Centre for Molecular and Cellular Biology, University of Stellenbosch, Tygerberg, South Africa
    World J Biol Psychiatry 9:126-34. 2008
    ..The present investigation forms part of ongoing research to elucidate the genetic components involved in the aetiology of OCD and OCD-related characteristics...
  69. ncbi request reprint Single photon emission computed tomography in posttraumatic stress disorder before and after treatment with a selective serotonin reuptake inhibitor
    Soraya Seedat
    Department of Psychiatry, University of Stellenbosch, Tygerberg, 7505, Cape Town, South Africa
    J Affect Disord 80:45-53. 2004
    ..However, the neural substrates of PTSD remain poorly understood and the effect of selective serotonin reuptake inhibition on regional cerebral activity is deserving of further investigation...
  70. ncbi request reprint Trauma and posttraumatic stress disorder in an urban Xhosa primary care population: prevalence, comorbidity, and service use patterns
    Paul D Carey
    MRC Unit for Stress and Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg 7505, Cape Town, South Africa
    J Nerv Ment Dis 191:230-6. 2003
    ..In this population, trauma and PTSD were highly prevalent and associated with significant unidentified morbidity and comorbidity. Patients remain untreated for years in the current system of primary care consultations...
  71. ncbi request reprint Measuring anxiety in patients with schizophrenia
    Soraya Seedat
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    J Nerv Ment Dis 195:320-4. 2007
    ..Accurate assessment is challenging yet important. More reliable measures of anxiety disorders in patients with schizophrenia and other psychotic disorders are clearly needed to allow for timely identification and treatment...
  72. ncbi request reprint Should OCD be classified as an anxiety disorder in DSM-V?
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Depress Anxiety 27:495-506. 2010
    ..If this change is made, the name of this category should be changed to reflect this proposed change...
  73. ncbi request reprint Psychobiology of mindfulness
    Dan J Stein
    Department of Psychiatry and Mental Health at the University of Cape Town, Cape Town, South Africa
    CNS Spectr 13:752-6. 2008
    ..A number of rigorous studies of mindfulness-based cognitive therapy for depression have been positive. However, much remains to be discovered about the underlying mechanisms of and clinical indications for mindfulness-based approaches...
  74. doi request reprint Evaluating the behavioural consequences of early maternal separation in adult C57BL/6 mice; the importance of time
    Johan H van Heerden
    Department of Molecular and Cell Biology, University of Cape Town, Private Bag 7701, Rondebosch, South Africa
    Behav Brain Res 207:332-42. 2010
    ..The extension of conventional analysis strategies, to include time as a significant dimension of behaviour on the EPM, identified behavioural nuances, which could reflect adaptive aspects of stress-driven behaviours in MS mice...
  75. ncbi request reprint Betting on dopamine
    Dan J Stein
    University of Stellenbosch, Cape Town, South Africa
    CNS Spectr 10:268-70. 2005
  76. ncbi request reprint Posttraumatic stress disorder and occupational disability in South African Security Force members
    Robin A Emsley
    Department of Psychiatry and Medical Research Council Unit for Anxiety and Stress Disorders, University of Stellenbosch, PO Box 19063, Tygerberg 7505, Cape Town, South Africa
    J Nerv Ment Dis 191:237-41. 2003
    ..These findings suggest that posttrauma factors may be as important as pretrauma and peritrauma variables in the development of PTSD...
  77. doi request reprint Social anxiety disorder
    Murray B Stein
    Department of Psychiatry, University of California San Diego 92093 0855, USA
    Lancet 371:1115-25. 2008
    ....
  78. ncbi request reprint Response of symptom dimensions in obsessive-compulsive disorder to treatment with citalopram or placebo
    Dan J Stein
    University of Cape Town, Cape Town, South Africa
    Rev Bras Psiquiatr 29:303-7. 2007
    ..There is increasing evidence that the symptoms of obsessive-compulsive disorder lie on discrete dimensions. Relatively little work has, however, explored the relationship between such factors and response to pharmacotherapy...
