D J Stein

Summary

Affiliation: University of Stellenbosch
Country: South Africa

Publications

  1. ncbi request reprint The efficacy of the selective serotonin reuptake inhibitors for social anxiety disorder (social phobia): a meta-analysis of randomized controlled trials
    G J van der Linden
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Int Clin Psychopharmacol 15:S15-23. 2000
  2. ncbi request reprint Cross-cultural aspects of social anxiety disorder
    D J Stein
    Medical Research Council Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    Psychiatr Clin North Am 24:773-82. 2001
  3. ncbi request reprint Single photon emission computed tomography (SPECT) in obsessive-compulsive disorder before and after treatment with inositol
    P D Carey
    MRC Research Unit for Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Metab Brain Dis 19:125-34. 2004
  4. ncbi request reprint Psychiatric aspects of women's health
    D J Stein
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Int Clin Psychopharmacol 15:S1-4. 2000
  5. ncbi request reprint Comorbidity in generalized anxiety disorder: impact and implications
    D J Stein
    Medical Research Council Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    J Clin Psychiatry 62:29-34; discussion 35-6. 2001
  6. ncbi request reprint A neural network of obsessive- compulsive disorder: modelling cognitive disinhibition and neurotransmitter dysfunction
    D J Stein
    Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    Med Hypotheses 55:168-76. 2000
  7. ncbi request reprint Mental health and sexual risk behaviours in a South African township: a community-based cross-sectional study
    J Smit
    Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa
    Public Health 120:534-42. 2006
  8. doi request reprint Validity of the Kessler 10 (K-10) in detecting DSM-IV defined mood and anxiety disorders among pregnant women
    G Spies
    Department of Psychiatry, South African Research Chairs Initiative SARChI, PTSD Program, University of Stellenbosch, Cape Town, South Africa
    Arch Womens Ment Health 12:69-74. 2009
  9. ncbi request reprint Sexual risk factors associated with volunteering for HIV vaccine research in South Africa
    J Smit
    University of Cape Town, Cape Town, South Africa
    AIDS Care 18:569-73. 2006
  10. doi request reprint Screening and pathways to maternal mental health care in a South African antenatal setting
    B Vythilingum
    Department of Psychiatry and Mental Health, University of Cape Town UCT, Building B, 46 Sawkins Road, Rondebosch, 7700, Cape Town, South Africa
    Arch Womens Ment Health 16:371-9. 2013

Collaborators

Detail Information

Publications95

  1. ncbi request reprint The efficacy of the selective serotonin reuptake inhibitors for social anxiety disorder (social phobia): a meta-analysis of randomized controlled trials
    G J van der Linden
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Int Clin Psychopharmacol 15:S15-23. 2000
    ..It may be concluded with a high degree of confidence that SSRI treatment for social anxiety disorder is effective, both in reducing total levels of social anxiety and in improving patients' overall clinical condition...
  2. ncbi request reprint Cross-cultural aspects of social anxiety disorder
    D J Stein
    Medical Research Council Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    Psychiatr Clin North Am 24:773-82. 2001
    ..Future investigation of the contribution of sociocultural mechanisms to the course of SAD may provide an important avenue toward understanding this complex disorder...
  3. ncbi request reprint Single photon emission computed tomography (SPECT) in obsessive-compulsive disorder before and after treatment with inositol
    P D Carey
    MRC Research Unit for Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Metab Brain Dis 19:125-34. 2004
    ..They may support the idea that inositol effects a clinical response through alternate neuronal circuitry to the SSRIs and may complement animal work proposing an overlapping but distinct mechanism of action...
  4. ncbi request reprint Psychiatric aspects of women's health
    D J Stein
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Int Clin Psychopharmacol 15:S1-4. 2000
    ..fronts is needed, advances in the pharmacotherapy of premenstrual dysphoric disorder, recent safety data on certain agents in pregnancy, and progress in the management of post-traumatic stress disorder provides cause for clinical..
  5. ncbi request reprint Comorbidity in generalized anxiety disorder: impact and implications
    D J Stein
    Medical Research Council Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    J Clin Psychiatry 62:29-34; discussion 35-6. 2001
    ....
  6. ncbi request reprint A neural network of obsessive- compulsive disorder: modelling cognitive disinhibition and neurotransmitter dysfunction
    D J Stein
    Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    Med Hypotheses 55:168-76. 2000
    ..Neural network modelling provides a surprisingly coherent perspective of the psychobiology of OCD, simulating both reduced cognitive disinhibition as well as neurotransmitter dysfunction...
