Research Topics
Species | Gayle G ShermanSummaryAffiliation: University of the Witwatersrand Country: South Africa Publications
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Detail Information
Publications
Evaluation of seven rapid HIV tests to detect HIV-exposure and seroreversion during infancyGayle G Sherman
Wits Paediatric HIV Clinics, Wits Health Consortium, University of the Witwatersrand, 8 Blackwood Avenue, Parktown, Johannesburg, South Africa
J Clin Virol 43:313-6. 2008..Failure to determine the HIV status of all pregnant women impedes progress in preventing and treating paediatric HIV because vertically exposed infants are not identified for prophylaxis, early HIV diagnosis and care...- The performance of 5 rapid HIV tests using whole blood in infants and children: selecting a test to achieve the clinical objectiveGayle G Sherman
Department of Molecular Medicine and Haematology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Pediatr Infect Dis J 31:267-72. 2012..This study aimed to assess the accuracy of rapid tests for detecting HIV exposure, excluding HIV infection in HIV-exposed infants, and diagnosing HIV infection in children older than 18 months of age... - Oral fluid tests for screening of human immunodeficiency virus-exposed infantsGayle G Sherman
Department of Molecular Medicine and Haematology, Medical School, University of the Witwatersrand, Parktown, Johannesburg, South Africa
Pediatr Infect Dis J 29:169-72. 2010..This first assessment of 2 rapid oral fluid HIV tests in early infancy demonstrates a sensitivity of <90% for detection of HIV-exposure resulting in failure to detect at least 1 in 10 HIV-infected infants... 
Polymerase chain reaction for diagnosis of human immunodeficiency virus infection in infancy in low resource settingsGayle G Sherman
Department of Molecular Medicine and Haematology, National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa
Pediatr Infect Dis J 24:993-7. 2005..The performance of an HIV-1 DNA polymerase chain reaction (PCR) test, and in particular a single test at 6 weeks of age, in diagnosing HIV subtype C infection acquired in utero or peripartum was assessed...- Is early HIV testing of infants in poorly resourced prevention of mother to child transmission programmes unaffordable?Gayle G Sherman
Department of Molecular Medicine and Haematology, National Health Laboratory Service and University of the Witwatersrand, Senderwood, Johannesburg, South Africa
Trop Med Int Health 10:1108-13. 2005..The cost of diagnosing HIV infection earlier in infancy was measured... - Dried blood spots improve access to HIV diagnosis and care for infants in low-resource settingsGayle G Sherman
Department of Molecular Medicine and Haematology, National Health Laboratory Service and University of the Witwatersrand, Johannesburg, South Africa
J Acquir Immune Defic Syndr 38:615-7. 2005..The Roche Amplicor assay yielded a sensitivity of 100% and a specificity of 99.6%. HIV DNA PCR tests on dried blood spots have the potential to improve health care delivery to HIV-affected children in low-resource settings right now... 
Natural killer cells that respond to human immunodeficiency virus type 1 (HIV‐1) peptides are associated with control of HIV‐1 infectionCaroline T Tiemessen
AIDS Virus Research Unit, National Institute for Communicable Diseases and Department of Virology, Coronation Women and Children Hospital, Enhancing Childhood HIV Outcomes, University of the Witwatersrand, Johannesburg, South Africa
J Infect Dis 202:1444-53. 2010..Peptide‐specific natural killer cells are associated with markers of less severe disease progression among HIV‐1-infected women (lower viral load and higher CD4 T cell count) and with stronger HIV‐specific T cell responses...- Natural killer cell responses to HIV-1 peptides are associated with more activating KIR genes and HLA-C genes of the C1 allotypeCaroline T Tiemessen
National Institute for Communicable Diseases, Johannesburg, South Africa
J Acquir Immune Defic Syndr 57:181-9. 2011..What characterizes individuals whose natural killer (NK) cells are able to respond to HIV-1 peptides is not known... - Evaluation of dried whole blood spots obtained by heel or finger stick as an alternative to venous blood for diagnosis of human immunodeficiency virus type 1 infection in vertically exposed infants in the routine diagnostic laboratoryJanet C Patton
Wits Pediatric HIV Clinics, Wits Health Consortium, University of the Witwatersrand, Johannesburg, Gauteng, South Africa
Clin Vaccine Immunol 14:201-3. 2007..The methodologies transfer successfully from the labor-intensive research laboratory to the high-throughput automated routine laboratory... - Oral fluid human immunodeficiency virus tests: improved access to diagnosis for infants in poorly resourced prevention of mother to child transmission programsGayle G Sherman
