Research Topics
| A D SteeleSummaryAffiliation: University of Limpopo Country: South Africa Publications
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Detail Information
Publications
Characterization of rotavirus infection in a hospital neonatal unit in Pretoria, South AfricaDuncan Steele
MRC Medunsa Diarrhoeal Pathogens Research Unit, Pretoria, South Africa
J Trop Pediatr 48:167-71. 2002..The strains were all characterized as G4P[6], which is similar to the antigenic make-up of the virus recovered 10 years before. This highlights the remarkable stability of rotavirus strains in neonatal units over long periods of time...
Seroepidemiology of human group C rotavirus in South AfricaA D Steele
MRC Medunsa Diarrhoeal Pathogens Research Unit, Medical University of Southern Africa, Pretoria, South Africa
J Clin Microbiol 37:4142-4. 1999..4% (range, 33 to 38%), with almost half of the population infected after the age of 20 years...- Comparative studies of human rotavirus serotype G8 strains recovered in South Africa and the United KingdomA D Steele
MRC Medunsa Diarrhoeal Pathogens Research Unit, PO Box 173, Medunsa 0204, Pretoria, South Africa
J Gen Virol 80:3029-34. 1999..The other two were subgroup I with a short RNA electropherotype. None of these strains exhibited the super-short RNA electropherotype described in the prototype G8 strains recovered from Indonesia (69M)... - Circulation of the novel G9 and G8 rotavirus strains in Nigeria in 1998/1999A D Steele
MRC Medunsa Diarrhoeal Pathogens Research Unit, Medical University of Southern Africa, Pretoria, South Africa
J Med Virol 67:608-12. 2002..Four G8 strains were detected and only one G2 and no G4 strains were identified. This report extends the description of the global distribution of G9 rotavirus strains... - Rotavirus immunisation in Africa: a perspective re-visitedDuncan Steele
MRC/MEDUNSA Diarrhoeal Pathogens Research Unit, Medunsa 0204, South Africa
Afr J Health Sci 9:113-6. 2002 - Anticipating rotavirus vaccines: epidemiology and surveillance of rotavirus in South AfricaA D Steele
MRC Medunsa Diarrhoeal Pathogens Research Unit, PO Box 173, Medunsa 0204, Pretoria, South Africa
Vaccine 21:354-60. 2003..The circulating rotavirus types observed in this study add to the knowledge of the natural history of rotavirus infection and provide the groundwork to consider future vaccine strategies... - Rotavirus strains circulating in Africa during 1996-1999: emergence of G9 strains and P[6] strainsA D Steele
MRC Diarrhoeal Pathogens Research Unit, PO Box 173, Medunsa, 0204, Pretoria, South Africa
Vaccine 21:361-7. 2003..G9 was the predominant strain in certain countries during 1999. The circulating types observed will have implications for the new rotavirus vaccine candidates... 
Comparison of 2 different regimens for reactogenicity, safety, and immunogenicity of the live attenuated oral rotavirus vaccine RIX4414 coadministered with oral polio vaccine in South African infantsA D Steele
MRC Diarrhoeal Pathogens Research Unit, University of Limpopo, Pretoria, Republic of South Africa
J Infect Dis 202:S93-100. 2010....- Study of Norwalk virus and Mexico virus infections at Ga-Rankuwa Hospital, Ga-Rankuwa, South AfricaT K Smit
Department of Virology, Medical University of Southern Africa, South Africa
J Clin Microbiol 35:2381-5. 1997..Although the viral antigens are not highly prevalent in diarrheal stools, it was determined by the two assays for NV and MxV that children are, nevertheless, infected early in life... - Characterization and molecular epidemiology of rotavirus strains recovered in Northern Pretoria, South Africa during 2003-2006L M Seheri
University of Limpopo, Pretoria, South Africa
J Infect Dis 202:S139-47. 2010..In addition, unusual G12P[6] and G8 strains were detected at a low frequency. These results reflect the diversity of rotavirus strains circulating in South African communities... - A first report on the characterization of rotavirus strains in Sierra LeoneK C Jere
MRC Diarrhoeal Pathogens Research Unit, Department of Virology, University of Limpopo Medunsa Campus, Pretoria, South Africa
J Med Virol 83:540-50. 2011..Such information will be useful before considering administration of specific rotavirus vaccine candidates in countries like Sierra Leone where little is known about circulating rotavirus strains... - Antigenic and genetic characterization of serotype G2 human rotavirus strains from South Africa from 1984 to 1998N A Page