  7. ncbi request reprint Mental health and sexual risk behaviours in a South African township: a community-based cross-sectional study
    J Smit
    Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa
    Public Health 120:534-42. 2006
    ..The objective of this study was to examine the association between mental illness and HIV risk behaviours in a South African township...
  8. doi request reprint Validity of the Kessler 10 (K-10) in detecting DSM-IV defined mood and anxiety disorders among pregnant women
    G Spies
    Department of Psychiatry, South African Research Chairs Initiative SARChI, PTSD Program, University of Stellenbosch, Cape Town, South Africa
    Arch Womens Ment Health 12:69-74. 2009
    ..66), posttraumatic stress disorder (0.69), panic disorder (0.71), and social phobia (0.76). The K-10 may be a useful screening measure for mood and anxiety disorders in pregnant women...
  9. ncbi request reprint Sexual risk factors associated with volunteering for HIV vaccine research in South Africa
    J Smit
    University of Cape Town, Cape Town, South Africa
    AIDS Care 18:569-73. 2006
    ..These findings suggest that volunteers for vaccine-related research may be at greater risk of HIV infection than the general population from which they are recruited...
  10. doi request reprint Screening and pathways to maternal mental health care in a South African antenatal setting
    B Vythilingum
    Department of Psychiatry and Mental Health, University of Cape Town UCT, Building B, 46 Sawkins Road, Rondebosch, 7700, Cape Town, South Africa
    Arch Womens Ment Health 16:371-9. 2013
    ..750 for this combination of three items). A small number of items may be useful in screening for mental illness in pregnancy which requires higher levels of care. Such screening may contribute to a more efficient stepped care approach...
  11. ncbi request reprint Suicide attempts in an African schizophrenia population: an assessment of demographic risk factors
    D J H Niehaus
    Department of Psychiatry, PO Box 19090, University of Stellenbosch, Tygerberg 7505, South Africa
    Suicide Life Threat Behav 34:320-7. 2004
    ..These findings raise the possibility that affected sib pair status may be protective in nature. Given the counter-intuitive nature of this finding, further work is needed to replicate it, and to explore possible underlying mechanisms...
  12. doi request reprint Dopamine transporter binding in social anxiety disorder: the effect of treatment with escitalopram
    J M Warwick
    Nuclear Medicine, Faculty of Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa
    Metab Brain Dis 27:151-8. 2012
    ..This is consistent with previous work indicating decreased DAT binding in SAD, and increased DAT binding after SSRI administration...
  13. doi request reprint The psychometric properties of the K10 and K6 scales in screening for mood and anxiety disorders in the South African Stress and Health study
    L S Andersen
    Department of Psychiatry, University of Stellenbosch, South Africa
    Int J Methods Psychiatr Res 20:215-23. 2011
    ..016). The difference in time period assessed on the K10/K6 (past 30  days) versus the CIDI (past 12  months) was a notable limitation of this study. Additional validation studies using clinician diagnostic instruments are recommended...
  14. doi request reprint DSM-IV personality disorders and their axis I correlates in the South African population
    S Suliman
    MRC Anxiety and Stress Disorders Unit, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Psychopathology 41:356-64. 2008
    ..The prevalence of personality disorders (PD) in the South African population is largely unknown. Thus, we undertook to estimate prevalence, demographic correlates, co-morbidity and treatment rates of DSM-IV PD among South Africans...
  15. pmc The mental health impact of AIDS-related mortality in South Africa: a national study
    L Myer
    School of Public Health and Family Medicine, University of Cape Town, Anzio Road, Cape Town, South Africa
    J Epidemiol Community Health 63:293-8. 2009
    ..Few data exist on how the HIV/AIDS epidemic may influence population mental health. The associations were examined between knowing someone who died of HIV/AIDS and common mental disorders among South African adults...
  16. ncbi request reprint The factor structure for positive and negative symptoms in South African Xhosa patients with schizophrenia
    R A Emsley
    Department of Psychiatry, PO Box 19063, University of Stellenbosch, Tygerberg 7505, South Africa
    Schizophr Res 47:149-57. 2001
    ..This is particularly true for negative symptoms...
  17. doi request reprint Validity of the K-10 in detecting DSM-IV-defined depression and anxiety disorders among HIV-infected individuals
    G Spies
    South African Research Chairs Initiative SARChI, PTSD Program, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    AIDS Care 21:1163-8. 2009
    ..77), generalized anxiety disorder (0.78), and posttraumatic stress disorder (PTSD) (0.77). The K-10 may be a useful screening measure for detecting mood and anxiety disorders, including PTSD, in patients with HIV/AIDS...