  79. pmc The mental health impact of AIDS-related mortality in South Africa: a national study
    L Myer
    School of Public Health and Family Medicine, University of Cape Town, Anzio Road, Cape Town, South Africa
    J Epidemiol Community Health 63:293-8. 2009
    ..Few data exist on how the HIV/AIDS epidemic may influence population mental health. The associations were examined between knowing someone who died of HIV/AIDS and common mental disorders among South African adults...
  80. ncbi request reprint Violence in male patients with schizophrenia: risk markers in a South African population
    L Koen
    Department of Psychiatry, PO Box 19063, Tygerberg, 7505, South Africa
    Aust N Z J Psychiatry 38:254-9. 2004
    ....
  81. doi request reprint Clinical correlates of HIV-associated neurocognitive disorders in South Africa
    John A Joska
    Department of Psychiatry and Mental Health, University of Cape Town, South Africa, Anzio Road, Observatory, Cape Town 7925, South Africa
    AIDS Behav 14:371-8. 2010
    ..This underlines the impact of HIV on the nervous system and the importance of screening for co morbid mental health conditions...
  82. ncbi request reprint Anxiety symptom severity and functional recovery or relapse
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Groote Schuur Hospital J 2, Anzio Rd, Observatory 7925, Cape Town, South Africa
    Ann Clin Psychiatry 21:81-8. 2009
    ..Recovery could potentially be defined as a lack of disability, with an associated reduction in symptom severity. Conversely, relapse could potentially be defined in terms of either increased disability or increased symptoms...
  83. ncbi request reprint Escitalopram for the treatment of GAD: efficacy across different subgroups and outcomes
    Dan J Stein
    University of Stellenbosch, Department of Psychiatry, P O Box 19063, Tygerberg, 7505, South Africa
    Ann Clin Psychiatry 17:71-5. 2005
    ..In this study, we determined whether the selective serotonin reuptake inhibitor escitalopram, was effective across different subgroups and outcomes (anxious symptoms, depressive symptoms, and quality of life)...
  84. ncbi request reprint Community attitudes toward and knowledge of mental illness in South Africa
    Charmaine J Hugo
    MRC Unit on Anxiety Disorders, Dept of Psychiatry, University of Stellenbosch, Tygerberg 7505, South Africa
    Soc Psychiatry Psychiatr Epidemiol 38:715-9. 2003
    ..Nevertheless, there is little research on the attitudes of lay persons toward mental illness within the South African community...
  85. ncbi request reprint Efficacy of sertraline in posttraumatic stress disorder secondary to interpersonal trauma or childhood abuse
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Ann Clin Psychiatry 18:243-9. 2006
    ..This analysis was conducted to specifically assess the efficacy of sertraline in the treatment of PTSD secondary to interpersonal trauma or childhood abuse...
  86. ncbi request reprint Psychopathology and coping in recently diagnosed HIV/AIDS patients--the role of gender
    Benjamin O Olley
    Medical Research Council Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, W Cape
    S Afr Med J 93:928-31. 2003
    ..This study compared psychiatric morbidity, coping responses, and disability in male and female outpatients recently diagnosed with HIV/AIDS...
  87. ncbi request reprint Predictors of response to pharmacotherapy with citalopram in obsessive-compulsive disorder
    D J Stein
    Department of Psychiatry, University of Stellebosch, Tygerberg, Cape Town, South Africa
    Int Clin Psychopharmacol 16:357-61. 2001
    ..The data here emphasize the crucial importance of early diagnosis and treatment of OCD, and of pharmacotherapy with appropriate dose and duration...
  88. doi request reprint Obsessive-compulsive disorder: diagnostic and treatment issues
    Dan J Stein
    Deparment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    Psychiatr Clin North Am 32:665-85. 2009
    ..There is a growing evidence base on OCD symptom dimensions and subtyping, and it is timely to consider incorporating some of these emerging data into diagnostic classification systems...
  89. ncbi request reprint Brain-derived neurotrophic factor: the neurotrophin hypothesis of psychopathology
    Dan J Stein
    Department of Psychiatry and Mental Health at the University of Cape Town, Cape Town, South Africa
    CNS Spectr 13:945-9. 2008
    ..Nevertheless, the neurotrophin hypothesis has already given impetus to a range of valuable research...