Department of Molecular Medicine and Haematology, National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa
Pediatr Infect Dis J 24:253-6. 2005..CONCLUSIONS: OF HIV tests perform well in children and have the potential to increase accessibility and acceptability of HIV diagnosis for infants in the context of PMTCT programs in low resource settings... - Affordable diagnosis of human immunodeficiency virus infection in infants by p24 antigen detectionGayle G Sherman
Department of Molecular Medicine and Haematology, National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa
Pediatr Infect Dis J 23:173-6. 2004..A sensitivity of 98.1% and specificity of 98.7% was obtained testing 203 samples from 24 HIV-infected and 66 uninfected infants born to HIV subtype C-infected women... - Host CCL3L1 gene copy number in relation to HIV-1-specific CD4+ and CD8+ T-cell responses and viral load in South African womenSharon Shalekoff
AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa
J Acquir Immune Defic Syndr 48:245-54. 2008..017), and women who had CD4 and CD8 Gag-specific responses had significantly lower viral loads (P=0.004) and higher CCL3L1 copy number (P=0.015) than those women with only CD8 Gag-specific responses... - KIR-HLA and maternal-infant HIV-1 transmission in sub-Saharan AfricaMaria Paximadis
AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa
PLoS ONE 6:e16541. 2011..In conclusion this study has identified a number of significant associations that suggest an important role for NK cells in maternal-to-infant HIV-1 transmission... - Low risk of contamination with automated and manual excision of dried blood spots for HIV DNA PCR testing in the routine laboratoryGlenn A Driver
Wits Paediatric HIV Clinics, Wits Health Consortium, 8 Blackwood Avenue, Parktown, Johannesburg, South Africa
J Virol Methods 146:397-400. 2007.... - Evaluation of the ultrasensitive human immunodeficiency virus type 1 (HIV-1) p24 antigen assay performed on dried blood spots for diagnosis of HIV-1 infection in infantsJanet C Patton
Wits Pediatric HIV Clinics, Wits Health Consortium, University of the Witwatersrand, Johannesburg, South Africa
Clin Vaccine Immunol 15:388-91. 2008..5% to 98.3%). Laboratory services with limited resources should assess this option for routine infant diagnosis... - Early diagnosis of in utero and intrapartum HIV infection in infants prior to 6 weeks of ageRivka R Lilian
Paediatric HIV Diagnostic Syndicate, Wits Health Consortium, Johannesburg, South Africa
J Clin Microbiol 50:2373-7. 2012..CAP/CTM was the only assay with 100% specificity at all ages. Testing at birth versus 6 weeks of age identifies a higher total number of HIV-infected infants, irrespective of the assay... - Ultrasensitive human immunodeficiency virus type 1 p24 antigen assay modified for use on dried whole-blood spots as a reliable, affordable test for infant diagnosisJanet C Patton
Wits Paediatric HIV Unit, Wits Health Consortium, University of the Witwatersrand, 7 York Rd, Parktown 2193, Johannesburg, South Africa
Clin Vaccine Immunol 13:152-5. 2006..1 filter paper. The modified assay was found to be reliable and accurate, making it an affordable tool for pediatric HIV diagnosis in developing countries... - CD38 expression on CD8(+) T cells as a prognostic marker in vertically HIV-infected pediatric patientsGayle G Sherman
Department of Haematology and Molecular Medicine, School of Pathology, South African Institute for Medical Research, Johannesburg, South Africa
Pediatr Res 51:740-5. 2002..043). These findings support the view that increased CD38 expression on CD8(+) T cells has the same prognostic significance in pediatric as in adult HIV disease... - Can clinical algorithms deliver an accurate diagnosis of HIV infection in infancy?Stephanie A Jones
Bull World Health Organ 83:559-60. 2005 - Infant human immunodeficiency virus diagnosis in resource-limited settings: issues, technologies, and country experiencesTracy L Creek
Centers for Disease Control and Prevention National Center for HIV, Hepatitis, STD, TB Prevention Global AIDS Program, Atlanta, GA 30333, USA
Am J Obstet Gynecol 197:S64-71. 2007..This paper reviews challenges and progress in the field and suggests ways to facilitate early infant testing in resource-limited settings... - African infants' CCL3 gene copies influence perinatal HIV transmission in the absence of maternal nevirapineLouise Kuhn
Gertrude H Sergievsky Centre, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
AIDS 21:1753-61. 2007..We investigated whether maternal or infant CCL3L1 gene copy numbers are associated with perinatal HIV transmission when single-dose nevirapine is given for prevention... - PMTCT programme--partial assessments can build the pictureGayle G Sherman
S Afr Med J 94:934. 2004