  18. pmc Twelve-month treatment of psychiatric disorders in the South African Stress and Health Study (World Mental Health Survey Initiative)
    Soraya Seedat
    MRC Unit on Anxiety Disorders, University of Stellenbosch, PO Box 19063, Tygerberg, 7505, Cape Town, South Africa
    Soc Psychiatry Psychiatr Epidemiol 43:889-97. 2008
    ..The proportion of people with mental disorders in treatment is relatively small in low and middle income countries. However, little is known about patterns of recent service use in a country like South Africa...
  19. ncbi request reprint Depressive and anxiety symptoms in patients with schizophrenia and schizophreniform disorder
    R A Emsley
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    J Clin Psychiatry 60:747-51. 1999
    ..They may compromise social and vocational functioning, and they are associated with an increased risk of relapse and suicide. Various treatment approaches have been reported to be successful...
  20. doi request reprint The relationship between behavioural inhibition, anxiety disorders, depression and CD4 counts in HIV-positive adults: a cross-sectional controlled study
    D Fincham
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    AIDS Care 20:1279-83. 2008
    ..While BI was linked to certain anxiety disorders, we found no evidence to suggest that BI, a diagnosis of an anxiety disorder, and/or depressive symptoms were associated with CD4 counts among HIV-positive adults...
  21. ncbi request reprint A culture-bound syndrome 'amafufunyana' and a culture-specific event 'ukuthwasa': differentiated by a family history of schizophrenia and other psychiatric disorders
    D J H Niehaus
    Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    Psychopathology 37:59-63. 2004
    ....
  22. doi request reprint Predictors of distress and anxiety during pregnancy
    A Roos
    Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa
    Afr J Psychiatry (Johannesbg) 16:118-22. 2013
    ..We determined whether temperament and character, trait anxiety, resilience, and social support predicted distress and anxiety symptoms in pregnancy...
  23. ncbi request reprint Explanatory models of mental disorders and treatment practices among traditional healers in Mpumulanga, South Africa
    K R Sorsdahl
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Afr J Psychiatry (Johannesbg) 13:284-90. 2010
    ..The present study examines traditional healers' explanatory models (EMs) and treatment practices for psychotic and non-psychotic mental illnesses...
  24. pmc Prevalence and correlates of atypical patterns of drug use progression: findings from the South African Stress and Health Study
    B Myers
    Alcohol and Drug Abuse Research Unit, Medical Research Council, Tygerberg, South Africa
    Afr J Psychiatry (Johannesbg) 14:38-44. 2011
    ..The extent to which this assumption holds for South African populations is unknown. This paper attempts to address this gap by examining the prevalence and correlates of atypical patterns of drug progression among South Africans...
  25. ncbi request reprint Post-traumatic stress disorder among recently diagnosed patients with HIV/AIDS in South Africa
    B O Olley
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    AIDS Care 17:550-7. 2005
    ..In some cases, PTSD is secondary to the diagnosis of HIV/AIDS but in most cases it is seen after other traumas, with sexual violation and intimate partner violence in women being particularly important...
  26. ncbi request reprint Selective serotonin reuptake inhibitors in the treatment of post-traumatic stress disorder: a meta-analysis of randomized controlled trials
    D J Stein
    MRC Research Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    Int Clin Psychopharmacol 15:S31-9. 2000
    ..In the interim, however, the SSRIs can be recommended as a first-line medication for the treatment of PTSD...
  27. ncbi request reprint Early life trauma decreases glucocorticoid receptors in rat dentate gyrus upon adult re-stress: reversal by escitalopram
    J D K Uys
    Medical Research Council Research Unit for Anxiety and Stress related Disorders, Department of Medical Physiology, University of Stellenbosch, Tygerberg, 7505 South Africa
    Neuroscience 137:619-25. 2006
    ....
  28. ncbi request reprint Determinants of unprotected sex among HIV-positive patients in South Africa
    B O Olley
    Medical Research Council Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    AIDS Care 17:1-9. 2005
    ..6, 95% CI = 0.45-0.96) were significantly associated with unprotected sex. These data suggest the need for interventions to further reduce sexual risk behaviours in HIV-positive patients in South Africa...
  29. ncbi request reprint Self-disclosure of HIV serostatus in recently diagnosed patients with HIV in South Africa
    B O Olley
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Afr J Reprod Health 8:71-6. 2004
    ..83, 1.88) were significantly associated with non-disclosure of HIV serostatus. Preventive strategies among HIV-positive patients should place emphasis on the management of self-disclosure and its importance in safe sexual behaviour...