  90. ncbi request reprint Specific phobia: a disorder of fear conditioning and extinction
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    CNS Spectr 11:248-51. 2006
    ..Advances in the cognitive-affective neuroscience of fear processing may ultimately lead to new approaches to the clinical management of phobias...
  91. ncbi request reprint An A-B-C model of habit disorders: hair-pulling, skin-picking, and other stereotypic conditions
    Dan J Stein
    Department of Mental Health and Psychiatry, University of Cape Town, South Africa
    CNS Spectr 11:824-7. 2006
    ..An affect regulation, behavioral addiction, and cognitive control (A-B-C) approach is outlined to conceptualizing and managing these conditions...
  92. doi request reprint The interleukin-6, serotonin transporter, and monoamine oxidase A genes and endurance performance during the South African Ironman Triathlon
    Liesl de Milander
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Appl Physiol Nutr Metab 34:858-65. 2009
    ..The neurogenetic basis of the central governor requires further investigation...
  93. doi request reprint Onset of activity and time to response on individual CAPS-SX17 items in patients treated for post-traumatic stress disorder with venlafaxine ER: a pooled analysis
    Dan J Stein
    University of Cape Town, Cape Town, South Africa
    Int J Neuropsychopharmacol 12:23-31. 2009
    ..The early and persistent effect of venlafaxine ER over placebo on anger/irritability is noteworthy in view of the clinical significance of these symptoms in PTSD...
  94. ncbi request reprint Emotional regulation: implications for the psychobiology of psychotherapy
    Dan J Stein
    Department of Mental Health and Psychiatry, University of Cape Town, South Africa
    CNS Spectr 13:195-8. 2008
    ..It may be hypothesized that during interventions such as psychotherapy there are improvements in emotional regulation, together with the normalization of related psychobiological mechanisms...
  95. ncbi request reprint Problematic internet use: proposed classification and diagnostic criteria
    Nathan A Shapira
    Department of Psychiatry, E f and W L McKnight Brain Institute, University of Florida, Gainesville, Florida 32610 0383, USA
    Depress Anxiety 17:207-16. 2003
    ..For these reasons, we propose specific diagnostic criteria that will allow for consistent identification and assist in further study of this behavior...
  96. ncbi request reprint Cognitive-affective neuroscience of somatization disorder and functional somatic syndromes: reconceptualizing the triad of depression-anxiety-somatic symptoms
    Dan J Stein
    Department of Mental Health and Psychiatry, University of Cape Town, South Africa
    CNS Spectr 13:379-84. 2008
    ....
  97. ncbi request reprint Psychobiology of anxiety disorders and obsessive-compulsive spectrum disorders
    Dan J Stein
    Department of Psychiatry and Mental Health at the University of Cape Town, Cape Town, South Africa
    CNS Spectr 13:23-8. 2008
    ....
  98. ncbi request reprint Suffer the children: the psychobiology of early adversity
    Dan J Stein
    University of Stellenbosch, Cape Town, South Africa
    CNS Spectr 10:612-5. 2005
  99. ncbi request reprint A culture-bound syndrome 'amafufunyana' and a culture-specific event 'ukuthwasa': differentiated by a family history of schizophrenia and other psychiatric disorders
    D J H Niehaus
    Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    Psychopathology 37:59-63. 2004
    ....
  100. ncbi request reprint Self-disclosure of HIV serostatus in recently diagnosed patients with HIV in South Africa
    B O Olley
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Afr J Reprod Health 8:71-6. 2004
    ..83, 1.88) were significantly associated with non-disclosure of HIV serostatus. Preventive strategies among HIV-positive patients should place emphasis on the management of self-disclosure and its importance in safe sexual behaviour...
  101. ncbi request reprint A comparison of the effects of citalopram and moclobemide on resting brain perfusion in social anxiety disorder
    J M Warwick
    MRC Unit for Stress and Anxiety Disorders, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
    Metab Brain Dis 21:241-52. 2006
    ..In this study we investigate the effects of these compounds on resting brain function using single photon emission computed tomography (SPECT)...