Alison V September
Affiliation: University of Cape Town
Country: South Africa
Lulińska Kuklik E, Rahim M, Moska W, Maculewicz E, Kaczmarczyk M, Maciejewska Skrendo A, et al
. Are MMP3, MMP8 and TIMP2 gene variants associated with anterior cruciate ligament rupture susceptibility?. J Sci Med Sport. 2019;: pubmed publisher
..05-1.81). These results support the hypothesis that genetic variation within MMP3 contributes to inter-individual susceptibility to non-contact ACLR. However, these results need to be explored further in larger, independent sample sets. ..
Rahim M, Mannion S, Klug B, Hobbs H, van der Merwe W, Posthumus M, et al
. Modulators of the extracellular matrix and risk of anterior cruciate ligament ruptures. J Sci Med Sport. 2017;20:152-158 pubmed publisher
..Furthermore, these genetic variants may potentially modulate ECM remodelling in response to loading and ultimately contribute to ligament capacity. ..
Mc Fie S, Abrahams S, Patricios J, Suter J, Posthumus M, September A. The association between harm avoidance personality traits and self-reported concussion history in South African rugby union players. J Sci Med Sport. 2018;21:16-21 pubmed publisher
..Contrasting associations in the professional cohort suggest further research is required to understand the role of personality in concussion. ..
September A, Rahim M, Collins M. Towards an Understanding of the Genetics of Tendinopathy. Adv Exp Med Biol. 2016;920:109-16 pubmed publisher
..Through collaboration, our chances of harnessing these "omics" technologies to further our clinical understanding of tendinopathy will increase. ..
Abrahams S, Mc Fie S, Patricios J, Suter J, Posthumus M, September A. An association between polymorphisms within the APOE gene and concussion aetiology in rugby union players. J Sci Med Sport. 2018;21:117-122 pubmed publisher
..Although similar preliminary results were found when juniors were separately analysed, the under-powered sample size for junior subgroup requires future investigation in larger cohorts of junior-level athletes. ..
Willard K, Mannion S, Saunders C, Collins M, September A. The interaction of polymorphisms in extracellular matrix genes and underlying miRNA motifs that modulate susceptibility to anterior cruciate ligament rupture. J Sci Med Sport. 2018;21:22-28 pubmed publisher
..The biological significance of these genomic signatures needs to be explored to understand their effect on the ligaments functional capacity. ..