  30. ncbi request reprint Violent trauma among child and adolescent girls: current knowledge and implications for clinicians
    D Kaminer
    University of Stellenbosch, Cape Town, South Africa
    Int Clin Psychopharmacol 15:S51-9. 2000
    ..The implications of current findings for clinical practice are discussed, in order to facilitate optimal assessment and treatment of young female victims of violence...
  31. doi request reprint Early maternal separation leads to down-regulation of cytokine gene expression
    J J Dimatelis
    Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Cape Town, South Africa
    Metab Brain Dis 27:393-7. 2012
    ..Further work is needed to delineate fully the relationship between early adversity, immune alterations, and behavioural changes...
  32. ncbi request reprint Psychosis and relapse in bipolar disorder are related to GRM3, DAOA, and GRIN2B genotype
    S Dalvie
    Division of Human Genetics, MRC UCT Human Genetics Research Unit, Faculty of Health Sciences, University of Cape Town Medical School, Observatory, Cape Town, South Africa
    Afr J Psychiatry (Johannesbg) 13:297-301. 2010
    ..In this pilot study, we investigated the frequency of SNP variants in these 3 genes within South African population groups, and assessed interactions between genes and phenotypes of BD disease severity...
  33. ncbi request reprint The selective serotonin reuptake inhibitor paroxetine is effective in more generalized and in less generalized social anxiety disorder
    D J Stein
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Psychopharmacology (Berl) 158:267-72. 2001
    ..There are, however, few data to address whether more generalized and less generalized subgroups of social anxiety disorder differ in response to medication...
  34. ncbi request reprint Predictors of response to pharmacotherapy with citalopram in obsessive-compulsive disorder
    D J Stein
    Department of Psychiatry, University of Stellebosch, Tygerberg, Cape Town, South Africa
    Int Clin Psychopharmacol 16:357-61. 2001
    ..The data here emphasize the crucial importance of early diagnosis and treatment of OCD, and of pharmacotherapy with appropriate dose and duration...
  35. ncbi request reprint Comparison of obsessive-compulsive disorder patients with and without comorbid putative obsessive-compulsive spectrum disorders using a structured clinical interview
    P L du Toit
    Medical Research Council Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Compr Psychiatry 42:291-300. 2001
    ..Further research, particularly genetic and neuroimmunological work, may ultimately be useful in validating the obsessive-compulsive spectrum...
  36. doi request reprint The effects of lobeline and naltrexone on methamphetamine-induced place preference and striatal dopamine and serotonin levels in adolescent rats with a history of maternal separation
    J J Dimatelis
    Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Cape Town, South Africa
    Metab Brain Dis 27:351-61. 2012
    ..However the data are consistent with the hypothesis that early life stress influences neurochemical pathways that predispose an individual to drug dependence...
  37. doi request reprint Predicting referral practices of traditional healers of their patients with a mental illness: an application of the Theory of Planned Behaviour
    K Sorsdahl
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    Afr J Psychiatry (Johannesbg) 16:35-40. 2013
    ..The present study applies the Theory of Planned Behaviour (TPB) to predict traditional healer referral practices of patients with a mental illness...
  38. ncbi request reprint A comparison of the effects of citalopram and moclobemide on resting brain perfusion in social anxiety disorder
    J M Warwick
    MRC Unit for Stress and Anxiety Disorders, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
    Metab Brain Dis 21:241-52. 2006
    ..In this study we investigate the effects of these compounds on resting brain function using single photon emission computed tomography (SPECT)...
  39. ncbi request reprint Gender differences in the prevalence of childhood sexual abuse and in the development of pediatric PTSD
    J L Walker
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Arch Womens Ment Health 7:111-21. 2004
    ..Further work is needed to explore the mechanisms that underlie these differences...
  40. ncbi request reprint Association between sexual violence and psychiatric morbidity among HIV positive women in South Africa
    B O Olley
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Afr J Med Med Sci 35:143-7. 2006
    ..As part of the comprehensive medical care of HIV, it is important that health workers assess past sexual abuse and current psychiatric symptoms...
  41. ncbi request reprint Sadistic personality disorder in perpetrators of human rights abuses: a South African case study
    D Kaminer
    Department of Psychology, University of Cape Town, Rondebosch 7701, Cape Town, South Africa
    J Pers Disord 15:475-86. 2001
    ..Implications for diagnostic criteria are discussed...
  42. ncbi request reprint An open trial of citalopram in adolescents with post-traumatic stress disorder
    S Seedat
    Department of Psychiatry, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Int Clin Psychopharmacol 16:21-5. 2001
    ..Citalopram was well-tolerated overall with reported adverse experiences being relatively benign. However, larger, controlled trials are needed to consolidate these preliminary results...