MRC Medunsa Diarrhoeal Pathogens Research Unit, Medical University of Southern Africa, Medunsa, South Africa
J Med Virol 72:320-7. 2004..The use of monoclonal antibodies and PCR primers designed against older G2 strains has resulted in the failure to serotype G2 strains circulating currently... - Antigenic and genetic characterization of serotype G2 human rotavirus strains from the African continentN A Page
MRC Medunsa Diarrhoeal Pathogens Research Unit, Medical University of Southern Africa, Medunsa 0204, South Africa
J Clin Microbiol 42:595-600. 2004.... - Prevalence of rotavirus, adenovirus and astrovirus infection in young children with gastroenteritis in Gaborone, BotswanaG Basu
MRC Diarrhoel Path Research Unit, Pretoria, South Africa
East Afr Med J 80:652-5. 2003..The prevalence rate of adenovirus and astrovirus is similar to other studies in parts of Southern Africa. However, continued enteric virus surveillance and epidemiology amongst this group is required... - Co-administration study in South African infants of a live-attenuated oral human rotavirus vaccine (RIX4414) and poliovirus vaccinesA D Steele
MRC Diarrhoeal Pathogens Research Unit, Medunsa, Pretoria, South Africa
Vaccine 28:6542-8. 2010..This study provided evidence that RIX4414 can be co-administered with routine EPI immunizations including OPV and that two doses of RIX4414 were well tolerated and immunogenic in South African infants... - Central nervous system involvement in neonatal rotavirus infectionF P R de Villiers
Department of Paediatrics and Child Health, Medunsa, South Africa
Ann Trop Paediatr 23:309-12. 2003..One had apnoea, the other no CNS symptoms. Although rotavirus infection in neonates is hardly ever asymptomatic and may cause death, it has not been associated with CNS symptomatology in our studies... - Rotavirus epidemiology: the Asian Rotavirus Surveillance NetworkE A S Nelson
Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
Vaccine 26:3192-6. 2008.... - Molecular characterization of unusual human G5P[6] rotaviruses identified in ChinaDan di Li
National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China
J Clin Virol 42:141-8. 2008..We found an unusual human rotavirus, LL36755 of G5P[6] genotype, in a stool sample collected in Lulong County, Hebei Province, China. This is the first detection of rotavirus serotype G5 in Asia... - [Investigation of human calicivirus (HuCV) diarrhea among infantile and young children in China, 1999--2005]Zhao Yin Fang
National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China
Bing Du Xue Bao 23:9-15. 2007.... - Evaluation of recombinant BCG expressing rotavirus VP6 as an anti-rotavirus vaccineMaureen Dennehy
Division of Medical Virology, Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, and National Health Laboratory Service, Groote Schuur Hospital, Cape Town, South Africa
Vaccine 25:3646-57. 2007..Protection occurred in the absence of detectable anti-rotavirus antibody in serum or faeces, implicating cellular immunity in protection... - Novel human rotavirus of genotype G5P[6] identified in a stool specimen from a Chinese girl with diarrheaZhao Jun Duan
National Institute for Viral Disease Control and Prevention, Beijing, China
J Clin Microbiol 45:1614-7. 2007..5% homologous to those of the porcine P[6] strains 134/04-10, 134/04-11, 221/04-7, and 221/04-13. Our findings indicate a dynamic interaction between human and porcine rotaviruses... - Rotavirus vaccine for developing countriesDuncan Steele
Lancet 372:444-5; author reply 445. 2008 - What is a safe vaccine?Duncan Steele
Vaccine 20:1481-2. 2002 - Microbial-gut interactions in health and disease. Progress in enteric vaccine developmentAnn Mari Svennerholm
Department of Medical Microbiology and Immunology, and Göteborg University Vaccine Institute GUVAX, Goteborg University, P O Box 435, Goteborg S 405 30, Sweden
Best Pract Res Clin Gastroenterol 18:421-45. 2004..In this chapter we describe the properties and availability of the recently licensed vaccines and present an update on the diverse efforts being made to achieve new or improved vaccines against the most prevalent enteropathogens...