  43. ncbi request reprint Forgiveness: toward an integration of theoretical models
    D Kaminer
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg 7505, South Africa
    Psychiatry 63:344-57. 2000
    ..A new theoretical model, integrating the most valuable aspects of existing approaches, is proposed...
  44. ncbi request reprint The Truth and Reconciliation Commission in South Africa: relation to psychiatric status and forgiveness among survivors of human rights abuses
    D Kaminer
    Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    Br J Psychiatry 178:373-7. 2001
    ..Lack of forgiveness may be an important predictor of psychiatric risk in this population...
  45. ncbi request reprint Characteristics and phenomenology of hair-pulling: an exploration of subtypes
    P L du Toit
    Medical Research Council Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    Compr Psychiatry 42:247-56. 2001
    ..The present study provided limited support for the existence of possible subtypes of chronic hair-pulling. Recommendations are made for further investigations into such subtypes...
  46. ncbi request reprint Advances in the neurobiology of obsessive-compulsive disorder. Implications for conceptualizing putative obsessive-compulsive and spectrum disorders
    D J Stein
    Medical Research Council Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    Psychiatr Clin North Am 23:545-62. 2000
    ..Ultimately, the delineation of such mechanisms will allow for a more rigorous approach to the putative obsessive-compulsive spectrum disorders...
  47. doi request reprint Augmentation of cognitive behavioral therapy with pharmacotherapy
    K A Ganasen
    Department of Psychiatry, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa
    Psychiatr Clin North Am 33:687-99. 2010
    ..Issues for future research include delineating optimal dosing, and demonstrating effectiveness in real-world settings...
  48. doi request reprint Using a treatment partner and text messaging to improve adherence to psychotropic medication: a qualitative formative study of service users and caregivers in Cape Town, South Africa
    S Mall
    Alan J Flisher Centre for Public Mental Health, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    Afr J Psychiatry (Johannesbg) 16:364-70. 2013
    ..The intervention will entail the support of individuals with serious mental disorder by a treatment partner and short message service (SMS) text messaging...
  49. doi request reprint The neural correlates of intimate partner violence in women
    S J Flegar
    Department of Psychiatry, Stellenbosch University, South Africa
    Afr J Psychiatry (Johannesbg) 14:310-4. 2011
    ..To examine hippocampal volume and white matter tracts in women with and without intimate partner violence (IPV)...
  50. doi request reprint Resting brain perfusion in social anxiety disorder: a voxel-wise whole brain comparison with healthy control subjects
    J M Warwick
    MRC Unit for Stress and Anxiety Disorders, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
    Prog Neuropsychopharmacol Biol Psychiatry 32:1251-6. 2008
    ..SAD may be related to a dysregulation or hyperactivity of cortico-limbic circuitry. This is the first voxel-based whole brain study comparing resting function in SAD to a normal control group...
  51. ncbi request reprint Predictors of major depression in recently diagnosed patients with HIV/AIDS in South Africa
    B O Olley
    MRC Unit on Anxiety Disorders, Department of Psychiatry University of Stellenbosch, Cape Town, South Africa
    AIDS Patient Care STDS 18:481-7. 2004
    ..51, CI, 1.28, 1.80) predicted current major depression. It is well known from non-HIV populations that female gender and increased negative life events predict depression. These data also emphasize the importance of these links in HIV...
  52. ncbi request reprint Psychiatric research in South Africa: a systematic review of Medline publications
    J Fourie
    Department of Psychiatry, University of Stellenbosch
    Curationis 24:9-11. 2001
    ..Given the limited resources, and the nature of modern research, increased emphasis on collaboration seems advisable. A number of areas in psychiatry deserve particular attention from future researchers...
  53. ncbi request reprint A neuro-evolutionary approach to the anxiety disorders
    D J Stein
    Department of Psychiatry, University of Stellenbosch, South Africa
    J Anxiety Disord 11:409-29. 1997
    ..Although the theoretical basis for such an approach has become increasingly appealing over the last several years, this foundation requires supplementation by further empirical research...
  54. ncbi request reprint Serotonin and anxiety: current models
    D J Stein
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Int Clin Psychopharmacol 15:S1-6. 2000
    ....
  55. ncbi request reprint The psychobiology of obsessive-compulsive disorder: how important is the role of disgust?
    D J Stein
    Medical Research Council Unit on Anxiety Disorders, University of Stellenbosch, Cape Town, South Africa
    Curr Psychiatry Rep 3:281-7. 2001
    ....
  56. doi request reprint Differences in the association between childhood trauma and BMI in black and white South African women
    J H Goedecke
    Department of Human Biology, University of Cape Town, Cape Town, South Africa
    Afr J Psychiatry (Johannesbg) 16:201-5. 2013
    ..Childhood trauma has previously been associated with adult obesity. The aim of this study was to determine if ethnicity altered the relationship between childhood trauma and obesity in South African women...
  57. doi request reprint Psychiatric contributions from South Africa: ex Africa semper aliquid novi
    D J Stein
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    Afr J Psychiatry (Johannesbg) 15:323-8. 2012
    ..It briefly covers seminal contributions in evolutionary theory, psychotherapy, and neuroscience, as well as conceptual and practical contributions to reconciliation...
  58. doi request reprint Mental health services in South Africa: scaling up and future directions
    K Sorsdahl
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    Afr J Psychiatry (Johannesbg) 15:168-71. 2012
    ..New research is needed to determine what interventions work best in the South African context...
  59. doi request reprint Effects of maternal separation and methamphetamine exposure on protein expression in the nucleus accumbens shell and core
    J J Dimatelis
    Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory, 7925 Cape Town, South Africa
    Metab Brain Dis 27:363-75. 2012
    ....
  60. ncbi request reprint The effects of repeated intra-amygdala CRF injections on rat behavior and HPA axis function after stress
    W M U Daniels
    Department of Medical Physiology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Western Cape, South Africa
    Metab Brain Dis 19:15-23. 2004
    ..These findings may have important implications for patients suffering from psychiatric illnesses such as posttraumatic stress disorder and depression that are characterized by abnormalities in cortisol release...
  61. doi request reprint Maternal separation exaggerates the toxic effects of 6-hydroxydopamine in rats: implications for neurodegenerative disorders
    I S Pienaar
    Division of Medical Physiology, Department of Biomedical Sciences, University of Stellenbosch, Tygerberg, South Africa
    Stress 11:448-56. 2008
    ....
  62. ncbi request reprint Muscle dysmorphia: a South African sample
    V Hitzeroth
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Psychiatry Clin Neurosci 55:521-3. 2001
    ..Its conceptualization as a subtype of BDD seems valid. The disorder deserves additional attention from both clinicians and researchers...
  63. ncbi request reprint Pharmacotherapy for post-traumatic stress disorder - a systematic review and meta-analysis
    J Ipser
    Medical Research Council Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Western Cape, South Africa
    S Afr Med J 96:1088-96. 2006
    ..Post-traumatic stress disorder (PTSD) is a prevalent and disabling condition. Evidence that PTSD is characterized by specific psychobiological dysfunctions has contributed to a growing interest in use of medication in its treatment...
  64. ncbi request reprint Serotonergic targets in the treatment of antidepressant induced sexual dysfunction: a pilot study of granisetron and sumatriptan
    M Berk
    Department of Psychiatry, University of the Witwatersrand Medical School, Parktown, Johannesburg, South Africa
    Int Clin Psychopharmacol 15:291-5. 2000
    ....
  65. ncbi request reprint Violence in male patients with schizophrenia: risk markers in a South African population
    L Koen
    Department of Psychiatry, PO Box 19063, Tygerberg, 7505, South Africa
    Aust N Z J Psychiatry 38:254-9. 2004
    ....
  66. ncbi request reprint Use of the selective serotonin reuptake inhibitor citalopram in treatment of trichotillomania
    D J Stein
    Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    Eur Arch Psychiatry Clin Neurosci 247:234-6. 1997
    ..Given the relatively low response rate, however, a controlled trial is needed before this agent can be said to be more effective than placebo. The pharmacotherapy of trichotillomania deserves further study...
  67. ncbi request reprint Trauma exposure and post-traumatic stress symptoms in urban African schools. Survey in CapeTown and Nairobi
    S Seedat
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Capetown, South Africa
    Br J Psychiatry 184:169-75. 2004
    ..There is a lack of comparative data on the prevalence and effects of exposure to violence in African youth...
  68. ncbi request reprint Willingness to participate in HIV vaccine research in a peri-urban South African community
    J Smit
    MRC Unit for Anxiety and Stress Disorders, University of Stellenbosch, South Africa
    Int J STD AIDS 17:176-9. 2006
    ..40-26.12). These results suggest that while willingness to participate in HIV vaccine trials is relatively low in this setting, educational campaigns may have a substantial impact on individuals' willingness to participate in research...
  69. ncbi request reprint Pathological gambling behaviour: emergence secondary to treatment of Parkinson's disease with dopaminergic agents
    S Seedat
    Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    Depress Anxiety 11:185-6. 2000
    ..Pharmacotherapeutic management of pathological gambling secondary to medical causes deserves further study...
  70. doi request reprint Proteomic analysis reveals differentially expressed proteins in the rat frontal cortex after methamphetamine treatment
    J J Faure
    Division of Medical Physiology, University of Stellenbosch, Tygerberg, South Africa
    Metab Brain Dis 24:685-700. 2009
    ..Proteomic research may be useful in exploring the complex underlying molecular mechanisms of MA dependence...
  71. ncbi request reprint Trauma and post-traumatic stress disorder in women: a review
    S Seedat
    Department of Psychiatry, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Int Clin Psychopharmacol 15:S25-33. 2000
    ..This article reviews gender differences in exposure to trauma and subsequent PTSD, emphasizing those features that characterize trauma and PTSD in women...
  72. ncbi request reprint Mental health literacy: focus on developing countries
    K A Ganasen
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Afr J Psychiatry (Johannesbg) 11:23-8. 2008
    ..It is likely that strategies for improvement will need to be comprehensive and innovative, taking advantage of opportunities and meeting challenges faced in the developing world...
  73. ncbi request reprint A risk-benefit assessment of pharmacotherapy for anxiety disorders in children and adolescents
    S M Hawkridge
    Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    Drug Saf 19:283-97. 1998
    ..The decision to use pharmacotherapy should be made after consideration of multiple factors, and firm recommendations for the use of drug therapy in anxiety disorders in children and adolescents await more rigorous data...
  74. ncbi request reprint Maternal separation in rats leads to anxiety-like behavior and a blunted ACTH response and altered neurotransmitter levels in response to a subsequent stressor
    W M U Daniels
    Department of Medical Physiology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, Western Cape, South Africa
    Metab Brain Dis 19:3-14. 2004
    ..We conclude that maternal separation induced abnormal behaviors and stress responses that were associated with altered neurotransmitter levels...
  75. ncbi request reprint Moclobemide is effective and well tolerated in the long-term pharmacotherapy of social anxiety disorder with or without comorbid anxiety disorder
    D J Stein
    Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Int Clin Psychopharmacol 17:161-70. 2002
    ..These data confirm and extend previous findings on the value of moclobemide in the treatment of social anxiety disorder, and strengthen the range of therapeutic options for managing this important disorder...
  76. ncbi request reprint Intoxication, criminal offences and suicide attempts in a group of South African problem drinkers
    A Allan
    Forensic Psychology Programme, Edith Cowan University, Perth, Australia
    S Afr Med J 91:145-50. 2001
    ..CONCLUSIONS: There was an association between intoxication and both violent crime and suicide attempts. The importance of population studies and the need for intervention programmes aimed at teenagers who are drinking, are emphasised...
  77. ncbi request reprint Improvement of quality of life in panic disorder with escitalopram, citalopram, or placebo
    B Bandelow
    Department of Psychiatry and Psychotherapy, University of Gottingen, Gottingen, Germany
    Pharmacopsychiatry 40:152-6. 2007
    ..It has been argued that measurement of outcome in panic disorder should not be limited to monitoring the number of panic attacks, but should include all domains that affect patient quality of life...
  78. ncbi request reprint Olfactory reference syndrome: diagnostic criteria and differential diagnosis
    C Lochner
    MRC Unit on Stress and Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    J Postgrad Med 49:328-31. 2003
    ....
  79. ncbi request reprint The effects of co-morbidity on the onset and persistence of generalized anxiety disorder in the ICPE surveys. International Consortium in Psychiatric Epidemiology
    R C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115 5899, USA
    Psychol Med 32:1213-25. 2002
    ..These associations are examined in the current report using data from four community surveys in the World Health Organization (WHO) International Consortium in Psychiatric Epidemiology (ICPE)...
  80. ncbi request reprint Maternal aggression in Wistar rats: effect of 5-HT2A/2C receptor agonist and antagonist microinjected into the dorsal periaqueductal gray matter and medial septum
    R M M de Almeida
    Laboratorio de Neurociencias, Centro 2, UNISINOS, Sao Leopoldo, RS, Brasil
    Braz J Med Biol Res 38:597-602. 2005
    ..We interpret these findings as evidence for a specific role of 5-HT2A/2C receptors in the DPAG in the inhibition of female aggressive behavior, dissociated from those on motor activity...
  81. pmc Twelve-month mental disorders in South Africa: prevalence, service use and demographic correlates in the population-based South African Stress and Health Study
    D R Williams
    Harvard University School of Public Health, Boston, MA, USA
    Psychol Med 38:211-20. 2008
    ..South Africa's history and current social conditions suggest that mental disorders are likely to be a major contributor to disease burden, but there has been no national study using standardized assessment tools...
  82. ncbi request reprint Obsessive-compulsive disorder with poor insight
    H Matsunaga
    Department of Neuropsychiatry, Osaka City University Medical School, Osaka, Japan
    Compr Psychiatry 43:150-7. 2002
    ..OCD patients demonstrate a range of insight with PI accompanied by significant dysfunction. Comorbid SPD in PI patients may be associated with worse prognosis...
  83. ncbi request reprint Barriers to treatment among members of a mental health advocacy group in South Africa
    S Seedat
    Department of Psychiatry, University of California San Diego, La Jolla 92037, USA
    Soc Psychiatry Psychiatr Epidemiol 37:483-7. 2002
    ....
  84. ncbi request reprint Treatment utilisation and trauma characteristics of child and adolescent inpatients with posttraumatic stress disorder
    A Traut
    Curationis 25:67-72. 2002
    ..This study was undertaken to document demographic, clinical, and treatment characteristics of child and adolescent inpatients with PTSD...
  85. ncbi request reprint Treatment utilisation and trauma characteristics of child and adolescent inpatients with posttraumatic stress disorder
    A Traut
    Department of Nursing, University of the Western Cape
    Curationis 26:44-8. 2003
    ..This study was undertaken to document demographic, clinical, and treatment characteristics of child and adolescent inpatients with PTSD...
  86. ncbi request reprint Selective serotonin reuptake inhibitors in children and adolescents
    S M Hawkridge
    S Afr Med J 96:82-4. 2006
  87. ncbi request reprint Depression-anxiety relationships with chronic physical conditions: results from the World Mental Health Surveys
    K M Scott
    Department of Psychological Medicine, Wellington School of Medicine and Health Sciences, PO Box 7343 Wellington South, New Zealand
    J Affect Disord 103:113-20. 2007
    ....
  88. ncbi request reprint Challenges faced by South African health services in implementing the Mental Health Care Act
    C Lund
    S Afr Med J 97:352-3. 2007
  89. ncbi request reprint Quetiapine augmentation of serotonin reuptake inhibitors in obsessive-compulsive disorder
    N Mohr
    MRC Unit on Anxiety Disorders, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Int Clin Psychopharmacol 17:37-40. 2002
    ..Quetiapine, a relatively well tolerated agent, deserves further controlled study in this context...
  90. ncbi request reprint Attitudes towards and beliefs about schizophrenia in Xhosa families with affected probands
    N I Mbanga
    Department of Psychiatry, University of Stellenbosch
    Curationis 25:69-73. 2002
    ..In order to establish the need for adaptation of Western psychoeducational programs, these variables were investigated in Xhosa speaking families in South Africa...
  91. ncbi request reprint Consensus statement on generalized anxiety disorder from the International Consensus Group on Depression and Anxiety
    J C Ballenger
    Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, SC 29425-0742, USA
    J Clin Psychiatry 62:53-8. 2001
    ..Cognitive-behavioral therapy is the preferred form of psychotherapy for GAD, although when GAD is comorbid with depression, pharmacotherapy is increasingly indicated...
  92. ncbi request reprint Association between a catechol-o-methyltransferase polymorphism and obsessive-compulsive disorder in the Afrikaner population
    D J Niehaus
    Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    J Affect Disord 65:61-5. 2001
    ..The present association study assessed the risk for OCD conferred by this COMT polymorphism in a geographically different patient group, namely, the relatively genetically homogeneous Afrikaner population of South Africa...
  93. ncbi request reprint Identification of polysubstance abuse in the parturient
    D J Birnbach
    Department of Anesthesiology and Obstetrics and Gynecology, St Luke's-Roosevelt Hospital Center, College of Physicians and Surgeons of Columbia University, 1000 Tenth Ave, New York, NY 10019, USA
    Br J Anaesth 87:488-90. 2001
    ..TesTcup is a clinically accurate test that allows the rapid assessment of several drugs of abuse, which may impact on anaesthetic care...
  94. ncbi request reprint Obsessive-compulsive disorder and a novel polymorphism adjacent to the oestrogen response element (ERE 6) upstream from the COMT gene
    C Kinnear
    MRC US Centre for Molecular and Cellular Biology, University of Stellenbosch, Tygerberg, South Africa
    Psychiatr Genet 11:85-7. 2001
    ..93) or gender (P = 0.67). These findings, although limited by a small sample size, suggest that the novel polymorphism adjacent to ERE 6 in the promoter area of COMT does not play a major role in the genetic predisposition to OCD...
  95. ncbi request reprint Land of promise: challenges and opportunities for research in South Africa
    S Seedat
    Mol Psychiatry 9:891-2. 2004